Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget’s disease

Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma

(2018) Reka P. Toth et al.   Frontiers in Immunology

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

(2017) Isabel Jaco et al.   MOLECULAR CELL

Age-dependent Changes in the Articular Cartilage and Subchondral Bone of C57BL/6 Mice after Surgical Destabilization of Medial Meniscus

(2017) Henry Huang et al.   Scientific Reports

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling

(2016) Karolina Slowicka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The TBK1-binding domain of optineurin promotes type I interferon responses

(2016) Netra Pal Meena et al.   FEBS LETTERS

Measles virus nucleocapsid protein increases osteoblast differentiation in Paget’s disease

(2016) Jumpei Teramachi et al.   JOURNAL OF CLINICAL INVESTIGATION

Men and mice: Relating their ages

(2016) Sulagna Dutta et al.   LIFE SCIENCES

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

(2016) Yasushi Ito et al.   SCIENCE

Cellular Functions of Optineurin in Health and Disease

(2016) Karolina Slowicka et al.   TRENDS IN IMMUNOLOGY

Visual impairment in an optineurin mouse model of primary open-angle glaucoma

(2015) Henry C. Tseng et al.   NEUROBIOLOGY OF AGING

Bone turnover markers in Paget’s disease of the bone: A Systematic review and meta-analysis

(2015) A. A. Al Nofal et al.   OSTEOPOROSIS INTERNATIONAL

Sexual Dimorphism in MAPK-Activated Protein Kinase-2 (MK2) Regulation of RANKL-Induced Osteoclastogenesis in Osteoclast Progenitor Subpopulations

(2015) Bethany A. Herbert et al.   PLoS One

Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-κB and Interferon Signaling: Implications for Paget’s Disease

(2015) Rami Obaid et al.   Cell Reports

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

Genetics of Paget’s Disease of Bone

(2014) Stuart H. Ralston et al.   Current Osteoporosis Reports

Increased IL-6 Expression in Osteoclasts Is Necessary But Not Sufficient for the Development of Paget's Disease of Bone

(2013) Jumpei Teramachi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation

(2013) Yan Xiu et al.   JOURNAL OF CLINICAL INVESTIGATION

Optineurin Insufficiency Impairs IRF3 but Not NF- B Activation in Immune Cells

(2013) I. Munitic et al.   JOURNAL OF IMMUNOLOGY

NF-κB signaling and bone resorption

(2013) Y. Abu-Amer   OSTEOPOROSIS INTERNATIONAL

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis

(2012) Neng-Yu Lin et al.   ANNALS OF THE RHEUMATIC DISEASES

Mutant p62P392LStimulation of Osteoclast Differentiation in Paget's Disease of Bone

(2011) Kumaran Sundaram et al.   ENDOCRINOLOGY

RANKL/RANK—beyond bones

(2011) Reiko Hanada et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone

(2010) Omar M E Albagha et al.   NATURE GENETICS

Myosin VI and Optineurin Are Required for Polarized EGFR Delivery and Directed Migration

(2010) Margarita V. Chibalina et al.   TRAFFIC

Paget’s Disease of Bone: Histologic Analysis of 754 Patients

(2008) Sebastian Seitz et al.   JOURNAL OF BONE AND MINERAL RESEARCH