Article
Geriatrics & Gerontology
Rui Liang, Xiaopeng Shen, Fan Wang, Xin Wang, Alex DesJarlais, Anam Syed, Raymond Saba, Zhi Tan, Fang Yu, Xuan Ji, Shreesti Shrestha, Yinghong Ren, Jin Yang, Yoonjung Park, Robert J. Schwartz, Benjamin Soibam, Bradley K. McConnell, M. David Stewart, Ashok Kumar, Yu Liu
Summary: The study reveals that H19X microRNAs regulate skeletal muscle growth and atrophy by controlling the abundance of translation initiation factors, affecting protein synthesis. It highlights the crucial role of translation initiation factors in multiple signaling pathways that control skeletal muscle mass.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Biochemistry & Molecular Biology
Erin A. Nekritz, Ruth Rodriguez-Barrueco, Koon-Kiu Yan, Meredith L. Davis, Rachel L. Werner, Laura Devis-Jauregui, Partha Mukhopadhyay, Jiyang Yu, David Llobet-Navas, Jose Silva
Summary: The miR-424/503 cluster plays a crucial role in regulating Wnt signaling, MaSC fate, and breast cancer development, with its function involving targeting the LRP6 co-receptor to reduce its expression.
Article
Cell Biology
Victoria Zyulina, Koon-Kiu Yan, Bensheng Ju, Elke Schwarzenberger, Christina Passegger, Carmen Tam-Amersdorfer, Qingfei Pan, Tommaso Sconocchia, Christian Pollack, Bridget Shaner, Armin Zebisch, John Easton, Jiyang Yu, Jose M. Silva, Herbert Strobl
Summary: The TGF-beta family ligands play a crucial role in dendritic cell differentiation and activation. Through investigating differentially expressed microRNAs, it was found that miR-424/503 is significantly inversely regulated between moDCs and LCs. Further study revealed that miR-424/503 induction promotes moDC differentiation, while its repression facilitates TGF-beta 1-dependent LC differentiation from monocytes.
Article
Oncology
Lin-Lin Ma, Lin Liang, Dan Zhou, Shao-Wei Wang
Summary: The study revealed that miR-424-5p negatively regulates ferroptosis by targeting ACSL4 in ovarian cancer cells, while high expression of ACSL4 sensitizes ovarian cancer cells to ferroptosis inducers.
Article
Oncology
Bing Li, Ge Lou, Jiahui Zhang, Ning Cao, Xi Yu
Summary: This study explores the specific mechanism of lncRNA PART1 in ovarian cancer (OC), finding that PART1 regulates the cell viability, migration, and invasion in OC via the miR-503-5p/FOXK1 axis.
Article
Medicine, General & Internal
Yuqi Gong, Lingna Zhou, Liya Ding, Jing Zhao, Zhe Wang, Guoping Ren, Jing Zhang, Zhengrong Mao, Ren Zhou
Summary: This study aimed to identify potential biomarkers for Diffuse Large B Cell Lymphoma (DLBCL). Through gene expression analysis and functional enrichment analysis, KIF23 was found to be a potential risk factor and involved in multiple cell signaling pathways in DLBCL. Furthermore, DNA methylation analysis suggested that the hypomethylation in the promoter region of KIF23 might contribute to its higher expression in DLBCL.
Article
Medicine, Research & Experimental
Baolin Wang, Hang Yin, Hongmei Zhang, Tiantian Wang
Summary: The study demonstrates that circNRIP1 contributes to keloid progression by aiding in pre-miR-503 maturation through stabilizing FXR1 and impeding its degradation. High expression of circNRIP1 in keloid tissue and fibroblasts suggests its potential as a therapeutic target for keloid treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Oncology
Jie Li, Yuliang Zou, Meili Pei, Yun Zhang, Yu Jiang
Summary: Experimental findings demonstrate that berberine inhibits the Warburg effect in ovarian cancer cells by up-regulating miR-145, which is achieved through promoting TET3 expression to decrease the methylation level of the miR-145 precursor gene's promoter region.
Article
Medicine, Research & Experimental
Ping Li, Hongyan Xin, Lili Lu
Summary: This study demonstrates that MSC-derived EVs transfer miR-424 to down-regulate MYB and inhibit tumorigenesis and angiogenesis of ovarian cancer. The findings suggest a potential prognostic marker and therapeutic target for ovarian cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Xi Han, Dan Liu, Yuanyuan Zhou, Lijie Wang, Huilian Hou, He Chen, Lirui Zhang, Wei Chen, Xu Li, Le Zhao
Summary: Emerging evidence suggests that miR-143 plays a crucial role in regulating tumor sensitivity to chemotherapeutic agents, particularly in reversing cisplatin resistance in ovarian cancer. The study revealed that miR-143 can inhibit the growth of cisplatin-resistant ovarian cancer cells through downregulating DNMT3A, which is involved in hypermethylation of the miR-143 precursor gene. These findings highlight the important interaction between miR-143 and DNMT3A as a key epigenetic modifier of cisplatin resistance in ovarian cancer.
CELL BIOLOGY INTERNATIONAL
(2021)
Review
Pharmacology & Pharmacy
Yanjing He, Yin Cai, Pearl Mingchu Pai, Xinling Ren, Zhengyuan Xia
Summary: microRNAs (miRs) are short non-coding RNAs that regulate gene expression, and miR-503, a member of the miR-16 family, has been extensively studied in cardiovascular disease and cancer. Studies have shown that miR-503 may serve as a potential diagnostic marker or therapeutic target in cardiovascular disease or cancer by regulating gene expression through various pathological processes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Caihong Wen, Xiaoqing Fen, Honggang Yuan, Yong Gong, Guangsheng Wang
Summary: The circRNA circ_0003266 is significantly reduced in colorectal cancer (CRC) tissues and cell lines. Overexpression of circ_0003266 inhibits CRC cell proliferation, migration, and invasion, promotes cell apoptosis, but its overexpression enhances the malignant phenotypes of CRC cells. Circ_0003266 regulates PDCD4 expression by competitively sponging miR-503-5p, thereby suppressing CRC progression.
Article
Biology
Domenico Albino, Martina Falcione, Valeria Uboldi, Dada Oluwaseyi Temilola, Giada Sandrini, Jessica Merulla, Gianluca Civenni, Aleksandra Kokanovic, Alessandra Sturchler, Dheeraj Shinde, Mariangela Garofalo, Ricardo Pereira Mestre, Vera Constancio, Martha Wium, Jacopo Burrello, Nicolo Baranzini, Annalisa Grimaldi, Jean-Philippe Theurillat, Daniela Bossi, Lucio Barile, Rui M. Henrique, Carmen Jeronimo, Luiz Fernando Zerbini, Carlo Catapano, Giuseppina M. Carbone
Summary: This study shows that circulating miR-424 positive EVs are more frequent in patients with metastatic prostate cancer. These EVs promote stem-like traits in normal prostate epithelial cells and enhance tumorigenesis in transformed prostate epithelial cells, indicating their role in tumor self-sustenance and progression. Intravenous administration of miR-424 positive EVs to mice promotes miR-424 transfer and tumor growth in xenograft models, highlighting the potential for novel approaches in prostate cancer management and therapy.
COMMUNICATIONS BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xin He, Juan Wang, Ru Zhou, Shanshan Yu, Jue Jiang, Qi Zhou
Summary: This study found that KIF23 is highly expressed in breast cancer and is associated with adverse clinical outcomes. Functional experiments showed that down-regulation of KIF23 inhibited malignant behaviors of breast cancer cells, while overexpression of KIF23 stimulated these behaviors. Mechanistic studies revealed that KIF23 exerts its protumor effect in breast cancer by inhibiting the Wnt/beta-catenin pathway. This study suggests that KIF23 may have potential value as a target for therapy and prognosis assessment in breast cancer.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Esra Dirimtekin, Maria Mortoglou, Ceren Alavanda, Asmaa Benomar Yemlahi, Esra Arslan Ates, Ilter Guney, Pinar Uysal-Onganer
Summary: miR-34a is downregulated and associated with inhibition of tumor growth and invasion in ovarian cancer, while FOXP1 is reported as either an oncogene or tumor suppressor. It is found that miR-34a and FOXP1 are reversely correlated, and inhibition of miR-34a leads to upregulation of FOXP1 expression and increased cellular invasion. miR-34a could be a potential biomarker for improving the diagnostic efficiency of ovarian cancer, and its overexpression may reduce pathogenesis by targeting FOXP1.
Article
Oncology
Yaqi Gan, Yimin Li, Tong Li, Guang Shu, Gang Yin
CANCER MANAGEMENT AND RESEARCH
(2018)
Article
Multidisciplinary Sciences
Tong Li, Wenjuan Zhou, Yimin Li, Yaqi Gan, Yulong Peng, Qing Xiao, Chunli Ouyang, Anqi Wu, Sai Zhang, Jiaqi Liu, Lili Fan, Duo Han, Yu Wei, Guang Shu, Gang Yin
Article
Biochemistry & Molecular Biology
Juanni Li, Ayesha B. Alvero, Sudhakar Nuti, Roslyn Tedja, Cai M. Roberts, Mary Pitruzzello, Yimin Li, Qing Xiao, Sai Zhang, Yaqi Gan, Xiaoying Wu, Gil Mor, Gang Yin
Article
Cell Biology
Yimin Li, Jiaxin Liu, Qing Xiao, Ruotong Tian, Zhengwei Zhou, Yaqi Gan, Yuanyuan Li, Guang Shu, Gang Yin
CELL DEATH & DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Qing Xiao, Yaqi Gan, Yimin Li, Lili Fan, Jiaqi Liu, Pengyan Lu, Jiaxin Liu, Aoao Chen, Guang Shu, Gang Yin
Summary: The study identified MEF2A as a critical oncogene in promoting growth and metastasis of CRC, with potential as a novel therapeutic target for intervention. Aberrant expression of MEF2A in CRC clinical specimens was significantly associated with poor prognosis and metastasis, indicating its important role in the disease progression.
Article
Cell Biology
Jiaxin Liu, Yimin Li, Yaqi Gan, Qing Xiao, Ruotong Tian, Guang Shu, Gang Yin
Summary: The dysregulation of transcription factors is associated with malignant growth and colorectal cancer development. By analyzing differential transcription factors in colorectal cancer patients and establishing a genetic risk scoring model, ZNF26 was identified as a potential novel biomarker for diagnosis and prognostic evaluation of colorectal cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
