Journal
CARBOHYDRATE POLYMERS
Volume 221, Issue -, Pages 202-208Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.05.082
Keywords
Carboxymethylation; Chitosan; Cellulose; Cotton; Hemosasis
Categories
Funding
- National Key R & D Program of China [2017YFB0309700]
- National Natural Science Foundation of China [21872025]
- Taishan Industrial Leading Talents Project Special Funds of Shandong Province, China
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Cotton fabric (CF) is commonly used in wound treatment, however, its hemostatic efficiency is far from sufficient. In this study, modified cotton fabric (MCF-0.39) was obtained by a carboxymethylation process, which endowed MCF-0.39 with good swelling ability and water absorption capacity. Chitosan (CHI) was bound to MCF-0.39 by the binder sodium carboxymethyl cellulose (NaCMC) via flat-screen printing technique to prepare the hybrid hemostatic material (CHI-MCF-0.39). The blood clotting index (BCI) of CHI-MCF-0.39 was 3.15-fold lower than that of CF, demonstrating the good clotting ability of the material. In rat liver injury and femoral artery animal model, the groups using CHI-MCF-0.39 had less hemostasis time and blood loss compared with those groups using CF. All the above results indicate that the prepared CHI-MCF-0.39 has promising future applications as effective hemostatic material in trauma treatment.
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