Article
Medicine, Research & Experimental
Luka Rejc, Vanessa Gomez-Vallejo, Ana Joya, Oscar Moreno, Ander Egimendia, Pilar Castellnou, Xabier Rios-Anglada, Unai Cossio, Zurine Baz, Rossana Passannante, Ignacio Tobalina-Larrea, Pedro Ramos-Cabrer, Albert Giralt, Magdalena Sastre, Estibaliz Capetillo-Zarate, Urban Kosak, Damijan Knez, Stanislav Gobec, Mariel Marder, Abraham Martin, Jordi Llop
Summary: The study investigated the potential of butyrylcholinesterase (BChE) as an early biomarker for Alzheimer's disease (AD) by analyzing its abundance in the brains of AD model animals and controls. The results suggested that BChE accumulation in the brain is associated with amyloid beta deposition, indicating its promising role as an early biomarker for AD.
Article
Chemistry, Multidisciplinary
Sara F. F. Almeida, Alexandra Fonseca, Jose Sereno, Hugo R. S. Ferreira, Mariana Lapo-Pais, Tania Martins-Marques, Teresa Rodrigues, Rui C. Oliveira, Catarina Miranda, Luis P. Almeida, Henrique Girao, Amilcar Falcao, Antero J. Abrunhosa, Celia M. Gomes
Summary: This study develops an imaging tool using exosomes derived from osteosarcoma cells as natural nanocarriers for the noninvasive detection of lung micrometastasis. The results demonstrate that these exosomes accumulate specifically in metastatic lesions and primary tumors in vivo, showing excellent targeting ability. Optical imaging using exosomes is also able to detect lung metastasis. These findings suggest that tumor-derived exosomes have great potential as targeted imaging agents for the noninvasive detection of small lung metastasis using PET.
Article
Chemistry, Multidisciplinary
Catherine G. Fitzgerald Dickmann, Alexander F. F. McDonald, Nhi Huynh, Angela Rigopoulos, Zhanqi Liu, Nancy Guo, Laura D. D. Osellame, Michael A. A. Gorman, Michael W. W. Parker, Hui K. K. Gan, Andrew M. M. Scott, Uwe Ackermann, Ingrid J. G. Burvenich, Jonathan M. M. White
Summary: A novel molecule, [F-18]BiPET-2, radiolabelled with positron emitting fluorine-18, has been developed and evaluated in vitro and preclinically in glioblastoma models.
CHEMICAL COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Michael R. Kilbourn
Summary: The application of positron emission tomography (PET) imaging to study brain biochemistry, especially dopamine neurotransmission, has significantly grown over the past 40 years. PET imaging of dopaminergic functions in the central nervous system is routinely used for research in neurology, psychiatry, drug abuse and addiction, as well as drug development. The key advancement in PET imaging is the development of unique radiotracers labeled with positron-emitting radionuclides like carbon-11 and fluorine-18, which have greatly contributed to the progress in this field.
Article
Medicine, General & Internal
Csaba Csikos, Adrienn Vagner, Gabor Nagy, Ibolya Kalman-Szabo, Judit P. Szabo, Minh Toan Ngo, Zoltan Szoboszlai, Dezso Szikra, Zoard Tibor Krasznai, Gyorgy Trencsenyi, Ildiko Garai
Summary: The aim of this study was to evaluate the biodistribution and tumor-targeting potential of Mn-52-labeled DOTAGA-bevacizumab. The VEGF-A targeting potential of the new immuno-PET ligand was assessed using the VEGF-A expressing KB-3-1 (human cervix carcinoma) tumor-bearing CB17 SCID mouse model and in vivo PET/MRI imaging. Due to the high and specific accumulation found in the subcutaneously located experimental cervix carcinoma tumors, [Mn-52]Mn-DOTAGA-bevacizumab is a promising PET probe for the detection of VEGF-A positive gynecological tumors, for patient selection, and monitoring the efficacy of therapies targeting angiogenesis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Fernando U. Kay, Vinh Ho, Edmund B. Dosunmu, Avneesh Chhabra, Keenan Brown, Xinhui Duan, Orhan K. Oz
Summary: Low bone mineral density (BMD) was found to be common in oncologic patients undergoing F-18-FDG PET/CT. Decreased F-18-FDG avidity of bone marrow correlated with decreased BMD, validating the link between osteoporosis and bone marrow fat. CT attenuation value of L1 vertebrae could serve as a simple and accurate approach for detecting patients at risk for osteoporosis-related fractures using PET/CT data.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Evangelos Tzolos, Rong Bing, Jack Andrews, Mark G. MacAskill, Adriana A. S. Tavares, Gillian Macnaught, Tim Clark, Nicholas L. Mills, Takeshi Fujisawa, Jennifer Nash, Damini Dey, Piotr J. Slomka, Norman Koglin, Andrew W. Stephens, Marcus-Andre Deutsch, Edwin J. R. van Beek, Michelle C. Williams, Sven Hermann, Verena Hugenberg, Marc R. Dweck, David E. Newby
Summary: This study aimed to noninvasively detect in vivo thrombus formation in human coronary arteries using 18F-GP1 radiotracer through positron emission tomographic (PET) and computed tomographic (CT) imaging. The study found that coronary 18F-GP1 uptake was apparent in patients with acute myocardial infarction, which has the potential to inform the diagnosis, management, and treatment of these patients.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan Gallagher, Kuiying Xu, Hsiaoju Lee, Shihong Li, Meagan J. McManus, Robert H. Mach
Summary: In this study, the utility of a novel PET tracer, [F-18]ROStrace, as a biomarker of oxidative stress in Alzheimer's disease (AD) was investigated. The results showed that [F-18]ROStrace could identify oxidative stress and neuroinflammation in early stages of AD, and these markers were associated with amyloid burden.
Article
Pharmacology & Pharmacy
Judit P. Szabo, Katalin Csige, Ibolya Kalman-Szabo, Viktoria Arato, Gabor Opposits, Istvan Joszai, Istvan Kertesz, Zita Kepes, Gabor Mehes, Ferenc Fenyvesi, Istvan Hajdu, Gyorgy Trencsenyi
Summary: This study evaluated the tumor-targeting potential of 68Ga-labelled cyclodextrin derivatives (CyDs). The results showed that both 68Ga-NODAGA-RAMEB and 68Ga-NODAGA-HP8CD can be used to identify different types of tumors, with the highest accumulation observed in PGE2 positive tumors.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Environmental Sciences
Samantha Delaney, Cindy Rodriguez, Samantha M. Sarrett, Eric J. Dayts, Brian M. Zeglis, Outi Keinanen
Summary: Microplastics and nanoplastics, ubiquitous environmental pollutants, pose a threat to human health. PET imaging was used to track the fate of these plastics when administered to mice via different routes. The study found that the distribution of plastic particles in the body differed depending on the administration route, and particle size significantly influenced their retention in the lungs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Neurosciences
Mengfei Xiong, Sahar Roshanbin, Johanna Rokka, Eva Schlein, Martin Ingelsson, Dag Sehlin, Jonas Eriksson, Stina Syvanen
Summary: The study investigated synaptic density in transgenic mouse models of Alzheimer's disease and Parkinson's disease using [C-11]UCB-J PET, suggesting that the PET imaging reflects synaptic density in mouse models of neurodegeneration with large inter-subject variation. Additionally, the study proposed that the model-independent AUCbrain/blood ratio can be used to evaluate [C-11]UCB-J binding as an alternative to full pharmacokinetic modeling.
Article
Oncology
Marcus Unterrainer, Christophe M. Deroose, Ken Herrmann, Markus Moehler, Lennart Blomqvist, Roberto Cannella, Caroline Caramella, Damiano Caruso, Manil D. Chouhan, Timm Denecke, Carolina De la Pinta, Lioe-Fee De Geus-Oei, Audrius Dulskas, Michel Eisenblatter, Kieran G. Foley, Sofia Gourtsoyianni, Frederic E. Lecouvet, Egesta Lopci, Monique Maas, Markus M. Obmann, Daniela E. Oprea-Lager, Joost J. C. Verhoeff, Ines Santiago, Sylvain Terraz, Melvin D'Anastasi, Daniele Regge, Andrea Laghi, Regina G. H. Beets-Tan, Volker Heinemann, Florian Lordick, Elizabeth C. Smyth, Jens Ricke, Wolfgang G. Kunz
Summary: This study aimed to establish an imaging protocol for colorectal cancer that promotes standardization and reduces variations. Through the formation of a multidisciplinary panel and the use of the Delphi method, the EORTC-ESOI-ESGAR core imaging protocol was identified.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Kevin J. H. Allen, Rubin Jiao, Jason Li, Denis R. Beckford-Vera, Ekaterina Dadachova
Summary: PET imaging with Zr-89-lintuzumab demonstrates high specific uptake in CD33 positive human OCI-AML3 tumors. The findings from the image study are consistent with the observations from the ex vivo biodistribution study. Our results collectively suggest that PET imaging using Zr-89-lintuzumab could be a powerful drug development tool to evaluate binding properties of anti-CD33 monoclonal antibodies in preclinical cancer models.
Article
Hematology
Beth Whittington, Evangelos Tzolos, Rong Bing, Jack Andrews, Christophe Lucatelli, Mark G. Macaskill, Adriana A. S. Tavares, Tim Clark, Nicholas L. Mills, Jennifer Nash, Damini Dey, Piotr J. Slomka, Norman Koglin, Andrew W. Stephens, Edwin J. R. van Beek, Colin Smith, Marc R. Dweck, Michelle C. Williams, William Whiteley, Joanna M. Wardlaw, David E. Newby
Summary: Using F-18-GP1 positron emission tomography and computed tomography angiography, it is possible to identify activated platelets and thrombus noninvasively, which has potential clinical application in establishing the role and origin of thrombus in ischemic stroke.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Libor Kostka, Lenka Kotrchova, Eva Randarova, Carolina A. Ferreira, Iva Malatova, Hye Jin Lee, Aeli P. Olson, Jonathan W. Engle, Marek Kovar, Weibo Cai, Milada Sirova, Tomas Etrych
Summary: nanomedicines are being developed as an improved therapeutic option with reduced side effects, and this study introduces tailored nanosystems for the treatment of solid tumors or hematological malignancies. The relationship between the structure of the nanosystem and its distribution in the body was evaluated through independent assessments of the polymer carrier and drug pharmacokinetics. The results showed enhanced tumor accumulation of the polymer carriers in mice with solid tumors, as well as significant accumulation of doxorubicin bound to the polymer carriers in specific tumor types.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Asim K. Bag, Melissa N. Wing, Noah D. Sabin, Scott N. Hwang, Gregory T. Armstrong, Yuanyuan Han, Yimei Li, Scott E. Snyder, Giles W. Robinson, Ibrahim Qaddoumi, Alberto Broniscer, John T. Lucas, Barry L. Shulkin
Summary: This study evaluated the role of C-11-methionine PET in assessing MRI changes in PHGGs patients, to differentiate tumor recurrence from pseudoprogression. The results showed that C-11-methionine PET had slightly higher sensitivity and accuracy in correctly predicting tumor existence, with good interobserver agreement. The study also found that quantitative C-11-methionine PET can predict overall survival.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Wassim Chemaitilly, Zhenghong Li, Tara M. Brinkman, Angela Delaney, Sujuan Huang, Kari L. Bjornard, Catherine G. Lam, Carmen L. Wilson, Nicole Barnes, Karen L. Clark, Matthew J. Krasin, Monika L. Metzger, Anthony Sheyn, Michael W. Bishop, Noah D. Sabin, Rebecca M. Howell, Sara Helmig, Barry L. Shulkin, Brandon M. Triplett, Ching-Hong Pui, Amar Gajjar, Deo Kumar Srivastava, Daniel M. Green, Gregory T. Armstrong, Leslie L. Robison, Melissa M. Hudson, Kristen K. Ness, Charles A. Sklar, Kevin R. Krull
Summary: This study examined the prevalence and risk factors of primary hypothyroidism in childhood cancer survivors, and found associations with physical frailty, dyslipidemia, impaired physical quality of life, and having health care insurance. The impact of thyroid hormone replacement practices on these outcomes should be further investigated.
Article
Oncology
Wayne L. Furman, Beth McCarville, Barry L. Shulkin, Andrew Davidoff, Matthew Krasin, Chia-Wei Hsu, Haitao Pan, Jianrong Wu, Rachel Brennan, Michael W. Bishop, Sara Helmig, Elizabeth Stewart, Fariba Navid, Brandon Triplett, Victor Santana, Teresa Santiago, Jacquelyn A. Hank, Stephen D. Gillies, Alice Yu, Paul M. Sondel, Wing H. Leung, Alberto Pappo, Sara M. Federico
Summary: Combining hu14.18K322A with chemotherapy improves early response and outcomes in high-risk neuroblastoma. This treatment is well-tolerated and reduces tumor volume in most patients, leading to improved end-of-induction response rates and encouraging 3-year event-free survival.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Genetics & Heredity
Masoumeh Sadeghi, Abolfazl Bahrami, Aliakbar Hasankhani, Hamed Kioumarsi, Reza Nouralizadeh, Sarah Ali Abdulkareem, Farzad Ghafouri, Herman W. Barkema
Summary: Understanding the molecular mechanisms of fertility is crucial for breeding, but little success has been achieved in sheep fertility. This study constructed a competitive endogenous RNA network to evaluate the molecular mechanisms responsible for fertility in Romanov and Baluchi sheep breeds. The study identified several important RNA and regulatory networks involved in biological processes related to fertility. These findings provide insights into the contribution of different breed transcriptomes to fertility differences and can help in genetic improvement.
Article
Oncology
Kyle J. Morgan, Andrew Dudas, Wayne L. Furman, M. Beth McCarville, Barry L. Shulkin, Zhaohua Lu, Himani Darji, Doralina L. Anghelescu
Summary: This study examined the association between opioid consumption and tumor response in children with neuroblastoma. The results showed that there was no significant correlation between opioid use and tumor volume or burden.
PEDIATRIC BLOOD & CANCER
(2023)
Editorial Material
Oncology
Hollie A. Lai, Susan E. Sharp, Aashim Bhatia, Kelly R. Dietz, Beth McCarville, Dhanashree Rajderkar, Sabah Servaes, Barry L. Shulkin, Sudh A. Singh, Andrew T. Trout, Pankaj Watal, Marguerite T. Parisi
Summary: This manuscript provides consensus-based imaging recommendations for diagnosing and monitoring pediatric neuroblastoma patients.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Mitchell A. Rees, Cara E. Morin, Gerald G. Behr, J. Christopher Davis, Hollie Lai, Ajaykumar C. Morani, Marguerite T. Parisi, Gaurav Saigal, Sudha Singh, Sireesha Yedururi, Alexander J. Towbin, Barry L. Shulkin
Summary: This paper provides consensus recommendations for imaging of pediatric patients with adrenal malignancies other than neuroblastoma.
PEDIATRIC BLOOD & CANCER
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Hedieh Khalatbari, Barry L. Shulkin, Marguerite T. Parisi
Summary: The most common indication for 18F-FDG PET/CT is tumor imaging, but in pediatric nuclear medicine, most coincidental findings of infectious, inflammatory, and autoimmune processes are not the main indication and it is important to interpret these findings correctly. This review focuses on recent literature on fever of unknown origin and inflammation of unknown origin in pediatrics, as well as the PET/CT imaging findings in two specific diseases with increased immune reactivity.
SEMINARS IN NUCLEAR MEDICINE
(2023)
Article
Oncology
Samuel N. Rogers, Unni Udayasankar, Sumit Pruthi, Hollie A. Lai, Nadja Kadom, Julie Guerin, Michael Malinzak, Barry L. Shulkin, Tina Y. Poussaint, Zoltan Patay, Asim K. Bag
Summary: This paper provides consensus-based recommendations for optimized imaging of childhood spinal tumors, including diagnosis, follow-up during and after therapy, and response assessment.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Nutrition & Dietetics
Mohamed J. Saadh, Rashmi Saxena Pal, Jose Luis Arias-Gonzales, Juan Carlos Orosco Gavilan, J. C. Darshan, Mohamed Mohany, Salim S. Al-Rejaie, Abolfazl Bahrami, Mustafa Jawad Kadham, Ali H. Amin, Hrosti Georgia
Summary: This study used Mendelian randomization (MR) analysis to investigate the causal relationship between variable risk factors and various nutrients with inflammatory bowel diseases (IBDs). The results showed that certain genetically predicted risk factors and nutrients are associated with the occurrence of IBDs. These findings provide new evidence and suggestions for the treatment and prevention of IBDs.
Review
Immunology
Aliakbar Hasankhani, Abolfazl Bahrami, Bahareh Tavakoli-Far, Setare Iranshahi, Farnaz Ghaemi, Majid Reza Akbarizadeh, Ali H. Amin, Bahman Abedi Kiasari, Alireza Mohammadzadeh Shabestari
Summary: COVID-19 is a severe respiratory disease caused by SARS-CoV-2 infection. The hyperinflammatory response, characterized by cytokine storm, plays a crucial role in disease severity and mortality. Targeting key inflammatory factors, particularly PPARs, can be a potential therapeutic approach for controlling the hyperinflammatory response in severe COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Amy K. Erbe, Mitch B. Diccianni, Rajen Mody, Arlene Naranjo, Fan F. Zhang, Jen Birstler, KyungMann Kim, Arika S. Feils, Jung-Tung Hung, Wendy B. London, Barry L. Shulkin, Varsha Mathew, Marguerite T. Parisi, Sabah Servaes, Shahab Asgharzadeh, John M. Maris, Julie Park, Alice L. Yu, Paul M. Sondel, Rochelle Bagatell
Summary: In the Children's Oncology Group ANBL1221 trial, the presence or absence of certain killer immunoglobulin-like receptors (KIRs) and their ligands was associated with clinical outcomes in patients with high-risk neuroblastoma treated with chemoimmunotherapy. The study confirms the importance of KIR/KIR-ligand genotype in the context of this treatment regimen.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Geovanny Genaro Reivan Ortiz, Carmen Iulia Ciongradi, M. V. N. L. Chaitanya, Jayasankar Narayanan, Mohamed Mohany, Salim S. Al-Rejaie, Jose Luis Arias-Gonzales, Ioan Sarbu, Marjan Assefi, Shaik Vaseem Akram, Yusuf Dogus, Abolfazl Bahrami, Reza Akhavan-Sigari
Summary: Cancer-associated fibroblasts (CAFs) of ovarian cancer (OvC) play a crucial role in promoting tumor growth by changing the extracellular matrix and initiating epithelial cells. The IL-33/ST2 signaling axis is involved in this process and leads to increased inflammatory factors in tumor CAFs and epithelial cells. Targeting the IL-33/ST2 axis could be a potential strategy for preventing OvC progression.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Medicine, Research & Experimental
Mohamed J. Saadh, Amera Bekhatroh Rashed, Azfar Jamal, Roxana Yolanda Castillo-Acobo, Mohammad Azhar Kamal, Juan Carlos Cotrina-Aliaga, Jose Luis Arias Gonzales, Abdulaziz S. Alothaim, Wardah A. Alhoqail, Fuzail Ahmad, Natrayan Lakshmaiya, Ali H. Amin, Dhuha Ghassan Younus, Gregorio Gilmer Rosales Rojas, Abolfazl Bahrami, Reza Akhavan-Sigari
Summary: The study found that upregulation of miR-199a-3p may offer a therapeutic avenue for mitigating bone cancer pain in mice by suppressing neuroinflammation and inhibiting the MyD88/NF-kappa B signaling pathway.
Article
Multidisciplinary Sciences
Aliakbar Hasankhani, Maryam Bakherad, Abolfazl Bahrami, Hossein Moradi Shahrbabak, Renzon Daniel Cosme Pecho, Mohammad Moradi Shahrbabak
Summary: A deeper understanding of the molecular interactome involved in mastitis was gained through the combination of RNA-seq and miRNA-seq techniques, along with computational systems biology approaches. The study identified highly-correlated modules associated with clinical traits of mastitis and revealed the regulatory network between immunoregulatory mRNAs, miRNAs, and lncRNAs during Streptococcus uberis infection.
SCIENTIFIC REPORTS
(2023)