Article
Medicine, Research & Experimental
Meng Jiang, Kai Xu, Huafeng Ren, Mingmin Wang, Ximin Hou, Jianping Cao
Summary: The study revealed that lincRNA-Cox2 plays a protective role in osteoarthritis by targeting miR-150, activating the Wnt/beta-catenin pathway, enhancing chondrocyte proliferation, and inhibiting apoptosis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Haitao Gu, Zhiquan Xu, Jianbo Zhang, Yanbing Wei, Ling Cheng, Jijian Wang
Summary: circ_0038718 is highly expressed in colon cancer and can sponge miR-195-5p in the cytoplasm, facilitating malignant progression of colon cancer cells through the miR-195-5p/Axin2 axis.
Article
Agriculture, Dairy & Animal Science
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Kai Quan, Tesfaye Getachew, Joram M. M. Mwacharo, Aynalem Haile, Yutao Li, Shanhe Wang, Wei Sun
Summary: In our study, we found that CRABP2 was highly expressed in Hu sheep hair follicles, indicating its potential influence on dermal papilla cells (DPCs). Our experiments demonstrated that overexpression of CRABP2 promoted DPC proliferation and activated the Wnt/beta-catenin pathway. These findings highlight the crucial role of CRABP2 in Hu sheep DPC proliferation and shed light on its function in hair follicles.
Article
Oncology
Bing Xiao, Shi-gang Lv, Miao-jing Wu, Xiao-li Shen, Wei Tu, Min-hua Ye, Xin-gen Zhu
Summary: The study showed that Circ_CLIP2 and HMGB3 were upregulated while miR-195-5p was downregulated in glioma cells. Silencing of Circ_CLIP2 inhibited cell proliferation and promoted cell apoptosis. MiR-195-5p inhibited HMGB3 expression by directly targeting HMGB3, leading to the suppression of the Wnt/beta-catenin signaling pathway.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Oncology
Anil Belur Nagaraj, Matthew Knarr, Sreeja Sekhar, R. Shae Connor, Peronne Joseph, Olga Kovalenko, Alexis Fleming, Arshia Surti, Elmar Nurmemmedov, Luca Beltrame, Sergio Marchini, Michael Kahn, Analisa DiFeo
Summary: Wnt signaling plays a critical role in ovarian cancer, and miR-181a has been identified as a novel driver of the Wnt/β-catenin signaling pathway, promoting stemness and chemoresistance. Targeting the miR-181a-SFRP4 axis may offer a potential therapeutic strategy for HGSOC.
Article
Pharmacology & Pharmacy
Lingna Sun, Yuping Cui, Kongdi Jiang, Juan Li
Summary: The study demonstrated that down-regulation of lncRNA ANRIL effectively suppressed OVCAR-3 cell proliferation and invasion, induced apoptosis, and prevented Wnt/β-catenin signal transduction.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Environmental Sciences
Yuan Li, Jinsong Yu, Manran Jia, Pei Ma, Chunrong Dong
Summary: SIK2 acts as a tumor suppressor in HCC by inhibiting cell proliferation and invasion while activating apoptosis, with its mechanism of action involving the inactivation of the Wnt/beta-catenin signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Cong Liu, Yani Yan, Fusheng Di, Weiwei Li, Xiurong Yin, Lixia Dong
Summary: The study revealed that NCAPG is highly expressed in EC tissues and cells, and its knockdown inhibits cell proliferation and induces apoptosis in EC cells by suppressing the Wnt/beta-catenin pathway.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Oncology
Chun Tang, Xuehui Wang, Changle Ji, Wenfang Zheng, Yunhe Yu, Xiaochong Deng, Xiqian Zhou, Lin Fang
Summary: The study demonstrated that miR-640 suppresses the tumorigenesis of breast cancer cells by regulating the Wnt/β-catenin signaling pathway, making it a potential novel target for targeted therapy in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Zhi Fang, Min Zhong, Ling Zhou, Yi Le, Heng Wang, Ziling Fang
Summary: LRP8 is markedly overexpressed in NSCLC tissues and cell lines, correlating with poor clinicopathological characteristics and prognosis. Depletion of LRP8 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of NSCLC cells, partly by inhibiting the Wnt/beta-catenin pathway.
Article
Oncology
Qiong Wu, Liang Jiang, Jiang Wu, HaiFang Dong, Yaping Zhao
Summary: The study showed that Klotho inhibits cell proliferation and promotes apoptosis in RET fusion models of PTC by inhibiting the Wnt/beta-catenin pathway, suggesting a potential target for developing treatments for PTC.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yi Dai, Chunyan Zheng, Hao Li
Summary: MicroRNAs, especially miR-23a-3p, play a crucial role in bone development and metabolism. Inhibition of miR-23a-3p promotes proliferation and differentiation of osteoblasts in osteoporosis rats by targeting the PGC-1 alpha/WNT/beta-catenin signaling pathway.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Si Ying Li, Chen Yi Wang, Xiao Gao Wei, Xiao Bing Tang, Zheng Wei Yuan, Yu Zuo Bai
Summary: This study revealed that aberrantly high expression of circJag1 promotes epithelial apoptosis by suppressing the canonical Wnt/beta-catenin pathway via the miR-137-3p/Sox9 axis, leading to the occurrence of anorectal malformations (ARMs).
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Duoduo Zhang, Xingtao Zhou, Linyuan Liu, Mi Guo, Tongwen Huang, Wengan Zhou, Fang Geng, Steve W. Cui, Shaoping Nie
Summary: The study revealed that glucomannan from Aloe vera gel promoted proliferation and differentiation of intestinal stem cells through the Wnt/β-catenin signaling pathway, facilitating epithelial cell regeneration and alleviating colitis in mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)