Review
Respiratory System
Joshua Holmes, Liam G. Heaney, Lorcan P. A. McGarvey
Summary: The use of objective and subjective tools to measure the characteristics and burden of cough in patients with asthma has not been widely reported. This systematic review examines the current literature and finds that the clinical features and healthcare burden of cough in asthma have been infrequently studied, with significant variations in measurement methods. Consistent use of cough-specific measurement tools is necessary to better understand the nature and burden of cough in asthma.
Article
Respiratory System
Jonathan Schelfhout, Allison Martin Nguyen, Surinder S. Birring, Elizabeth D. Bacci, Margaret Vernon, David R. Muccino, Carmen La Rosa, Jaclyn A. Smith
Summary: The objective of this study was to explore the relationship between objective cough frequency and cough-specific patient-reported outcomes (PROs) and estimate a clinically meaningful change threshold (MCT) for objective cough frequency. The results showed significant but low to moderate correlations between 24-h cough frequency and cough-specific PROs. A >= 30% reduction in 24-h cough frequency was suggested as a reasonable MCT to define treatment response in chronic cough clinical trials.
Article
Respiratory System
Ji-Su Shim, Byung-Keun Kim, Sae-Hoon Kim, Jae-Woo Kwon, Kyung-Min Ahn, Sung-Yoon Kang, Han-Ki Park, Heung-Woo Park, Min-Suk Yang, Min-Hye Kim, Sang Min Lee
Summary: This study applied an AI-based cough algorithm to accurately count coughs using a smartphone application and found a strong correlation with other indicators of patient health status. The findings validate the reliability of the algorithm in acute asthma patients and suggest that CoughyTM could be a novel solution for objectively monitoring cough in a clinical setting.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Respiratory System
Jianmeng Zhou, Fang Yi, Feng Wu, Pusheng Xu, Meihua Chen, Huahao Shen, Lin Lin, Yunhui Zhang, Suyun Li, Changgui Wu, Yadong Yuan, Gang Wang, Xianwei Ye, Ping Zhang, Huaping Tang, Qianli Ma, Lanqing Huang, Zhongmin Qiu, Haiyan Deng, Chen Qiu, Guochao Shi, Jiayu Pan, Wei Luo, Kian Fan Chun, Nanshan Zhong, Kefang Lai
Summary: This study compared the clinical and pathophysiological characteristics of different phenotypes of asthma, and found differences in cough sensitivity and airflow obstruction between patients with cough predominant asthma and patients with cough variant asthma.
RESPIRATORY RESEARCH
(2022)
Article
Respiratory System
William Do, Richard Russell, Christopher Wheeler, Hamza Javed, Cihan Dogan, George Cunningham, Vikaran Khanna, Maarten De Vos, Imran Satia, Mona Bafadhel, Ian Pavord
Summary: This study evaluated the measurement characteristics of nocturnal cough monitoring using Albus Home compared to manual counts. The results showed that Albus Home provided an accurate system for cough monitoring, with strong agreement with reference counts. It enables the collection of high-quality longitudinal data.
Article
Medicine, General & Internal
Noga Arwas, Sharon Uzan Shvartzman, Aviv Goldbart, Romi Bari, Itai Hazan, Amir Horev, Inbal Golan Tripto
Summary: Asthma is a common chronic respiratory disease in children, and there is a lack of data on the association of neutrophil-to-lymphocyte ratio (NLR) with acute asthma exacerbations. This cross-sectional study included children aged 2-18 years who visited the emergency department (ED) for asthma exacerbation between 2016 and 2021. The study found that NLR upon admission was associated with the severity of asthma exacerbation and higher chances of hospitalization among children in the ED.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Virology
Erwan Sallard, Frank Schult, Carolin Baehren, Eleni Buedding, Olivier Mboma, Parviz Ahmad-Nejad, Beniam Ghebremedhin, Anja Ehrhardt, Stefan Wirth, Malik Aydin
Summary: Respiratory viruses play a significant role in exacerbating asthma, and human rhinovirus (HRV) infection is a strong biomarker for exacerbation.
Article
Microbiology
Tsunglin Liu, Cheng-Han Lin, Yi-Lin Chen, Shuen-Lin Jeng, Hui-Ju Tsai, Chung-Liang Ho, Wen-Shuo Kuo, Miao-Hsi Hsieh, Pei-Chi Chen, Lawrence Shih-Hsin Wu, Jiu-Yao Wang
Summary: This study aimed to investigate the relationship between nasal, throat, and stool microbiota and asthma status in children. The results showed that nasal microbiota during acute exacerbation was associated with mite allergy, while stool microbiota during exacerbation was associated with ABO blood type and in the recovery phase with frequency of subsequent exacerbations.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pediatrics
Chunyu Tian, Shiqiu Xiong, Shuo Li, Xin Song, Yantao Zhang, Xinmei Jiang, Xinyue Hou, Yifan Zhang, Chuanhe Liu
Summary: This study found that children with cough variant asthma (CVA) have lower pulmonary function parameters compared to healthy children. Changes in small airway parameters during bronchodilator tests can be valuable in diagnosing CVA, and the logistic regression (LR) prediction model incorporating age and several pulmonary parameters can assist physicians in accurately identifying CVA in clinical practice.
PEDIATRIC PULMONOLOGY
(2023)
Article
Infectious Diseases
Hossein Esmaeilzadeh, Anahita Sanaei Dashti, Negar Mortazavi, Hossein Fatemian, Mohebat Vali
Summary: This study aimed to determine the risk of developing persistent cough and asthma-like symptoms in hospitalized children due to COVID-19. The results showed that a family history of asthma, previous history of asthma, and allergic rhinitis are risk factors for developing asthma-like symptoms after COVID-19 hospitalization.
BMC INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Olufemi Desalu, Olutobi B. Ojuawo, Adeniyi O. Aladesanmi, Adekunle O. Adeoti, Christopher M. Opeyemi, Taofeek Oloyede, Oluwafemi J. Afolayan, Ademola E. Fawibe
Summary: The purpose of this study was to determine the etiology and clinical patterns of chronic cough in Nigeria. The results showed that COPD, PTB, and asthma were the most common causes of chronic cough. It was also found that the occurrence of chronic cough differed between genders and age groups. The study highlighted the importance of considering geographical variations in etiologies and clinical presentation when evaluating and managing chronic cough.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Pediatrics
Abdullah Al-Shamrani, Khalid Al-Shamrani, Maram Al-Otaibi, Ayed Alenazi, Hareth Aldosaimani, Zeyad Aldhalaan, Haleimah Alalkami, Abdullah A. Yousef, Sumayyah Kobeisy, Saleh Alharbi
Summary: COVID-19 affects all age groups, including pediatric patients. Many children experience persistent coughing symptoms post-COVID-19, which adversely affect school attendance and daily activities.
Article
Pediatrics
Maria Mallet, Rebeca Mozun, Cristina Ardura-Garcia, Eva S. L. Pedersen, Maja Jurca, Philipp Latzin, Claudia E. LUIS Study Grp, Alexander Moeller, Claudia Kuehni
Summary: This study compared the differences between children with dry night cough alone and those who also wheeze. The results showed that children with dry night cough tend to have more frequent colds, rhinitis, and snoring, while those with wheeze or both wheeze and cough are more likely to have hay fever, eczema, and parental histories of asthma.
PEDIATRIC PULMONOLOGY
(2023)
Article
Pediatrics
Ela Beyyumi, Mohamed Tawil, Huda AlDhanhani, Sara Jameel, Manal Mouhssine, Hasa M. AlNuaimi, Osama Hamdoun, Amnah Alabdouli, Mohammed T. Alsamri, Ghassan A. Ghatasheh, Taoufik Zoubeidi, Abdul-Kader Souid
Summary: This study found a high rate of chest radiographs requested for children with asthma, especially in younger children. Furthermore, only a small proportion of chest radiographs showed signs of pneumonia, raising questions about the necessity of antibiotic use.
FRONTIERS IN PEDIATRICS
(2021)
Article
Critical Care Medicine
Nina Bisballe-Muller, Anne B. Chang, Erin J. Plumb, Victor M. Oguoma, Susanne Halken, Gabrielle B. McCallum
Summary: The study suggests that cough characteristics alone are not sufficient to accurately differentiate between common acute respiratory illnesses in children, indicating the need for further research in this area.
