Review
Immunology
Wenli Shang, Guizuo Wang, Yan Wang, Dong Han
Summary: This study aimed to evaluate the safety of long-term use of ICS in patients with asthma through a systematic review and meta-analysis. The results showed that, apart from mild local adverse events, the long-term use of ICS was safe for patients with asthma.
CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Scott P. Ginebaugh, Matthias Hagner, Anuradha Ray, Serpil C. Erzurum, Suzy A. A. Comhair, Loren C. Denlinger, Nizar N. Jarjour, Mario Castro, Prescott G. Woodruff, Stephanie A. Christenson, Eugene R. Bleecker, Deborah A. Meyers, Annette T. Hastie, Wendy C. Moore, David T. Mauger, Elliot Israel, Bruce D. Levy, Sally E. Wenzel, Matthew J. Camiolo
Summary: This study investigated the transcriptional response of bronchial epithelial cells to inhaled corticosteroids. It was found that a subset of asthma patients with poor hormone treatment response had worse lung function and quality of life. Furthermore, the response to hormone treatment could be predicted using blood samples.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
Priyadarshini Kachroo, Joanne E. Sordillo, Sharon M. Lutz, Scott T. Weiss, Rachel S. Kelly, Michael J. McGeachie, Ann Chen Wu, Jessica A. Lasky-Su
Summary: Metabolomic profiles associated with asthma exacerbations during inhaled corticosteroid treatment were analyzed in this study, revealing potential biomarkers of treatment response variability. Sex differences were observed in the levels of fatty acid metabolites during exacerbations, while interactions between age and metabolites on exacerbation were also detected. These findings suggest that plasma metabolites may play a role in elucidating metabolic pathways underlying variability in asthma treatment responses.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Allergy
Fahad H. Alahmadi, Brian Keevil, Lynn Elsey, Kate George, Robert Niven, Stephen J. Fowler
Summary: LC-MS/MS can reliably detect commonly used ICSs in the blood at least 8 hours after dosing, providing a measure of adherence in severe asthma patients. Lower blood levels were associated with higher exacerbation rates and poorer lung function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Ahmed Edris, Emmely W. de Roos, Michael J. McGeachie, Katia M. C. Verhamme, Guy G. Brusselle, Kelan G. Tantisira, Carlos Iribarren, Meng Lu, Ann Chen Wu, Bruno H. Stricker, Lies Lahousse
Summary: Genetic variants in CRHR1 and TBXT genes were found to be associated with poor and improved ICS response in adults with asthma, respectively. These associations may indicate specific endotypes that could potentially predict exacerbation risk and response to ICS treatment.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Chemistry, Multidisciplinary
Elzbieta Dembowska, Aleksandra Jaron, Karolina Skoczek-Szlosser, Ewa Gabrysz-Trybek, Joanna Bladowska, Grzegorz Trybek
Summary: Asthma, a common allergic disease, affects both general health and oral health. This study observed the oral health status of 120 adult patients aged 18 to 71, finding significantly deeper pockets in the lateral segments of the dentition in all study groups, especially in the bronchial-only group. However, there was no significant worsening of periodontal status in asthma patients treated with inhalation, regardless of baseline periodontal status. The history of asthma and the use of inhaled corticosteroids (ICS) have an impact on patients' periodontal status.
APPLIED SCIENCES-BASEL
(2022)
Article
Physiology
Sarah Basin, Simon Valentin, Silvia Demoulin-Alexikova, Bruno Demoulin, Laurent Foucaud, Delphine Gerard, Celso Pouget, Edem Allado, Bruno Chenuel, Mathias Poussel
Summary: This study evaluated the impact of inhaled corticosteroids on cough reflex during artificial limb exercise in an animal model of eosinophilic airway inflammation. The results showed that inhaled corticosteroids were able to restore desensitization of the cough reflex, suggesting potential benefits for managing exercise-induced cough in asthma patients.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Allergy
Arnaud Bourdin, Alberto A. Papi, Jonathan Corren, J. Christian Virchow, Megan S. Rice, Yamo Deniz, Michel Djandji, Paul Rowe, Ian D. Pavord
Summary: Dupilumab significantly reduced severe exacerbations and improved lung function and asthma control in patients with type 2-high asthma on high-dose ICS at baseline.
Article
Allergy
Ian D. Pavord, Trung N. Tran, Rupert C. Jones, Javier Nuevo, Maarten van den Berge, Guy G. Brusselle, Andrew N. Menzies-Gow, Derek Skinner, Victoria Carter, Janwillem W. H. Kocks, David B. Price
Summary: A historic cohort study was conducted to determine the effectiveness of stepping up to high-dose inhaled corticosteroids (ICSs) in patients with asthma. The study found no evidence that increasing the dose to high-dose ICSs is effective in preventing future asthma exacerbations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Pediatrics
Bing Wei, Yan-Hong Dang, Xiang-Ping Liu, Miao Li
Summary: This study aimed to investigate the differences in characteristics of Mycoplasma pneumoniae pneumonia (MPP) among children with and without asthma, as well as among children with asthma with and without inhaled corticosteroid (ICS) therapy. The study found that children with asthma had higher chances of wheezing compared to those without asthma. Furthermore, children with asthma who received ICS therapy had fewer and less severe exacerbations of MPP compared to those without ICS therapy. ICS therapy was identified as an independent protective factor against exacerbation.
FRONTIERS IN PEDIATRICS
(2022)
Article
Allergy
Pontus Mertsch, Jeremias Goetschke, Julia Walter, Carlo Muemmler, Alessandro Ghiani, Ulrike Schuermann, Rosemarie Kiefl, Rudolf Maria Huber, Juergen Behr, Nikolaus Kneidinger, Katrin Milger
Summary: The study analyzed the impact of high altitude environment on lung function in mild seasonal asthmatics, finding that using inhaled corticosteroid treatment can prevent the decrease in FEV1 caused by high altitude factors, while untreated asthmatics experience a reduction in FEV1 in such conditions.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Yousif S. Alakeel, Ebtihal F. Alharbi, Haifa A. Alhaidal, Aisha M. Jumaa, Latifah K. Albaiahy, Noura S. Alsagami, Shatha A. Alshahrani
Summary: This study investigated the relationship between the use of inhaled corticosteroids (ICS) by asthmatic patients and the severity of COVID-19. The findings showed that ICS therapy did not alter the severity or mortality of COVID-19 in asthmatic patients.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Respiratory System
Yuxuan Zhang, Jun Liu, Yanjie Zhi, Xuan You, Bing Wei
Summary: This study found that single-nucleotide variants (SNVs) in the GAB1 gene are not associated with asthma susceptibility, but the AGGAGC haplotype is a risk factor for asthma. GAB1 variants are associated with eosinophils and the response to inhaled corticosteroids (ICS) treatment in asthma patients. Furthermore, gene-environment interaction was observed.
BMC PULMONARY MEDICINE
(2023)
Review
Medicine, General & Internal
Dimos Gidaris, Stella Stabouli, Andrew Bush
Summary: Inhaled corticosteroids have been a cornerstone in the management of atopic, allergic asthma for over half a century, despite having side effects. Empathetic physicians need to understand parental concerns and dispel myths surrounding inhaled corticosteroids by emphasizing their established benefits and safety profile.
SWISS MEDICAL WEEKLY
(2021)
Article
Pediatrics
Louise Mandrup Bach, Sune Rubak, Adam Holm-Weber, Julie Prahl, Mette Hermansen, Kirsten Skamstrup Hansen, Bo Chawes
Summary: This study aimed to determine the risk factors for non-adherence to asthma treatment in preschool children. The study found that 75% of children under 6 years old diagnosed with asthma were not adherent to their medication. Increasing adherence was associated with co-existing allergies and experiencing loss of control events, while lower adherence was associated with atopic predisposition.