Review
Biochemistry & Molecular Biology
Palgan Krzysztof, Tretyn Andrzej
Summary: Anaphylaxis is a life-threatening hypersensitivity reaction, often caused by drugs and food. Factors such as physical exercise, acute infections, drugs, alcohol, and menstruation can exacerbate the severity of the reaction. This review highlights the role of platelet-activating factor in the development of severe anaphylactic reactions, including anaphylactic shock.
Article
Health Care Sciences & Services
Nikolaos Pyrpyris, Maria Kritikou, Xenofon Aggelidis, Ioanna Manolaraki, Michael Makris, Nikolaos G. Papadopoulos, Paraskevi Xepapadaki
Summary: This study analyzes the characteristics of anaphylaxis in a pediatric cohort in Greece and finds a low rate of adrenaline autoinjector administration by lay people. However, drug prescription and counseling after the reaction could help improve correct acute anaphylaxis management in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Allergy
Ioana Maris, Sabine Doelle-Bierke, Jean-Marie Renaudin, Lars Lange, Alice Koehli, Thomas Spindler, Jonathan Hourihane, Kathrin Scherer, Katja Nemat, C. Kemen, Irena Neustaedter, Christian Vogelberg, Thomas Reese, Ismail Yildiz, Zsolt Szepfalusi, Hagen Ott, Helen Straube, Nikolaos G. Papadopoulos, Susanne Haemmerling, Ute Staden, Michael Polz, Tihomir Mustakov, Ewa Cichocka-Jarosz, Renata Cocco, Alessandro Giovanni Fiocchi, Montserrat Fernandez-Rivas, Margitta Worm
Summary: The study showed that peanut allergy is a major cause of severe allergic reactions in European children, with characteristics such as asthma comorbidity and a higher rate of biphasic reactions. The use of intramuscular adrenaline as first-line treatment is low and needs improvement. The European Anaphylaxis Registry provides a valuable tool for continuous assessment of anaphylactic reactions.
Article
Allergy
Julia E. M. Upton, Jennifer A. Hoang, Matilde Leon-Ponte, Yaron Finkelstein, Yue (Jennifer) Du, Khosrow Adeli, Thomas Eiwegger, Eyal Grunebaum, Peter Vadas
Summary: This study found that decreased serum PAF-AH activity is a biomarker of severe anaphylaxis and levels of this enzyme do not change during acute anaphylaxis. The results suggest that PAF-AH may modulate susceptibility to severe anaphylaxis.
Article
Allergy
Torsten Zuberbier, Tamara Doerr, Werner Aberer, Montserrat Alvaro, Elizabeth Angier, Stefania Arasi, Hasan Arshad, Barbara Ballmer-Weber, Joan Bartra, Lisa Beck, Philippe Begin, Carsten Bindslev-Jensen, Jovanka Bislimovska, Jean Bousquet, Knut Brockow, Andrew Bush, Antonella Cianferoni, Michael J. Cork, Adnan Custovic, Ulf Darsow, Nicolette Jong, Diana Deleanu, Stefano Del Giacco, Antoine Deschildre, Audrey Dunn Galvin, Motohiro Ebisawa, Montserrat Fernandez-Rivas, Marta Ferrer, Alessandro Fiocchi, Roy Gerth van Wijk, Maia Gotua, Kate Grimshaw, Josefine Gruenhagen, Enrico Heffler, Michihiro Hide, Karin Hoffmann-Sommergruber, Cristoforo Incorvaia, Christer Janson, Swen Malte John, Carla Jones, Marek Jutel, Norito Katoh, Benjamin Kendziora, Tamar Kinaciyan, Edward Knol, Oksana Kurbacheva, Susanne Lau, Richard Loh, Carlo Lombardi, Mika Makela, Mary Jane Marchisotto, Michael Makris, Marcus Maurer, Rosan Meyer, Dragan Mijakoski, Jordan Minov, Joaquim Mullol, Caroline Nilsson, Anna Nowak-Wegrzyn, Bright Nwaru, Mikela Odemyr, Giovanni Battista Pajno, Sushil Paudel, Nikolaos G. Papadopoulos, Harald Renz, Giampaolo Ricci, Johannes Ring, Barbara Rogala, Hugh Sampson, Gianenrico Senna, Brigita Sitkauskiene, Peter Kenneth Smith, Katarina Stevanovic, Sasho Stoleski, Hania Szajewska, Akio Tanaka, Ana Todo-Bom, Fatih Alexander Topal, Erkka Valovirta, Ronald Van Ree, Carina Venter, Stefan Woehrl, Gary W. K. Wong, Zuotao Zhao, Margitta Worm
Summary: Based on a systematic review, it is unlikely that cross-contamination of major food allergens below 0.5 mg/100 g will endanger most food allergic patients when consuming a standard portion of food. The suggestion is to use a voluntary declaration on processed food packages stating that the product contains named allergens and may contain traces of other contaminations at concentrations less than 0.5 mg per 100 g of the product, which can be technically achieved in most processed foods. Further research on threshold levels is encouraged for a legally binding solution in the future.
Review
Allergy
Hans C. Oettgen
Summary: Mast cells throughout the gastrointestinal tract play a crucial role in IgE-mediated allergic reactions to foods. Aside from immediate reactions, recent evidence suggests that mast cells are also important regulators of adaptive immunity to foods. They provide cytokines that initiate and consolidate immune responses to allergens in the gastrointestinal mucosa, as well as molecules that recruit leukocytes causing tissue inflammation. By counteracting the activating effects of IgE antibodies, food-specific IgG antibodies suppress both immediate allergic reactions and mast cell-mediated immune responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Riccardo Asero, Renato Ariano, Arianna Aruanno, Claudio Barzaghi, Paolo Borrelli, Moira Busa, Giorgio Celi, Massimo Cinquini, Gabriele Cortellini, Francesca D'Auria, Marco De Carli, Camilla Di Paolo, Giulia Garzi, Fabio Lodi Rizzini, Monica Magnani, Giuseppina Manzotti, Alessandro Marra, Stefano Miceli Sopo, Francesco Murzilli, Eleonora Nucera, Elena Pinter, Valerio Pravettoni, Federica Rivolta, Angela Rizzi, Nicoletta Saporiti, Enrico Scala, Danilo Villalta, Mona-Rita Yacoub, Giuliana Zisa
Summary: The study found that systemic reactions induced by PR-10 and profilin are facilitated by PPI, ingestion of large amounts of unprocessed foods, and fasting. Soybean beverages represent a risk for PR-10 hypersensitive patients.
Article
Allergy
Raymond James Mullins, Keith B. G. Dear, Mimi L. K. Tang
Summary: While overall rates of food anaphylaxis continue to increase, there is evidence of a slowed rate of increase in the age groups of 1-14 years after the introduction of updated infant feeding and allergy prevention guidelines. However, the rates of increase have accelerated in those younger than 1 year and in the age groups older than 15 years.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Tiago Azenha Rama, Diana Martins, Nuno Gomes, Jorge Pinheiro, Ana Nogueira, Luis Delgado, Jose Luis Placido, Alice Coimbra
Summary: Mastocytosis is a rare and heterogeneous group of disorders characterized by expansion and accumulation of clonal mast cells, presenting mainly with cutaneous lesions and anaphylaxis. Due to its unusual features, the diagnosis of mastocytosis may be delayed for several years.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Dimitris Efthymiou, Persefoni Panayi, Gavriela Feketea, Constantinos Pitsios, Ioana Adriana Muntean, Emilia Vassilopoulou
Summary: The study evaluated allergy management competences in primary schools in Cyprus and found that most schools did not meet safety standards in coping with allergic reactions in children with food allergies, including the availability and training in using epinephrine auto-injectors.
Article
Medicine, General & Internal
Saerom Kim, Wanho Yoo, Hye-Kyung Park, Eun-Jung Jo
Summary: A 36-year-old woman experienced anaphylaxis after drinking a beverage containing erythritol. The skin prick test confirmed that she was allergic to erythritol, and she was advised to avoid foods with erythritol.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Allergy
Jennifer R. Yonkof, Irene J. Mikhail, Benjamin T. Prince, David Stukus
Summary: This study compared the clinical features of reactions to baked egg and baked milk with other oral food challenges, showing differences in reaction phenotypes, including significantly increased frequencies of new symptoms beginning 60 minutes or later after challenge termination.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Medicine, General & Internal
Jesus Gilberto Aramburo-Galvez, Oscar Gerardo Figueroa-Salcido, Giovanni Isai Ramirez-Torres, Eli Teran-Cabanillas, Martina Hilda Gracia-Valenzuela, Aldo Alejandro Arvizu-Flores, Cesar Antonio Sanchez-Cardenas, Jose Antonio Mora-Melgem, Luisamaria Valdez-Zavala, Feliznando Isidro Cardenas-Torres, Noe Ontiveros
Summary: This study aimed to estimate the prevalence of food allergies in a Mexican preschool population and found that a significant number of cases required emergency room visits. Proper management of food allergies and prevention of cross-contamination should be prioritized.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Waheeda Samady, Christopher Warren, Lucy A. A. Bilaver, Justin Zaslavsky, Jialing Jiang, Ruchi Gupta
Summary: This study aimed to explore US caregivers' awareness, beliefs, practices, and outcomes around peanut introduction. The survey revealed disparities and shortcomings in the practice of peanut introduction, despite some caregivers being aware of the peanut allergy prevention guidelines. Therefore, future efforts should focus on increasing guideline adherence, providing support for medical providers, and educating about the true incidence of reactions.
Article
Immunology
Catherine Ptaschinski, Andrew J. Rasky, Wendy Fonseca, Nicholas W. Lukacs
Summary: Food allergy is a growing public health concern affecting approximately 15 million people in the United States. Targeting a specific isoform of stem cell factor (SCF248) with a monoclonal antibody in a model of food allergy has shown to reduce mast cell mediated disease activation and symptoms of anaphylaxis, indicating a potential therapeutic approach for alleviating food allergy severity.
FRONTIERS IN IMMUNOLOGY
(2021)
