Article
Oncology
Archita Goyal, Gabrielle E. Milner, Ashley Cimino-Mathews, Kala Visvanathan, Antonio C. Wolff, Dipali Sharma, Jennifer Y. Sheng
Summary: Obesity following breast cancer diagnosis is associated with poor overall survival. Understanding weight trajectories will help inform breast cancer survivors at greater risk of weight gain, and those who would benefit from earlier anti-obesity interventions.
Article
Nutrition & Dietetics
Dan Lin, Kathleen M. M. Sturgeon, Brett R. R. Gordon, Justin C. C. Brown, Dorothy D. D. Sears, David B. B. Sarwer, Kathryn H. H. Schmitz
Summary: Adipocyte dysregulation is a mechanism connecting overweight and breast cancer recurrence. Exercise and weight loss can lower the risk of breast cancer recurrence in survivors with overweight or obesity, which may be due to changes in leptin levels and the adiponectin to leptin ratio. The WISER Survivor trial studied the effects of exercise, weight loss, and the combination of exercise and weight loss on adipokine levels in overweight or obese breast cancer survivors. It was found that weight loss alone or in combination with exercise significantly reduced leptin levels and increased the adiponectin to leptin ratio. However, exercise alone did not have an impact on these adipokine levels. Overall, weight loss, especially a reduction of ≥5%, was associated with decreased leptin levels and improved adipokine secretion profile.
Review
Oncology
Vicki Vuong, Vibhuti Rao, Carolyn Ee
Summary: Yoga and mindfulness-based interventions have shown effectiveness in managing obesity/overweight after breast cancer, but there are limitations in the current research on this topic that need to be addressed.
INTEGRATIVE CANCER THERAPIES
(2022)
Article
Endocrinology & Metabolism
Rebecca L. Scalzo, Rebecca M. Foright, Sara E. Hull, Leslie A. Knaub, Stevi Johnson-Murguia, Fotobari Kinanee, Jeffrey Kaplan, Julie A. Houck, Ginger Johnson, Rachel R. Sharp, Austin E. Gillen, Kenneth L. Jones, Anni M. Y. Zhang, James D. Johnson, Paul S. MacLean, Jane E. B. Reusch, Sabrina Wright-Hobart, Elizabeth A. Wellberg
Summary: Breast cancer survivors treated with tamoxifen and aromatase inhibitors may experience adipose accumulation, adipocyte hypertrophy, hepatic steatosis, hyperinsulinemia, and glucose intolerance, especially in obese individuals. These findings suggest the need to monitor glucose tolerance and consider interventions targeting insulin action for some women receiving life-saving endocrine therapies for breast cancer.
Article
Endocrinology & Metabolism
Rebecca L. Scalzo, Rebecca M. Foright, Sara E. Hull, Leslie A. Knaub, Stevi Johnson-Murguia, Fotobari Kinanee, Jeffrey Kaplan, Julie A. Houck, Ginger Johnson, Rachel R. Sharp, Austin E. Gillen, Kenneth L. Jones, Anni M. Y. Zhang, James D. Johnson, Paul S. MacLean, Jane E. B. Reusch, Sabrina Wright-Hobart, Elizabeth A. Wellberg
Summary: Breast cancer survivors treated with tamoxifen and aromatase inhibitors may experience weight gain and an elevated risk of type 2 diabetes, particularly in cases of obesity. Research on animal models of obesity and breast adipose tissue samples from women taking tamoxifen suggests that endocrine therapies may disrupt adipocyte progenitors and promote adipocyte hypertrophy, potentially leading to ectopic lipid deposition and a higher risk of type 2 diabetes.
Article
Oncology
Chul-Hyo Jeon, Ki Bum Park, Sojung Kim, Ho Seok Seo, Kyo Young Song, Han Hong Lee
Summary: We developed a user-friendly tool to predict weight change after curative gastrectomy for gastric cancer, based on clinicopathological variables. The tool takes into account factors such as age, sex, performance status, body mass index, extent of resection, pathological stage, and postoperative levels of hemoglobin, albumin, ferritin, and total iron-binding capacity. We also created an online weight prediction calculator based on the predictive model.
Article
Public, Environmental & Occupational Health
Qiao-Li Wang, Mingyang Song, Steven K. Clinton, Lorelei A. Mucci, Jesper Lagergren, Edward L. Giovannucci
Summary: This study found that lifetime body fatness accumulation, especially after age 21, was associated with increased prostate cancer angiogenesis, while weight gain in early-life adulthood was associated with lower cancer angiogenesis.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Nutrition & Dietetics
Carla Micaela Cuttica, Irene Maria Briata, Andrea DeCensi
Summary: It is established that obesity is associated with higher cancer incidence. Effective obesity treatment provides new perspectives in managing a modifiable cancer risk factor. This review summarizes the correlations between weight loss in obesity and cancer, exploring the potential of obesity treatment in clinical cancer management. The evidence for the effects of obesity therapy on proliferation, apoptosis, and chemotherapy response is reviewed. Further studies and collaboration among oncologists and obesity treatment experts are needed to fully evaluate the relationship between anti-obesity treatment and cancer.
Article
Oncology
Heather Spencer Feigelson, Clara Bodelon, J. David Powers, Rochelle E. Curtis, Diana S. M. Buist, Lene H. S. Veiga, Erin J. Aiello Bowles, Amy Berrington de Gonzalez, Gretchen L. Gierach
Summary: The study found that an increase in BMI was associated with an increased risk of developing second cancers among breast cancer survivors, especially obesity-related cancers and second breast cancers. These findings have important public health implications, highlighting the need for effective prevention strategies.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Article
Multidisciplinary Sciences
Michela Palleschi, Andrea Prochowski Iamurri, Emanuela Scarpi, Marita Mariotti, Roberta Maltoni, Francesca Mannozzi, Domenico Barone, Giovanni Paganelli, Michela Casi, Emanuela Giampalma, Ugo De Giorgi, Andrea Rocca
Summary: This study found that high baseline subcutaneous fat index and total abdominal fat index were associated with worse progression-free survival in patients with HER2-positive metastatic breast cancer receiving first-line pertuzumab/trastuzumab-based treatment.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Carolyn Ee, Anna C. Singleton, Michael de Manincor, Elisabeth Elder, Nikki Davis, Christine Mitchell, Tinashe Dune, Freya MacMillan, Kate McBride, Suzanne Grant
Summary: This study aimed to assess the feasibility and acceptability of using yoga, mindfulness meditation, and acupuncture as adjunctive therapies for weight management in breast cancer survivors. The results showed that yoga and mindfulness meditation were perceived as feasible and acceptable, but acupuncture was seen as too invasive. Factors such as focusing on wellness, flexible program delivery, trusted advice, participant burden and benefit, and peer-support were found to increase feasibility and acceptability.
INTEGRATIVE CANCER THERAPIES
(2022)
Article
Nutrition & Dietetics
Berta Mas-Pares, Silvia Xargay-Torrent, Ariadna Gomez-Vilarrubla, Gemma Carreras-Badosa, Anna Prats-Puig, Francis De Zegher, Lourdes Ibanez, Judit Bassols, Abel Lopez-Bermejo
Summary: Excessive gestational weight gain during pregnancy has negative effects on the health of offspring, which is mediated by epigenetic modifications and changes in gene expression. This study investigated the association between gestational weight gain and DNA methylation in umbilical cord tissue, and examined whether DNA methylation and the expression of corresponding genes were related to obesity-related parameters in 6-year-old children. The results showed that certain methylated CpG sites in umbilical cord tissue were associated with gestational weight gain, and higher levels of methylation in SETD8 and RPTOR genes and lower levels of methylation in SLIT3 gene were associated with an increased risk of obesity in offspring. The findings suggest that epigenetic changes in umbilical cord tissue could be potential early biomarkers for preventing childhood overweight and obesity.
Article
Immunology
Kristine M. Erlandson, Christoph C. Carter, Kathleen Melbourne, Todd T. Brown, Cal Cohen, Moupali Das, Stefan Esser, Hailin Huang, John R. Koethe, Hal Martin, Grace A. McComsey, Chloe Orkin, Frank A. Post, Juergen K. Rockstroh, Paul E. Sax, Hans-Juergen Stellbrink, Laura Waters, Xuelian Wei, Jordan E. Lake
Summary: A pooled analysis of 12 prospective clinical trials found that moderate weight gain was common after ART switch in people living with HIV, with participants who switched off of efavirenz and tenofovir having the greatest weight gain. Further study is needed to understand the biological mechanisms behind these differential effects and their clinical implications.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Food Science & Technology
Mohsen Mazidi, Emily R. Leeming, Jordi Merino, Long H. Nguyen, Somesh Selvachandran, Joan Capdavila Pujal, Tyler Maher, Kirstin Kade, Benjamin Murray, Mark S. Graham, Carole H. Sudre, Jonathan Wolf, Christina Hu, David A. Drew, Claire J. Steves, Sebastien Ourselin, Christopher Gardner, Tim D. Spector, Andrew T. Chan, Paul W. Franks, Rachel Gibson, Sarah E. Berry
Summary: Big data collected through mobile health apps shows that the COVID-19 pandemic has had diverse and extensive impacts on the diets and lifestyles of adults in the United States and the United Kingdom. The study found that disruption of health behaviors was higher in younger, female, and socio-economically deprived individuals, with greater weight loss observed in highly disrupted individuals.
Article
Oncology
Tal Sella, Yue Zheng, Zhenying Tan-Wasielewski, Shoshana M. Rosenberg, Philip D. Poorvu, Nabihah Tayob, Kathryn J. Ruddy, Shari Gelber, Rulla M. Tamimi, Lidia Schapira, Steven E. Come, Jeffrey M. Peppercorn, Virginia F. Borges, Ann H. Partridge, Jennifer A. Ligibel
Summary: One third of young breast cancer survivors experience clinically significant weight gain 3 years after diagnosis, with no observed treatment-related factors. Age-appropriate lifestyle interventions, including the reduction of financial barriers, are needed to prevent weight gain in this high-risk population.
Article
Urology & Nephrology
Saira Khan, K. Y. Wolin, R. Pakpahan, R. L. Grubb, G. A. Colditz, L. Ragard, J. Mabie, B. N. Breyer, G. L. Andriole, S. Sutcliffe
Summary: The study suggests that late-life body size is associated with adverse BPH outcomes, and interventions to reduce body size in later life could potentially reduce the burden of BPH-related outcomes and nocturia.
Article
Urology & Nephrology
Lin Yang, Jung Ae Lee, Emily Heer, Claire Pernar, Graham A. Colditz, Ratna Pakpahan, Kellie R. Imm, Eric H. Kim, Robert L. Grubb, Kathleen Y. Wolin, Adam S. Kibel, Siobhan Sutcliffe
Summary: Following RP treatment, most patients experienced a rapid decline in urinary function at 5 weeks, with gradual recovery to near or below baseline levels by 12 months, with some patients experiencing improvements beyond baseline levels on each sub-scale. Having baseline BPH symptoms was associated with post-surgical improvements in voiding and sexual function bother at both 5 weeks and 12 months, supporting consideration of baseline BPH symptoms when selecting optimal therapy for early-stage prostate cancer.
Editorial Material
Sport Sciences
David E. Conroy, Gary G. Bennett, Constantino M. Lagoa, Kathleen Y. Wolin
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Article
Nutrition & Dietetics
Cindy K. Blair, Prajakta Adsul, Dolores D. Guest, Andrew L. Sussman, Linda S. Cook, Elizabeth M. Harding, Joseph Rodman, Dorothy Duff, Ellen Burgess, Karen Quezada, Ursa Brown-Glaberman, Towela King, Erika Baca, Zoneddy Dayao, Vernon Shane Pankratz, Sally Davis, Wendy Demark-Wahnefried
Summary: The Harvest for Health program, targeting cancer survivors with a home-based vegetable gardening intervention, has shown positive outcomes in increasing vegetable and fruit consumption among adult survivors. Despite challenges posed by the COVID-19 pandemic, the program maintained a 100% retention rate and received high satisfaction ratings, indicating its feasibility and potential for further dissemination.
Article
Environmental Sciences
Tamar Ginossar, Heidi Rishel Brakey, Andrew L. Sussman, Brittany Price, Miria Kano, Sally Davis, Cindy K. Blair
Summary: The study found that older cancer survivors in rural areas are very interested in using wearable activity trackers, which helps alleviate barriers associated with the digital divide. The results will be used to inform future interventions and policies focusing on increasing physical activity in older cancer survivors residing in rural communities.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Nutrition & Dietetics
Claudia M. Rice, Pooja P. Singh, Nila S. Judd, Elizabeth Yakes Jimenez, Cindy K. Blair, Amy Washburn, Christine Calvin, Alison Steiber, Yiliang Zhu, Christos Argyropoulos, Mark Unruh, Mary Amanda Dew, Larissa Myaskovsky
Summary: This study aims to provide a culturally tailored diet and exercise intervention for kidney transplant recipients using novel technology to improve feasibility and acceptability. A registered dietitian and physical rehabilitation therapist will create individualized plans based on patients' cultural background and health obstacles, providing medical nutrition therapy throughout the intervention. The Twistle Patient Engagement Platform will be used for data collection, communication, and retention, with outcomes assessed on intervention efficacy and patient outcomes.
JOURNAL OF RENAL NUTRITION
(2022)
Article
Environmental Sciences
Elizabeth M. Harding, Ann L. Gibson, Huining Kang, Micah N. Zuhl, Harsh Sharma, Cindy K. Blair
Summary: The study found that older cancer survivors self-select a faster walking cadence to meet their daily step goals during a light-intensity physical activity intervention, leading to increased steps taken in moderate-intensity physical activity cadence bands.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Oncology
Brett R. Gordon, Maxime Caru, Cindy K. Blair, Shirley M. Bluethmann, David E. Conroy, Shawna E. Doerksen, Jonathon G. Hakun, Kathleen M. Sturgeon, Melanie Potiaumpai, Christopher N. Sciamanna, Kathryn H. Schmitz
Summary: With an aging population, rising breast cancer incidence, and obesity epidemic, there is a growing population of older adult breast cancer survivors with obesity. This complex population faces multiple poor health outcomes and symptoms, and adherence to recommended levels of moderate-to-vigorous physical activity is challenging. Therefore, research on light-intensity physical activity is warranted.
Article
Oncology
Anne LR. Schuster, Norah L. Crossnohere, Melinda Bachini, Cindy K. Blair, John D. Carpten, Elizabeth B. Claus, Graham A. Colditz, Li Ding, Bettina F. Drake, Ryan C. Fields, Katherine A. Janeway, Bethany M. Kwan, Heinz-Josef Lenz, Qin Ma, Shiraz I. Mishra, Electra D. Paskett, Timothy R. Rebbeck, Charite Ricker, Mariana C. Stern, Andrew L. Sussman, Jessica C. Timer, Jeffrey M. Trent, Roel GW. Verhaak, Nikhi Wagle, Chery Willman, John FP. Bridges
Summary: The NCI Participant Engagement and Cancer Genome Sequencing (PE-CGS) Network aims to engage diverse populations in cancer genomics research. Through a four-phase process, they have identified five priorities for participant engagement: tailoring education and communication materials, identifying measures of engagement, finding optimal engagement strategies, understanding cancer disparities, and personalized return of genomic findings to participants.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Wendy Demark-Wahnefried, Robert A. Oster, Tracy E. Crane, Laura Q. Rogers, W. Walker Cole, Harleen Kaur, David Farrell, Kelsey B. Parrish, Hoda J. Badr, Kathleen Y. Wolin, Dori W. Pekmezi
Summary: A 6-month online intervention program called DUET was conducted to promote weight loss, a healthy diet, and increased physical activity among cancer survivors and their partners. The program showed promising results in terms of weight loss, reduced caloric intake, improved physical activity and function, as well as better blood glucose and inflammation indicators. The study highlights the importance of scalable and multi-behavior interventions for cancer prevention and control.
Article
Health Care Sciences & Services
Harsh Sharma, Vernon S. Pankratz, Wendy Demark-Wahnefried, Claire R. Pestak, Cindy K. Blair
Summary: This study examined potential factors associated with maintaining or improving self-reported physical function among older cancer survivors participating in a gardening intervention impacted by the COVID-19 pandemic. The results showed that depression, fatigue, and sleeplessness were significantly associated with worse physical function scores. Better social participation and physical activity were associated with better physical function scores. Encouraging social participation and physical activity may improve the long-term health of older cancer survivors.
Article
Oncology
Cindy K. Blair, Elizabeth Harding, Charles Wiggins, Huining Kang, Matthew Schwartz, Amy Tarnower, Ruofei Du, Anita Y. Kinney
Summary: A home-based mHealth program to disrupt and replace sedentary time with stepping was feasible among and acceptable to older cancer survivors.
Article
Health Care Sciences & Services
Cindy K. Blair, Elizabeth Harding, Carla Herman, Tawny Boyce, Wendy Demark-Wahnefried, Sally Davis, Anita Y. Kinney, Vernon S. Pankratz
JMIR RESEARCH PROTOCOLS
(2020)
Article
Medicine, Research & Experimental
Anita Y. Kinney, Cindy K. Blair, Dolores D. Guest, Julianne K. Ani, Elizabeth M. Harding, Fabiano Amorim, Tawny Boyce, Joseph Rodman, C. Graham Ford, Matthew Schwartz, Larissa Rosenberg, Olivia Foran, Jerry Gardner, Yong Lin, Wadih Arap, Michael R. Irwin
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2019)
Article
Oncology
Cindy K. Blair, Charles L. Wiggins, Andrea M. Nibbe, Curt B. Storlie, Eric R. Prossnitz, Melanie Royce, Lesley C. Lomo, Deirdre A. Hill