Article
Clinical Neurology
Mohd Faizal Mohd Zulkifly, Ornela Merkohitaj, Juergen Brockmoeller, Walter Paulus
Summary: The study investigated the impact of caffeine on brain plasticity and found that it increased motor cortex excitability in caffeine-naive subjects, enhanced PAS 25 effects, and affected alertness and motor evoked potentials under light deprivation. Time of day had no effect on tACS-induced plasticity in caffeine consumers.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Ryoki Sasaki, Wei-Yeh Liao, George M. Opie, John G. Semmler
Summary: Repetitive paired-pulse transcranial magnetic stimulation can enhance the plasticity of the primary motor cortex. The orientation of the TMS coil and muscle activation can affect the activity of I-waves, but their influence on M1 plasticity with iTMS is still unclear.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Rehabilitation
Yan Gong, Xian-Ming Long, Ying Xu, Xiu-Ying Cai, Ming Ye
Summary: The study demonstrated that 1Hz rTMS combined with anodal tDCS stimulation protocol showed significant effects on motor function and cortex excitability in subacute stroke patients, making it a potential preferred rehabilitative strategy for motor recovery.
CLINICAL REHABILITATION
(2021)
Article
Clinical Neurology
Sinan Yasaroglu, Joachim Liepert
Summary: This study aimed to characterize the changes in motor excitability and motor performance induced by a single session of anodal and cathodal transcranial direct current stimulation (tDCS) in stroke patients. The results showed that anodal tDCS significantly reduced short interval intracortical inhibition (SICI) without affecting intracortical facilitation (ICF) or long interval intracortical inhibition (LICI). Cathodal tDCS did not change motor excitability. Both types of tDCS did not alter motor performance. The SICI in the affected hemisphere was lower than in the unaffected hemisphere even before anodal tDCS, and it was correlated with changes in motor performance after anodal tDCS.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shane M. Fresnoza, Giorgi Batsikadze, Lynn Elena Mueller, Constanze Rost, Michael Chamoun, Walter Paulus, Min-Fang Kuo, Michael A. Nitsche
Summary: Dopamine plays a crucial role in neuroplasticity and has dosage-dependent effects on motor cortex plasticity. Different dosages of dopamine precursor such as L-DOPA can either impair, abolish, preserve, or reverse plasticity in healthy individuals. Similarly, selective D1-like and D2-like receptor activation has excitatory and inhibitory effects on plasticity. However, the effects of nonselective dopamine agonists like apomorphine on plasticity have not been extensively explored in humans.
Article
Clinical Neurology
Lorena Melo, Mohsen Mosayebi-Samani, Elham Ghanavati, Michael A. Nitsche, Min-Fang Kuo
Summary: The study found that acute serotonin enhancement can modulate tDCS after-effects and has similar modulatory effects on motor cortex neuroplasticity regardless of the specific dosage. Only a minor dosage-dependent effect was observed for cathodal tDCS.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Milan Pantovic, Lidio Lima de Albuquerque, Sierra Mastrantonio, Austin S. Pomerantz, Erik W. Wilkins, Zachary A. Riley, Mark A. Guadagnoli, Brach Poston
Summary: Transcranial direct current stimulation (tDCS) applied to the primary motor cortex (M1) improves motor learning in relatively simple motor tasks performed with the hand and arm, but its effect on complex motor tasks involving whole-body coordination is unclear. This study found that tDCS applied over multiple days can improve motor learning in a complex overhand throwing task.
Article
Behavioral Sciences
Michael William Simpson, Margaret Mak
Summary: Patients with Parkinson's disease have the ability to learn explicit sequences of movements, but motor cortex tDCS does not improve explicit motor learning in Parkinson's disease and anodal tDCS may even suppress the rate of learning.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Medicine, Research & Experimental
Akihiro Watanabe, Daisuke Sawamura, Hisato Nakazono, Yukina Tokikuni, Hiroshi Miura, Kazuhiro Sugawara, Kanako Fuyama, Harukazu Tohyama, Susumu Yoshida, Shinya Sakai
Summary: This study aimed to investigate the effect of transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) on non-dominant hand dexterity performance and examine whether its efficacy depends on the cognitive demand of the task. The results showed that participants in the active tDCS group performed significantly better than those in the sham group after tDCS, particularly in tasks with high cognitive demands.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Soichiro Nakashima, Michihiko Koeda, Yumiko Ikeda, Tomoko Hama, Takuya Funayama, Tomomi Akiyama, Ryosuke Arakawa, Amane Tateno, Hidenori Suzuki, Yoshiro Okubo
Summary: This study aimed to investigate whether anodal tDCS at the left DLPFC affects cognitive performance and the neural basis of verbal fluency.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2021)
Article
Physiology
Brodie J. Hand, George M. Opie, Simranjit K. Sidhu, John G. Semmler
Summary: Previous research has shown that regular exercise increases plasticity in primary motor cortex (M1) and a single session of aerobic exercise can also increase M1 plasticity in untrained individuals. This study found that the effect of acute exercise on M1 plasticity is greater in endurance-trained cyclists compared to untrained individuals. Exercise history is an important factor in exercise-induced cortical plasticity.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Review
Neurosciences
Shuo Qi, Zhiqiang Liang, Zhen Wei, Yu Liu, Xiaohui Wang
Summary: This systematic review examines the effects of transcranial direct current stimulation (tDCS) on motor skills learning in healthy adults and explores the underlying neurophysiological mechanism. The review includes 11 studies that demonstrate the positive impact of tDCS on motor skills learning, as evidenced by improvements in reaction time and task performance. The activation of different brain regions, such as the primary motor cortex, left dorsolateral prefrontal cortex, and right cerebellum, contributes to these effects. However, more research with larger sample sizes is needed to further validate and explore the neurophysiological mechanisms of tDCS.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Psychiatry
Pejman Sehatpour, Johanna Kreither, Javier Lopez-Calderon, Adithya M. Shastry, Heloise M. De Baun, Antigona Martinez, Daniel C. Javitt
Summary: Motor learning dysfunction in schizophrenia is associated with poor social and functional outcomes. Transcranial direct current stimulation (tDCS) has potential for improving motor learning in schizophrenia. EEG analysis methods help evaluate the underlying neural mechanisms of this improvement.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neurosciences
Keita Takano, Natsuki Katagiri, Takatsugu Sato, Masafumi Jin, Tadaki Koseki, Daisuke Kudo, Kaito Yoshida, Shigeo Tanabe, Masahiro Tsujikawa, Kunitsugu Kondo, Tomofumi Yamaguchi
Summary: This study investigated changes in corticospinal excitability and motor control during ctDCS in healthy individuals. The results showed that MEP amplitudes were decreased and pinch force control was impaired during anodal ctDCS. These findings contribute to a basic understanding of the clinical application of ctDCS to neurorehabilitation.
Article
Anatomy & Morphology
Brenton Hordacre, Mitchell R. Goldsworthy, Lynton Graetz, Michael C. Ridding
Summary: This research investigated the impact of baseline resting state functional connectivity on responses to continuous theta burst stimulation (cTBS). The results showed that a low beta frequency band model of connectivity played a crucial role in determining responses to spaced cTBS, suggesting that M1-frontocentral networks may have an important role in the effects of cTBS on corticospinal excitability.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Neurosciences
Lingdi Fu, Lorenzo Rocchi, Ricci Hannah, Guizhi Xu, John C. Rothwell, Jaime Ibanez
Summary: The study highlights the importance of timing in inducing plastic changes in corticospinal excitability (CSE) by associating peripheral nerve stimulation with electromyogram (EMG) activity just before movement initiation. Furthermore, it demonstrates that background voluntary muscle activity can abolish the effect on CSE, suggesting that synapses inactive at rest but anticipating movement play a crucial role in plasticity induction.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Editorial Material
Clinical Neurology
Ricci Hannah, Lorenzo Rocchi, Sara Tremblay, Eleanor Wilson, John C. Rothwell
Article
Biology
Sumitash Jana, Ricci Hannah, Vignesh Muralidharan, Adam R. Aron
Review
Neurosciences
Ricci Hannah
EXPERIMENTAL BRAIN RESEARCH
(2020)
Article
Neurosciences
Sumiaki Maeo, Thomas G. Balshaw, Marcel B. Lanza, Ricci Hannah, Jonathan P. Folland
Summary: The study compared corticospinal excitability and motor representation assessed with transcranial magnetic stimulation (TMS) between long-term resistance trained (LRT, >= 3 years) and untrained (UNT) males. The results showed that long-term resistance trained individuals have higher neural efficiency and that TMS map size is mainly determined by TMS intensity, even when MEP responses at the hotspot are matched among individuals.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Po-Yu Fong, Danny Spampinato, Lorenzo Rocchi, Ricci Hannah, Yinghui Teng, Alessandro Di Santo, Mohamed Shoura, Kailash Bhatia, John C. Rothwell
Summary: By investigating the effects of different conditioning stimuli on short-interval intracortical inhibition, it was found that different current directions may activate distinct inhibitory pathways, resulting in different impacts in various tasks.
Editorial Material
Behavioral Sciences
Ricci Hannah, Sumitash Jana, Vignesh Muralidharan
Article
Neurosciences
Rachel Malcolm, Simon Cooper, Jonathan Folland, Christopher Tyler, Ricci Hannah, Caroline Sunderland
Summary: The study aimed to determine the reliability of TMS and peripheral nerve stimulation for assessing changes in the corticospinal pathway. Results showed that TMS provided reliable estimates of motor cortex output to the knee extensors, with high reliability both between-day and within-day. These findings have practical implications for estimating sample sizes in future research using TMS.
HUMAN MOVEMENT SCIENCE
(2021)
Review
Neurosciences
Ricci Hannah, Adam R. Aron
Summary: The study discusses the role of the prefrontal-basal ganglia circuit in action-stopping, mentioning research in both laboratory and real-world scenarios, as well as its clinical applications. It suggests that while the circuit plays a crucial role in various contexts, further studies are needed to prove its effectiveness in practical applications.
NATURE REVIEWS NEUROSCIENCE
(2021)
Article
Neurosciences
Jan Haeckert, John Rothwell, Ricci Hannah, Alkomiet Hasan, Wolfgang Strube
Summary: This study investigated the effects of two cTBS protocols on healthy participants, finding that there was no specific excitability modulating effect of cTBS applied to the human motor cortex under pre-relaxed muscle conditions.
Article
Neurosciences
Yazi Al'joboori, Ricci Hannah, Francesca Lenham, Pia Borgas, Charlotte J. P. Kremers, Karen L. Bunday, John Rothwell, Lynsey D. Duffell
Summary: Rehabilitative interventions involving electrical stimulation, such as transcutaneous Spinal Cord stimulation (tSCS) and Peripheral Nerve Stimulation (PNS), show promise for neuroplastic recovery in people living with Spinal Cord Injury (SCI). This study compared the immediate and short-term effects of pairing Transcranial Magnetic Stimulation (TMS) with tSCS or PNS on Corticospinal excitability in healthy subjects, demonstrating that tSCS can increase corticospinal excitability, potentially optimizing stimulation parameters for neuroplasticity in individuals with SCI.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Ricci Hannah, Vignesh Muralidharan, Adam R. Aron
Summary: Real transcranial magnetic stimulation (TMS) directly activates the brain and affects beta oscillations, while rhythmic stimulation does not enhance oscillatory activity via entrainment mechanisms.
Article
Engineering, Biomedical
Sarah Massey, Danielle Konig, Pratham Upadhyay, Zehra Beril Evcil, Rebbekha Melin, Memoona Fatima, Ricci Hannah, Lynsey Duffell
Summary: This study compared the effects of sub-threshold TSCS and TSCS-kHz at similar relative intensities to their own threshold. The results showed that TSCS-kHz decreased spinal excitability while TSCS did not. Additionally, TSCS-kHz had a greater effect on motor-evoked potential amplitude compared to TSCS at higher intensities.
Article
Psychology, Mathematical
Ricci Hannah, Vignesh Muralidharan, Adam R. Aron
Summary: This study demonstrates the validity of a new method for estimating stopping performance using kinematics and computational models. Results show good correspondence between kinematics- and model-based estimates of stopping performance at both the group and individual level.
BEHAVIOR RESEARCH METHODS
(2022)
Article
Psychology, Developmental
Eleanor R. Palser, Alejandro Galvez-Pol, Clare E. Palmer, Ricci Hannah, Aikaterini Fotopoulou, Elizabeth Pellicano, James M. Kilner
Summary: Research has found that autistic children show less differentiation in bodily maps of emotion, but this does not impact their objective or subjective interoceptive processing.