Article
Pediatrics
Mari Bratteteig, Sigmund Alfred Anderssen, Corina Silvia Rueegg, Ellen Ruud, Ingrid Kristin Torsvik, Susi Kriemler, May Grydeland
Summary: This study aimed to compare cardiovascular disease (CVD) risk factors in childhood cancer survivors (CCS) with reference values and explore the association between physical activity (PA) intensities and CVD risk factors in CCS. The study found that male CCS had less favorable values of CVD risk factors compared to reference values, and vigorous-intensity PA was associated with clinically meaningful favorable values of CVD risk factors.
FRONTIERS IN PEDIATRICS
(2022)
Article
Nutrition & Dietetics
Montserrat Gomez-Recasens, Silvana Alfaro-Barrio, Lucia Tarro, Elisabet Llaurado, Rosa Sola
Summary: Contradictory data exist on the impact of occupational physical activity (OPA) on cardiovascular health. This study found that OPA is negatively associated with cardiometabolic risk factors such as obesity, blood pressure, blood lipids, and associated medical conditions. This suggests that OPA may be beneficial for cardiovascular health.
Article
Oncology
Ali Amiri, Patrik Krumpolec, Michal Mego, Barbara Ukropcova, Michal Chovanec, Jozef Ukropec
Summary: Habitual physical activity (PA) can decrease the occurrence of cardiometabolic toxicity in long-term testicular germ cell tumor (TGCT) survivors and has positive effects on cardiometabolic health and chronic inflammation markers.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Nutrition & Dietetics
Mercedes Gil-Campos, Alexandra Perez-Ferreiros, Francisco Jesus Llorente-Cantarero, Augusto Anguita-Ruiz, Juan Jose Bedoya-Carpente, Anton Kalen, Luis A. Moreno, Gloria Bueno, Angel Gil, Concepcion M. Aguilera, Rosaura Leis
Summary: This study aimed to identify dietary and physical activity patterns in children with overweight and obesity through cluster analysis. Three clusters were identified with varying levels of physical activity and adherence to dietary recommendations. The study found that cluster 3, with the highest physical activity level, had lower body fat percentage and higher lean body mass compared to cluster 2. Adherence to both physical activity and dietary guidelines is important in understanding obesogenic habits in pediatric populations.
Article
Public, Environmental & Occupational Health
Min Chen, Yantao Liu, Xue Yang, Yu Hong, Jiaqi Ni
Summary: The objective of this study was to analyze the inpatient cost of hematopoietic stem cell transplantation (HSCT) in children to support clinical decision-making. The results showed that the total cost associated with HSCT treatment was substantial for pediatric patients. HLA compatibility between donors and recipients, as well as post-transplant complications, were important factors influencing the total cost.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Francesca Mainieri, Cosimo Giannini, Francesco Chiarelli
Summary: Cancer is a leading cause of death among children worldwide, and while survival rates have improved, survivors are at risk of metabolic abnormalities that may increase the risk of cardiovascular disease and premature mortality. Further research is needed to understand and improve long-term cardiometabolic outcomes for these patients.
Article
Environmental Sciences
Joseph M. Braun, George D. Papandonatos, Nan Li, Clara G. Sears, Jessie P. Buckley, Kim M. Cecil, Aimin Chen, Charles B. Eaton, Heidi J. Kalkwarf, Karl T. Kelsey, Bruce P. Lanphear, Kimberly Yolton
Summary: In this cohort, physical activity during adolescence modified the association between prenatal serum PFOA concentrations and cardiometabolic risk in children, suggesting that lifestyle interventions may alleviate the adverse effects of PFOA exposure. However, diet did not modify any associations.
ENVIRONMENTAL RESEARCH
(2022)
Review
Oncology
Divyanshu Mohananey, Alexandra Sarau, Rohit Kumar, David Lewandowski, Sol M. Abreu-Sosa, Sunita Nathan, Tochukwu M. Okwuosa
Summary: HSCT is a standard treatment for malignancies, with cardiovascular disease and risk factors becoming significant issues for morbidity and mortality in this patient population. Studies show beneficial effects of physical activity in HSCT patients, although data may be limited. Further research is needed on the use of cardiac rehabilitation in this population.
JACC: CARDIOONCOLOGY
(2021)
Article
Oncology
Eileen Danaher Hacker, Rae Lee Richards, Mohammad Abu Zaid, Shu-Yu Chung, Susan Perkins, Sherif Shafik Farag
Summary: This pilot study tested the acceptability, feasibility, and preliminary effects of a free-living physical activity intervention for MM patients after HCT. The results showed that the intervention was acceptable and feasible, but there were some declines in symptoms and physical performance. This study provides implications for nurses to help patients increase physical activity.
Article
Oncology
Emma R. Lipshultz, Eric J. Chow, David R. Doody, Saro H. Armenian, Barbara L. Asselin, K. Scott Baker, Smita Bhatia, Louis S. Constine, David R. Freyer, Lisa M. Kopp, Cindy L. Schwartz, Steven E. Lipshultz, Lynda M. Vrooman
Summary: The study found that childhood cancer survivors have similar or even better cardiometabolic and lifestyle profiles compared to the general population, but are still at risk for clinically significant cardiovascular disease in the future. Further strategies to support optimal control of cardiometabolic risk factors in survivors are necessary.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Biophysics
Maria Otth, Sophie Yammine, Jakob Usemann, Philipp Latzin, Luzius Mader, Ben Spycher, Tayfun Gungor, Katrin Scheinemann, Claudia E. Kuehni
Summary: This study longitudinally examined pulmonary function and associated risk factors in childhood cancer survivors after hematopoietic stem cell transplantation. While FEV1, FVC, and TLC z-scores were below expected, RV, MMEF, and DLCO were not. Factors such as female gender, chest radiotherapy, and relapse were associated with lower pulmonary function z-scores.
BONE MARROW TRANSPLANTATION
(2022)
Review
Nutrition & Dietetics
Dorota Drozdz, Julio Alvarez-Pitti, Malgorzata Wojcik, Claudio Borghi, Rosita Gabbianelli, Artur Mazur, Vesna Herceg-Cavrak, Beatriz Gonzalez Lopez-Valcarcel, Michal Brzezinski, Empar Lurbe, Elke Wuehl
Summary: Obesity is a major epidemic in the 21st century that increases the risk of various cardiometabolic factors. Early recognition of CV damage and prevention strategies are crucial in reducing CV morbidity and mortality. Recognizing and tracking risk factors from prenatal age to adulthood is essential in addressing the impact of obesity on cardiovascular health.
Article
Oncology
Anu Suominen, Anu Haavisto, Sidsel Mathiesen, Malene Mejdahl Nielsen, Paivi M. Lahteenmaki, Kaspar Sorensen, Marianne Ifversen, Christian Molgaard, Anders Juul, Klaus Muller, Kirsi Jahnukainen
Summary: The prevalence of frailty is increased among young adult childhood cancer survivors and is associated with early morbidity and mortality. Our study found that male long-term survivors of pediatric allogeneic hematopoietic stem cell transplantation showed significantly lower muscle strength and muscle endurance compared to normal values. 30% of the survivors were considered pre-frail or frail. Common cardiovascular risk factors and chronic graft-versus-host disease were associated with poor physical fitness. These findings highlight the need for long-term cardiovascular and metabolic follow-up in survivors of pediatric HSCT.
Review
Oncology
Libby Moberg, Jordan Fritch, Danielle Westmark, Daniel Santa Mina, Crystal Krause, Laura Bilek, Melissa Acquazzino
Summary: There is a lack of evidence on the effect of physical activity on fatigue in childhood cancer survivors. However, some studies have shown that increasing physical activity can help reduce fatigue in young adult survivors of childhood cancer.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Endocrinology & Metabolism
Amalia Christina Vadmand, Anne Anker Nissen, Sidsel Mathiesen, Maria Schou Ebbesen, Tina Gerbek, Martin Kaj Fridh, Kaspar Sorensen, Bolette Hartmann, Jens Juul Holst, Klaus Muller
Summary: This study demonstrates that survivors of pediatric HSCT previously treated with total body irradiation have altered production of incretin hormones, resulting in dyslipidemia and abdominal adiposity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Oncology
K. E. Effinger, R. Haardorfer, J. Gilleland Marchak, C. Escoffery, W. Landier, A. Kommajosula, E. Hendershot, K. T. Sadak, D. Eshelman-Kent, K. Kinahan, D. R. Freyer, E. J. Chow, A. C. Mertens
Summary: The purpose of this study is to examine the survivor services provided by COG institutions. A survey was conducted among 209 COG member institutions, and the results showed that the majority of these institutions offer care for pediatric and young adult survivors of childhood cancer. However, less than 75% of eligible patients have access to this care due to various barriers, including lack of dedicated time and funding for program development. The study also revealed an increase in the provision of treatment summaries by institutions in 2017 compared to 2007.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Oncology
Leena Chehab, David R. Doody, Adam J. Esbenshade, Gregory M. T. Guilcher, Christopher C. Dvorak, Brian T. Fisher, Beth A. Mueller, Eric J. Chow, Jenna Rossoff
Summary: Infections pose a significant risk for childhood cancer patients during therapy, but little is known about the risk of infection in long-term survivors. A retrospective observational study in Washington State found that survivors of childhood cancer had a higher incidence of hospitalized infections compared to individuals without cancer. The risk remained elevated even years after the initial diagnosis.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Timothy J. D. Ohlsen, David R. Doody, Beth A. Mueller, Arti D. Desai, Eric J. Chow
Summary: This retrospective cohort study found that childhood cancer-related mortality is associated with socioeconomic factors and residential location. However, the impact of rurality and neighborhood-level socioeconomic disadvantage is not well-characterized.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Eric J. Chow, Sanjeev Aggarwal, David R. Doody, Richard Aplenc, Saro H. Armenian, K. Scott Baker, Smita Bhatia, Nancy Blythe, Steven D. Colan, Louis S. Constine, David R. Freyer, Lisa M. Kopp, Caroline Laverdiere, Wendy M. Leisenring, Nao Sasaki, Lynda M. Vrooman, Barbara L. Asselin, Cindy L. Schwartz, Steven E. Lipshultz
Summary: Through evaluating four randomized trials of children with acute lymphoblastic leukemia or Hodgkin lymphoma and a nonrandomized trial of patients with osteosarcoma, it was found that dexrazoxane has cardioprotective effects for survivors of childhood cancer treated with doxorubicin, even after nearly 20 years.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Brent R. Weil, Andrew J. Murphy, Qi Liu, Rebecca M. Howell, Susan A. Smith, Christopher B. Weldon, Elizabeth A. Mullen, Arin L. Madenci, Wendy M. Leisenring, Joseph P. Neglia, Lucie M. Turcotte, Kevin C. Oeffinger, Amanda M. Termuhlen, Sogol Mostoufi-Moab, Jennifer M. Levine, Kevin R. Krull, Yutaka Yasui, Leslie L. Robison, Gregory T. Armstrong, Eric J. Chow, Saro H. Armenian
Summary: This study evaluated long-term morbidity and mortality rates among unilateral, nonsyndromic Wilms tumor (WT) survivors based on conventional treatment regimens. The results showed that survivors in different treatment groups were at risk for late mortality and chronic health conditions, especially an elevated risk for intestinal obstruction and kidney failure. The intensity of treatment was associated with an increased risk for severe chronic health conditions.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Anne E. Bantle, Kheng Joe Lau, Qi Wang, Samar Malaeb, Tasma Harindhanavudhi, Emily N. C. Manoogian, Satchidananda Panda, Douglas G. Mashek, Lisa S. Chow
Summary: In adults with overweight or obesity and without diabetes, time-restricted eating (TRE) did not significantly alter insulin sensitivity, insulin secretion, or beta-cell function over a 12-week intervention. Further investigation is needed to determine the potential benefits of TRE in adults with prediabetes or type 2 diabetes mellitus.
Review
Oncology
MatthewJ Ehrhardt, Jan M. Leerink, Renee L. Mulder, Annelies Mavinkurve-Groothuis, Wouter Kok, Anju Nohria, Paul C. Nathan, Remy Merkx, Esmee de Baat, Ogechukwu A. Asogwa, Roderick Skinner, Hamish Wallace, E. A. M. Lieke Feijen, Maelle de Ville de Goyet, Maya Prasad, Edit Bardi, Vesna Pavasovic, Helena van der Pal, Brice Fresneau, Charlotte Demoor-Goldschmidt, Ulrike Hennewig, Julia Steinberger, Chris Plummer, Ming Hui Chen, ArcoJ Teske, Nadia Haddy, Elvira C. van Dalen, Louis S. Constine, Eric J. Chow, Gill Levitt, Melissa M. Hudson, Leontien C. M. Kremer, Saro H. Armenian
Summary: Survivors of childhood, adolescent, and young adult cancer who were previously treated with anthracycline chemotherapy or radiotherapy that exposed the heart have an increased risk of developing cardiomyopathy. Specialist organizations have endorsed guidelines on cardiac surveillance for these high-risk cancer survivors, as symptomatic cardiomyopathy is typically preceded by asymptomatic changes in heart structure and function. The International Late Effects of Childhood Cancer Guideline Harmonization Group compiled these guidelines into a uniform set of recommendations applicable to different clinical environments. This systematic review and guideline provide updated recommendations based on evidence published up to September 2020.
Article
Oncology
Allison Close, Karen Burns, Kari Bjornard, Martine Webb, Josuah Chavez, Eric J. Chow, Lillian Meacham
Summary: Consultations on treatment-related risk for infertility and gonadal late effects are recommended at the time of diagnosis and during survivorship. This study provides a standardized guide to assess gonadotoxic risk and improve fertility counseling in patients undergoing COG-based leukemia/lymphoma care.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Casey R. Cai, Shelby Cornelius, Jenna Demedis, Anna M. Hagen, Mark Abbey-Lambertz, Gregory T. Armstrong, Kevin C. Oeffinger, Karen L. Syrjala, Sarah L. Taylor, Jean C. Yi, Eric J. Chow
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Oncology
Jordan Gilleland Marchak, Karim T. Sadak, Karen E. Effinger, Regine Haardorfer, Cam Escoffery, Karen E. Kinahan, David R. Freyer, Eric J. Chow, Ann Mertens
Summary: This study aimed to assess the state of healthcare transition services for childhood cancer survivors. It found that most institutions transfer adult-aged survivors to other institutions for care and few offer recognized standards for healthcare transition. The main barriers include clinicians' lack of late-effects knowledge and survivors' unwillingness to transfer care.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Public, Environmental & Occupational Health
Julia H. Rogers, Sarah N. Cox, Amy C. Link, Gift Nwanne, Peter D. D. Han, Brian Pfau, Eric J. Chow, Caitlin R. Wolf, Michael Boeckh, James P. Hughes, M. Elizabeth Halloran, Timothy M. Uyeki, M. Mia Shim, Jeffrey Duchin, Janet A. Englund, Emily Mosites, Melissa A. Rolfes, Lea A. Starita, Helen Y. Y. Chu
Summary: Homeless shelter residents and staff are at higher risk of SARS-CoV-2 infection. The study conducted routine surveillance and outbreak testing in 23 homeless shelters in King County, Washington, and found an infection rate of 4.74 per 100 individuals, with most infections being asymptomatic.
EPIDEMIOLOGY AND INFECTION
(2023)
Article
Health Care Sciences & Services
Ashley A. Meehan, Sarah N. Cox, Nicholas B. Thuo, Julia H. Rogers, Amy C. Link, Miguel A. Martinez, Natalie K. Lo, Brian J. Manns, Melissa A. Rolfes, Eric J. Chow, Helen Y. Chu, Emily Mosites, Morhaf Al Achkar
Summary: The purpose of this study was to investigate where homeless shelter residents receive health care, what contributes to positive or negative health care experiences among them, and their perceptions toward health care. Interviews and focus group discussions were conducted, revealing that participants received health care in various settings and identified four elements that influenced their experiences: access to health care financially, physically, and technologically; clarity of communication from providers and staff; ease of securing timely follow-up services; and respect versus stigma and discrimination from providers and staff. It was found that improving the patient experience for those experiencing homelessness can enhance engagement and improve health outcomes.
JOURNAL OF PATIENT-CENTERED RESEARCH AND REVIEWS
(2023)
Article
Oncology
Timothy J. D. Ohlsen, Huiqi Wang, David Buchbinder, I-Chan Huang, Arti D. Desai, Zhiyuan Zheng, Anne C. Kirchhoff, Elyse R. Park, Kevin Krull, Rena M. Conti, Yutaka Yasui, Wendy Leisenring, Gregory T. Armstrong, K. Robin Yabroff, Paul C. Nathan, Eric J. Chow
Summary: Adult siblings of childhood cancer survivors may experience greater aspects of financial hardship compared with the general population. Childhood cancer may adversely affect entire households, with potentially lasting implications.
Article
Cardiac & Cardiovascular Systems
Kasey J. Leger, Nora Robison, Hari K. Narayan, Amanda M. Smith, Tenaadam Tsega, Jade Chung, Amber Daniels, Zhen Chen, Virginia Englefield, Biniyam G. Demissei, Benedicte Lefebvre, Gemma Morrow, Ilona Dizon, Robert B. Gerbing, Reena Pabari, Kelly D. Getz, Richard Aplenc, Jessica A. Pollard, Eric J. Chow, W. H. Wilson Tang, William L. Border, Ritu Sachdeva, Todd A. Alonzo, E. Anders Kolb, Todd M. Cooper, Bonnie Ky
Summary: This study aims to compare the efficacy of a liposomal anthracycline formulation with dexrazoxane in preventing cardiotoxicity during pediatric AML therapy. It also investigates the potential of sensitive echo indices and cardiac biomarkers to predict subsequent LVSD. In addition, the study establishes expert consensus-based strategies for cardiac monitoring and anthracycline dose modification to balance the competing priorities of cardiotoxicity reduction and optimal leukemia therapy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Hematology
David Buchbinder, Neel S. Bhatt, Huiqi Wang, Yutaka Yasui, Saro Armenian, Smita Bhatia, Eric J. Chow, I. -Chan Huang, Anne C. Kirchoff, Wendy Leisenring, Elyse R. Park, K. Robin Yabroff, Gregory T. Armstrong, Paul C. Nathan, Nandita Khera
Summary: Long-term survivors of childhood cancer who received hematopoietic cell transplantation (HCT) do not report greater overall financial hardship compared to non-HCT survivors, but they do report greater overall financial hardship compared to sibling controls. Factors such as household income and chronic health conditions, rather than HCT, are associated with financial hardship among all survivors.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)