Derivation of adult canine intestinal organoids for translational research in gastroenterology

Mo1059 - Comparison of Endoscopically (Egd/Colo) Procured Enteroids and Colonoids from Normal Dogs and Dogs with Naturally Occurring Chronic Enteropathies (IBD)

(2018) Dawn D. Kingsbury et al.   GASTROENTEROLOGY

Coexpression of CD3 and CD20 in Canine Enteropathy-Associated T-cell Lymphoma

(2018) Erica L. Noland et al.   VETERINARY PATHOLOGY

Profiling extracellular vesicle release by the filarial nematode Brugia malayi reveals sex-specific differences in cargo and a sensitivity to ivermectin

(2018) Hiruni Harischandra et al.   PLoS Neglected Tropical Diseases

Advanced three-dimensional culture of equine intestinal epithelial stem cells

(2017) A. Stieler Stewart et al.   EQUINE VETERINARY JOURNAL

Localization of Toll-like Receptor (TLR) 2 and TLR4 mRNA in the Colorectal Mucosa of Miniature Dachshunds with Inflammatory Colorectal Polyps

(2017) N. Yokoyama et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

(2017) Devanjali Dutta et al.   TRENDS IN MOLECULAR MEDICINE

Long-term culture-induced phenotypic difference and efficient cryopreservation of small intestinal organoids by treatment timing of Rho kinase inhibitor

(2017) Sung-Hoon Han et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells

(2017) Kodandaramireddy Nalapareddy et al.   Cell Reports

WRN conditioned media is sufficient forin vitropropagation of intestinal organoids from large farm and small companion animals

(2017) Robin H. Powell et al.   Biology Open

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Intestinal tuft cells: epithelial sentinels linking luminal cues to the immune system

(2016) F Gerbe et al.   Mucosal Immunology

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Animal models of metabolic syndrome: a review

(2016) Sok Kuan Wong et al.   Nutrition & Metabolism

Is Science the Only Driver in Species Selection? An Internal Study to Evaluate Compound Requirements in the Minipig Compared to the Dog in Preclinical Studies

(2016) Kai Schaefer et al.   TOXICOLOGIC PATHOLOGY

Dog and human inflammatory bowel disease rely on overlapping yet distinct dysbiosis networks

(2016) Yoshiki Vázquez-Baeza et al.   Nature Microbiology

Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive function

(2015) Christa N. Grant et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

An analysis of the attrition of drug candidates from four major pharmaceutical companies

(2015) Michael J. Waring et al.   NATURE REVIEWS DRUG DISCOVERY

Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency

(2015) M. J. Ciancanelli et al.   SCIENCE

Drug discovery through stem cell-based organoid models

(2014) Adrian Ranga et al.   ADVANCED DRUG DELIVERY REVIEWS

Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon

(2014) Masayoshi Fukuda et al.   GENES & DEVELOPMENT

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

(2014) Kyle W. McCracken et al.   NATURE

Cystic fibrosis genetics: from molecular understanding to clinical application

(2014) Garry R. Cutting   NATURE REVIEWS GENETICS

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Comparative Anatomy, Physiology, and Mechanisms of Disease Production of the Esophagus, Stomach, and Small Intestine

(2014) Howard B. Gelberg   TOXICOLOGIC PATHOLOGY

Paneth Cells: Maestros of the Small Intestinal Crypts

(2013) Hans C. Clevers et al.   Annual Review of Physiology

Strategies for Improving Animal Models for Regenerative Medicine

(2013) Jose Cibelli et al.   Cell Stem Cell

Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function

(2013) Johannie Du Plessis et al.   JOURNAL OF HEPATOLOGY

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Large animal models for stem cell therapy

(2013) John Harding et al.   Stem Cell Research & Therapy

Animal Experiments in Biomedical Research: A Historical Perspective

(2013) Nuno Franco   Animals

Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

(2012) Jurian Schuijers et al.   EMBO JOURNAL

Assessing the zoonotic potential of Ascaris suum and Trichuris suis: looking to the future from an analysis of the past

(2012) P. Nejsum et al.   JOURNAL OF HELMINTHOLOGY

Distinct levels of Sox9 expression mark colon epithelial stem cells that form colonoids in culture

(2011) S. Ramalingam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture

(2011) Louise C. Laurent et al.   Cell Stem Cell

Intestinal development and differentiation

(2011) Taeko K. Noah et al.   EXPERIMENTAL CELL RESEARCH

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Copy number variation and selection during reprogramming to pluripotency

(2011) Samer M. Hussein et al.   NATURE

International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of Prostanoid Receptors, Updating 15 Years of Progress

(2011) D. F. Woodward et al.   PHARMACOLOGICAL REVIEWS

Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro

(2010) Adam D. Gracz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Naturally occurring mutations in the canine CFTR gene

(2010) Domenico Spadafora et al.   PHYSIOLOGICAL GENOMICS

Inflammatory bowel disease in the dog: Differences and similarities with humans

(2010) Matteo Cerquetella   WORLD JOURNAL OF GASTROENTEROLOGY

Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium

(2009) Eric J. Formeister et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

Molecular-phylogenetic characterization of microbial communities imbalances in the small intestine of dogs with inflammatory bowel disease

(2008) Panagiotis G. Xenoulis et al.   FEMS MICROBIOLOGY ECOLOGY

Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition

(2008) R. F. Goldberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

(2007) Andrea Hartsock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES