Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1872, Issue 1, Pages 60-65Publisher
ELSEVIER
DOI: 10.1016/j.bbcan.2019.05.008
Keywords
Mitotic checkpoint; DNA damage checkpoint; Defective chromosome segregations; Chromosome abnormalities; Aneuploidy; Hepatocellular carcinoma
Categories
Funding
- [2017A5TXC3]
Ask authors/readers for more resources
Hepatocellular carcinoma (HCC), the most common form of liver cancer, represents a health problem in hepatic viruses-eradicating era because obesity, type 2 diabetes, and nonalcoholic steatohepatitis (NASH) are considered emerging pathogenic factors. Metabolic disorders underpin mitotic errors that lead to numerical and structural chromosome aberrations in a significant proportion of cell divisions. Here, we review that genomically unstable HCCs show evidence for a paradoxically DNA damage response (DDR) which leads to ongoing chromosome segregation errors. The understanding of DDR induced by defective mitoses is crucial to our ability to develop or improve liver cancer therapeutic strategies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available