Article
Multidisciplinary Sciences
Chin-Kuo Lin, Tzu-Hsiung Huang, Cheng-Ta Yang, Chung-Sheng Shi
Summary: The study found that lung-recruited monocytes post-VILI are predominantly Ly6C(+low), and pulmonary VEGF decreases initially but increases significantly on days 7 and 14 after injury. There is a strong positive correlation between VEGF expression and alveolar epithelial cell proliferation, and the restoration of pulmonary VEGF by monocytes may play a crucial role in post-VILI lung repair.
Review
Clinical Neurology
Gan Gao, Si-meng Liu, Fang-bin Hao, Qian-Nan Wang, Xiao-Peng Wang, Min-jie Wang, Xiang-Yang Bao, Cong Han, Lian Duan
Summary: Indirect revascularization is a crucial technique for treating Moyamoya disease. The formation of collateral circulation is key in improving cerebral blood perfusion and reducing the risk of stroke, and serves as a major indicator of the success of indirect revascularization. Predicting and promoting collateral circulation formation before and after surgery is important for the success of indirect revascularization in Moyamoya disease. Factors such as vascular endothelial growth factor, endothelial progenitor cells, Caveolin-1, and the genetic factor RNF213 play significant roles in the formation of collateral vessels after indirect revascularization through endothelial hyperplasia and smooth muscle migration.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Haiyan Yang, Cancan He, Yang Bi, Xu Zhu, Dan Deng, Tingting Ran, Xiaojuan Ji
Summary: This study found that VEGF and SDF-1 alpha synergistically enhance the migration, differentiation, and proliferation capabilities of EPCs, but not VSMCs. This finding provides a promising strategy for the prevention of vascular stenosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Yelda Pakize Kina, Ali Khadim, Werner Seeger, Elie El Agha
Summary: Multiple factors converge to coordinate organogenesis, particularly in the context of lung development where airway branching is considered a rate-limiting step. The reciprocal interaction between the vascular network and airway tree plays a critical role in their patterning, branching, and alignment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Pengcheng Cai, Rui Ni, Mengzhu Lv, Huijuan Liu, Jieqiong Zhao, Jianbo He, Lingfei Luo
Summary: This study reveals the crucial role of VEGF signaling in initiating BEC-to-hepatocyte transdifferentiation, mediated by the activation of the PI3K-mTORC1 axis. Modulation of VEGF signaling in BECs could be a potential therapeutic approach for patients with end-stage liver diseases.
Article
Multidisciplinary Sciences
Yoshiya Asano, Daisuke Okano, Michiya Matsusaki, Tetsuro Watabe, Yasuhiro Yoshimatsu, Mitsuru Akashi, Hiroshi Shimoda
Summary: In this study, an artificial vascular tissue constructed by human adipose tissue-derived stromal cells (hASCs) and HUVECs (ASCVT) showed higher vascular network density and expression of angiogenesis-related factors. Subcutaneous transplantation of ASCVT into nude mice resulted in the formation of functional vessel networks within 4 weeks.
SCIENTIFIC REPORTS
(2021)
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Article
Physiology
Jianwen Liang, Jian Shi, Wenbin Wei, Guifu Wu
Summary: The study showed that enhanced external counterpulsation therapy can reduce systolic and diastolic blood pressure in hypertension, increase endothelial dilation function, and improve the migration and adhesion functions of endothelial progenitor cells. The function of endothelial progenitor cells is closely related to vascular dilation function.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Review
Cell Biology
Alice Costa, Gianandrea Pasquinelli
Summary: Extensive evidence indicates that air pollution exposure is associated with an increased risk of cardiovascular disease development. Fine particulate matter, one of the main components of urban pollution, exerts adverse effects on the cardiovascular system through unknown mechanisms. This review provides an overview of the potential mechanisms by which air pollution hinders vascular repair by altering the functionality of stem cells and progenitor cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Carlos Escudero, Jesenia Acurio, Eduardo Lopez, Andres Rodriguez, Antonia Benavente, Evelyn Lara, Steven J. Korzeniewski
Summary: Circulating VEGF levels were found to be elevated 24-48 hours after acute ischemic stroke and were associated with prognosis of moderate to severe disability at 6 months. Combining VEGF with interleukin 6 and C-reactive protein significantly improved predictive performance compared to using VEGF alone.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Jiannan Gong, Zihang Feng, Abigail L. Peterson, Jennifer F. Carr, Xuexin Lu, Haifeng Zhao, Xiangming Ji, You-Yang Zhao, Monique E. De Paepe, Phyllis A. Dennery, Hongwei Yao
Summary: The study showed that hyperoxia can exacerbate abnormal endothelial cell proliferation and dysmorphic vascular growth in neonatal mice through the pentose phosphate pathway (PPP), while inhibition of the PPP can reduce these effects.
Article
Cell Biology
Marion Mesnieres, Anna-Marei Bohm, Nicolas Peredo, Dana Trompet, Roger Valle-Tenney, Manmohan Bajaj, Nikky Corthout, Elena Nefyodova, Ruben Cardoen, Pieter Baatsen, Sebastian Munck, Andras Nagy, Jody J. Haigh, Satish Khurana, Catherine M. Verfaillie, Christa Maes
Summary: The balanced local crosstalk within the skeletal niche is crucial for the successful settlement of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow, with overproduction of VEGF by osteoprogenitor cells impacting stromal-vessel interface and vascular architecture, resulting in impaired HSPC homing and survival. These findings highlight potential targets for improving stem cell therapies, as similar osteo-angiogenic niche changes are induced by irradiation in adult mice.
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Yolanda Fernandez-Cladera, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Agustin F. Gonzalez-Rivero, Antonia De Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study analyzed the relationship between VEGF and sVEGFR with SLE disease-related features and found that serum levels of VEGF and sVEGFR in SLE patients were associated with disease damage, with musculoskeletal manifestations being the most commonly associated feature.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)