Nanoparticle Therapy for Vascular Diseases

Effect of an siRNA Therapeutic Targeting PCSK9 on Atherogenic Lipoproteins: Pre-Specified Secondary End Points in ORION 1

(2018) Kausik K. Ray et al.   CIRCULATION

The role of non-resolving inflammation in atherosclerosis

(2018) Canan Kasikara et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

(2018) Tom T.P. Seijkens et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Nanoparticles for Detection and Treatment of Peripheral Arterial Disease

(2018) Linda C. Noukeu et al.   Small

Copper sulfide nanoparticles as a photothermal switch for TRPV1 signaling to attenuate atherosclerosis

(2018) Wen Gao et al.   Nature Communications

Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates

(2018) Marnix Lameijer et al.   Nature Biomedical Engineering

Targeted Therapy of Atherosclerosis by a Broad-Spectrum Reactive Oxygen Species Scavenging Nanoparticle with Intrinsic Anti-inflammatory Activity

(2018) Yuquan Wang et al.   ACS Nano

Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk

(2017) Brian A. Ference et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9

(2017) Kevin Fitzgerald et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol

(2017) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeted Nanotherapeutics Encapsulating Liver X Receptor Agonist GW3965 Enhance Antiatherogenic Effects without Adverse Effects on Hepatic Lipid Metabolism in Ldlr−/− Mice

(2017) Mikyung Yu et al.   Advanced Healthcare Materials

Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis

(2016) Nazila Kamaly et al.   ACS Nano

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeted Nitric Oxide Delivery by Supramolecular Nanofibers for the Prevention of Restenosis After Arterial Injury

(2016) Edward S.M. Bahnson et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of Thrombin With PPACK-Nanoparticles Restores Disrupted Endothelial Barriers and Attenuates Thrombotic Risk in Experimental AtherosclerosisSignificance

(2016) Rohun U. Palekar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pioglitazone-Incorporated Nanoparticles Prevent Plaque Destabilization and Rupture by Regulating Monocyte/Macrophage Differentiation inApoE−/−MiceSignificance

(2016) Soichi Nakashiro et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

(2016) Yoko Kojima et al.   NATURE

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction

(2016) Hendrik B. Sager et al.   Science Translational Medicine

In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models

(2016) Carlos Pérez-Medina et al.   JACC-Cardiovascular Imaging

Safety of Nanoparticles in Medicine

(2015) Joy Wolfram et al.   CURRENT DRUG TARGETS

Cardiovascular Drug Development

(2015) Christopher B. Fordyce et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pharmaceutical development and preclinical evaluation of a GMP-grade anti-inflammatory nanotherapy

(2015) Mark E. Lobatto et al.   Nanomedicine-Nanotechnology Biology and Medicine

Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration

(2015) Fleur M. van der Valk et al.   Nanomedicine-Nanotechnology Biology and Medicine

Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo

(2015) Daniel R. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice

(2015) Gabrielle Fredman et al.   Science Translational Medicine

Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation

(2015) J. Tang et al.   Science Advances

Construction and Evaluation of Fe3O4-Based PLGA Nanoparticles Carrying rtPA Used in the Detection of Thrombosis and in Targeted Thrombolysis

(2014) Jun Zhou et al.   ACS Applied Materials & Interfaces

Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis

(2014) Yoko Kojima et al.   JOURNAL OF CLINICAL INVESTIGATION

Selective uptake of single-walled carbon nanotubes by circulating monocytes for enhanced tumour delivery

(2014) Bryan Ronain Smith et al.   Nature Nanotechnology

A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation

(2014) Raphaël Duivenvoorden et al.   Nature Communications

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

Nanoparticle Drug- and Gene-eluting Stents for the Prevention and Treatment of Coronary Restenosis

(2014) Rui-Xing Yin et al.   Theranostics

Nanoparticle-Mediated Delivery of Pitavastatin Inhibits Atherosclerotic Plaque Destabilization/Rupture in Mice by Regulating the Recruitment of Inflammatory Monocytes

(2013) Shunsuke Katsuki et al.   CIRCULATION

Adventitial Nab-Rapamycin Injection Reduces Porcine Femoral Artery Luminal Stenosis Induced by Balloon Angioplasty via Inhibition of Medial Proliferation and Adventitial Inflammation

(2013) Warren J. Gasper et al.   Circulation-Cardiovascular Interventions

Local drug delivery to prevent restenosis

(2013) Stephen M. Seedial et al.   JOURNAL OF VASCULAR SURGERY

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

(2013) Kevin Fitzgerald et al.   LANCET

Near Infrared Imaging and Photothermal Ablation of Vascular Inflammation Using Single‐Walled Carbon Nanotubes

(2013) Hisanori Kosuge et al.   Journal of the American Heart Association

Targeted anti-inflammatory systemic therapy for restenosis: The Biorest Liposomal Alendronate with Stenting sTudy (BLAST)—a double blind, randomized clinical trial

(2012) Shmuel Banai et al.   AMERICAN HEART JOURNAL

Inflammation in Atherosclerosis

(2012) Peter Libby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pitavastatin-Incorporated Nanoparticle-Eluting Stents Attenuate In-Stent Stenosis without Delayed Endothelial Healing Effects in a Porcine Coronary Artery Model

(2012) Noriaki Tsukie et al.   Journal of Atherosclerosis and Thrombosis

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

A New Drug Delivery System for Intravenous Coronary Thrombolysis With Thrombus Targeting and Stealth Activity Recoverable by Ultrasound

(2012) Hiroyuki Kawata et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Imatinib Mesylate-Incorporated Nanoparticle-Eluting Stent Attenuates In-Stent Neointimal Formation in Porcine Coronary Arteries

(2011) Seigo Masuda et al.   Journal of Atherosclerosis and Thrombosis

siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids

(2011) Marija Tadin-Strapps et al.   JOURNAL OF LIPID RESEARCH

A fibrin-specific thrombolytic nanomedicine approach to acute ischemic stroke

(2011) Jon N Marsh et al.   Nanomedicine

Therapeutic siRNA silencing in inflammatory monocytes in mice

(2011) Florian Leuschner et al.   NATURE BIOTECHNOLOGY

In vivo prevention of arterial restenosis with paclitaxel-encapsulated targeted lipid-polymeric nanoparticles

(2011) J. M. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local arterial nanoparticle delivery of siRNA for NOX2 knockdown to prevent restenosis in an atherosclerotic rat model

(2010) J M Li et al.   GENE THERAPY

Multimodal Clinical Imaging To Longitudinally Assess a Nanomedical Anti-Inflammatory Treatment in Experimental Atherosclerosis

(2010) Mark E. Lobatto et al.   MOLECULAR PHARMACEUTICS

Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields

(2010) M. Chorny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Light-Activated Theranostic Nanoagent for Targeted Macrophage Ablation in Inflammatory Atherosclerosis

(2010) Jason R. McCarthy et al.   Small

Segmental Heterogeneity of Vasa Vasorum Neovascularization in Human Coronary Atherosclerosis

(2010) Mario Gössl et al.   JACC-Cardiovascular Imaging

Chemical conjugation of urokinase to magnetic nanoparticles for targeted thrombolysis

(2009) Feng Bi et al.   BIOMATERIALS

Magnetically targeted thrombolysis with recombinant tissue plasminogen activator bound to polyacrylic acid-coated nanoparticles

(2009) Yunn-Hwa Ma et al.   BIOMATERIALS

Formulation of Nanoparticle-Eluting Stents by a Cationic Electrodeposition Coating Technology

(2009) Kaku Nakano et al.   JACC-Cardiovascular Interventions

Sorafenib for Treatment of Renal Cell Carcinoma: Final Efficacy and Safety Results of the Phase III Treatment Approaches in Renal Cancer Global Evaluation Trial

(2009) Bernard Escudier et al.   JOURNAL OF CLINICAL ONCOLOGY

Nitric Oxide-Loaded Echogenic Liposomes for Nitric Oxide Delivery and Inhibition of Intimal Hyperplasia

(2009) Shao-Ling Huang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Collagens in the progression and complications of atherosclerosis

(2009) Eser Adiguzel et al.   VASCULAR MEDICINE

Intramural Delivery of Rapamycin With α v β 3 -Targeted Paramagnetic Nanoparticles Inhibits Stenosis After Balloon Injury

(2008) Tillmann Cyrus et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Site-Specific Targeting of Nanoparticle Prednisolone Reduces In-Stent Restenosis in a Rabbit Model of Established Atheroma

(2008) Michael Joner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nanotechnology in Medical Imaging

(2008) David P. Cormode et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Atherosclerosis Inflammation Imaging with 18F-FDG PET: Carotid, Iliac, and Femoral Uptake Reproducibility, Quantification Methods, and Recommendations

(2008) J. H.F. Rudd et al.   JOURNAL OF NUCLEAR MEDICINE

A role for VEGF as a negative regulator of pericyte function and vessel maturation

(2008) Joshua I. Greenberg et al.   NATURE

Carbon nanotubes as photoacoustic molecular imaging agents in living mice

(2008) Adam De La Zerda et al.   Nature Nanotechnology

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

(2008) M. Frank-Kamenetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiangiogenic Synergism of Integrin-Targeted Fumagillin Nanoparticles and Atorvastatin in Atherosclerosis

(2008) Patrick M. Winter et al.   JACC-Cardiovascular Imaging

Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis

(2007) Matthias Nahrendorf et al.   CIRCULATION