Article
Biophysics
Victoria L. Abdo, Lina J. Suarez, Lucca Gomes de Paula, Raphael C. Costa, Jamil Shibli, Magda Feres, Valentim A. R. Bara, Martinna Bertolini, Joao Gabriel Silva Souza
Summary: This study investigates the issue of microbial contamination of resorbable membranes, finding that different types of bacteria colonize the exposed membrane surface, thereby affecting the effectiveness of bone regeneration therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Polymer Science
Manuel Toledano-Osorio, Cristina Vallecillo, Marta Vallecillo-Rivas, Francisco-Javier Manzano-Moreno, Raquel Osorio
Summary: Polymeric membranes are commonly utilized in bone regeneration for oral and periodontal surgeries by providing mechanical support and enhancing cell proliferation. Local antibiotic therapy using polymeric membranes has shown promising antibacterial effects, although further research and clinical studies are needed for validation.
Review
Biotechnology & Applied Microbiology
Ze Yang, Chang Wu, Huixin Shi, Xinyu Luo, Hui Sun, Qiang Wang, Dan Zhang
Summary: Guided bone regeneration (GBR) is a widely used technique for alveolar bone augmentation. The success of GBR relies on the barrier membrane, which should have satisfactory biological and mechanical properties. Currently, the bone augmentation effect of barrier membranes used in clinical practice depends on the body's own growth potential, and the osteogenic effect is difficult to predict. Therefore, researchers have been exploring new barrier membranes to improve the success rate of bone enhancement.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Engineering, Biomedical
Zili Zhou, Jiahao Yun, Jie Li, Yimeng Chen, Tingting Duan, Liqiao Wang, Jianmin Han, Heng Bo Jiang, Guangliang Niu
Summary: This review evaluated the osteogenic properties, degradation characteristics, and postoperative complications of eight biodegradable membranes in animal experiments. Natural polymer membranes were found to be more effective for bone regeneration, and magnesium alloys were proven to be promising barrier materials.
BIOMEDICAL MATERIALS
(2023)
Review
Polymer Science
Ali M. Alqahtani
Summary: This comprehensive review provides an in-depth analysis of the use of biomaterials in guided tissue and bone regeneration in dental therapeutic interventions. The review explores different types of membranes and biomaterials used in guided bone regeneration procedures, as well as the manufacturing technologies for the scaffold. The significance of guided bone regeneration and the critical role of membranes in successful bone and tissue regeneration are emphasized.
Article
Polymer Science
Yue Gao, Shuai Wang, Biying Shi, Yuxuan Wang, Yimeng Chen, Xuanyi Wang, Eui-Seok Lee, Heng-Bo Jiang
Summary: This review discusses the GTR/GBR materials used in bone/tissue regeneration engineering and the functional properties required for these membranes. While no single modern membrane meets all the necessary characteristics, the development of novel modified materials provides new possibilities in this field.
Article
Chemistry, Multidisciplinary
Sorina-Mihaela Solomon, Irina-Georgeta Sufaru, Silvia Teslaru, Cristina Mihaela Ghiciuc, Celina Silvia Stafie
Summary: Guided tissue regeneration (GTR) and guided bone regeneration (GBR) are common procedures in periodontal treatment, which require the use of a barrier membrane to prevent cell invasion into newly formed bone structure. There are absorbable membranes and non-absorbable membranes available, with absorbable membranes being more widely used but non-absorbable membranes preferred in cases of significant tissue loss.
APPLIED SCIENCES-BASEL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Alberto Turri, Omar Omar, Margarita Trobos, Peter Thomsen, Christer Dahlin
Summary: This study compared the molecular events in the overlying soft tissue, membrane, and underlying bone defect during guided bone regeneration using dual-layered expanded PTFE membranes versus dense PTFE membranes. The results showed that both membranes promoted overall bone formation, with the dual-layered expanded PTFE membrane leading to a significantly higher proportion of new bone. The soft tissue in the dual-layered expanded PTFE group exhibited increased expression of genes related to regeneration and vascularization, as well as lower expression of proinflammatory cytokines, compared to the dense PTFE group.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Review
Materials Science, Multidisciplinary
Yuwei Zhu, Lei Zhao, To Ngai
Summary: Periodontal disease can lead to severe degeneration of periodontium tissue, and the prevalence of this disease is increasing worldwide. Guided tissue regeneration (GTR) therapy with advanced multiphasic membranes/scaffolds has been successful in restoring periodontal tissues and functions. This review discusses the recent advancements in the design of multiphasic GTR membranes/scaffolds and their therapeutic efficacy in vitro and in vivo.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Cell Biology
Siddharth Shanbhag, Carina Kampleitner, Niyaz Al-Sharabi, Samih Mohamed-Ahmed, Karol Ali Apaza Alccayhuaman, Patrick Heimel, Stefan Tangl, Andreas Beinlich, Neha Rana, Mariano Sanz, Einar K. Kristoffersen, Kamal Mustafa, Reinhard Gruber
Summary: Functionalizing collagen membranes (MEM) with conditioned media (CM) from human bone marrow MSC (MEM-CM) enhanced new bone formation in rat calvarial defects. Lyophilized MEM-CM (CM-LYO) showed superior radiographic and histological outcomes compared to soaking prepared MEM-CM (CM-SOAK), MEM with rat MSC (CEL), and native MEM groups. Proteomic analysis of CM-LYO revealed enriched proteins and biological processes related to bone formation.
Article
Materials Science, Multidisciplinary
Qin Luo, Xuzhao He, Xiyue Duan, Haoqing Liu, Zhiyuan Zhou, Kui Cheng
Summary: A Poly(vinylidene fluoride-trifluoroethylene)-coated-Poly methyl methacrylate Janus membrane was developed to modulate cell response by adjusting surface potentials, potentially guiding bone regeneration and preventing soft tissue adhesion.
Review
Engineering, Biomedical
Soo-Ling Bee, Zuratul Ain Abdul Hamid
Summary: This article reviews the latest developments and applications of asymmetric barrier membranes used in periodontal regeneration. It first presents the requirements for constructing barrier membranes and the principles behind the asymmetric design, then discusses various innovative methods, and finally summarizes the application and evaluation of different types of asymmetric barrier membranes.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Roberto Rossi, Michele Modoni, Riccardo Monterubbianesi, Giacomo Dallari, Lucia Meme
Summary: This paper discusses the positive effects of using bone lamina in guided bone regeneration, including the GBR effect on edentulous ridges and the augmented support to neighboring natural dentition, known as the 'GTR effect'. The technique has low complication rates and additional benefits.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Lin Zhang, Yunsheng Dong, Yufei Liu, Xiangsheng Liu, Zhitao Wang, Jinpeng Wan, Xinyi Yu, Shufang Wang
Summary: Multifunctional composite scaffolds have potential applications in the treatment of periodontal diseases, promoting bone regeneration and preventing fibrous tissue infiltration into bone defects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Manuel Toledano, Marta Vallecillo-Rivas, Maria T. Osorio, Esther Munoz-Soto, Manuel Toledano-Osorio, Cristina Vallecillo, Raquel Toledano, Christopher D. Lynch, Maria-Angeles Serrera-Figallo, Raquel Osorio
Summary: The study highlights the significant role of zinc-doped membranes in guided bone regeneration, showing their ability to inhibit bacterial colonization, promote bioactivity and bone regeneration, as well as demonstrating good biocompatibility and mechanical properties.
Article
Dentistry, Oral Surgery & Medicine
F. Hernandez-Alfaro, C. Mezquida-Fernandez, P. J. Brabyn, E. Querejeta-Lomas, J. Torres-Gaya, A. Valls-Ontanon
Summary: The objective of this study was to update and redefine some concepts of the surgery-first approach after 10 years of experience. The study found that the surgery-first approach is especially suitable for patients who desire immediate aesthetic result, short-term orthodontics, or treatment of sleep-related breathing disorders.
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Federico Hernandez-Alfaro, Gian Maria Ragucci, Adaia Valls-Ontanon, Ali Adnan Hamawandi, Jorge Bertos-Quilez
Summary: Covering the extrasinusal length of extramaxillary zygomatic implants with a pedicled buccal fat pad flap appears to reduce the risk of soft tissue recession and exposure of the implant surface to the oral cavity.
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
(2022)
Review
Chemistry, Physical
Ernest Lucas-Taule, Anna Bofarull-Ballus, Marc Llaquet, Montse Mercade, Federico Hernandez-Alfaro, Jordi Gargallo-Albiol
Summary: Tooth autotransplantation is a viable treatment option with high survival and success rates, regardless of the apical condition. Open-apex donor teeth are preferable, showing lower complication rates compared to closed-apex donor teeth.
Article
Chemistry, Physical
Maria Giralt-Hernando, Gian Maria Ragucci, Oriol Canto-Naves, Adaia Valls-Ontanon, Federico Hernandez-Alfaro
Summary: The study aimed to identify contributing covariates to implant failure and marginal bone loss (MBL) at the 1-year follow-up of a novel triangular-neck implant design placed by inexperienced post-graduate students. The survival and success rates of the V3 triangular-neck implant placed by inexperienced post-graduate students were high at the 1-year follow-up, similar to those published in the literature by experienced teams on other implants.
Article
Dentistry, Oral Surgery & Medicine
I. Camps-Pereperez, R. Guijarro-Martinez, B. M. da Rosa, O. L. Haas Jr, F. Hernandez-Alfaro
Summary: This study used cone beam computed tomography (CBCT) to evaluate dentoskeletal changes in minimally invasive surgically assisted rapid palatal expansion (SARPE). The results showed a statistically significant increase in the linear transverse dimensions of the maxilla, as well as dental inclination to the buccal aspect. However, significant expansion of the maxilla at the skeletal and dentoalveolar levels was confirmed.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
A. Valls-Ontanon, S. Triginer-Roig, I. Trujillo, P. J. Brabyn, M. Giralt-Hernando, F. Hernandez-Alfaro
Summary: The study aimed to compare the stability of surgery-first and surgery-late approaches using standardized protocols. Three-dimensional evaluation was conducted after 1 year of follow-up. A retrospective study included a test group (surgery-first) and a control group (surgery-late) with a follow-up period of at least 1 year. Results showed that both groups demonstrated comparable three-dimensional stability, with significant changes in measurements post-surgery but no statistically significant differences between the two groups at the end of treatment. However, a relapse in SNA angle was more significant in the surgery-late group at the 1-year follow-up, and only present in Class III patients.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2023)
Review
Chemistry, Physical
Andrea Galve-Huertas, Maria Jose Zilleruelo-Pozo, Susana Garcia-Gonzalez, Octavi Ortiz-Puigpelat, Federico Hernandez-Alfaro, Samir Aboul-Hosn Centenero
Summary: This study conducted a systematic review to evaluate the application of a novel macroimplant with an angled platform in immediate implant treatment. The results showed a 95.9% survival rate, low marginal bone loss, and minimal soft tissue recession at one year of follow-up. However, caution should be taken in interpreting the findings due to the heterogeneity of the data.
Review
Dentistry, Oral Surgery & Medicine
Federico Hernandez-Alfaro, Jocelyn Vivas-Castillo, Rogerio Belle de Oliveira, Orion Hass-Junior, Maria Giralt-Hernando, Adaia Valls-Ontanon
Summary: The study aimed to validate the previously published facial anteroposterior reference, the upper incisor (UI) to soft tissue plane or Barcelona line (BL), which traces the aesthetic sagittal position of the maxilla. A cross-sectional multicentre evaluation was conducted on Caucasian patients from Spain and Brazil with different maxillary positions. The results indicate that protrusive middle-third facial profiles are preferred, and the BL is proposed as a simple tool for tracing an aesthetic sagittal position of the maxilla in orthognathic surgery.
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
F. Hernandez-Alfaroa, M. Ghuloom, M. Giralt-Hernando, A. Lazaro-Abdulkarim, A. Valls-Ontanon
Summary: The aim of this study was to evaluate the accuracy and clinical implications of a transmucosal pterygomaxillary junction (PMJ) osteotomy using a piezoelectric hand-piece device in the context of Le Fort I osteotomy. The study found that the accuracy of the PMJ disjunction path was higher when the transmucosal PMJ osteotomy was performed. The need for bone trimming and removal of the upper third molar were identified as relevant factors affecting the accuracy.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
F. Hernandez-Alfaro, G. -M. -M. Ragucci, M. Giralt-Hernando, J. Carames, A. Valls-Ontanon
Summary: This study proposes a method for dental rehabilitation using zygoma implants to improve lip support in severe maxillary atrophy. Three patients were treated with zygomatic implants and the pillow technique. The results showed successful osseointegration, with a mean improvement in skeletal projection and high patient satisfaction.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Federico Hernandez-Alfaro, Adaia Valls-Ontanon
ORAL AND MAXILLOFACIAL SURGERY CLINICS OF NORTH AMERICA
(2023)
Review
Dentistry, Oral Surgery & Medicine
Orion L. Haas Junior, Bibiana M. Rosa, Navid Pourtaheri, Raquel Guijarro-Martinez, Adaia Valls-Ontanon, Federico Hernandez-Alfaro, Rogerio B. de Oliveira, Derek M. Steinbacher
Summary: This systematic review compares different fat-grafting techniques for cleft lip and palate repair. The review includes 25 articles and demonstrates that fat grafting can improve outcomes in cleft lip and palate repair. The use of dermis-fat grafts in lip repair and fat infiltration in lip augmentation have shown positive results. However, further studies are needed to determine the superiority of one technique over the other.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2023)
Article
Chemistry, Physical
Erika Brancacci, Susana Garcia Gonzalez, Andrea Galve-Huertas, Aida Bennani, Federico Hernandez Alfaro, Samir Aboul-Hosn Centenero
Summary: This ex vivo study investigated the effects of increasing insertion torques on three different types of dental implants. Higher torques (45 Ncm and above) resulted in significant deformations on the implant surfaces and compromised prosthetic connections.
Article
Dentistry, Oral Surgery & Medicine
Adaia Valls-Ontanon, Ozlem Kesmez, Thomas Starch-Jensen, Sergi Triginer-Roig, David Neagu-Vladut, Federico Hernandez-Alfaro
Summary: This study compared the intra- and postoperative complications as well as bone healing between bilateral sagittal split osteotomy (BSSO) with or without concomitant removal of third molars. A retrospective analysis was conducted on two cohorts, one in which third molars were extracted during BSSO (test group) and the other in which third molars were extracted at least 6 months prior to BSSO (control group), with a follow-up period of at least 1 year. The results showed that concomitant molar extraction increased surgery time but did not result in additional complications. Bone density increased in both groups, with the same magnitude of increase, although the control group had higher immediate and final postoperative bone densities.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jordi Marques-Guasch, Rafel Rodriguez-Bauza, Marta Satorres-Nieto, Wang Hom-Lay, Federico Hernandez-Alfaro, Jordi Gargallo-Albiol
Summary: Based on a study performed by a novice operator on a cadaveric model, dynamic navigation-guided surgery (DNGS) allows for accurate implant positioning, with practice required to develop the necessary eye-hand coordination.
INTERNATIONAL JOURNAL OF COMPUTERIZED DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Engku Nasiha Engku Ngah Sayuddin, Muhammad Taher, Mohd Hafiz Arzmi, Nor Aszlitah Burhanudin, Muhamad Ashraf Rostam
Summary: This article reviews the role of podoplanin in oral cancer and its potential as a therapeutic agent. High expression of podoplanin has been observed in oral cancer and pre-cancerous lesions, suggesting that inhibitors targeting podoplanin could be effective in treating oral cancer.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Doris Haydee Rosero Salazar, Sydney Honnlee, Zi-Jun Liu
Summary: This study analyzed the dynamics and coordination of oropharyngeal muscles during natural chewing and swallowing, revealing the key role of palatal and pharyngeal muscles in chewing and the simultaneous changes in muscle activity and respiratory cycle during these processes.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Junkang Quan, Yang Liu, Lingli Ji, Yuming Zhao, Shuguo Zheng
Summary: This study identified a new DLX3 gene mutation in a Chinese family with enamel dysplasia and found that this mutation may affect ameloblast differentiation by inhibiting the transcriptional activity of Amelx/Odam/Klk4, thereby interfering with enamel formation.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Viviane Martins dos Santos Ribeiro, Mauricio Gonsalves da Costa Sousa, Paula Ribeiro Garcia, Lucas Souza dos Santos, Eliza Carla Barroso Duarte, Jose Raimundo Correa, Carlos Alberto Labate, Thais Regiani Cataldi, Rosiane Andrade da Costa, Marcelo Henrique Soller Ramada, Juliana Lott de Carvalho, Taia Maria Berto Rezende
Summary: This study compared the structural and proteomic architecture of decellularized human dental pulp using two different protocols. The results showed that the ECM preserved in the MG protocol was more intact. Proteomic analysis revealed that the MG protocol maintained around 69.56% of the proteins identified in the untreated pulp tissue, while the SG protocol only maintained 28.26%.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Jinjin Lu, Lixin Zhang, Ningxin Zhu, Dan Wang, Fei Xie, Man Qin, Yuanyuan Wang
Summary: The study investigated the effects of varying glucose concentrations on the proliferation and senescence of SHED and hBMSC. It was found that high glucose levels promoted proliferation in both cell types, but delayed senescence in SHED through autophagy inhibition and accelerated senescence in hBMSC. Additionally, the glycolysis in SHED was enhanced under high glucose culture conditions compared to hBMSC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Luciana O. Almeida, Luan Cesar Silva, Carolina Emerick, Juliana Amorim dos Santos, Rogerio M. Castilho, Cristiane H. Squarize
Summary: This study found that the loss of PTEN signaling increases the population of HNSCC CSCs, which can be targeted by rapamycin. However, a deficiency in mTORC2 can lead to problematic selection of the parasphere CSC subtype.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Elham Mohebbi, Zainab Alimoradi, Laura S. Rozek, Azadeh Mohebbi, Elahe Jafari
Summary: This study conducted a systematic review and meta-analysis to investigate the risk of head and neck cancer among opium users. The findings showed a significant correlation between opium use and the development of head and neck cancers, particularly lip and oral cavity cancers and laryngeal cancer. This highlights the importance of further research and targeted preventive measures to address this concerning association.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Antonio Alexandre Coelho, Rute Romao Carvalho, Ana Luiza Muniz, Andre Alves Crispim, Anderson Maia Meneses, Carla Welch da Silva, Dayrine Silveira de Paula, Ana Paula Negreiros Nunes Alves, Fabricio Bitu Sousa, Paulo Goberlanio de Barros Silva
Summary: The study aimed to evaluate the role of CD20 + cells in the healing process of oral traumatic ulcers (OTU) in rats. The results showed that blocking CD20 + cells with anti-CD20 rituximab (RTX) reduced cell migration, acute inflammation, and wound healing in OTU.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Meimei Cui, Jinling Cheng, Huijuan Cheng, Ming Zhao, Dan Zhou, Min Zhang, Jingjing Jia, Limei Luo
Summary: This study explored the characteristics of human papillomavirus (HPV) in oropharyngeal carcinoma (OPC) and found that high-risk HPV infection is common in OPC patients, with higher prevalence in North America, Oceania, and Europe. Females and older patients are more susceptible to infection. Tonsil and base of tongue are the most frequent sites of infection. This study provides important theoretical basis for the prevention and treatment of OPC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Xiaoyue Guan, Chen Shi, Yuting Wang, Yani He, Yingxue Li, Yao Yang, Wenli Mu, Wenlan Li, Tiezhou Hou
Summary: The study revealed that Gremlin1 expression levels are significantly increased in periapical lesions and may be positively correlated with IL-18 levels. Blocking Gremlin1 can significantly suppress bone resorption loss and restrain inflammatory status by affecting the activation levels of phosphorylated-CREB, ICAM-1, VCAM-1, IL-18.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Giliano Nicolini Verzeletti, Eduardo Jose Gaio, Keilla Gomes Machado, Tobias Rauber Spuldaro, Clarissa Favero Demeda, Rafaele Frassini, Andre Felipe Streck, Sidnei Moura E. Silva, Cassiano Kuchenbecker Rosing, Joao Antonio Pegas Henriques, Mariana Roesch-Ely
Summary: This study investigates the effects of D. anceps seaweed on ligature-induced experimental periodontitis in rats. The results show that D. anceps can modulate the inflammatory response and have potential therapeutic effects for periodontitis.
ARCHIVES OF ORAL BIOLOGY
(2024)
