Enantioselective synthesis and biological investigation of tetrahydro‐β‐carboline‐based HDAC6 inhibitors with improved solubility

Carboxylic acid derivatives display potential selectivity for human histone deacetylase 6: Structure-based virtual screening, molecular docking and dynamics simulation studies

(2018) Abdullahi Ibrahim Uba et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Epigenetics of inflammatory arthritis

(2018) Deepa Hammaker et al.   CURRENT OPINION IN RHEUMATOLOGY

Design and biological evaluation of tetrahydro- β -carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors

(2018) Michel Leonhardt et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in the discovery of potent and selective HDAC6 inhibitors

(2018) Xiu-Xiu Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors

(2018) Andreas Sellmer et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel class of anthraquinone-based HDAC6 inhibitors

(2018) Yoojin Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates

(2016) Vincent Zwick et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot–Marie–Tooth Disease

(2015) Sida Shen et al.   ACS Chemical Neuroscience

Synthesis and biological evaluation of novel histone deacetylases inhibitors with nitric oxide releasing activity

(2015) Wenwen Duan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Epigenetics in rheumatoid arthritis

(2015) Kerstin Klein et al.   CURRENT OPINION IN RHEUMATOLOGY

Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer

(2015) Zhuang Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

ST7612AA1, a Thioacetate-ω(γ-lactam carboxamide) Derivative Selected from a Novel Generation of Oral HDAC Inhibitors

(2014) Giuseppe Giannini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a Novel Aminotetralin Class of HDAC6 and HDAC8 Selective Inhibitors

(2014) Guozhi Tang et al.   JOURNAL OF MEDICINAL CHEMISTRY

3-Hydroxypyridin-2-thione as Novel Zinc Binding Group for Selective Histone Deacetylase Inhibition

(2013) Vishal Patil et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of N-Hydroxycinnamamide-Based Histone Deacetylase Inhibitors with an Indole-Containing Cap Group

(2013) Yingjie Zhang et al.   ACS Medicinal Chemistry Letters

Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells

(2011) Ulf H Beier et al.   CURRENT OPINION IN IMMUNOLOGY

Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity

(2010) Jerome C. Bressi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

HDAC family: What are the cancer relevant targets?

(2008) Olaf Witt et al.   CANCER LETTERS

Catalytic Enantioselective Additions of Indoles to Nitroalkenes

(2008) Madhu Ganesh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY