Journal
APPLIED BIOCHEMISTRY AND MICROBIOLOGY
Volume 55, Issue 2, Pages 145-151Publisher
PLEIADES PUBLISHING INC
DOI: 10.1134/S0003683819020030
Keywords
antimicrobial peptides; micromycetes of the Emericellopsis genus; peptaibols; biological activity; pathogenic fungi; multiple resistance
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Funding
- Russian Science Foundation [18-74-10073]
- Russian Foundation for Basic Research [17-53-53130, AAAA-A16-116021660088-9]
- Russian Science Foundation [18-74-10073] Funding Source: Russian Science Foundation
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The ability of 22 strains of the Emericellopsis alkalina species to synthesize the antimicrobial peptaiboles A118-35, A118-36, and A118-37 with antifungal activity was studied. The ability to synthesize peptaibols is typical for 72% of the studied strains of the species. It was established that peptaibol production is a strain-specific feature and depends on the cultivation conditions and the concentration of sugars and carbon sources. The isolated peptaibol A118-37 was active against opportunistic Candida albicans yeast and Apergillus niger mold fungus, as well as against clinical fungal isolates of mycosis pathogens with multiple resistance.
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