Antibiotic therapy as personalized medicine – general considerations and complicating factors

Long-Term Outcomes of Partial Oral Treatment of Endocarditis

(2019) Henning Bundgaard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis

(2018) Kasper Iversen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phenotypic shift in Pseudomonas aeruginosa populations from cystic fibrosis lungs after 2-week antipseudomonal treatment

(2017) Laia Fernández-Barat et al.   Journal of Cystic Fibrosis

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Diffusion Retardation by Binding of Tobramycin in an Alginate Biofilm Model

(2016) Bao Cao et al.   PLoS One

Unraveling the Physiological Complexities of Antibiotic Lethality

(2015) Daniel J. Dwyer et al.   Annual Review of Pharmacology and Toxicology

ESCMID∗ guideline for the diagnosis and treatment of biofilm infections 2014

(2015) N. Høiby et al.   CLINICAL MICROBIOLOGY AND INFECTION

The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock

(2015) Sarah A. Sterling et al.   CRITICAL CARE MEDICINE

Augmented renal clearance and therapeutic monitoring of β-lactams

(2015) Andrew A. Udy et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Augmented renal clearance, low β-lactam concentrations and clinical outcomes in the critically ill: An observational prospective cohort study

(2015) Angela Huttner et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Incidence of infective endocarditis in England, 2000–13: a secular trend, interrupted time-series analysis

(2015) Mark J Dayer et al.   LANCET

DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current  -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

(2014) J. A. Roberts et al.   CLINICAL INFECTIOUS DISEASES

Escherichia coli bacteraemia in pregnant women is life-threatening for foetuses

(2014) L. Surgers et al.   CLINICAL MICROBIOLOGY AND INFECTION

Using the Number Needed to Treat to Assess Appropriate Antimicrobial Therapy as a Determinant of Outcome in Severe Sepsis and Septic Shock*

(2014) Cristina Vazquez-Guillamet et al.   CRITICAL CARE MEDICINE

Empiric Antibiotic Treatment Reduces Mortality in Severe Sepsis and Septic Shock From the First Hour

(2014) Ricard Ferrer et al.   CRITICAL CARE MEDICINE

Polymorphonuclear Leukocytes Restrict Growth of Pseudomonas aeruginosa in the Lungs of Cystic Fibrosis Patients

(2014) Kasper N. Kragh et al.   INFECTION AND IMMUNITY

Candida colonization index and subsequent infection in critically ill surgical patients: 20 years later

(2014) Philippe Eggimann et al.   INTENSIVE CARE MEDICINE

Effect of meropenem administration in extended infusion on the clinical outcome of febrile neutropenia: a retrospective observational study

(2014) Csaba Fehér et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Population pharmacokinetics and dosing simulations of cefuroxime in critically ill patients: non-standard dosing approaches are required to achieve therapeutic exposures

(2014) M. Carlier et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions

(2014) Jason A Roberts et al.   LANCET INFECTIOUS DISEASES

Microbiological effects of sublethal levels of antibiotics

(2014) Dan I. Andersson et al.   NATURE REVIEWS MICROBIOLOGY

The cervical mucus plug inhibits, but does not block, the passage of ascending bacteria from the vagina during pregnancy

(2013) Lea K. Hansen et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

Sublethal Ciprofloxacin Treatment Leads to Rapid Development of High-Level Ciprofloxacin Resistance during Long-Term Experimental Evolution of Pseudomonas aeruginosa

(2013) Karin Meinike Jørgensen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Considerations for Higher Doses of Daptomycin in Critically Ill Patients With Methicillin-Resistant Staphylococcus aureus Bacteremia

(2013) Marco Falcone et al.   CLINICAL INFECTIOUS DISEASES

Respiratory bacterial infections in cystic fibrosis

(2013) Oana Ciofu et al.   CURRENT OPINION IN PULMONARY MEDICINE

Systemic inflammatory response syndrome criteria and vancomycin dose requirement in patients with sepsis

(2013) Yuko Shimamoto et al.   INTENSIVE CARE MEDICINE

Patients enrolled in randomised clinical trials are not representative of critically ill patients in clinical practice: Observational study focus on tigecycline

(2013) Johannes B. Zimmermann et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Bactericidal effect of colistin on planktonic Pseudomonas aeruginosa is independent of hydroxyl radical formation

(2013) Rikke Prejh Brochmann et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin againstPseudomonas aeruginosabiofilms

(2013) Peter Ø. Jensen et al.   Pathogens and Disease

Continuous Infusion of Beta-Lactam Antibiotics in Severe Sepsis: A Multicenter Double-Blind, Randomized Controlled Trial

(2012) J. M. Dulhunty et al.   CLINICAL INFECTIOUS DISEASES

Decreased meropenem levels in Intensive Care Unit patients with augmented renal clearance: benefit of therapeutic drug monitoring

(2012) Uwe Tröger et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Augmented renal clearance in septic patients and implications for vancomycin optimisation

(2012) João Pedro Baptista et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms

(2011) Wang Hengzhuang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacodynamics of meropenem in critically ill patients with febrile neutropenia and bacteraemia

(2011) Sutep Jaruratanasirikul et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Support for higher ciprofloxacin AUC24/MIC targets in treating Enterobacteriaceae bloodstream infection

(2010) S. A. Zelenitsky et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Colistin‐Tobramycin Combinations Are Superior to Monotherapy Concerning the Killing of BiofilmPseudomonas aeruginosa

(2010) Gloria Herrmann et al.   JOURNAL OF INFECTIOUS DISEASES

Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis

(2010) Michael A. Kohanski et al.   MOLECULAR CELL

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY

Augmented Renal Clearance

(2009) Andrew A. Udy et al.   CLINICAL PHARMACOKINETICS

Usefulness of the “Candida score” for discriminating between Candida colonization and invasive candidiasis in non-neutropenic critically ill patients: A prospective multicenter study

(2009) Cristóbal León et al.   CRITICAL CARE MEDICINE

Widespread microbial invasion of the chorioamniotic membranes is a consequence and not a cause of intra-amniotic infection

(2009) Mi Jeong Kim et al.   LABORATORY INVESTIGATION

Cefazolin pharmacokinetics in maternal plasma and amniotic fluid during pregnancy

(2008) Karel Allegaert et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections

(2008) Peggy S. McKinnon et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Early aggressive eradication therapy for intermittent Pseudomonas aeruginosa airway colonization in cystic fibrosis patients: 15 years experience

(2008) C.R. Hansen et al.   Journal of Cystic Fibrosis

Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes

(2008) Sünje Johanna Pamp et al.   MOLECULAR MICROBIOLOGY