Article
Rheumatology
Rosalinde Stal, Xenofon Baraliakos, Desiree van der Heijde, Floris van Gaalen, Sofia Ramiro, Rosaline van den Berg, Monique Reijnierse, Juergen Braun, Robert Landewe, Alexandre Sepriano
Summary: MRI-detected vertebral corner inflammation and vertebral corner fat deposition are positively associated with syndesmophyte development. However, almost half of all bone formation occurs in corners without vertebral corner inflammation or vertebral corner fat deposition.
Article
Medicine, General & Internal
Chin-Man Wang, Yeong-Jian Jan Wu, Jing-Chi Lin, Li-Yu Huang, Jianming Wu, Ji-Yih Chen
Summary: This study found a significant association between the intergenic SNP rs10865331 and susceptibility to ankylosing spondylitis (AS) in Taiwanese individuals. B3GNT2 SNPs associated with clinical characteristics of AS patients were also found to be associated with disease severity.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Rheumatology
Yulong Tang, Kai Yang, Qingmei Liu, Yanyun Ma, Hao Zhu, Kunhai Tang, Chengchun Geng, Jiangnan Xie, Dachun Zhuo, Wenyu Wu, Li Jin, Wenze Xiao, Jiucun Wang, Qi Zhu, Jing Liu
Summary: This study aimed to discover the key cytokine associated with ankylosing spondylitis (AS) and assess its pathogenic role in AS. It was found that PDGFB stimulates the GRB2/ERK/RUNX2 pathway in adipose-derived stem cells (ADSCs), promoting osteoblastogenesis of ADSCs and enhancing the extracellular matrix of osteoblasts, which may contribute to pathological bone formation in AS.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hamza Rahimi, Ali Guermazi, Frank W. Roemer, Oleg M. Teytelboym, Robert-Yves Carlier, Mohamed Jarraya
Summary: Imaging plays a central role in the diagnosis of axial spondylarthritis (axSpA), with MRI considered the reference standard for early detection of inflammatory changes. Recognizing vertebral involvement patterns can help establish a diagnosis early and initiate therapy before irreversible changes occur. This review aims to present an overview of imaging findings in axSpA with vertebral involvement and detail the current recommendations for diagnosis in patients with isolated vertebral involvement.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Rheumatology
Tae-Han Lee, Seunghun Lee, Bon San Koo, Kyung Bin Joo, Tae-Hwan Kim
Summary: By comparing radiographic evidence of ankylosis in cervical facet joints and cervical vertebral bodies, this study found that cervical facet joint ankylosis appears as often as bridging syndesmophytes in patients with ankylosing spondylitis. Cervical facet joint ankylosis may have a higher disease burden and should be considered in the assessment of the disease.
Article
Rheumatology
Mary Lucy Marques, Nuno Pereira da Silva, Desiree van der Heijde, Monique Reijnierse, Xenofon Baraliakos, Juergen Braun, Floris A. van Gaalen, Sofia Ramiro
Summary: Objective: We analyzed the trabecular bone density of patients with r-axSpA using low-dose CT scans and assessed the inter-reader reliability. Our results showed that ldCT measurement of HU is a feasible method to assess vertebral bone density in r-axSpA with excellent inter-reader reliability from C3 to L5.
Article
Medicine, General & Internal
Tao Bian, Liang Zhang, Siliang Man, Hongchao Li, Weiyi Li, Yixin Zhou
Summary: Hip involvement in ankylosing spondylitis is associated with functional impairment, and early diagnosis can improve prognosis. This study investigated the relationship between gluteal muscle parameters and hip involvement in patients with AS. The results showed that AS patients had lower gluteal muscle CSA than controls, and the severity of hip involvement was negatively associated with muscle parameters. Computed tomography may be more sensitive than radiographs in assessing muscle parameters.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Michael M. Ward, Sovira Tan
Summary: The purpose of this study was to review recent studies on risk factors for syndesmophyte growth in AS and on treatment effects. Recent findings showed limited evidence of specific genetic associations with radiographic severity. Inflammation indicators, like vertebral osteitis and C-reactive protein level, were strongly associated with radiographic progression, while studies on adipokines had mixed results. It was also found that mesenchymal stem cells from HLA-B27 positive AS patients promoted vertebral ossification. Several observational studies suggested that tumor necrosis factor inhibitors could reduce radiographic severity, especially with long-term use.
CURRENT RHEUMATOLOGY REPORTS
(2023)
Article
Rheumatology
M. Baniaamam, S. C. Heslinga, T. C. Konings, M. L. Handoko, O. Kamp, V. P. van Halm, I. E. van der Horst-Bruinsma, M. T. Nurmohamed
Summary: This study found a significantly increased aortic root index in HLA-B27 positive AS patients compared to HLA-B27 negative patients, especially in male patients. However, there was no difference in the prevalence of aortic valve regurgitation between the two groups. Echocardiographic monitoring in elderly male HLA-B27 positive AS patients may be considered due to the progressive nature of aortic valve regurgitation.
RHEUMATOLOGY INTERNATIONAL
(2022)
Review
Immunology
Fataneh Tavasolian, Chiara Pastrello, Zuhaib Ahmed, Igor Jurisica, Robert D. Inman
Summary: This article investigates the pathogenesis of ankylosing spondylitis (AS), a chronic inflammatory disease, focusing on the role of T cells. It suggests that impaired self-antigen recognition may be a contributing factor to the development of AS, indicating a crucial role of immune system regulation in this disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Karin Bengtsson, Johan Askling, Mattias Lorentzon, Bjoern Rosengren, Anna Deminger, Eva Klingberg, Lennart Jacobsson, Helena Forsblad-d'Elia
Summary: Both men and women with AS have a slightly higher risk of non-vertebral fractures than the general population, with men having a particularly higher risk of fractures of the proximal humerus, distal forearm or hip.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ga Young Ahn, Bon San Koo, Kyung Bin Joo, Tae-Hwan Kim, Seunghun Lee
Summary: Quantitative measurement of fat fraction in the vertebrae of AS patients using MRI can help assess both disease activity and chronicity, which remains significantly correlated even after adjusting for patient age, sex, and other factors.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Rheumatology
Mikkel Ostergaard, Joseph Wu, Lara Fallon, Sarah P. Sherlock, Cunshan Wang, Dona Fleishaker, Keith S. Kanik, Walter P. Maksymowych
Summary: This post hoc analysis evaluated the efficacy of tofacitinib on MRI outcomes in patients with ankylosing spondylitis. The results showed that tofacitinib treatment significantly reduced MRI scores of spinal inflammation, especially in the posterolateral and facet joint areas.
RHEUMATOLOGY AND THERAPY
(2023)
Article
Rheumatology
Rashmi Dhital, Ibiyemi Oke, Anthony Donato, Anish Paudel, Dilli Ram Poudel, Prakash Paudel, Paras Karmacharya
Summary: A study showed that AS patients are at higher risk of vertebral compression fractures (VCF) and there is an increasing trend of VCF hospitalizations in AS patients. The rate of VCF hospitalization in AS patients is higher compared to the general population and RA, with longer hospital stays and higher inpatient mortality rates.
CLINICAL RHEUMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Shanshan Xu, Jiangping Kong, Li Huang, Huimin Xie, Feier Wang, Tingting Zhou, Xiaoyi Zhang, Lingxiang Yu, Shengqian Xu, Faming Pan
Summary: The study found that the rs3750511 polymorphism of the TRAF2 gene may be associated with the susceptibility and severity of AS, while the interaction of the TRAF2 and TRAF5 genes may be associated with AS susceptibility, but many questions remain unanswered.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Rheumatology
Runsheng Wang, Abhijit Dasgupta, Michael M. Ward
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Letter
Rheumatology
Michael M. Ward, Abhijit Dasgupta, Runsheng Wang
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Article
Rheumatology
Sovira Tan, Abhijit Dasgupta, Jianhua Yao, John A. Flynn, Lawrence Yao, Michael M. Ward
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Article
Orthopedics
Nicholas C. Laucis, Mohammed Chowdhury, Abhijit Dasgupta, Timothy Bhattacharyya
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2016)
Article
Rheumatology
Michael M. Ward, Lori C. Guthrie, Abhijit Dasgupta
ARTHRITIS CARE & RESEARCH
(2017)
Letter
Rheumatology
Michael M. Ward, Abhijit Dasgupta, Maria Tektonidou
ARTHRITIS & RHEUMATOLOGY
(2017)
Article
Rheumatology
Michael M. Ward, Lori C. Guthrie, Maria Alba, Abhijit Dasgupta
JOURNAL OF RHEUMATOLOGY
(2018)
Review
Rheumatology
Runsheng Wang, Abhijit Dasgupta, Michael M. Ward
JOURNAL OF RHEUMATOLOGY
(2018)
Article
Endocrinology & Metabolism
Smita Jha, Nicholas Laucis, Lauren Kim, Ashkan Malayeri, Abhijit Dasgupta, Georgios Z. Papadakis, Apostolos Karantanas, Miguel Torres, Timothy Bhattacharyya
Article
Endocrinology & Metabolism
Smita Jha, Nadja Fratzl-Zelman, Paul Roschger, Georgios Z. Papadakis, Edward W. Cowen, Heeseog Kang, Tanya J. Lehky, Katharine Alter, Zuoming Deng, Aleksandra Ivovic, Lauren Flynn, James C. Reynolds, Abhijit Dasgupta, Markku Miettinen, Eileen Lange, James Katz, Klaus Klaushofer, Joan C. Marini, Richard M. Siegel, Timothy Bhattacharyya
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Article
Rheumatology
Abhijit Dasgupta, Michael M. Ward
ARTHRITIS CARE & RESEARCH
(2019)
Article
Engineering, Environmental
Derek A. Newcomer, Peter LaPuma, Robert Brandys, Amanda Northcross, Abhijit Dasgupta
JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
(2019)
Article
Rheumatology
Maria G. Tektonidou, Abhijit Dasgupta, Michael M. Ward
Review
Rheumatology
Maria G. Tektonidou, Laura B. Lewandowski, Jinxian Hu, Abhijit Dasgupta, Michael M. Ward
ANNALS OF THE RHEUMATIC DISEASES
(2017)