Article
Acoustics
Liyan Cui, Zhennan Ma, Defu Wang, Yanbing Niu
Summary: This study evaluated the reuse potential of Astragalus membranaceus waste as a source of food antioxidants and developed an economical and efficient method for extracting flavonoids. The results showed that the waste has good antioxidant and antifungal activities, providing potential for the development of natural food antioxidants.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Chemistry, Analytical
Ruoyao Liu, Yuchi Zhang, Sainan Li, Chunming Liu, Siyuan Zhuang, Xu Zhou, Yanjie Li, Yutong Zhang, Jiaqi Liang
Summary: An efficient method using receptor-ligand affinity ultrafiltration-liquid chromatography with 5-lipoxygenase and acetylcholinesterase as target molecules was developed to screen enzyme inhibitors from Astragalus membranaceus stems and leaves. Response surface methodology was used to investigate the effects of extraction time, extraction cycles, ethanol concentration, and liquid-solid ratio on target compound yield. The bioactive components were isolated using high-performance liquid chromatography and countercurrent chromatography, followed by screening for potential anti-Alzheimer's disease effects. The method provides a new approach for the discovery and preparation of natural active ingredients.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Plant Sciences
Xu Zeng, Jiaxue Li, Xinkai Lyu, Xiao-Mei Chen, Shunxing Guo
Summary: This study cultivated oyster mushroom using waste products from the stems and leaves of Astragalus membranaceus var. mongolicus (AMM) and analyzed the nutritional and chemical composition of the fruiting body. The results showed that the addition of AMM to the substrate affected the composition of oyster mushroom and detected many active phytometabolites previously identified in AMM herbs, indicating a high nutritional therapy value of oyster mushroom cultured with AMM stems and leaves.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Liyan Cui, Zhennan Ma, Wenhui Li, Haihui Ma, Shang Guo, Defu Wang, Yanbing Niu
Summary: This study investigated the antibacterial activity of Astragalus membranaceus stem and leaf extracts, finding significant inhibitory effects against Bacillus cereus. The main active component was identified to be isoliquiritigenin, suggesting the potential use of Astragalus membranaceus as a substitute for feed antibiotics.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Xianju Wang, Changsheng Hu, Luming Ding, Yiguo Tang, Haiyan Wei, Cuixia Jiang, Qi Yan, Quanmin Dong, Abraham Allan Degen
Summary: Astragalus membranaceus supplementation in Tibetan sheep increased the diversity of rumen bacteria, promoted fiber decomposing bacteria, improved antioxidant capacities and immunity indices of small intestinal mucosa and meat tissue, and upregulated metabolites for energy synthesis in liver tissue.
Article
Biochemistry & Molecular Biology
Xue-Feng Bao, Pei-Hong Cao, Jin Zeng, Luo-Min Xiao, Zhi-Hui Luo, Jian Zou, Chuan-Xi Wang, Zhong-Xiang Zhao, Zheng-Qun Zhou, Hui Zhi, Hao Gao
Summary: Eleven unknown and three known pterocarpans were isolated and identified from Huang-qi, a traditional Chinese medicine. Among them, nine rare apiosyl-containing pterocarpan glycosides were discovered. These compounds exhibited hypoglycemic and antioxidant activities.
Article
Biochemistry & Molecular Biology
Zhili Sheng, Yueming Jiang, Junmei Liu, Bao Yang
Summary: Astragalus membranaceus is a valuable medicinal plant species widely distributed in Asia with its root being the main medicinal tissue rich in methoxylated flavonoids. The chemical composition and antioxidant activity of the plant can be influenced by its origin, as shown through UHPLC-MS/MS analysis of extracts from four different origins. The study identified key compounds that can differentiate A. membranaceus from different regions and found that extracts from Inner Mongolia exhibited the highest antioxidant activity.
Article
Pharmacology & Pharmacy
Jianzheng He, Xu Li, Shipei Yang, Yan Shi, Yuting Dai, Shuzhen Han, Yixuan Wang, Xingyao Lin, Benjun Wei, Yongqi Liu, Minghui Xiu
Summary: Astragalus membranaceus extract (AME) provides protection against sodium dodecyl sulfate (SDS)-induced colitis in Drosophila flies by suppressing oxidative stress-associated JNK and JAK-STAT signaling pathways, offering a potential natural medicine for intestinal inflammatory disease in humans.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Mahmoud Alagawany, Mayada R. Farag, Mohammed A. Al-Harthi, Khalid A. Asiry, Fulvia Bovera, Youssef A. Attia
Summary: Dietary Astragalus membranaceus has different effects on blood parameters and immune functions in quail. It improves feed conversion ratio, production, hatchability, blood lipid levels, and shell quality.
Article
Agronomy
Li Ma, Zhengzhong Luo, Jiubing Chen, Zhenlong Du, Tao Zhou, Yixin Huang, Xueping Yao, Liuhong Shen, Shumin Yu, Xiaodong Shi, Suizhong Cao
Summary: This study investigated the effect of Astragalus membranaceus root (AMR) on the serum metabolic profiles of preweaning calves. The results showed that AMR had a positive impact on protein synthesis and gluconeogenesis in calves, leading to enhanced antioxidant and anti-inflammatory capacity.
Article
Biochemistry & Molecular Biology
Xiaoxia Chen, Chun Chen, Xiong Fu
Summary: AMP, a polysaccharide from Astragalus membranaceus, exhibits antioxidant activity, inhibits alpha-glucosidase and binds to cholate. It can help alleviate type 2 diabetes by lowering blood glucose, improving insulin resistance, and regulating lipid profiles.
Article
Multidisciplinary Sciences
Anim Okyere Samuel, Bao-Ting Huang, Yuan Chen, Feng-Xia Guo, Dou-Dou Yang, Jian-Qin Jin
Summary: Studies have shown that compared to the dry roots, the dry leaves and leaf tea of Astragalus membranaceus contain higher bioactive components and exhibit stronger antioxidant and antimicrobial activities.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Jingru Yang, Shengjie Zhou, Zhengyi Fu, Bo Xiao, Minghao Li, Gang Yu, Zhenhua Ma, Humin Zong
Summary: This study evaluated the effects of fermented Astragalus membranaceus on the liver and intestinal health of tiger grouper. The results showed that adding fermented Astragalus membranaceus to the feed improved liver health, regulated intestinal microbiota, and the optimal addition ratio was 1%-2%.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Ji Yeon Lee, Hye Min Park, Chang-Ho Kang
Summary: This study evaluated the antioxidant mechanism of fermented Astragalus membranaceus using Lactiplantibacillus plantarum MG5276 (MG5276F-AM) in both HepG2 cells and an animal model. The results showed that fermentation increased the amount of bioactive compounds and enhanced the antioxidant activity of A. membranaceus.
FERMENTATION-BASEL
(2022)
Article
Fisheries
Hong-Tao Shi, Sheng-Zhen Zhao, Kun-Li Wang, Ming-Xia Fan, Ying-Qian Han, Huan-Ling Wang
Summary: The study revealed that Astragalus Membranaceus and Lactobacillus p/antarum-fermented Astragalus Membranaceus significantly improved growth performance in common carp and had a major impact on intestinal microbiota and metabolism. Lactobacillus p/antarum-fermented Astragalus Membranaceus demonstrated superior beneficial metabolic effects in fish.
AQUACULTURE REPORTS
(2022)