Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 25, Pages 8551-8555Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201902642
Keywords
amines; copper; enamines; enantioselectivity; hydroamination
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Funding
- Swedish Research Council
- Royal Physiographic Society of Lund
- Chinese Scholarship Council
- Lund University
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The asymmetric formal hydroamination of enamines using a CuH catalyst is reported. The method provides a straightforward and efficient approach to the synthesis of chiral 1,2-dialkyl amines in good yields with high levels of enantioselectivities for a broad range of substrates, and should have significant value for the preparation of molecules bearing a 1,2-diamine motif.
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