Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 31, Pages 10582-10586Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201904044
Keywords
Fe3O4 nanoparticle; lead poisoning; capture-fix-separate; magnetic mesoporous silica nanoparticle; red blood cells
Categories
Funding
- National Natural Science Foundation of China [21603105
- 21571104] Funding Source: Medline
- Huaian Biofunctional Materials and Analysis Technology Innovation Platform [HAP201612
- HAS201619] Funding Source: Medline
- Jiangsu Key Technology RD Program [BE2016010
- BE2015603] Funding Source: Medline
- the Excellent Young Scholars NSFC [81622033] Funding Source: Medline
- Jiangsu Collaborative Innovation Center of Biomedical Functional Materials [51641104] Funding Source: Medline
- Technology Support Program of Science and Technology Department of Jiangsu Province [BE2015703
- 15KJA350002] Funding Source: Medline
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Lead poisoning is an important problem because of its serious effects on human health. Yet a solution is not available due to an incomplete understanding of the state of lead ions in blood. Since most blood lead binds to hemoglobin (Hb) in red blood cells, identifying and capturing lead-contaminated Hb in RBCs is important. Herein, a magnetic blood lead remover with hyperbranched poly(amidoamine)s (HPAM) as template/co-adsorbent and core-shell mesoporous structure was synthesized. Lead-containing Hb was selectively captured and then fixed by mesoporous channels. The magnetic separation technology was used to separate the magnetic remover from blood. A related blood lead clean-up apparatus was used to remove lead from the blood of a pig in vivo. Results of physical/chemical characterizations, biocompatibility experiments, animal tests, and theoretical simulation verify the safety and efficiency of this removal strategy and the high efficiency of the blood lead clean-up apparatus.
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