Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 24, Pages 8034-8038Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201901833
Keywords
molecular machine; molecular swing; supramolecular chemistry; synthetic ion channel
Categories
Funding
- Institute of Bioengineering and Nanotechnology
- NanoBio Lab (Biomedical Research Council, Agency for Science, Technology and Research, Singapore)
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Ions are transported across membrane mostly via carrier or channel mechanisms. Herein, a unique class of molecular-machine-inspired membrane transporters, termed molecular swings is reported that utilize a previously unexplored swing mechanism for promoting ion transport in a highly efficient manner. In particular, the molecular swing, which carries a 15-crown-5 unit as the ion-binding and transporting unit, exhibits extremely high ion-transport activities with EC50 values of 46 nm (a channel:lipid molar ratio of 1:4800 or 0.021 mol % relative to lipid) and 110 nm for K+ and Na+ ions, respectively. Remarkably, such ion transport activities remain high in a cholesterol-rich environment, with EC50 values of 130 (0.045 mol % relative to lipid/cholesterol) and 326 nm for K+ and Na+ ions, respectively.
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