Article
Medicine, General & Internal
Lotte E. Terwindt, Jaap Schuurmans, Bjorn J. P. van der Ster, Carin A. G. C. L. Wensing, Marijn P. Mulder, Marije Wijnberge, Thomas G. Cherpanath, Wim K. Lagrand, Alain A. Karlas, Mark H. Verlinde, Markus W. Hollmann, Bart F. Geerts, Denise P. Veelo, Alexander P. J. Vlaar
Summary: This study observed the incidence and severity of hypotension in ICU patients and found that the incidence of hypotension is remarkably high with a certain level of severity. Age, sex, BMI, and cardiogenic shock are associated clinical factors for hypotension.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Anesthesiology
Tyler Ballweg, Marissa White, Margaret Parker, Cameron Casey, Amber Bo, Zahra Farahbakhsh, Austin Kayser, Alexander Blair, Heidi Lindroth, Robert A. Pearce, Kaj Blennow, Henrik Zetterberg, Richard Lennertz, Robert D. Sanders
Summary: The study found that changes in tau levels were associated with the incidence and severity of postoperative delirium, and resolved over time along with delirium features. Clinical predictors such as age and prior stroke/transient ischemic attack impacted the changes in tau levels. The study suggests that tau could be a potential biomarker for predicting recovery from delirium.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Anesthesiology
Ashish K. Khanna, Nathaniel S. O'Connell, Sanchit Ahuja, Amit K. Saha, Lynnette Harris, Bruce D. Cusson, Ann Faris, Carolyn S. Huffman, Saraschandra Vallabhajosyula, Clancy J. Clark, Scott Segal, Brian J. Wells, Eric S. Kirkendall, Daniel I. Sessler
Summary: This study aimed to determine changes in blood pressure and heart rate in postoperative patients and estimate the proportion of missed vital sign changes with intermittent checks.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Medicine, General & Internal
Isla S. Mackenzie, Amy Rogers, Neil R. Poulter, Bryan Williams, Morris J. Brown, David J. Webb, Ian Ford, David A. Rorie, Greg Guthrie, J. W. Kerr Grieve, Filippo Pigazzani, Peter M. Rothwell, Robin Young, Alex McConnachie, Allan D. Struthers, Chim C. Lang, Thomas M. MacDonald
Summary: The TIME study aimed to investigate whether evening dosing of antihypertensive medication improves cardiovascular outcomes compared with morning dosing. The results showed that there was no difference in major cardiovascular outcomes between evening dosing and morning dosing, and patients can choose a convenient time to take their medications.
Article
Peripheral Vascular Disease
Minju Han, Young-Ro Lee, Taeyoung Park, Sang-Hyun Ihm, Wook Bum Pyun, Thilo Burkard, Myeong-Chan Cho, Miguel Camafort, Eugene Yang, George S. Stergiou, Hae Young Lee, Jong-Mo Seo, Korean Soc Hypertension
Summary: This study evaluated the feasibility and measurement stability of smartwatch-based cuffless blood pressure monitoring in real-world conditions. The results showed that smartwatch-based blood pressure monitoring is feasible for out-of-office monitoring in patients. Blood pressure levels showed considerable variability, mainly depending on the time and day of measurement.
HYPERTENSION RESEARCH
(2023)
Article
Anesthesiology
Barak Cohen, Eva Rivas, Xuan Pu, Kamal Maheshwari, Jorge A. Araujo-Duran, Oguz Turan, Andrew Volio, Esra Kutlu Yalcin, Alparslan Turan
Summary: Abnormal diurnal blood pressure patterns are common in adults during the initial 2 days after abdominal surgery, lack of normal night-time decrease in blood pressure is associated with less postoperative hypotension.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Hematology
Florian Brettner, Markus Heitzer, Friederike Thiele, Nikolai Hulde, Claudia Nussbaum, Stefan Achatz, Matthias Jacob, Bernhard F. Becker, Peter Conzen, Erich Kilger, Daniel Chappell
Summary: The study found that some patients require vasopressor support during induction of general anesthesia to maintain blood pressure, and these patients had lower cardiac indices before induction. NE did not restore these cardiac parameters to levels seen in the group without NE, indicating that NE supports MAP by increasing peripheral arterial resistance. Additionally, general anesthesia and surgical stimuli lead to impairment of the microcirculation.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2021)
Article
Medicine, General & Internal
Anastasia Murtha-Lemekhova, Juri Fuchs, Miriam Teroerde, Heike Rau, Otto R. Frey, Daniel Hornuss, Adrian Billeter, Rosa Klotz, Ute Chiriac, Jan Larmann, Markus A. Weigand, Pascal Probst, Katrin Hoffmann
Summary: The RESISTAAS I study aims to investigate the impact of redosing antibiotic prophylaxis in major abdominal surgery, including postoperative infections, patient pathogens, and economic outcomes. The study will be conducted in accordance with the guidelines of the Medical Ethics Review Board of Heidelberg University, and the results are planned to be disseminated in a peer-reviewed journal.
Article
Health Care Sciences & Services
Szymon Czajka, Maria Taborek, Lukasz J. Krzych
Summary: This study assessed the association between frailty and postoperative complications in patients undergoing elective, abdominal surgery. The findings showed that frailty scores were not effective predictors of in-hospital complications, while perioperative risk assessment methods performed better.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Multidisciplinary Sciences
C. Kedor, H. Freitag, L. Meyer-Arndt, K. Wittke, L. G. Hanitsch, T. Zoller, F. Steinbeis, M. Haffke, G. Rudolf, B. Heidecker, T. Bobbert, J. Spranger, H. D. Volk, C. Skurk, F. Konietschke, F. Paul, U. Behrends, J. Bellmann-Strobl, C. Scheibenbogen
Summary: Some COVID-19 patients experience long-lasting symptoms, such as fatigue and exertion intolerance, even after recovery. These symptoms are similar to those seen in non-COVID-19 patients and may be related to low-level inflammation and hypoperfusion.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Sujung Park, Young In Kwon, Hyun Joo Kim
Summary: This study evaluated the pressure changes in the endotracheal tube cuff during otorhinolaryngologic surgery. It found that 96.0% of patients had cuff pressure outside the appropriate range, with a mean time in the therapeutic range of 79.7%. Head and neck surgery had the lowest mean time in the therapeutic range at 69.0%. The factors causing inappropriate cuff pressure included positional changes, surgical procedures, anatomical manipulation, and anesthetic procedures. Therefore, close continuous monitoring of cuff pressure during anesthesia for otorhinolaryngologic surgery is recommended.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Rodrigo M. Carrillo-Larco, Wilmer Cristobal Guzman-Vilca, Dinesh Neupane
Summary: Simplified blood pressure screening approaches may reduce misdiagnosis rates, and cardiovascular risk may be lower among missed cases than among consistent hypertension cases.
Article
Biochemistry & Molecular Biology
Chun-Yi Tsai, Keng-Hao Liu, Cheng-Chou Lai, Jun-Te Hsu, Shun -Wen Hsueh, Chia-Yen Hung, Kun-Yun Yeh, Yu-Shin Hung, Yung -Chang Lin, Wen-Chi Chou
Summary: This study aimed to investigate the association between frailty and postoperative delirium (POD) in aged cancer patients undergoing elective abdominal surgery. It found that frailty status was an independent risk factor for POD occurrence. Thus, preoperative assessment of frailty in older cancer patients is important in order to improve postoperative care.
BIOMEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Isla S. Mackenzie, Christopher J. Hawkey, Ian Ford, Nicola Greenlaw, Filippo Pigazzani, Amy Rogers, Allan D. Struthers, Alan G. Begg, Li Wei, Anthony J. Avery, Jaspal S. Taggar, Andrew Walker, Suzanne L. Duce, Rebecca J. Barr, Jennifer S. Dumbleton, Evelien D. Rooke, Jonathan N. Townend, Lewis D. Ritchie, Thomas M. MacDonald
Summary: The ALL-HEART study aimed to determine whether allopurinol therapy improves major cardiovascular outcomes in patients with ischaemic heart disease. The study found no difference in the primary outcome of non-fatal myocardial infarction, non-fatal stroke, or cardiovascular death between participants receiving allopurinol therapy and those receiving usual care.
Article
Medicine, General & Internal
Wang Ningning, Hu Ying, Lin Shudong, Zhang Zhilong, Cai Qibo, Deng Yuting, Zhang Hao, Wu Nan, Qiu Changchun, Yang Xiujing, Jin Ming, Li Jingping
Summary: This study aimed to investigate the association between blood pressure variation (BPV) and early functional outcomes in acute ischemic stroke patients. The results showed that high BPV was associated with poor early prognosis, with higher coefficients of variation and standard deviations of systolic and diastolic blood pressure increasing the risk of poor outcomes.
Article
Anesthesiology
Yuwei Qiu, Eva Rivas, Marianne Tanios, Roshni Sreedharan, Guangmei Mao, Ilker Ince, Ahmed Salih, Remie Saab, Jagan Devarajan, Kurt Ruetzler, Alparslan Turan
Summary: The study aimed to investigate whether seasonal variation is associated with the occurrence of postoperative delirium and hospital length of stay (LOS) in non-cardiac surgical patients. The results showed that the incidence of delirium was not associated with seasons, but LOS was longer in summer compared to winter.
BRAZILIAN JOURNAL OF ANESTHESIOLOGY
(2023)
Article
Anesthesiology
Kurt Ruetzler, Mateo Montalvo, Omer Bakal, Hani Essber, Julian Rossler, Edward J. Mascha, Yanyan Han, Mangala Ramachandran, Allen Keebler, Alparslan Turan, Daniel I. Sessler
Summary: This study aimed to investigate the effect of NOL-guided fentanyl administration on postoperative pain. The results showed that although more intraoperative fentanyl was given in the NOL group, there was no significant difference in pain scores during the first 60 minutes after surgery compared to routine care.
ANESTHESIA AND ANALGESIA
(2023)
Article
Anesthesiology
Marc T. Schmidt, Stephania Paredes, Julian Rossler, Rupashi Mukhia, Xuan Pu, Guangmei Mao, Alparslan Turan, Kurt Ruetzler
Summary: This retrospective cohort study analyzed the use of sugammadex and neostigmine in patients undergoing noncardiac surgery. The study found no significant difference in the risk of postoperative transfusion between the two drugs. However, patients receiving sugammadex had a higher likelihood of postoperative ICU admission.
ANESTHESIA AND ANALGESIA
(2023)
Article
Anesthesiology
Eva Rivas, Barak Cohen, Wael Saasouh, Guangmei Mao, Esra K. Yalcin, Fabio Rodriguez-Patarroyo, Kurt Ruetzler, Alparslan Turan
Summary: The occurrence of hypoventilation during the first hour of postoperative recovery in abdominal surgery is associated with similar events during the rest of the first 48 postoperative hours, with a positive predictive value approaching 100%.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Anesthesiology
Jochen Hinkelbein, Janusz Andres, Bernd W. Boettiger, Luca Brazzi, Edoardo De Robertis, Sharon Einav, Carl Gwinnutt, Bahar Kuvaki, Pawel Krawczyk, Matthew D. Mcevoy, Pieter Mertens, Vivek K. Moitra, Jose Navarro-Martinez, Mark E. Nunnally, Michael O'Connor, Marcus Rall, Kurt Ruetzler, Jan Schmitz, Karl Thies, Jonathan Tilsed, Mauro Zago, Arash Afshari
Summary: This guideline provides information and recommendations for the treatment of cardiac arrest in the operating room environment, including controversial topics such as open chest cardiac massage, resuscitative endovascular balloon occlusion, resuscitative thoracotomy, pericardiocentesis, needle decompression, and thoracostomy.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2023)
Article
Anesthesiology
Alparslan Turan, Eva Rivas, P. J. Devereaux, Xuan Pu, Fabio A. Rodriguez-Patarroyo, Esra Kutlu Yalcin, Rod Nault, Kamal Maheshwari, Kurt Ruetzler, Daniel I. Sessler
Summary: Hypotension and postoperative anaemia are associated with myocardial and renal injury after noncardiac surgery, but the interaction between them remains unknown.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2023)
Article
Anesthesiology
Marc Schmidt, Julian Rossler, Jack Brooker, Valentina Lara-Erazo, Elyad Ekrami, Xuan Pu, Alparslan Turan, Daniel I. Sessler, Kurt Ruetzler
Summary: This study aimed to compare the postoperative lung function of patients undergoing neuromuscular block reversal using sugammadex versus neostigmine. The results showed similar lung function with both methods, but patients given sugammadex had more minor pulmonary complications.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Editorial Material
Anesthesiology
Lukas M. Muller-Wirtz, Kurt Ruetzler, Julian Roster
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Anesthesiology
Eva Rivas, Peter Shehata, Mauro Bravo, Federico Almonacid-Cardenas, Karan Shah, Orkun Kopac, Kurt Ruetzler, Christopher A. Troianos, Alparslan Turan
Summary: Atrial fibrillation and delirium are common complications after cardiac surgery, but the incidence is not higher in adult patients with preoperative obstructive sleep apnea (OSA).
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Review
Anesthesiology
Corina Bello, Julian Rossler, Peter Shehata, Nathaniel R. Smilowitz, Kurt Ruetzler
Summary: Myocardial injury after non-cardiac surgery (MINS) is a common and serious complication that significantly affects perioperative survival. Despite rare intraoperative anesthesia-related deaths, about 1% of non-cardiac surgery patients die within 30 days after surgery. With a large number of surgeries performed annually, postoperative death is the second leading cause of death in the United States. MINS is defined as an elevation in troponin concentrations within 30 days postoperatively. Preventive measures, systematic surveillance approaches, and treatment standards for MINS are still lacking, but there are modifiable factors that can be considered in clinical practice, such as hemodynamic control, adequate oxygen supply, metabolic homeostasis, perioperative medication use, and anesthesia choices.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Editorial Material
Anesthesiology
Carolin Muller, Kurt Ruetzler
JOURNAL OF CLINICAL ANESTHESIA
(2024)
Review
Obstetrics & Gynecology
Pan Li, Xiaoting Ma, Shuang Han, Izumi Kawagoe, Kurt Ruetzler, Amos Lal, Longlu Cao, Ran Duan, Jianli Li
Summary: This study aims to provide an updated analysis of the incidence of conversion from epidural analgesia to general anesthesia and to evaluate and analyze potential risk factors contributing to the failure of this transition. The study found that the overall incidence of conversion was 6% and identified several factors associated with the failure group, including higher rates of incomplete block, emergency cesarean sections, provision of anesthesia by non-obstetric anesthesiologists, higher dosage of epidural administration, and greater height.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Anesthesiology
Johann Stuby, Alexander Kaserer, Sascha Ott, Kurt Ruetzler, Julian Rossler
Summary: The ideal perioperative oxygen concentration is controversial, and the effects of perioperative hyperoxia on complications and mortality are inconsistent. Current evidence suggests that perioperative hyperoxia is unlikely to increase the incidence of complications or mortality, but it may have some potential beneficial effects such as reducing surgical wound infections and postoperative nausea and vomiting. However, it is still recommended to avoid perioperative hyperoxia and aim for normoxia based on the current state of evidence.
Review
Anesthesiology
Julian Rossler, Jacek B. Cywinski, Maged Argalious, Kurt Ruetzler, Sandeep Khanna
Summary: This narrative review aims to provide guidance to anesthesiologists for the assessment and management of patients undergoing catheter-based thrombectomy for acute pulmonary embolism. It covers available techniques for catheter-based thrombectomy, risk stratification tools for pulmonary embolism, assessment of patients prior to the procedure, risks and benefits of anesthetic strategies, and considerations for managing right ventricular failure with mechanical circulatory support.
JOURNAL OF CLINICAL ANESTHESIA
(2024)
Meeting Abstract
Anesthesiology
Valentina Lara-Erazo, Marc Schmidt, Julian Roessler, Jack Brooker, Elyad Ekrami, Xuan Pu, Alparslan Turan, Daniel Sessler, Kurt Ruetzler
ANESTHESIA AND ANALGESIA
(2023)