Article
Immunology
Astrid Fabri, Khalil Kandara, Remy Coudereau, Morgane Gossez, Paul Abraham, Celine Monard, Martin Cour, Thomas Rimmele, Laurent Argaud, Guillaume Monneret, Fabienne Venet
Summary: The study analyzed the impact of IL-10 production in septic patients' whole blood, revealing monocytes and CD4+ T cells as the main IL-10 producers associated with global immunosuppression in septic shock. Further research is needed to determine the pathophysiological mechanisms leading to increased IL-10 production in monocytes and CD4+ T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Iole Cordone, Serena Masi, Diana Giannarelli, Alessia Pasquale, Laura Conti, Stefano Telera, Andrea Pace, Elena Papa, Mirella Marino, Paolo de Fabritiis, Andrea Mengarelli
Summary: This study successfully used CSF flow cytometry to analyze CSF samples from patients with non-Hodgkin lymphoma, finding that T lymphocytes were the main cell type with a predominance of CD4-positive T cells. A normal non-clonal B-cell population was identified in some patients with primary central nervous system lymphoma, suggesting a potential involvement of blood-brain barrier cell permeability. Highly significant differences were observed between the lymphoid phenotype in CSF and paired peripheral blood samples, indicating an active mechanism of lymphoid migration through the meninges.
FRONTIERS IN ONCOLOGY
(2021)
Article
Infectious Diseases
Nathalie Layios, Christian Gosset, Nathalie Maes, Celine Delierneux, Alexandre Hego, Justine Huart, Christelle Lecut, Pierre Damas, Cecile Oury, Andre Gothot
Summary: The purpose of this study was to identify early changes in leukocyte phenotype that would correlate with later development of sepsis. The results showed that patients who developed secondary sepsis or septic shock had higher monocyte counts, CRP levels, and expression of CD62L(neg) monocytes compared to non-septic patients. In addition, higher SOFA score at admission and lower mHLA-DR levels later on were also associated with sepsis occurrence.
Article
Oncology
Kelsey-Leigh A. Garcia, Sindhu Cherian, Philip A. Stevenson, Christen H. Martino, Andrei R. Shustov, Pamela S. Becker, Mary-Elizabeth M. Percival, Vivian G. Oehler, Anna B. Halpern, Roland B. Walter, Johnnie J. Orozco, Sioban B. Keel, Elihu H. Estey, Ryan D. Cassaday
Summary: Multiparameter flow cytometry (MFC) of cerebrospinal fluid (CSF) is more effective than conventional cytospin (CC) in identifying adults at high risk for CNS relapse after treatment with hyperCVAD. However, surveillance of CSF by MFC has limited utility, as no CSF- patients became CSF+ during initial treatment despite multiple tests.
Article
Immunology
Michael Heming, Louisa Mueller-Miny, Leoni Rolfes, Andreas Schulte-Mecklenbeck, Tobias J. Brix, Julian Varghese, Marc Pawlitzki, Hermann Pavenstaedt, Martin A. Kriegel, Catharina C. Gross, Heinz Wiendl, Gerd Meyer zu Hoerste
Summary: By studying immune cell compositions using flow cytometry, this study found that an expansion of plasma cells in the blood can be used to distinguish connective tissue diseases (CTD) with neurological manifestations from clinically similar diseases. This provides a new method for the differential diagnosis of CTD.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Aida Kamalian, Sara G. Ho, Megha Patel, Alexandria Lewis, Arnold Bakker, Marilyn Albert, Richard J. O'Brien, Abhay Moghekar, Michael W. Lutz
Summary: This study measured 3072 proteins in the CSF samples of AD-biomarker positive MCI patients and controls, and found an upregulation of neuroinflammatory pathways, particularly chemotactic and granulocyte recruitment pathways, in the CSF of early AD patients.
Article
Hematology
Maria Thastrup, Hanne Vibeke Marquart, Mette Levinsen, Signe Modvig, Jonas Abrahamsson, Birgitte Klug Albertsen, Britt-Marie Frost, Arja Harila-Saari, Jouni Pesola, Aina Ulvmoen, Dorota Malgorzata Wojcik, Mervi Taskinen, Marianne Hoffmann, Birgitte Lausen, Kjeld Schmiegelow
Summary: CSF flow cytometry may have prognostic value in infant ALL, but larger studies are needed to confirm.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Letter
Clinical Neurology
Christiane Pillny, Louisa Nitsch, Sabine Proske-Schmitz, Amit Sharma, Ullrich Wuellner
Summary: Classical and nonclassical monocytes were found to be increased in the cerebrospinal fluid of Parkinson's Disease patients.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Hematology
Fatemeh Shahneh, Hans Christian Probst, Sabine C. Wiesmann, Noelia A-Gonzalez, Wolfram Ruf, Kerstin Steinbrink, Verena K. Raker, Christian Becker
Summary: This study investigated the role of inflammatory Ly6C(hi) monocytes in deep vein thrombosis, and found that thrombus formation, growth, and resolution can be therapeutically manipulated with a NR4A1 agonist.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria Thastrup, Hanne Vibeke Marquart, Kjeld Schmiegelow
Summary: Despite the good prognosis of acute lymphoblastic lymphoma in children and adolescents, involvement of the central nervous system (CNS) remains a therapeutic challenge. The current method for detecting CNS involvement has low sensitivity, while flow cytometric analysis of cerebrospinal fluid (CSF) offers a novel and sensitive approach. Prospective studies have shown that flow cytometry detects CNS involvement at a higher rate than conventional methods and is particularly sensitive in detecting low-level CNS disease. Flow cytometry-detected CNS involvement is linked to a higher risk of relapse and poor outcomes in childhood ALL.
Article
Neurosciences
Alexandra L. Clark, Alexandra J. Weigand, Kelsey R. Thomas, Seraphina K. Solders, Lisa Delano-Wood, Mark W. Bondi, Rachel A. Bernier, Erin E. Sundermann, Sarah J. Banks, Katherine J. Bangen
Summary: The study revealed differential effects of pulse pressure and inflammation on Alzheimer's disease-related cerebrospinal fluid proteins, indicating that vascular risk is associated with greater AD pathology in both cognitively normal and mild cognitive impairment older adults.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Multidisciplinary Sciences
Antonio Scollato, Saverio Caini, Lucia Angelini, Giancarlo Lastrucci, Nicola Di Lorenzo, Berardino Porfirio, Pasquale Gallina
Summary: This study reviewed the records of 69 patients and found that maintaining stroke volume values within a definite range could maximize clinical benefit and avoid the risk of CSF overdrainage. The odds of negative outcome between two consecutive checks increased significantly with certain stroke volume differences.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Zo Andriamanantena, Fanirisoa Randrianarisaona, Maheninasy Rakotondrainipiana, Prisca Andriantsalama, Ravaka Randriamparany, Rindra Randremanana, Frederique Randrianirina, Sophie Novault, Darragh Duffy, Francois Huetz, Milena Hasan, Matthieu Schoenhals, Philippe J. Sansonetti, Pascale Vonaesch, Ines Vigan-Womas, Afribiota Investigators
Summary: This study analyzed the major systemic immune cell populations in stunted and non-stunted children using flow cytometry. The results showed that stunting had an impact on innate and adaptive immune cell percentages and activation status, with age-specific differences in regulatory T cell subsets. This study provides valuable insights into the understanding of systemic immune system changes in stunted children.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuzhe Yang, Yuan Yuan, Guo Zhang, Hao Wang, Ying-Cong Chen, Yingcheng Liu, Christopher G. Tarolli, Daniel Crepeau, Jan Bukartyk, Mithri R. Junna, Aleksandar Videnovic, Terry D. Ellis, Melissa C. Lipford, Ray Dorsey, Dina Katabi
Summary: Parkinson's disease can be diagnosed and monitored based on breathing patterns during sleep using a neural network model. The model shows high accuracy in detecting PD and can also estimate severity and progression.
Article
Agriculture, Dairy & Animal Science
Alicja Rzepecka, Dariusz Jagielski, Anna Cywinska, Rafal Sapierzynski, Magdalena Zmigrodzka, Olga Witkowska-Pilaszewicz, Anna Winnicka
Summary: This study evaluated the changes in MHCII expression in monocytes of dogs with lymphoma, and found an increase in the percentage of MHCII- monocytes regardless of treatment. However, only in dogs that had received glucocorticoids, changes in the proportion of MHCII+ and MHCII- monocytes were reflected by the changes in the number of MHCII- monocytes in the blood, which was significantly higher. These results suggest that evaluating MHCII expression changes in monocytes could be helpful in diagnosing lymphoma, monitoring treatment, or assessing immune status in dogs.
Article
Surgery
Olachi O. Oleru, Neil V. Shah, Peter L. Zhou, Dillon Sedaghatpour, Jaydev B. Mistry, Bradley C. Wham, Joey Kurtzman, Suhail K. Mithani, Steven M. Koehler
Summary: This study investigated the impact of smoking on 30-day standardized outcomes following upper extremity microsurgical reconstruction. The results showed that recent smoking history was not associated with any adverse outcomes in replantation/revascularization or free flap transfer surgeries.
Article
Anesthesiology
Camilo Toro, Sonia Jain, Shelly Sun, Nancy Temkin, Jason Barber, Geoffrey M. Manley, Jordan M. Komisarow, Tetsu Ohnuma, Brandon Foreman, Frederick L. Korley, Michael L. James, Daniel S. Laskowitz, Monica S. Vavilala, Adrian P. Hernandez, Joseph P. J. Mathew, Amy J. Markowitz, Vijay Krishnamoorthy
Summary: This retrospective cohort study assessed the impact of brain injury biomarkers on the risk of circulatory shock in patients with moderate-severe traumatic brain injury. The study found an association between the levels of neuronal injury biomarkers and the development of circulatory shock. The results suggest that neuronal injury biomarkers may provide early identification of patients at risk for early circulatory shock following TBI.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2023)
Review
Urology & Nephrology
Guohua Zeng, Olivier Traxer, Wen Zhong, Palle Osther, Margaret S. Pearle, Glenn M. Preminger, Giorgio Mazzon, Christian Seitz, Petrisor Geavlete, Cristian Fiori, Khurshid R. Ghani, Ben H. Chew, Kah Ann Git, Fabio Carvalho Vicentini, Athanasios Papatsoris, Marianne Brehmer, Juan Lopez Martinez, Jiwen Cheng, Fan Cheng, Xiaofeng Gao, Nariman Gadzhiev, Amelia Pietropaolo, Silvia Proietti, Zhangqun Ye, Kemal Sarica
Summary: This study aims to provide a clinical framework for urologists performing retrograde intrarenal surgery (RIRS). A total of 36 recommendations covering various aspects of RIRS were developed and graded. The recommendations include indications and contraindications, preoperative preparation, surgical procedures, and complications management.
Review
Cardiac & Cardiovascular Systems
Maham F. Karatela, Marat Fudim, Joseph P. Mathew, Jonathan P. Piccini
Summary: Atrial fibrillation is influenced by both sympathetic and parasympathetic influences through cardiac autonomic innervation. Innovative therapies targeting the neurocardiac axis, such as catheter ablation or pharmacologic suppression of ganglionated plexi, renal sympathetic denervation, low-level vagal stimulation, and stellate ganglion blockade, have variable efficacy. Improving our understanding of atrial fibrillation and the cardiac nervous system will lead to further advancements in therapeutic neuromodulation for the benefit of patients with AF.
Article
Urology & Nephrology
Sabrina Tran, Junqin Chen, Gunnar Kozel, Eric T. Chang, Trina Phung, Yanxi Peng, Zachary Dionise, Yuan Wu, W. Neal Simmons, Michael E. Lipkin, Glenn M. Preminger, Pei Zhong
Article
Cardiac & Cardiovascular Systems
Kamrouz Ghadimi, Jhaymie L. Cappiello, Mary Cooter Wright, Jerrold H. Levy, Benjamin S. Bryner, Adam D. Devore, Jacob N. Schroder, Chetan B. Patel, Sudarshan Rajagopal, Svati H. Shah, Carmelo A. Milano
Summary: In patients undergoing major cardiac surgery for advanced heart failure, inhaled pulmonary-selective vasodilator treatment using iEPO was associated with similar risks for RVF development and development of other postoperative secondary outcomes compared with treatment using iNO.
Article
Education, Scientific Disciplines
Jason L. Green, Kate B. Krucoff, Tracy Truong, Amie Kim, Brian J. Conway, Alexandra O. Polovneff, Kristen Rezak, Suhail K. Mithani, Paris D. Butler
Summary: This study aims to address the underrepresentation of African Americans in plastic surgery by improving the understanding of factors that may contribute to their interest in this field. The results show significant differences in demographics, specialty factors, and medical school experiences between African American medical students interested in plastic surgery and their Caucasian counterparts.
JOURNAL OF SURGICAL EDUCATION
(2023)
Article
Clinical Neurology
Mario Torso, Gerard R. Ridgway, Michele Valotti, Ian Hardingham, Steven A. Chance
Summary: This study aimed to investigate the associations between cortical diffusion imaging and post-mortem neuropathology of Alzheimer's disease (AD). The results showed significant associations between cortical diffusivity measures and AD neuropathological hallmarks. The study also highlighted the impact of co-pathologies on cortical microstructure, emphasizing the importance of recognizing these factors in diagnosis and treatment decision-making.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Genetics & Heredity
Konstantin G. Arbeev, Svetlana Ukraintseva, Olivia Bagley, Hongzhe Duan, Deqing Wu, Igor Akushevich, Eric Stallard, Alexander Kulminski, Kaare Christensen, Mary F. Feitosa, Jeffrey R. O'Connell, Daniel Parker, Heather Whitson, Anatoliy I. Yashin
Summary: Dysregulation of physiological processes may contribute to the development of Alzheimer's disease, and genes associated with an increase in physiological dysregulation may play a major role in AD onset.
FRONTIERS IN GENETICS
(2023)
Meeting Abstract
Clinical Neurology
Heberto Suarez-Roca, Negmeldeen Mamoun, Lana L. Watkins, Andrey V. Bortsov, Joseph P. Mathew
Meeting Abstract
Clinical Neurology
Matthew Z. Yuan, Junli Zhao, Aidan McGinnis, Joseph P. Mathew, Fan Wang, Ru-Rong Ji
Review
Geriatrics & Gerontology
Patrick J. Smith, Heather E. Whitson, Rhonda M. Merwin, C. Virginia O'Hayer, Timothy J. Strauman
Summary: Interventions to preserve functional independence in older adults are crucial, as chronic disease management is a major factor contributing to the loss of independence. Both cognitive and psychological factors play important roles in maintaining health behaviors, and social and structural supports can be beneficial in behavior change.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Urology & Nephrology
Arpit Mishra, Robert Medairos, Junqin Chen, Francois Soto-Palou, Yuan Wu, Jodi Antonelli, Glenn M. Preminger, Michael E. Lipkin, Pei Zhong
Summary: This study aimed to explore the optimal laser settings and treatment strategies for thulium fibre laser (TFL) lithotripsy. The findings suggest that high energy/low frequency settings are optimal for TFL lithotripsy in the treatment of calcium oxalate monohydrate (COM) stones, providing improved treatment efficiency and reduced residual fragments.
Article
Urology & Nephrology
Junqin Chen, Arpit Mishra, Robert Medairos, Jodi Antonelli, Glenn M. Preminger, Michael E. Lipkin, Pei Zhong
Summary: In this study, the stone ablation characteristics of thulium fiber laser (TFL) were investigated. The experiments were conducted using BegoStone phantoms and different types of stones, and various parameters were adjusted. The results showed that TFL had higher ablation efficiency and less char formation at high pulse energy/low frequency settings.
Article
Andrology
Zoe D. Michael, Srinath Kotamarti, Rohith Arcot, Kostantinos Morris, Anand Shah, John Anderson, Andrew J. Armstrong, Rajan T. Gupta, Steven Patierno, Nadine J. Barrett, Daniel J. George, Glenn M. Preminger, Judd W. Moul, Kevin C. Oeffinger, Kevin Shah, Thomas J. Polascik
Summary: Preliminary outcomes of a multidisciplinary screening algorithm showed that prostate cancer could be detected in a small percentage of men in their forties, highlighting the importance of early risk stratification and detection of high-risk patients.
WORLD JOURNAL OF MENS HEALTH
(2023)
