Article
Cardiac & Cardiovascular Systems
Aleksandra Stamenkovic, Kimberley A. O'Hara, David C. Nelson, Thane G. Maddaford, Andrea L. Edel, Graham Maddaford, Elena Dibrov, MohamadReza Aghanoori, Lorrie A. Kirshenbaum, Paul Fernyhough, Michel Aliani, Grant N. Pierce, Amir Ravandi
Summary: Oxidized phosphatidylcholines (OxPC) generated during reperfusion injury induce cardiomyocyte death through ferroptosis, which can be attenuated by neutralization of OxPC or with ferrostatin-1. Understanding this pathway may lead to novel strategies for preventing cell death during myocardial reperfusion injury.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiawei Zhao, Yuemeng Jia, Dilnar Mahmut, Amy A. Deik, Sarah Jeanfavre, Clary B. Clish, Vijay G. Sankaran
Summary: Reduced protein synthesis in HSCs leads to increased ferroptosis, which can be rescued by blocking ferroptosis. Overexpression of MYSM1 decreases the susceptibility of HSCs to ferroptosis.
Editorial Material
Biochemistry & Molecular Biology
Hyemin Lee, Li Zhuang, Boyi Gan
Summary: Recent studies have highlighted the critical role of ether-linked phospholipids in providing polyunsaturated fatty acid-containing phospholipids in ferroptosis, as well as the context-dependent role of TMEM189-mediated vinyl-ether phospholipid synthesis in ferroptosis.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Review
Cell Biology
Jingjing Deng, Mei Zhou, Tingting Liao, Wenlong Kuang, Hui Xia, Zhengrong Yin, Qi Tan, Yumei Li, Siwei Song, E. Zhou, Yang Jin
Summary: Recent years have seen success in cancer therapy using immune checkpoint inhibitors (ICIs) for advanced tumors, however, some patients do not respond well potentially due to low sensitivity. Researchers are now focusing on understanding the mechanisms behind resistance to ICI therapy, with a particular interest in ferroptosis as a potentially immunogenic cell death process that could reverse ICI therapy resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Siyu Ouyang, Jia You, Chenxi Zhi, Pin Li, Xiaoyan Lin, Xiaoqian Tan, Wentao Ma, Liang Li, Wei Xie
Summary: Cell death plays a crucial role in atherosclerosis, with ferroptosis accelerating endothelial dysfunction. Disordered intracellular iron damages various cell types and affects lipid peroxidation, oxidative stress, inflammation, and dyslipidemia in AS. The exact mechanisms through which ferroptosis initiates AS development and progression remain unclear.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Seonghun Kim, Shin-Wook Kang, Jeongho Joo, Seung Hyeok Han, Huiyoon Shin, Bo Young Nam, Jimin Park, Tae-Hyun Yoo, Gyuri Kim, Pureunchowon Lee, Jung Tak Park
Summary: The study evaluated the role of ferroptosis in diabetes-induced tubular injury. Results indicated that ferroptosis triggers kidney cell death by affecting glutathione concentration and lipid peroxidation, and the use of ferroptosis inhibitors can alleviate this process.
CELL DEATH & DISEASE
(2021)
Review
Cell Biology
Xin Chen, Jingbo Li, Rui Kang, Daniel J. Klionsky, Daolin Tang
Summary: Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation. Lipoxygenase is the main promoter of ferroptosis, while GPX4 is the central repressor of this process.
Article
Multidisciplinary Sciences
Joo-Won Kim, Dong Wha Min, Dasom Kim, Joohee Kim, Min Jung Kim, Hyangsoon Lim, Ji-Yun Lee
Summary: Ferroptosis can be induced through various mechanisms such as inhibiting antioxidant enzymes and lipid peroxidation. This study focused on investigating the effects of ferroptosis inducers on non-small cell lung cancer (NSCLC) cells and found that RSL3 was more effective than erastin in inducing cell death. The sensitivity of NSCLC cells to RSL3-induced death was dependent on GPX4 expression levels and was reversed by a ferroptosis inhibitor. RSL3 induced ferroptosis by promoting lipid peroxidation and disrupting the GSH conversion.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Weiwei Cui, Dong Liu, Wei Gu, Bo Chu
Summary: Ferroptosis is primarily induced by peroxidation of long-chain PUFA, but the role of SFA remains unclear. The study identified FAR1 as a key factor in SFA-mediated ferroptosis, involved in the synthesis of alkyl-ether lipids and plasmalogens, revealing a new pathway for ferroptosis.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Multidisciplinary Sciences
Bartosz Wiernicki, Sophia Maschalidi, Jonathan Pinney, Sandy Adjemian, Tom Vanden Berghe, Kodi S. Ravichandran, Peter Vandenabeele
Summary: Ferroptosis, a form of cell death characterized by iron accumulation and lipid peroxidation, has lower immunogenicity compared to other cell death modalities, inhibiting the maturation and antigen cross-presentation of immune cells and hence weakening the anti-tumor immune response.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Sheng Gao, Yun Zhang, Meixia Zhang
Summary: This article summarizes the mechanisms of three types of regulated cell death (RCD) in diabetic retinopathy (DR) and analyzes the recent advances in the association between novel RCD forms and DR. These findings provide new insights into the underlying pathogenic mechanisms of DR and propose potential therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Christina M. Bebber, Emily S. Thomas, Jenny Stroh, Zhiyi Chen, Ariadne Androulidaki, Anna Schmitt, Michaela N. Hoehne, Lukas Stueker, Cleidson de Padua Alves, Armin Khonsari, Marcel A. Dammert, Fatma Parmaksiz, Hannah L. Tumbrink, Filippo Beleggia, Martin L. Sos, Jan Riemer, Julie George, Susanne Brodesser, Roman K. Thomas, H. Christian Reinhardt, Silvia von Karstedt
Summary: The loss of TP53 and RB1 in treatment-naive small cell lung cancer (SCLC) indicates a need to inactivate cell death pathways prior to therapy. This study identifies non-neuroendocrine (NE) SCLC as vulnerable to ferroptosis and neuroendocrine (NE) SCLC as susceptible to TRX pathway inhibition, with combining these treatments showing promise in overcoming subtype plasticity in SCLC.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Mingming Wu, Xiao Zhang, Weijie Zhang, Yi Shiou Chiou, Wenchang Qian, Xiangtian Liu, Min Zhang, Hong Yan, Shilan Li, Tao Li, Xinghua Han, Pengxu Qian, Suling Liu, Yueyin Pan, Peter E. Lobie, Tao Zhu
Summary: The study reveals the role of breast cancer stem cell (BCSC) secretome in regulating the stem cell population, tumor-initiating capacity, and metastasis. DKK1 is identified as a key factor secreted by BCSCs that promotes differentiation and metastatic outgrowth. DKK1 increases the expression of SLC7A11 to protect metastasizing cancer cells from ferroptosis. Combination therapy with a ferroptosis inducer and a DKK1 inhibitor shows synergistic effects in reducing metastasis.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Lu Liu, Ling Zhou, Ling-Ling Wang, Peng-Dou Zheng, Feng-Qin Zhang, Zhen-Yu Mao, Huo-Jun Zhang, Hui-Guo Liu
Summary: Bronchial asthma, a complex heterogeneous airway disease, has become a global health issue. Understanding the different molecular mechanisms of asthma could improve clinical efficacy. Evidence suggests that various forms of programmed cell death (PCD) contribute to asthma pathogenesis and may be potential targets for future asthma treatment. This review discusses the molecular mechanisms and signaling pathways of PCD, summarizes their roles in asthma pathogenesis and treatment, and offers potential means to enhance clinical efficacy.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Cell Biology
Siyu Yuan, Can Wei, Guofang Liu, Lijun Zhang, Jiahao Li, Lingling Li, Shiyi Cai, Ling Fang
Summary: Sorafenib alleviates liver injury and fibrosis by inducing HSC ferroptosis through the HIF-1 alpha/SLC7A11 signaling pathway. Ferroptotic events triggered by sorafenib in HSC-T6 cells were not observed in hepatocytes or macrophages, highlighting the specificity of this process in liver fibrosis attenuation.
CELL PROLIFERATION
(2022)