Article
Oncology
Steven P. Bisch, Gregg Nelson
Summary: Enhanced Recovery After Surgery (ERAS) is a global surgical quality improvement program that has been shown to improve clinical outcomes and reduce costs by implementing evidence-based recommendations in various specialties.
Article
Oncology
G. Nelson, C. Fotopoulou, J. Taylor, G. Glaser, J. Bakkum-Gamez, L. A. Meyer, R. Stone, G. Mena, K. M. Elias, A. D. Altman, S. P. Bisch, P. T. Ramirez, S. C. Dowdy
Summary: This article presents the updated evidence and recommendations for implementing Enhanced Recovery After Surgery (ERAS) in gynecologic oncology surgery. It focuses on addressing implementation challenges and provides evidence-based guidelines.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Surgery
Hiromichi Sato, Hirofumi Ota, Koji Munakata, Yusuke Matsuura, Makoto Fujii, Noriko Wada, Daisuke Takiuchi, Naoki Hama, Kou Takachi, Masao Yukawa
Summary: The study evaluated the efficacy and safety of the enhanced recovery after surgery (ERAS) protocol and analyzed the impact of each ERAS item on postoperative outcomes. The findings showed that the ERAS protocol led to a shorter length of hospital stay (LOHS) without significantly increasing complication rates. Higher compliance with ERAS items resulted in lower complication rates and shorter LOHS. Perioperative fluid management had a crucial impact on the outcomes.
Article
Health Care Sciences & Services
Luca Pellegrino, Eva Pagano, Marco Ettore Allaix, Mario Morino, Andrea Muratore, Paolo Massucco, Federica Rinaldi, Giovannino Ciccone, Felice Borghi
Summary: In the Piedmont region, colorectal surgery units showed poor adoption of several items in the ERAS protocol during the baseline period of the ERAS Colon-Rectum Piedmont study and in the ERAS group. No significant obstacles to compliance with the ERAS protocol were identified.
Article
Obstetrics & Gynecology
Morgan L. Brown, Vidda Simpson, Annabelle B. Clark, Margarite D. Matossian, Stacey L. Holman, Amelia Marie Jernigan, Stacey A. Scheib, Jessica Shank, Alison Key, Andrew G. Chapple, Elizabeth Kelly, Navya Nair
Summary: Implementation of ERAS in patients with comorbid conditions, inadequate insurance, and barriers to healthcare can improve postoperative recovery, reducing pain scores and opioid use.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Article
Oncology
Stephanie Alimena, Parisa Fallah, Briana Stephenson, Colleen Feltmate, Sarah Feldman, Kevin M. Elias
Summary: The study aimed to compare differences in ERAS implementation and outcomes by race. It found that fewer non-white women received preadmission education, possibly due to language barriers. However, there were no differences in ERAS compliance, postoperative complications, readmissions, reoperations, and ICU transfers between different races.
GYNECOLOGIC ONCOLOGY
(2023)
Review
Oncology
S. P. Bisch, C. A. Jago, E. Kalogera, H. Ganshorn, L. A. Meyer, P. T. Ramirez, S. C. Dowdy, G. Nelson
Summary: ERAS implementation in gynecologic oncology surgery leads to decreased length of stay, complications, and cost, without increasing readmission or mortality rates.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Natalia R. Gomez-Hidalgo, Andrei Pletnev, Zoia Razumova, Nicolo Bizzarri, Ilker Selcuk, Charalampos Theofanakis, Kamil Zalewski, Tanja Nikolova, Maximilian Lanner, Joanna Kacperczyk-Bartnik, Houssein El Hajj, Assumpcio Perez-Benavente, Gregg Nelson, Antonio Gil-Moreno, Christina Fotopoulou, Jose Luis Sanchez-Iglesias
Summary: The survey revealed widespread implementation of ERAS protocols across Europe, but with varying degrees of adherence to different aspects of the protocol items.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Medicine, General & Internal
Biao Zhou, Haoyang Ji, Yumeng Liu, Zhe Chen, Nianrong Zhang, Xinyu Cao, Hua Meng
Summary: The study compared perioperative outcomes of laparoscopic bariatric surgery between patients with ERAS and conventional care, showing that ERAS group had shorter length of hospital stay, higher day 1 discharge rate, lower complications, and readmissions within 30 days postoperatively.
Article
Clinical Neurology
Bertrand Debono, Thomas W. Wainwright, Michael Y. Wang, Freyr G. Sigmundsson, Michael M. H. Yang, Henriette Smid-Nanninga, Aurelien Bonnal, Jean -Charles Le Huec, William J. Fawcett, Olle Ljungqvist, Guillaume Lonjon, Hans D. de Boer
Summary: ERAS protocols have shown significant improvements in outcomes by optimizing patient care pathways, reducing complications, enhancing patient experience, and shortening hospital stays. A multidisciplinary consensus review on lumbar fusion surgery with ERAS program was conducted, resulting in 28 recommendations covering various aspects of preoperative, intraoperative, and postoperative care.
Review
Oncology
Giorgio Bogani, Giuseppe Sarpietro, Gabriella Ferrandina, Valerio Gallotta, Violante Di Donato, Antonino Ditto, Ciro Pinelli, Jvan Casarin, Fabio Ghezzi, Giovanni Scambia, Francesco Raspagliesi
Summary: ERAS is a pathway designed to promote early recovery for patients undergoing major surgery, with three important components: preoperative, intraoperative, postoperative program. Adoption of ERAS can lead to lower complication rates, shorter hospital stays, improved patient outcomes, and reduced overall cost of care.
Article
Obstetrics & Gynecology
Susanne Reuter, Linn Woelber, Constantin C. Trepte, Daniel Perez, Antonia Zapf, Sinan Cevirme, Volkmar Mueller, Barbara Schmalfeldt, Anna Jaeger
Summary: The implementation of a mandatory ERAS protocol was associated with a lower rate of postoperative complications and a reduced length of stay in the hospital. However, the influence of ERAS on long-term outcomes needs further evaluation.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Surgery
Madeline L. Rasmussen, Steven G. Leeds, Edward P. Whitfield, Bola Aladegbami, Gerald O. Ogola, Marc A. Ward
Summary: This study aimed to develop an ERAS protocol for patients undergoing foregut surgery and determine its impact on outcomes. The results showed that implementing the ERAS protocol led to a 41% decrease in complications and a 33% reduction in length of stay compared to traditional protocols. Completing the ERAS protocol further reduced complications and length of stay compared to patients who deviated from the protocol.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Greg J. Haro, Bonnie Sheu, Sivan G. Marcus, Ankit Sarin, Lundy Campbell, David M. Jablons, Johannes R. Kratz
Summary: This study demonstrated that implementing a multidisciplinary, evidence-based Thoracic Enhanced Recovery After Surgery (ERAS) Program can significantly improve outcomes for perioperative lung resection patients, including reducing length of stay, complications, opioid use, and direct costs.
Article
Gastroenterology & Hepatology
Thais T. T. Tweed, Carmen Woortman, Stan Tummers, Maikel J. A. M. Bakens, James van Bastelaar, Jan H. M. B. Stoot
Summary: By implementing perioperative education and expected discharge date (EDD) within the ERAS program, it is possible to reduce length of stay (LOS) for colorectal cancer surgery patients, decrease postoperative complication rates, and lower hospital costs.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Oncology
Eun-Young Kang, Ashley Weir, Nicola S. Meagher, Kyo Farrington, Gregg S. Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J. Riggan, Adelyn Bolithon, Gordana Popovic, Betty Leung, Katrina Tang, Neil Lambie, Joshua Millstein, Jennifer Alsop, Michael S. Anglesio, Beyhan Ataseven, Ellen Barlow, Matthias W. Beckmann, Jessica Berger, Christiani Bisinotto, Hans Boesmueller, Jessica Boros, Alison H. Brand, Angela Brooks-Wilson, Sara Y. Brucker, Michael E. Carney, Yovanni Casablanca, Alicia Cazorla-Jimenez, Paul A. Cohen, Thomas P. Conrads, Linda S. Cook, Penny Coulson, Madeleine Courtney-Brooks, Daniel W. Cramer, Philip Crowe, Julie M. Cunningham, Cezary Cybulski, Kathleen M. Darcy, Mona A. El-Bahrawy, Esther Elishaev, Ramona Erber, Rhonda Farrell, Sian Fereday, Anna Fischer, Maria J. Garcia, Simon A. Gayther, Aleksandra Gentry-Maharaj, C. Blake Gilks, Marcel Grube, Paul R. Harnett, Shariska Petersen Harrington, Philipp Harter, Arndt Hartmann, Jonathan L. Hecht, Sebastian Heikaus, Alexander Hein, Florian Heitz, Joy Hendley, Brenda Y. Hernandez, Susanna Hernando Polo, Sabine Heublein, Akira Hirasawa, Estrid Hogdall, Claus K. Hogdall, Hugo M. Horlings, David G. Huntsman, Tomasz Huzarski, Andrea Jewell, Mercedes Jimenez-Linan, Michael E. Jones, Scott H. Kaufmann, Catherine J. Kennedy, Dineo Khabele, Felix K. F. Kommoss, Roy F. P. M. Kruitwagen, Diether Lambrechts, Nhu D. Le, Marcin Lener, Jenny Lester, Yee Leung, Anna Linder, Liselore Loverix, Jan Lubinski, Rashna Madan, G. Larry Maxwell, Francesmary Modugno, Susan L. Neuhausen, Alexander Olawaiye, Siel Olbrecht, Sandra Orsulic, Jose Palacios, Celeste Leigh Pearce, Malcolm C. Pike, Carmel M. Quinn, Ganendra Raj Mohan, Cristina Rodriguez-Antona, Matthias Ruebner, Andy Ryan, Stuart G. Salfinger, Naoko Sasamoto, Joellen M. Schildkraut, Minouk J. Schoemaker, Mitul Shah, Raghwa Sharma, Yurii B. Shvetsov, Naveena Singh, Gabe S. Sonke, Linda Steele, Colin J. R. Stewart, Karin Sundfeldt, Anthony J. Swerdlow, Aline Talhouk, Adeline Tan, Sarah E. Taylor, Kathryn L. Terry, Aleksandra Toloczko, Nadia Traficante, Koen K. Van de Vijver, Maaike A. van der Aa, Toon Van Gorp, Els Van Nieuwenhuysen, Lilian Van-Wagensveld, Ignace Vergote, Robert A. Vierkant, Chen Wang, Lynne R. Wilkens, Stacey J. Winham, Anna H. Wu, Javier Benitez, Andrew Berchuck, Francisco J. Candido Dos Reis, Anna DeFazio, Peter A. Fasching, Ellen L. Goode, Marc T. Goodman, Jacek Gronwald, Beth Y. Karlan, Stefan Kommoss, Usha Menon, Hans-Peter Sinn, Annette Staebler, James D. Brenton, David D. Bowtell, Paul D. P. Pharoah, Susan J. Ramus, Martin Kobel
Summary: This study validates that high-level amplification of CCNE1 is associated with shorter survival in tubo-ovarian high-grade serous carcinoma (HGSC), supporting its use as a prognostic biomarker in this disease.
Article
Oncology
Citadel J. J. Cabasag, Melina Arnold, Mark Rutherford, Jacques Ferlay, Aude Bardot, Eileen Morgan, John Butler, Dianne L. L. O'Connell, Gregg Nelson, Claus Hogdall, Tine Schnack, Anna Gavin, Mark Elwood, Louise Hanna, Charlie Gourley, Prithwish De, Nathalie Saint-Jacques, Lina Steinrud Morch, Ryan R. Woods, Alon D. D. Altman, Peter Sykes, Paul A. A. Cohen, Orla McNally, Bjorn Moller, Paul Walsh, David S. S. Morrison, Freddie Bray, Isabelle Soerjomataram
Summary: The aim of this study was to assess the incidence and survival trends of epithelial ovarian cancer (EOC) by histological subtype across seven high-income countries. Data from 1995 to 2014 were obtained from 20 cancer registries, and results showed that there was a significant increase in serous carcinoma incidence among women aged 65 to 99 years. On the other hand, the incidence of adenocarcinoma not otherwise specified showed a marked decrease in women aged 15 to 64 years. The overall survival of EOC has improved over the 20-year study period in all countries.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
G. Nelson, C. Fotopoulou, J. Taylor, G. Glaser, J. Bakkum-Gamez, L. A. Meyer, R. Stone, G. Mena, K. M. Elias, A. D. Altman, S. P. Bisch, P. T. Ramirez, S. C. Dowdy
Summary: This article presents the updated evidence and recommendations for implementing Enhanced Recovery After Surgery (ERAS) in gynecologic oncology surgery. It focuses on addressing implementation challenges and provides evidence-based guidelines.
GYNECOLOGIC ONCOLOGY
(2023)
Review
Surgery
Tamir N. Sholklapper, Jorge Ballon, Aref S. Sayegh, Anibal La Riva, Laura C. Perez, Sherry Huang, Michael Eppler, Gregg Nelson, Giovanni Marchegiani, Robert Hinchliffe, Luca Gordini, Marc Furrer, Michael J. Brenner, Salome Dell-Kuster, Chandra Shekhar Biyani, Nader Francis, Haytham M. A. Kaafarani, Matthias Siepe, Des Winter, Julie A. Sosa, Francesco Bandello, Robert Siemens, Jochen Walz, Alberto Briganti, Christian Gratzke, Andre L. Abreu, Mihir M. Desai, Rene Sotelo, Riaz Agha, Keith D. Lillemoe, Steven Wexner, Gary S. Collins, Inderbir Gill, Giovanni E. Cacciamani
Summary: This study assesses the prevalence and typology of perioperative adverse event reporting guidelines among surgery and anesthesiology journals. Results show that 46.5% of the queried journals recommend surgical adverse event reporting. Journals in the surgery, urology, and anesthesia categories are most likely to recommend reporting; those in the top SJR quartiles and based in Western Europe, North America, and the Middle East are also more likely to recommend.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Sabrina Piedimonte, Limor Helpman, Gregory Pond, Gregg Nelson, Janice Kwon, Alon Altman, Tomer Feigenberg, Laurie Elit, Susie Lau, Jeanelle Sabourin, Vanessa Samouelian, Karla Willows, Christa Aubrey, Ji-Hyun Jang, Ly-Ann Teo -Fortin, Norah Cockburn, Nora -Beth Saunders, Sarah Shamiya, Danielle Vicus, Marie Plante
Summary: This study aimed to determine whether close and positive surgical margins are associated with surgical approach and survival. The results showed that the surgical approach was not associated with margin status, but close margins were associated with a higher risk of death. Minimally invasive surgery was also associated with worse survival, suggesting that margin status may not be the main driver of worse survival in these cases.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Cristina Mitric, Sarah Daisy Kosa, Soyoun Rachel Kim, Gregg Nelson, Stephane Laframboise, Genevieve Bouchard-Fortier
Summary: The implementation of a peri-operative care program based on enhanced recovery after surgery principles for minimally invasive gynecologic oncology surgery led to an improvement in same day discharge rate and significant reductions in overall costs and some surgical and post-operative visit costs.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Anastasios Pandraklakis, Dimitrios Haidopoulos, Theodoros Lappas, Emmanouil Stamatakis, Dimitrios Valsamidis, Maria D. Oikonomou, Dimitrios Loutradis, Alexandros Rodolakis, Steven P. Bisch, Gregg Nelson, Nikolaos Thomakos
Summary: This study evaluated the safety and effectiveness of thoracic epidural analgesia in gynecologic oncology patients undergoing laparotomy as part of the enhanced recovery after surgery (ERAS) multimodal analgesic protocol. The results showed that thoracic epidural analgesia provided better pain relief and additional benefits during the peri-operative period, improving the overall recovery experience of patients with gynecologic cancer.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Medicine, General & Internal
Kevin M. Elias, Nicholas W. Ng, Kh U. Dam, Ankrish Milne, Emily R. Disler, Alison Gockley, Nicole Holub, Maya L. Seshan, George M. Church, Elizabeth S. Ginsburg, Raymond M. Anchan
Summary: This study demonstrates the potential of induced pluripotent stem cell (iPSC) transplantation for the treatment of premature ovarian insufficiency (POI) in a mouse model, as it successfully reversed the endocrine and reproductive issues caused by POI.
Article
Oncology
Thomas J. Gerton, Allen Green, Marco Campisi, Minyue Chen, Iliana Gjeci, Navin Mahadevan, Catherine A. A. Lee, Ranjan Mishra, Ha V. Vo, Koji Haratani, Ze-Hua Li, Kathleen T. Hasselblatt, Bryanna Testino, Trevor Connor, Christine G. Lian, Kevin M. Elias, Patrick Lizotte, Elena V. Ivanova, David A. Barbie, Daniela M. Dinulescu
Summary: High-grade serous ovarian cancer (HGSOC) is a leading cause of gynecology cancer-related deaths. Utilizing epigenetic modulators can maximize the effectiveness of personalized immuno-oncology treatments. The use of patient-derived tumor ascites in a 3D screening platform has shown that epigenetic priming can enhance immune checkpoint blockade therapies.
Article
Obstetrics & Gynecology
Valdete Aparecida Ribeiro da Silva, Izildinha Maesta, Roberto Antonio de Araujo Costa, Alinede Avila Campos, Antonio Braga, Neil Horowitz, Kevin M. Elias, Ross Berkowitz
Summary: This study examined the relationship between clinical status upon admission and distance traveled in women with gestational trophoblastic disease (GTD). The results showed that patients from areas outside the specialized center were more likely to have higher risk scores for hydatidiform mole and gestational trophoblastic neoplasia at admission. Long distances seemed to hinder access to specialized centers and negatively impact clinical status.
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2023)
Review
Medicine, General & Internal
Antonio Braga, Elaine Balthar, Lais Cristhine Santos Souza, Michelle Samora, Matheus Rech, Jose Mauro Madi, Joffre Amim, Jorge Rezende Filho, Kevin M. Elias, Neil S. Horowitz, Sue Yazaki Sun, Ross S. Berkowitz
Summary: This study evaluated the efficacy of immunotherapy for GTN treatment and presented 4 Brazilian cases. The results showed that immunotherapy was effective for high-risk GTN, with pembrolizumab achieving a high therapeutic response despite prior chemoresistance to multiple lines of treatment.
Review
Oncology
Anna V. V. Tinker, Neesha C. Dhani, Prafull Ghatage, Deanna McLeod, Vanessa Samouelian, Stephen A. Welch, Alon D. Altman
Summary: This review provides evidence-based guidance on the use of immune checkpoint inhibitors (ICIs) alone or in combination with tyrosine kinase inhibitors (TKIs) for the treatment of pretreated advanced, persistent, or recurrent metastatic endometrial cancer. The study findings suggest that pembrolizumab plus lenvatinib is effective for unselected pretreated metastatic endometrial cancer, while pembrolizumab monotherapy is recommended for patients with DNA mismatch repair/microsatellite instability-high (MMRd/MSI-H) tumors.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Oncology
Christa Aubrey, Gregory R. Pond, Limor Helpman, Danielle Vicus, Laurie Elit, Marie Plante, Susie Lau, Janice S. Kwon, Alon D. Altman, Karla Willows, Tomer Feigenberg, Jeanelle Sabourin, Vanessa Samouelian, Laurence Bernard, Norah Cockburn, Nora-Beth Saunders, Sabrina Piedimonte, Ly-Ann Teo-Fortin, Soyoun Rachel Kim, Noor Sadeq, Ji-Hyun Jang, Sarah Shamiya, Gregg Nelson
Summary: Minimally invasive surgery for macroscopic cervical cancer leads to worse outcomes than open surgery, but preoperative conization may help mitigate the risk. This retrospective study examined oncologic outcomes in cervical cancer cases treated initially with conization and subsequent hysterectomy using either minimally invasive or open approaches. The study found no significant differences in recurrence-free survival or overall survival between the two surgical approaches. However, further studies are needed to confirm these findings.