Article
Genetics & Heredity
Ashley M. Hesson, Elizabeth S. Langen, Olesya Plazyo, Johann E. Gudjonsson, Santhi K. Ganesh
Summary: This study compared the placental transcriptomes of pregnant women with hypertensive disorders to non-hypertensive controls and found significant differences in the transcriptome profiles of chronic hypertension superimposed on preeclampsia compared to preeclampsia without chronic hypertension. These findings suggest that preeclampsia superimposed on chronic hypertension may represent a distinct disease entity.
BMC MEDICAL GENOMICS
(2023)
Article
Cell Biology
Jeanne A. Ishimwe, Adesanya Akinleye, Ashley C. Johnson, Michael R. Garrett, Jennifer M. Sasser
Summary: The study suggests that there may be an association between chronic hypertension and gut microbiome dysbiosis in pregnancy, which hinders gut microbial composition remodeling during superimposed preeclampsia.
PHYSIOLOGICAL GENOMICS
(2021)
Review
Peripheral Vascular Disease
Christina Antza, Stella Stabouli, Vasilios Kotsis
Summary: Hypertensive disorders of pregnancy, such as gestational hypertension, preeclampsia, and eclampsia, are a global health problem affecting over 10% of pregnancies and causing increased mortality and morbidity for both mothers and fetuses. In addition to the focus on patient outcomes and family experiences, the economic impact of this disease is also noteworthy. Compared to pregnancies without hypertension, those with hypertension require more hospitalizations and incur higher healthcare costs. Therefore, this article aims to analyze hypertensive disorders of pregnancy and provide practical tips for their clinical management.
JOURNAL OF HYPERTENSION
(2022)
Article
Cell Biology
Sandra M. Blois, Paula D. Prince, Sophia Borowski, Monica Galleano, Gabriela Barrientos
Summary: Utilizing the SHRSP model, this study investigated placental mechanisms promoting superimposed preeclampsia in women with chronic hypertension. The findings revealed sustained activation of cellular stress response in SHRSP placentas, leading to redox imbalance and significant alterations in placental glycocode. The study highlights the potential role of glycoredox balance as a promising target for interventions in hypertensive disorders of pregnancy.
Article
Pediatrics
Marguerite Lockhart, Robin Chaux, Mathilde Chevin, Magali Celle, Tiphaine Raia-Barjat, Hugues Patural, Stephane Chabrier, Antoine Giraud
Summary: This study aimed to evaluate the classification performance of the Ages and Stages Questionnaire-Third Edition (ASQ-3) in preterm infant follow-up. The results showed low sensitivity and identified low maternal education level as a major risk factor for incorrectly evaluating children with the ASQ-3. Therefore, the ASQ-3 should not be used alone to follow the development of preterm children.
Review
Endocrinology & Metabolism
Shiyu Yan, Jinlang Lyu, Zheng Liu, Shuang Zhou, Yuelong Ji, Haijun Wang
Summary: This study conducted a systematic review and meta-analysis to evaluate the association between maternal gestational hypertension/preeclampsia and offspring adiposity outcomes. The results suggested that exposure to these pregnancy disorders was associated with obesity in offspring, extending from early childhood to adolescence. The meta-analysis showed a significant association between preeclampsia and higher BMI in female offspring.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Jing Zhu, Jun Zhang, Yi Wu, Li Gao, Xinrong Zhao, Weiwei Cheng, Yanlin Wang
Summary: This study aimed to compare the patterns of estimated fetal weight discordance throughout gestation among normotensive women, women with gestational hypertension, and women with preeclampsia and to evaluate the association between crown-rump length discordance at 11 to 14 weeks of gestation and hypertensive disorders of pregnancy. The study found that fetal weight discordance increased progressively throughout pregnancy in women with gestational hypertension and preeclampsia, while normotensive women did not show this trend. Crown-rump length discordance was associated with an increased risk of preeclampsia, especially early-onset preeclampsia.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zongli Ren, Ning Cui, Minglin Zhu, Raouf A. Khalil
Summary: The study suggests that placental ischemia-induced proinflammatory cytokines may be one of the causes of preeclampsia. Modulating cytokines and metalloproteinases can improve vascular and uteroplacental remodeling, alleviating symptoms of preeclampsia.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Obstetrics & Gynecology
Xiaobo Zhao, Sophia Twum Frempong, Tao Duan
Summary: The study found that elevated serum uric acid in Chinese Han women with gestational hypertension is associated with an increased risk of progression to preeclampsia and delivering small-for-gestational-age infants. ROC analysis showed moderate prediction values for preeclampsia, but relatively low prediction values for small-for-gestational-age infants, with improved accuracy in Han women with early onset gestational hypertension.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Psychology, Biological
Ashley Griffin, Shauna-Kay Spencer, Teylor Bowles, Lucia Solis, Reanna Robinson, Sumana Ramarao, Kedra Wallace
Summary: Offspring born to dams with PreE and HELLP show evidence of early onset neurodevelopmental delay, with male HELLP offspring exhibiting altered behavior in some sensorimotor tests compared to other groups.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Engineering, Environmental
Cheng Li, Jing-Jing Xu, Fang-Yue Zhou, Kai-Zhou Qin, Ying-Zhou Ge, He-Feng Huang, Yan-Ting Wu
Summary: The study found that there is an association between particulate matter (PM) and gestational hypertensive disorders (GHDs), but there is no evidence on the associations between PM and GHD progression, especially among those with assisted reproductive technology (ART) conceptions. The study included 185,140 pregnant women in Shanghai from 2014 to 2020 and found that increased PM concentrations during the preconception period were associated with an increased risk of gestational hypertension (GH) and preeclampsia among women with natural conception. Additionally, for women with ART conceptions who already had GHD, increased PM concentrations in the third trimester elevated the risk of progression.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lisa D. Levine, Bonnie Ky, Julio A. Chirinos, Jessica Koshinksi, Zoltan Arany, Valerie Riis, Michal A. Elovitz, Nathanael Koelper, Jennifer Lewey
Summary: Hypertensive disorders of pregnancy (HDP) are associated with increased risk of cardiovascular disease (CVD). This study found a 2.4-fold increased risk of hypertension 10 years after HDP. Differences in noninvasive measures of cardiovascular risk were primarily driven by the diagnosis of hypertension, suggesting that the long-term risk of CVD after HDP may be mainly attributed to the development of hypertension.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Arash Derakhshan, Tuija Mannisto, Liangmiao Chen, Joris A. J. Osinga, Ghalia Ashoor, Xuemian Lu, Sofie Bliddal, Fang-Biao Tao, Suzanne J. Brown, Bijay Vaidya, Andrew T. Hattersley, Sachiko Itoh, Polina Popova, Ashraf Aminorroaya, Reiko Kishi, Maryam Kianpour, Elena A. Vasukova, Abel Lopez-Bermejo, Emily Oken, Leda Chatzi, Marina Vafeiadi, Wichor M. Bramer, Judit Bassols, Aitana Lertxundi, Ana Fernandez-Somoano, Paula Carrasco, Juha Auvinen, Kun Huang, Ulla Feldt-Rasmussen, Elena N. Grineva, Erik K. Alexander, Elizabeth N. Pearce, Layal Chaker, John P. Walsh, Robin P. Peeters, Monica Guxens, Eila Suvanto, Kypros H. Nicolaides, Tim I. M. Korevaar
Summary: This study explores the association between gestational FT3 and TT3 levels and adverse obstetric outcomes. The findings suggest that FT3 and TT3 levels have different associations with various adverse obstetric outcomes, with high TT3 associated with an increased risk of gestational hypertension and low TT3 associated with a higher risk of very preterm birth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Xiujuan Su, Yang Liu, Guohua Li, Xiaosong Liu, Shijia Huang, Tao Duan, Qiaoling Du
Summary: This study found that hypothyroxinemia during pregnancy was associated with an increased risk of preeclampsia-eclampsia, especially in women with persistent hypothyroxinemia in early pregnancy. However, there was no significant association between hypothyroxinemia and gestational hypertension.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Antti Peltokorpi, Lisinen Irina, Viikari Liisa, Kaaja Risto
Summary: Leptin levels were higher in the GDM and PIH/PE groups compared to the control group, indicating a potential association between leptin levels and adverse pregnancy outcomes such as gestational diabetes and pregnancy-induced hypertension.
HYPERTENSION IN PREGNANCY
(2022)
Article
Acoustics
R. J. Burger, S. J. Gordijn, B. W. Mol, W. Ganzevoort, A. C. J. Ravelli
Summary: The study aimed to assess the association between birth-weight centile and intellectual development in term/near-term infants across the entire birth-weight spectrum. The results showed a positive association between birth-weight centile and school performance at the age of 12, highlighting the importance of developing better tools for diagnosing fetal growth restriction and reduced placental function, as well as identifying risks for associated short- and long-term consequences.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
He Cai, Ben Mol, Stephan Gordts, Hui Wang, Juanzi Shi
Summary: This study evaluated the effectiveness of elective single-blastocyst transfer (eSBT) in women aged 36 or older. The results showed that eSBT and double-blastocyst transfer (DBT) had comparable cumulative live birth rates (cLBR), but eSBT significantly reduced the odds of multiple live births and adverse perinatal outcomes. In addition, eSBT resulted in a lower number of twins and higher odds of singleton pregnancies when compared to DBT.
Editorial Material
Obstetrics & Gynecology
Ben W. Mol, Michelle L. Giles
FERTILITY AND STERILITY
(2023)
Editorial Material
Obstetrics & Gynecology
Ben W. Mol, John P. A. Ioannidis
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Tessa Copp, Rachel Thompson, Jenny Doust, Karin Hammarberg, Michelle Peate, Sarah Lensen, Erin Cvejic, Devora Lieberman, Ben W. Mol, Kirsten J. McCaffery
Summary: A survey in Australia finds that only 13% of women have heard of the anti-Mullerian hormone (AMH) test, and only 7% have undergone the test. The top reasons for testing include infertility investigations (51%), considering pregnancy and wanting to understand chances (19%), and finding out if a medical condition affected fertility (11%).
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Julia Oltman, Sanjana Balachander, Ben W. Mol, Andrea M. F. Woolner
Summary: Ectopic pregnancy can occur in both natural and assisted reproduction pregnancies, predominantly within the fallopian tube. Medical or expectant treatment may be offered to haemodynamically stable women. Methotrexate is currently the accepted medical treatment, although it has potential adverse effects and a significant proportion of women still require emergency surgery for removal of the ectopic pregnancy. Mifepristone, with its anti-progesterone effects, has a potential role in managing tubal ectopic pregnancy in haemodynamically stable women, given the pivotal role of progesterone in sustaining pregnancy, which may have been overlooked.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Scott C. Mackenzie, Catherine A. Moakes, Ann M. Doust, Ben W. Mol, W. Colin Duncan, Stephen Tong, Andrew W. Horne, Lucy H. R. Whitaker
Summary: The study aimed to investigate the capacity of the change between Day 1 and Day 4 post-treatment serum hCG levels for predicting single-dose methotrexate treatment success in tubal ectopic pregnancy. The results showed that any fall in serum hCG on Days 1-4 signified an 85% likelihood of treatment success for women with tubal ectopic pregnancy managed with single-dose methotrexate.
HUMAN REPRODUCTION
(2023)
Review
Public, Environmental & Occupational Health
Ritesh Rikain Warty, Vinayak Smith, Malitha Patabendige, Deborah Fox, Ben Mol
Summary: Medical technologies in the field of women's health, known as FemTech, are rapidly growing at a rate of 15.6% per annum. However, there are concerns that these technologies may not address the actual needs of women and caregivers. This review analyzes tools for clinical needs assessments and discusses concepts for a unified approach to improve women's healthcare.
HEALTH CARE FOR WOMEN INTERNATIONAL
(2023)
Article
Obstetrics & Gynecology
Thais Valeria Silva, Anderson Borovac-Pinheiro, Marcelo Santucci Franca, Kaline Fernandes Marquat, Juliana Passos Argenton, Ben Willem Mol, Rodolfo Carvalho Pacagnella
Summary: This study aimed to describe a reference curve for cervical length (CL) in mid-trimester twin gestations using transvaginal ultrasound (TVU), and investigate whether short CL increases the risk of spontaneous preterm birth (sPTB) in asymptomatic twin pregnancies. The results showed that CL does not perform well in predicting preterm birth in Brazilian asymptomatic twin pregnancies. However, a cutoff point of CL ≤ 20mm may be an interesting indicator to identify short cervix in Brazilian twin pregnancies.
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2023)
Article
Obstetrics & Gynecology
Melanie A. M. Baas, Claire A. I. Stramrood, Lea M. Dijksman, Joost W. Vanhommerig, Ad de Jongh, Marielle G. van Pampus
Summary: EMDR therapy is an effective treatment for pregnant women with fear of childbirth, as it does not have any adverse effects on pregnancy or the fetus.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Medicine, General & Internal
Jolijn Vissers, Saskia J. M. Klein Meuleman, Robert A. de Leeuw, Rik van Eekelen, Freek A. Groenman, Ben W. Mol, Wouter J. K. Hehenkamp, Judith A. F. Huirne
Summary: This study aims to investigate the effect of laparoscopic niche resection on reproductive outcomes in infertile women. The study includes 200 women with a large uterine niche and a total follow-up of 2 years. Participants will be randomly assigned to undergo surgery or receive expectant management, and reproductive outcomes and other relevant measures will be assessed. Rating: 8/10
Article
Obstetrics & Gynecology
Natalie Jardine Cameron, Dagmar Wertaschnigg, Mary-Ann Davey, Renee Janne Burger, Ben Willem Mol, Andrea Mary Woolner
Summary: This study analyzed the incidence and mode of birth for preterm and term PROM in Victoria, Australia from 2009 to 2017. The use of elective caesarean section (elCS) and induction of labor (IOL) in cases of PPROM is increasing, particularly between 34 and 36 weeks of pregnancy.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
C. McMahon, K. Hammarberg, S. Lensen, R. Wang, B. W. Mol, B. J. N. Vollenhoven
Summary: The study showed that only one in four Australian women undergoing IVF accurately estimated their chance of having a baby, with most women overestimating their chance.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Kan-feng Zheng, Madeleine N. Jones, Ben W. Mol, Daniel L. Rolnik
Summary: This study found that Class III obesity is associated with increased rates of caesarean delivery and intrapartum interventions. Additionally, obese women experienced longer duration of labor.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Review
Obstetrics & Gynecology
Pedro Melo, Adam Devall, Andrew H. Shennan, Manu Vatish, Christian M. Becker, Ingrid Granne, Aris T. Papageorghiou, Ben W. Mol, Arri Coomarasamy
Summary: This systematic review found that first-trimester initiated vaginal progesterone may reduce the risk of HDP and pre-eclampsia.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)