Article
Biotechnology & Applied Microbiology
Lingling Zhang, Hailing Zhou, Wei Zhang, Xueying Ling, Chunyuan Zeng, Yongjin Tang, Jiefeng Gan, Qinghua Tan, Xiangshu Hu, Hainan Li, Baijie Cheng, Hao Xu, Qiang Guo
Summary: This study analyzed the clinical, electrophysiological, and imaging characteristics of FCD type IIIa and identified potential predictors associated with postoperative outcomes. The study found that a shorter duration of epilepsy, absence of contralateral insular lobe hypometabolism on PET/MRI, and complete resection of the epileptogenic area were associated with better seizure outcomes. Careful evaluation of patients with FCD type IIIa can help identify ideal candidates for resection surgery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Rupesh Kumar Chikara, Saeed Jahromi, Eleonora Tamilia, Joseph R. Madsen, Steve M. Stufflebeam, Phillip L. Pearl, Christos Papadelis
Summary: The study aims to evaluate the diagnostic accuracy of electromagnetic source imaging (EMSI) in localizing spikes and predicting surgical outcome in children with drug resistant epilepsy (DRE) due to focal cortical dysplasia (FCD). We analyzed MEG and HD-EEG data from 23 children and compared the localization accuracy and predictive performance of EMSI, ESI, and MSI. The results showed that EMSI had superior localization accuracy and predictive performance compared to individual modalities.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Sita Jayalakshmi, Sudhindra Vooturi, Rammohan Vadapalli, Sailaja Madigubba, Manas Panigrahi
Summary: The authors analyzed predictors of surgical outcomes in patients with Focal Cortical Dysplasia (FCD) and its ILAE subtypes after noninvasive multimodal evaluation and calculated time to first seizure. It was found that multiple seizure types, type I FCD, and acute postoperative seizures (APOS) were predictors of persistent seizures. Furthermore, about 80% of patients experienced seizure recurrence within 6 months postsurgery.
JOURNAL OF NEUROSURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonio Giulio Gennari, Dorottya Cserpan, Ilona Stefanos-Yakoub, Raimund Kottke, Ruth O'Gorman Tuura, Georgia Ramantani
Summary: This study investigated the potential of diffusion tensor imaging (DTI) in paediatric structural epilepsy associated with focal cortical dysplasia (FCD). The results showed that DTI indices can differentiate between FCD and contralateral brain parenchyma (CBP), and that clinical features have an impact on these indices.
INSIGHTS INTO IMAGING
(2023)
Article
Clinical Neurology
Attila Racz, Albert J. Becker, Carlos M. Quesada, Valeri Borger, Hartmut Vatter, Rainer Surges, Christian E. Elger
Summary: Resective epilepsy surgery in patients with FCD II results in excellent outcomes at both 12-month and long-term follow-ups, with complete lesion resection and absence of FTBTCS prior to surgery associated with better prognosis. Positive family history for epilepsy has limited influence on long-term outcomes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Amanda Almacellas Barbanoj, Robert T. Graham, Benito Maffei, Jenna C. Carpenter, Marco Leite, Justin Hoke, Felisia Hardjo, James Scott-Solache, Christos Chimonides, Stephanie Schorge, Dimitri M. Kullmann, Vincent Magloire, Gabriele Lignani
Summary: Focal cortical dysplasias are a common type of cortical development abnormality that often leads to cognitive and behavioral abnormalities as well as drug-resistant epilepsy. A gene therapy approach targeting the overexpression of the Kv1.1 potassium channel has shown promising results in reducing seizures in a mouse model of frontal lobe focal cortical dysplasia.
Article
Clinical Neurology
Ariane Lewis, Steven Galetta
Summary: In their research article, Chassoux et al. conducted a retrospective review on 60 patients with focal cortical dysplasia type 2 (FCD2) in the central region who underwent surgical resection. They found that 88% of patients achieved seizure freedom after surgery, and although 87% experienced early transitory postoperative deficits, 40% of them fully recovered. It was also observed that patients with FCD2 can have preoperative and postoperative neurologic deficits, and some patients showed improvement after surgery.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongxiang Tang, Jie Yu, Ming Zhou, Jian Li, Tingting Long, Yulai Li, Li Feng, Dengming Chen, Zhiquan Yang, Yiyun Huang, Shuo Hu
Summary: In this study, the SV2A abnormalities in patients with FCD II were evaluated using F-18-SynVesT-1 PET and compared with F-18-FDG PET. The results showed that F-18-SynVesT-1 PET had a higher accuracy for the localization of FCD II lesions than MRI and a more restricted pattern of abnormality than F-18-FDG PET.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Clinical Neurology
Hyo M. Lee, Seok-Jun Hong, Ravnoor Gill, Benoit Caldairou, Irene Wang, Jian-guo Zhang, Francesco Deleo, Dewi Schrader, Fabrice Bartolomei, Maxime Guye, Kyoo Ho Cho, Carmen Barba, Sanjay Sisodiya, Graeme Jackson, R. Edward Hogan, Lily Wong-Kisiel, Gregory D. Cascino, Andreas Schulze-Bonhage, Iscia Lopes-Cendes, Fernando Cendes, Renzo Guerrini, Boris Bernhardt, Neda Bernasconi, Andrea Bernasconi
Summary: This study explores the associations between Focal cortical dysplasia (FCD) and cytoarchitecture, gene expression, and axes of cortical organization. The findings suggest that the vulnerability of the frontal lobe to FCD may be due to early termination of prenatal neurogenesis and aberrant postnatal synaptogenesis.
Article
Clinical Neurology
Krasimir Minkin, Kaloyan Gabrovski, Petar Karazapryanov, Yoana Milenova, Stanimir Sirakov, Vasil Karakostov, Kiril Romanski, Petia Dimova
Summary: The study demonstrated that awake craniotomy may be beneficial for patients with drug-resistant epilepsy caused by focal cortical dysplasia involving eloquent areas, potentially changing the preoperative plan and leading to good seizure control outcomes postoperatively.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Francine Chassoux
Summary: We appreciate Dr. Abe's comments on our research. As described in the Results section of the article, 11 patients had preoperative deficits that were either permanent or fluctuating. Postoperatively, all of them experienced a temporary worsening, followed by functional improvement in 4 cases. Among the 49 patients with normal preoperative examination, 41 had postoperative deficits, with 14 being major.
Article
Clinical Neurology
Baotian Zhao, Chao Zhang, Xiu Wang, Yao Wang, Chang Liu, Jiajie Mo, Zhong Zheng, Kai Zhang, Xiao-Qiu Shao, Wenhan Hu, Jianguo Zhang
Summary: The study concludes that sulcus-centered resection is an effective and safe surgical strategy for carefully selected FCD II cases, with majority of patients remaining seizure free after surgery but some experiencing permanent neurological deficits.
JOURNAL OF NEUROSURGERY
(2021)
Article
Behavioral Sciences
Cuiping Xu, Xiaohua Zhang, Guojun Zhang, Xiaoming Yan, Kai Ma, Liang Qiao, Xueyuan Wang, Xi Zhang, Tao Yu, Yuping Wang, Yongjie Li
Summary: This study evaluated the clinical and stereoelectroencephalography (SEEG) features of patients with focal cortical dysplasia (FCD) who underwent epilepsy surgery, finding that patients with different pathological types of FCD may have seizures at different ages. Distinct ictal onset patterns (IOPs) demonstrated different ripple features, highlighting the importance of distinguishing IOPs for understanding electrophysiological characteristics.
BRAIN AND BEHAVIOR
(2021)
Article
Behavioral Sciences
Yunling Wang, Chenmin He, Cong Chen, Zhongjin Wang, Wenjie Ming, Jingjing Qiu, Meiping Ying, Wei Chen, Bo Jin, Hong Li, Meiping Ding, Shuang Wang
Summary: The study found that focal cortical dysplasia (FCD) is a significantly independent risk factor associated with sleep-related epilepsy (SRE), with the highest incidence of SRE in the FCD group. A small lesion size of FCD further increased the risk of SRE.
EPILEPSY & BEHAVIOR
(2022)
Article
Clinical Neurology
Horst Urbach, Marcel Heers, Dirk-Matthias Altenmueller, Andreas Schulze-Bonhage, Anke Maren Staack, Thomas Bast, Marco Reisert, Ralf Schwarzwald, Christoph P. Kaller, Hans-Juergen Huppertz, Theo Demerath
Summary: Automated MRI postprocessing tool was evaluated for enhanced and rapid detection of focal cortical dysplasia (FCD). The results showed effective identification of FCD within a minute, with a need for careful comparison with conventional MRI images to reduce false positives.
Article
Clinical Neurology
Subrat Kumar Nanda, Sita Jayalakshmi, Surath Mohandas
PEDIATRIC NEUROLOGY
(2014)
Article
Medicine, General & Internal
Faiz M. H. Ahmad, S. K. Nanda, D. S. Grewal
JOURNAL OF THE ROYAL ARMY MEDICAL CORPS
(2019)
Article
Rehabilitation
Sudhindra Vooturi, A. N. R. Lakshmi, Sita Jayalakshmi
Summary: This study evaluated adherence to a tailor-made home exercise program in adult people with epilepsy. The results showed that only one-fourth of the participants were adherent to the exercise program. Fear of seizures and lack of support from family and friends were the main barriers to exercise adherence.
EUROPEAN JOURNAL OF PHYSIOTHERAPY
(2023)
Article
Clinical Neurology
Rajagopal Srinath, Fmh Ahmad, Vikram Asturkar, Ankit Mathur, Vishal Sondhi, Subrat Kumar Nanda
Summary: The risk of new-onset seizure at high altitudes is higher for individuals from lower elevations and increases with altitude, with a significant incidence observed in the immediate months of exposure.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2022)
Letter
Clinical Neurology
Vishal Sondhi, Rajagopal Srinath, Subrat Kumar Nanda
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2022)
Article
Clinical Neurology
Sita Jayalakshmi, Anuja Patil, Mihir Parekh, Sudhindra Vooturi, Sailaja Madigubba, Manas Panigrahi
EPILEPTIC DISORDERS
(2023)
Correction
Clinical Neurology
Madhamanchi Kishore, Madhamanchi Pradeep, Parimala Narne, Sita Jayalakshmi, Manas Panigrahi, Anuja Patil, Phanithi Prakash Babu
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Madhamanchi Kishore, Madhamanchi Pradeep, Parimala Narne, Sita Jayalakshmi, Manas Panigrahi, Anuja Patil, Phanithi Prakash Babu
Summary: The study aimed to identify the factors influencing Keap1-Nrf2 axis regulation in temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) patients. It was found that the Keap1-Nrf2 axis was downregulated, while histone methyltransferases and histone methylation were upregulated in patients with TLE-HS prone to seizure recurrence. Additionally, the Nrf2-interacting proteins HSP90 and p21 were decreased in patients with seizure recurrence. These findings suggest a dysfunctional antioxidant response in TLE-HS patients, partially due to the dysregulation of the Keap1-Nrf2 axis.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Manas Panigrahi, Vardhinedi Satyendra, Sudhindra Vooturi
Summary: This study aimed to explore the surgical management of suprasellar meningiomas (SMs). Choosing the surgical approach based on the attachment of SMs can lead to better resection and clinical outcomes. Further validation is needed in larger studies.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Subrat Kumar Nanda, Sita Jayalakshmi, Devashish Ruikar, Mohandas Surath
JOURNAL OF NEUROSCIENCES IN RURAL PRACTICE
(2013)