Article
Neurosciences
Domantas Vaiciulis, Alvita Vilkeviciute, Greta Gedvilaite, Brigita Glebauskiene, Loresa Kriauciuniene, Rasa Liutkeviciene
Summary: The study revealed that SIRT1 rs7895833 G/G genotype is associated with about 13-fold increased odds of active PA development, and SIRT1 serum levels are significantly higher in women with PA compared to healthy women.
Article
Clinical Neurology
Dimin Zhu, Zheng Xiao, Zongming Wang, Bin Hu, Chengbin Duan, Ziyan Zhu, Nailin Gao, Yonghong Zhu, Haijun Wang
Summary: MEG3 and MIR-3768-3P expression levels were found to be decreased in patients with CNFPA, and their excessive expression inhibited tumorigenesis and promoted apoptosis in PDFS cells. MEG3 acted as an enhancer of MIR-3768-3P expression, while HMGA2 served as an oncogene in pituitary adenoma that could be negatively regulated by MEG3 via enriching MIR-3768-3P, revealing a novel regulatory network in CNFPAs.
JOURNAL OF NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Petros Stefanidis, Georgios Kyriakopoulos, Andreas Miltiadis Seretis, Stefanos Korfias, Stamatios Theocharis, Anna Angelousi
Summary: This study evaluated the expression of Ki-67, CD-56, Cyclin-D1, and E-Cadherin in pituitary adenomas (PAs) and their association with clinical manifestation, tumor size, invasiveness, and risk of recurrence. Cyclin-D1 and Ki-67 were found to be positively correlated with tumor size, recurrence, extension beyond the sellar region, and invasion of the cavernous sinus. However, there was no correlation between CD-56 and E-Cadherin expression and the parameters mentioned above. Cyclin-D1 and Ki-67 may be promising markers in predicting the behavior and recurrence of PAs, but further studies are needed to confirm their role in routine evaluation of PAs.
Article
Medicine, General & Internal
Liang Lu, Xueyan Wan, Yu Xu, Juan Chen, Kai Shu, Ting Lei
Summary: Invasiveness is an important predictor of surgical outcome and long-term prognosis in patients with pituitary adenomas (PAs). This study assessed PA invasiveness through radiological, surgical, and histological perspectives and established a classification scheme to predict invasive behavior and poor prognosis. The study found that radiological and surgical invasiveness were better predictors of complete resection and recurrence/progression-free survival rates than histological invasiveness. Knosp grades with surgical invasiveness were also better predictors of prognosis compared to Knosp grades without surgical invasiveness. The classification schemes developed based on invasiveness and Knosp classification were found to be clinically valuable in predicting prognosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Keyi Zhang, Xuefei Shou, Hong Chen, Nidan Qiao, Wenqiang He, Zhengyuan Chen, Ming Shen, Shiqi Li, Yao Zhao, Zhaoyun Zhang, Yiming Li, Hongying Ye, Yongfei Wang
Summary: The study investigated the clinical characteristics of SCAs with positive and negative ACTH immunostaining, finding that ACTH-negative SCAs were more clinically silent and more likely to demonstrate multiple microcysts on MRI. The prevalence of SCAs, especially ACTH-negative SCAs, was substantially underestimated and should be given enough attention due to the high aggressiveness of this subtype of refractory pituitary adenoma.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Spectroscopy
Na Li, Dominic M. Desiderio, Xianquan Zhan
Summary: Pituitary adenoma is a common intracranial neoplasm, a complex, chronic whole-body disease with multiple causative factors, processes, and consequences. The advancement of multiomics and systems biology has shifted paradigms towards a systematic strategy for effective management of PAs, involving molecular alterations at multiple levels and a focus on phenomics for personalized, predictive, and preventive medicine.
MASS SPECTROMETRY REVIEWS
(2022)
Article
Clinical Neurology
Robert C. Osorio, Matheus P. Pereira, Rushikesh S. Joshi, Kevin C. Donohue, Patricia Sneed, Steve Braunstein, Philip Theodosopoulos, Ivan H. El-Sayed, Jose Gurrola, Sandeep Kunwar, Lewis S. Blevins, Manish K. Aghi
Summary: This study examined the influence of socioeconomic status (SES) on the clinical presentations and outcomes of nonfunctional pituitary adenoma (NFPA) resections. The presence of a primary care provider (PCP) was found to be the most important factor, affecting hospital lengths of stay, readmission rates, follow-up adherence, and tumor recurrence.
JOURNAL OF NEUROSURGERY
(2022)
Review
Endocrinology & Metabolism
Antonio Bianchi, Sabrina Chiloiro, Antonella Giampietro, Simona Gaudino, Rosalinda Calandrelli, Ciro Mazzarella, Carmelo Caldarella, Mario Rigante, Marco Gessi, Liverana Lauretti, Laura De Marinis, Alessandro Olivi, Alfredo Pontecorvi, Francesco Doglietto
Summary: Growth hormone-secreting adenomas exhibit a wide range of behaviors and outcomes, from mild disease to aggressive neoplasms. Treatment for patients who do not respond to surgery or first-generation somatostatin receptor ligands may involve multiple surgical, medical, and radiation treatments. Currently, there are no markers that can predict the prognosis or aggressiveness of acromegaly. A multidisciplinary approach is necessary to tailor treatment for difficult/aggressive cases, including radiation therapy, chemotherapy, and emerging treatments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Liang Lu, Xueyan Wan, Yu Xu, Juan Chen, Kai Shu, Ting Lei
Summary: This review summarizes the research progress on clinical and biological factors, including predictive factors and biomarkers, for recurrent pituitary adenomas. Comprehensive models and grading methods can be used to predict the prognosis of pituitary adenomas and may be beneficial for predicting recurrence.
Review
Medicine, General & Internal
Busra Aydin, Aysegul Caliskan, Kazim Yalcin Arga
Summary: Pituitary neuroendocrine tumors (PitNETs) are the second most common type of intracranial neoplasia, requiring effective management due to hormone hypersecretion. Diagnosis of non-functioning PitNETs can be challenging, with some tumors showing resistance or aggressive behavior. Early detection or identification of recurrence and remission post-surgery for hormone-secreting tumors is crucial for wiser disease management.
Article
Endocrinology & Metabolism
Zhiyu Xi, Pamela S. Jones, Masaaki Mikamoto, Xiaobin Jiang, Alexander T. Faje, Chuansheng Nie, Kathryn E. Labelle, Yunli Zhou, Karen K. Miller, Roy J. Soberman, Xun Zhang
Summary: Aggressive pituitary adenomas have increased expression of PD-L2, CD80, and CD86 compared to normal pituitary glands, and significantly higher levels of CD80 and CD86 compared to non-aggressive tumors. These findings support further research on the potential role of immune checkpoint inhibition therapy in the treatment of pituitary adenomas.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Ben A. Strickland, Shane Shahrestani, Robert G. Briggs, Anna Jackanich, Sherwin Tavakol, Kyle Hurth, Mark S. Shiroishi, Chia-Shang J. Liu, John D. Carmichael, Martin Weiss, Gabriel Zada
Summary: SCAs are a subtype of NFAs that are more biologically aggressive, with patients presenting with more cranial neuropathy and headaches, and a shorter progression-free survival duration.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Jinxian Hu, Jihu Yang, Lei Chen, Xiangbao Meng, Xiejun Zhang, Weiping Li, Zongyang Li, Guodong Huang
Summary: This study demonstrated significant differences in the gut microbiome between patients with pituitary adenoma and healthy controls, with Clostridium innocuum enriched and Fusobacterium mortiferum and Oscillibacter sp. 57_20 reduced in abundance in PA patients.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)
Article
Clinical Neurology
Rupa G. Juthani, Anne S. Reiner, Ankur R. Patel, Aimee Cowan, Marie Roguski, Katherine S. Panageas, Eliza B. Geer, Sasan Karimi, Marc A. Cohen, Viviane Tabar
Summary: The study evaluated the safety and efficacy of iMRI for pituitary adenoma resection, comparing endoscopic transsphenoidal and microscopic transsphenoidal approaches. Results showed that iMRI can improve the extent of resection for pituitary adenomas while preserving hormone function, with low rates of postoperative complications.
JOURNAL OF NEUROSURGERY
(2021)
Review
Oncology
Luigi Albano, Marco Losa, Lina Raffaella Barzaghi, Ajay Niranjan, Zaid Siddiqui, John C. Flickinger, Lawrence Dade Lunsford, Pietro Mortini
Summary: A systematic review and meta-analysis of outcomes of Gamma Knife radiosurgery for pituitary tumors over the past twenty years showed that it is safe and effective, with good tumor control and remission rates for both non-secreting and secreting tumors.
Article
Engineering, Electrical & Electronic
Jielong Li, Diwei Liu, Ruizhe Ren, Chuanhong Xiao, Zongjun Shi, Tao Zhao, Min Hu, Yanyu Wei, Zhaoyun Duan, Yubin Gong, Zhenhua Wu
Summary: In this study, a novel improvement on ladder line structure called longitudinally slotted structure is proposed, which increases the cross-sectional area of the electron beam and effective interaction area, thereby significantly improving the output power. The dispersion characteristics and field distribution of the slotted structure are analyzed through numerical and simulation calculations, and the optimal parameters are determined. A 94-GHz 2-D slotted structure EIO is designed and compared with the ladder line, it shows a 52.5% increase in cavity characteristic impedance $\textit{R}$ / $\textit{Q}$ and a 21.1% increase in output power. This new structure is expected to provide a new idea for power enhancement in millimeter-wave and terahertz EIOs.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Electrical & Electronic
Shaojie Chang, Zhenhua Wu, Diwei Liu, Renbin Zhong, Zhaoyun Duan, Yanyu Wei, Yubin Gong, Min Hu
Summary: A novel method for extracting and amplifying the third harmonic of an electron beam to generate high-power terahertz radiation is presented. This approach utilizes three planar grating structures operating in the backwave region to extract and amplify the electron beam from the fundamental modulation, resulting in an amplified output of the fundamental wave and a high power output of the fundamental triplet frequency. The planar grating structure is easier to machine and assemble compared to conventional harmonic amplifiers and allows for increased electron beam flow rate.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Electrical & Electronic
Jie Huang, Tao Song, Xu Qi, Taotao Mao, Chen Zhang, Peisheng Liang, Wei Wang, Jiao Jiao, Na Yao, Kaichun Zhang, Zhenhua Wu, Tao Zhao, Min Hu, Yanyu Wei, Yubin Gong, Diwei Liu
Summary: A frequency-tunable gyrotron with multi-band radiation has been designed, manufactured, and experimentally investigated. The frequency tuning scheme employing transverse modes switching and axial mode transition is used to achieve multiband radiation. Three modes TE02, TE43, and TE24 are excited successively with the increase of the magnetic field, and their main operating frequencies are 140, 250, and 263 GHz, respectively. Experimental results show that a certain frequency-tuning range can be obtained at each frequency band by exciting a series of high-order axial modes.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Electrical & Electronic
Jiali Huo, Zhaohao Zhang, Yadong Zhang, Fan Zhang, Gangping Yan, Guoliang Tian, Haoqing Xu, Guohui Zhan, Gaobo Xu, Qingzhu Zhang, Huaxiang Yin, Zhenhua Wu
Summary: In this work, ferroelectric field effect transistors (FeFETs) are demonstrated by integrating the ferroelectric Hf0.5Zr0.5O2 (HZO) gate insulator and 2-D ferroelectric semiconductor alpha-In2Se3 channel. These FeFETs feature enhanced large memory windows (MWs) and ultrahigh-speed. The results show that FeFETs have considerable potential in ultra-fast nonvolatile memory (NVM) applications.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Electrical & Electronic
Haoqing Xu, Jiaxin Yao, Zhizhen Yang, Lei Cao, Qingzhu Zhang, Yongliang Li, Anyan Du, Huaxiang Yin, Zhenhua Wu
Summary: This article presents a physics-based simulation study of a Si-core-SiGe-shell gate-all-around nanosheet FET. The study evaluates the effect of various factors on electrostatics and transport properties and suggests that the proposed core-shell structure is a potential candidate for advanced technology nodes.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Automation & Control Systems
Srinivasa Naik Bhukya, Zhenhua Wu, Abdelmageed Elmustafa, Aiman Al-Allaq, Manish Ojha, Yousuf Mohammed
Summary: This research investigates the effects of copper (Cu) donor material assisted friction stir welding (FSW) on AA2024-T4 and AA6061-T6 plates of 6.35 mm thickness. By introducing Cu donor material, the downward force generated during FSW process is gradually decreased, and the temperature at the beginning of welding process is increased. Defect-free joints with improved tensile strength can be obtained by placing high strength AA2024 alloy at the advancing side of the weld with 25% thick donor material. SEM Fractography images confirm mixed modes of brittle and ductile fracture surfaces after the inclusion of donor material in FSW.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Robotics
Dongxia Wang, Liangwen Wang, Hongchang Xie, Zhenzhen Wu, Guizhong Xie, Caidong Wang, Huadong Zheng, Zhuang Wang
Summary: This paper proposes a type of manipulator configuration with four-fingers for grasping fragile hollow workpieces, which has adjustable finger length and finger pad shape. The manipulator can be used to grasp the internal cross section of fragile objects within a certain range with different size of circular and oval shape. The design idea and structure of the manipulator are introduced, and the join positions between the finger pad and the finger body are comparatively analyzed and researched regarding forming force contact with workpiece. By analyzing the internal forces and deformations between finger pad and workpiece based on a finite element analysis model, the research provides a theoretical basis for the design optimization of the finger pad structure and the connection point positions. The experiments show that the proposed manipulator structure can meet the requirements of relevant tasks.
INTERNATIONAL JOURNAL OF ADVANCED ROBOTIC SYSTEMS
(2023)
Article
Chemistry, Multidisciplinary
Lanxing Wang, Chunxiao Qi, Hongmei Cao, Yanwen Zhang, Xing Liu, Lina Qiu, Hang Wang, Lijuan Xu, Zhenzhou Wu, Jianfeng Liu, Shusen Wang, Deling Kong, Yuebing Wang
Summary: Researchers have found that HAL-loaded engineered cytokine-primed MSC-EVs (H@TI-EVs) with high expression of immune checkpoint molecule PD-L1 can accumulate in injured pancreas and treat type 1 diabetes (T1D) by reducing T cell density and activation, and promoting macrophage transition. This study provides a novel strategy for imaging and treatment of T1D, with great potential for clinical application.
Review
Food Science & Technology
Yilan Sun, Xiaowei Xu, Zhenzhen Wu, Hanlin Zhou, Xiaoyu Xie, Qinhua Zhang, Renyi Liu, Jie Pang
Summary: This review summarizes recent advances in konjac glucomannan (KGM), including its structural characterization, formation mechanism, preparation methods, functional properties, and the preservation of aquatic food.
Article
Chemistry, Physical
Shangshu Qian, Hao Chen, Mengting Zheng, Yuxuan Zhu, Chao Xing, Yuhui Tian, Pan Yang, Zhenzhen Wu, Shanqing Zhang
Summary: Lithium metal anodes have a higher specific capacity than commercial graphite anodes, making them attractive for rechargeable batteries. However, the growth of lithium dendrites poses safety concerns, hindering their practical application. This review summarizes the strategies for protecting lithium metal anodes by preventing dendrite growth, regulating lithium deposition behaviors, and healing existing dendrites. Integrating different strategies can enhance their advantages, narrowing the gap between experimental research and commercial application of lithium metal batteries.
ENERGY STORAGE MATERIALS
(2023)
Article
Engineering, Biomedical
Tao Yang, Zhichao Hao, Zhenzhen Wu, Binxin Xu, Jiangchen Liu, Le Fan, Qinmei Wang, Yanshan Li, Dongying Li, Sangzhu Tang, Chuanzi Liu, Weichang Li, Wei Teng
Summary: In this study, researchers attempted to engineer compact constructs resembling the full-scale hierarchy of lamellar bone using bioskiving and mineralization techniques. The effect of mineralization on the physicochemical properties and bioactivities of the multi-sheeted collagen matrix was systematically investigated. By mineralizing the constructs for 9 days, accurate mimicry of each hierarchical scale and efficient promotion of osteogenesis were achieved. Bioinformatic analysis further revealed the activation of the integrin alpha 5-PI3K/AKT signaling pathway, which contributed to the repair of critical-sized bone defects. This study provides a bioinspired strategy for replicating the complex hierarchy of compact mineralized tissue and offers a critical research model for studying the structure-function relationship of bone in depth.
BIOACTIVE MATERIALS
(2023)
Article
Acoustics
Deshi Meng, Lijun Li, Zhenhua Wu
Summary: This study presents the design and experimental validation of acoustic metamaterials with ventilation and broadband asymmetric absorption. An asymmetric absorbing cell (AAC) consisting of detuned Helmholtz resonators connected by sound channels achieves near-perfect sound absorption from the left port, while maintaining a ventilation ratio of 40%. Parallel three-cell asymmetric absorber (PTAA) formed by paralleling three AACs exhibits broadband asymmetric absorption. Additionally, a multi-asymmetric absorber (MAA) with a frequency range of 1000 Hz to 1750 Hz and air circulation capability is designed and fabricated using 3D printing technology.
JOURNAL OF LOW FREQUENCY NOISE VIBRATION AND ACTIVE CONTROL
(2023)
Article
Computer Science, Interdisciplinary Applications
Yan Wang, Jian Cheng, Yixin Chen, Shuai Shao, Lanyun Zhu, Zhenzhou Wu, Tao Liu, Haogang Zhu
Summary: This paper proposes a Fourier Visual Prompting (FVP) method for Source-Free UDA (SFUDA) in medical image segmentation. By adding a visual prompt to the input target data, the frozen pre-trained model can perform well in the target domain. Experimental results demonstrate that the proposed FVP method achieves better segmentation results compared to existing methods.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Chemistry, Multidisciplinary
Hongyan Du, Dejun Jiang, Odin Zhang, Zhenxing Wu, Junbo Gao, Xujun Zhang, Xiaorui Wang, Yafeng Deng, Yu Kang, Dan Li, Peichen Pan, Chang-Yu Hsieh, Tingjun Hou
Summary: Contemporary structure-based molecular generative methods have shown great potential in drug design. However, existing methods have limitations such as contradicting chemical intuition and relying on large-scale structural data. To overcome these challenges, researchers have proposed a novel search-based framework, 3D-MCTS, which employs a fragment-based molecular editing strategy and achieves remarkable results in generating molecules with enhanced binding affinity.
Article
Medicine, Research & Experimental
Zan-Xiong Chen, Hong-Qian Liu, Zhen-Hua Wu, Jun-Lian He, Hao-Jie Zhong
Summary: This study found that the frequency of circulating ILC3s was elevated and positively correlated with levels of serum uric acid and serum creatinine in patients with HUA. Although there was no significant difference in the plasma concentration of IL-17A between patients with HUA and healthy controls, positive correlations between plasma IL-17A and the concentration of serum uric acid and frequency of circulating ILC3s were observed in the patients with HUA.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
