Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 145, Issue -, Pages 130-144Publisher
ELSEVIER
DOI: 10.1016/j.addr.2019.04.005
Keywords
Cancer therapy; Cowpea mosaic virus; CPMV; Drug delivery; eCPMV; Intravital imaging; Molecular targeting; Non-invasive imaging; Multifunctional; Virus-like particle
Categories
Funding
- Prostate Cancer Canada [2011-742]
- Alberta Cancer Foundation
Ask authors/readers for more resources
Nanoparticle platforms are particularly attractive for theranostic applications due to their capacity for multifunctionality and multivalency. Some of the most promising nano-scale scaffold systems have been coopted from nature including plant viruses such as cowpea mosaic virus (CPMV). The use of plant viruses like CPMV as viral nanoparticles is advantageous for many reasons; they are non-infectious and nontoxic to humans and safe for use in intravital imaging and drug delivery. The CPMV capsid icosahedral shape allows for enhanced multifunctional group display and the ability to carry specific cargoes. The native tropism of CPMV for cell-surface displayed vimentin and the enhanced permeability and retention effect allow them to preferentially extravasate from tumor neovasculature and efficiently penetrate tumors. Furthermore, CPMVs can be engineered via several straightforward chemistries to display targeting and imaging moieties on external, addressable residues and they can be loaded internally with therapeutic drug cargoes. These qualities make them highly effective as biocompatible platforms for tumor targeting, intravital imaging and cancer therapy. (C) 2019 Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available