Article
Food Science & Technology
Leila Nazari, Somayeh Komaki, Iraj Salehi, Safoura Raoufi, Zoleikha Golipoor, Masoumeh Kourosh-Arami, Alireza Komaki
Summary: Oxidative stress is an important factor in the development of Alzheimer's disease (AD). This study found that lutein, a carotenoid with antioxidant properties, has protective effects on memory and learning. Lutein reduces oxidative stress, improves memory and learning, and shows potential as a therapeutic agent for the treatment and prevention of AD.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Neurosciences
Asgeir Kobro-Flatmoen, Thea Meier Hormann, Gunnar Gouras
Summary: This study characterizes the expression of Aβ(42) in the brains of outbred Wistar rats and compares it to the brains of human subjects without neurological disease. The results show that Aβ(42) is expressed in neurons throughout the brain of healthy Wistar rats, with the highest levels found in certain brain regions. These findings are consistent with the expression of Aβ(42) in human subjects, indicating that the McGill-R-Thy1-APP rat model for AD accurately represents the normal vulnerability to Aβ(42) accumulation in wild-type neuronal populations.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Mehdi Sanati, Samaneh Aminyavari, Fariba Khodagholi, Mohammad Javad Hajipour, Payam Sadeghi, Marzieh Noruzi, Aynaz Moshtagh, Homayoon Behmadi, Mohammad Sharifzadeh
Summary: Low doses of SPIONs inhibit Aβ aggregation and ameliorate learning and memory deficits in the AD model, while also increasing hippocampal protein levels. However, at high doses, SPIONs do not improve the detrimental effects of Aβ aggregation on spatial memory and hippocampal protein expression.
Article
Behavioral Sciences
Elham Zahedi, Ashkan Sanaeierad, Marjan Nikbakhtzadeh, Mehrdad Roghani, Elham Zamani
Summary: This study investigated the protective effects of simvastatin in a rat model of Alzheimer's disease induced by ovariectomy and D-galactose injection. The results showed that simvastatin improved gut microbiome activity, increased the amount of SCFAs, strengthened intestinal cell tight junctions, reduced neuroinflammatory markers in plasma and hippocampus, and decreased cell death and Amyloid plaques in the hippocampus. These physiological changes led to better learning and memory performance.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Guangli He, Yue Zhou, Mifang Li, Yanzhen Guo, Hang Yin, Baocheng Yang, Shouren Zhang, Yibiao Liu
Summary: An ultrasensitive photoelectrochemical (PEC) sensor based on ZnO@polydopamine/Au nanocomposites was developed for quantitative detection of A beta, showing a wide linear range and low detection limit. Additionally, the sensor exhibited good selectivity, stability, and reproducibility, providing a promising method for advanced PEC immunoassays for AD biomarkers.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pattama Panmak, Chutikorn Nopparat, Kannika Permpoonpattana, Jatuporn Namyen, Piyarat Govitrapong
Summary: The study demonstrated that melatonin could prevent cognitive impairments and AD-like pathology in METH-treated rats. Melatonin mediated its protective effects through modulating neurotransmitters, protein kinases, and amyloidogenic pathways, suggesting its potential therapeutic role in METH-induced AD-like changes.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Engineering, Environmental
Monica Yonashiro Marcelino, Felipe Azevedo Borges, Liliana Scorzoni, Junya de Lacorte Singulani, Bruna Cambraia Garms, Julia Carina Niemeyer, Nayrim Brizuela Guerra, Giovana Sant'Ana Pegorin Brasil, Cassamo Ussemane Mussagy, Francisco Adriano de Oliveira Carvalho, Mateus Scontri, Maria Jose Soares Mendes-Giannini, Ana Marisa Fusco-Almeida, Rondinelli Donizetti Herculano
Summary: In this study, AuNPs were synthesized using two chemical routes and characterized through various assays. The stability and efficacy of AuNPs varied depending on the synthesis method, with AuNPs via sodium citrate showing better stability and those via sodium citrate/borohydride demonstrating superior formation. Both AuNPs exhibited slight dose- and size-dependent cytotoxicity, with higher survival rates observed in alternative animal models and non-avoidance responses in soil contamination tests.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Mehtab Parveen, Avadhesh Kumar, Mohd Shoeb Khan, Rakhshanda Rehman, Mohammad Furkan, Rizwan Hasan Khan, Shahab A. A. Nami
Summary: The present study successfully synthesized silver and gold nanoparticles using a biogenic approach. The silver nanoparticles were found to be more regular with smaller particle size and exhibited better inhibitory and antioxidant properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Lin Zhu, Fangjin Lu, Xiaoran Zhang, Siyuan Liu, Ping Mu
Summary: The study found that Pterostilbene (PTE) in blueberries has neuroprotective properties in the treatment of Alzheimer's disease, improving cognitive dysfunction and neuronal plasticity. Its mechanism may be related to inhibiting mitochondria-dependent apoptosis through the antioxidant effect regulated by SIRT1/Nrf2.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Bibin G. Anand, Qi Wu, Govindarajan Karthivashan, Kiran P. Shejale, Sara Amidian, Holger Wille, Satyabrata Kar
Summary: The study showed that surface-functionalized gold nanoparticles with mimosine can inhibit Aβ aggregation and stabilize it in its monomeric state, reducing neuronal toxicity associated with AD. Additionally, MimoAuNPs can trigger the disassembly of mature Aβ fibers, presenting a potential therapeutic effect on AD-related pathologies.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Baimei Shi, Jing Zhao, Zhuojia Xu, Chen Chen, Liguang Xu, Chuanlai Xu, Maozhong Sun, Hua Kuang
Summary: The study demonstrates that chiral nanoparticles can effectively accelerate the differentiation of neural stem cells into neurons under near-infrared light, with L-type nanoparticles outperforming D-type nanoparticles. This is due to their higher endocytosis efficiency. Gene expression analysis reveals that circularly polarized light and chiral nanoparticles upregulate specific genes associated with mechanical force and cytoskeleton proteins, leading to accelerated cell differentiation. In vivo experiments show that successful differentiation alleviates symptoms in Alzheimer's disease mice. Moreover, the combination of NIR irradiation and L-type nanoparticles enhances the clearance of amyloid and hyperphosphorylated p-tau proteins.
Article
Engineering, Environmental
Yufang Zhao, Shupei Qiao, Bosong Zhang, Yue Cao, Hui Tian, Runze Liu, Liuke Sun, Cao Wang, Liang Li, Ruiqi Wang, Yue Chen, Xiaolu Hou, Yongming Li, Jin Zhou, Liyi Li, Weiming Tian
Summary: Neuroinflammation plays a crucial role in the progression of Alzheimer's disease by triggering neuropathological amyloid-l3 deposition. Utilizing the unique brain microenvironment characteristics of naked mole rats, researchers developed an injectable hydrogel to alter the brain environment and successfully mitigated Alzheimer's disease progression in mice, showing potential for early intervention strategies.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Clinical Neurology
Dustin Hammers, Sara Nemes, Taylor Diedrich, Ani Eloyan, Kala Kirby, Paul Aisen, Joel Kramer, Kelly Nudelman, Tatiana Foroud, Malia Rumbaugh, Alireza S. Atri, Gregory Day, Ranjan R. Duara, Neill S. Graff-Radford, Lawrence T. Honig, David C. Jones, Joseph F. Masdeu, Mario Mendez, Erik U. Musiek, Chiadi Onyike, Meghan Riddle, Emily Rogalski, Steve J. Salloway, Sharon J. Sha, Raymond Scott Turner, Sandra S. Weintraub, Thomas A. Wingo, David Wolk, Bonnie C. Wong, Maria C. Carrillo, Bradford D. Dickerson, Gil G. Rabinovici, Liana Apostolova
Summary: This study investigated the limitations of learning slopes in early-onset dementias and aimed to highlight the sensitivity of learning slopes in discriminating disease severity in cognitively normal participants and those diagnosed with early-onset dementia. The results showed that learning slopes are highly sensitive to early-onset dementias, even when controlling for the effect of total learning and cognitive severity. The rating for the importance of this study is 8 out of 10.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Farimah Moazzam, Ashrafalsadat Hatamian-Zarmi, Bahman Ebrahimi Hosseinzadeh, Fariba Khodagholi, Meisam Rooki, Fatemehsadat Rashidi
Summary: This study utilized PMBN as a nanocarrier for targeted brain drug delivery of frankincense and lactoferrin as a ligand for precise targeting. The results showed that the nanoparticles exhibited the capability to alleviate stress and depression while enhancing short-term memory in scopolamine-induced animals. F-PMBN-Lf also counteracted the elevated AChE activity and GSH levels induced by scopolamine and exerted a notable neuroprotective effect, preserving neuronal cells.
Article
Chemistry, Inorganic & Nuclear
Bojana B. Laban, Tamara Lazarevic-Pasti, Djordje Veljovic, Mirjana Markovic, Urszula Klekotka
Summary: The silver and gold L-methionine capped nanoparticles (Ag and Au @LM NPs) were studied as potential acetylcholinesterase (AChE) inhibitors for treating cognitive impairment in depression and Alzheimer's disease. The stability of NPs and their ability to inhibit AChE were analyzed using UV-Vis and FTIR spectrophotometry. The study found that the negatively charged Ag and Au @LM NPs, with diameters of 17 nm and 31 nm respectively, showed moderate inhibitory potential against AChE.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Analytical
Sam Hosseinniay, Ali Hossein Rezayan, Forough Ghasemi, Marjan Malekmohamadi, Ramezan Ali Taheri, Morteza Hosseini, Hale Alvandi
Summary: C-reactive protein is a biomarker for inflammatory disorders, and a nanobiosensor has been developed to monitor and quantify its levels using gold nanorods.
ANALYTICA CHIMICA ACTA
(2023)
Article
Engineering, Biomedical
Mona Navaei-Nigjeh, Soheyl Mirzababaei, Mohammad Adel Ghiass, Kaveh Roshanbinfar, Mahdi Gholami, Mohammad Abdollahi
Summary: Islet-laden fibers generated with microfluidic technology can protect pancreatic islet cells from the immune response. Adding mesenchymal stromal cells (MSCs) improves cell function and suppresses the immune response in diabetic rats, leading to better treatment outcomes.
Review
Chemistry, Analytical
Forough Ghasemi, Nafiseh Fahimi-Kashani, Arafeh Bigdeli, Azad H. Alshatteri, Samira Abbasi-Moayed, Sabah H. Al-Jaf, Mariam Y. Merry, Khalid M. Omer, M. Reza Hormozi-Nezhad
Summary: Paper-based nanosensors using various nanostructures for optical signal visualization are important components of paper-based analytical devices (PADs). They have the potential for point-of-care testing and on-site detection of analytes with chemical, biochemical, and environmental importance due to their low cost, convenience, scalability, portability, and biocompatibility. This review focuses on the fundamentals, state of the art, and future trends of PADs and discusses topics such as paper types, fabrication approaches, nanostructure stabilization, signal acquisition, data handling, sensing mechanisms, and application areas.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Fatemeh Mamashli, Ali Akbar Meratan, Atiyeh Ghasemi, Nahal Obeidi, Bahram Salmani, Deyhim Atarod, Mitra Pirhaghi, Faezeh Moosavi-Movahedi, Mahya Mohammad-Zaheri, Mohammad Bagher Shahsavani, Zahra Habibi-Kelishomi, Bahram Goliaei, Mahdi Gholami, Ali Akbar Saboury
Summary: This study compared the neuroprotective effects of bulk and nano forms of propolis polyphenolic fraction (PFP) against Parkinson's disease models. The results showed that the nano form of PFP was more effective in reducing oxidative stress, improving antioxidant enzyme activity, and protecting animals from Parkinson's disease.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Chemistry, Analytical
Afsaneh Orouji, Forough Ghasemi, Mohammad Reza Hormozi-Nezhad
Summary: The oxidation state of an element is crucial for its toxicological impacts on biological ecosystems. Therefore, the development of robust sensing strategies for the detection of species based on their oxidation states or bonding conditions is of great importance. In this study, a multicolorimetric probe utilizing gold nanorods was designed for the identification and quantification of chromium species in water samples.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
Mohammad Reza Sepand, Banafsheh Bigdelou, Armin Salek Maghsoudi, Nima Sanadgol, Jim Q. Ho, Prashant Chauhan, Mohammad Raoufi, Atefeh Kermanian, Rahim Esfandyarpour, Mohammad Javad Hajipour, Steven Zanganeh
Summary: Ferroptosis is an iron-mediated cell death that combines cell metabolism, redox status, and human disease. Excessive reactive oxygen species (ROS) can lead to cellular oxidative changes, suppress protein activity, and trigger cell death. This review summarizes the effects of environmental chemical exposure on cellular redox signaling, ferroptosis, and cell death, providing critical information to mitigate the impact of ferroptosis on human health.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Physical
Behnaz Ghaemi, Mohammad Javad Hajipour
Summary: This study investigates the biological impacts of different nanoparticles on cancer cells at different pH levels. The researchers found that a slight change in the pH of the cancer cell microenvironment significantly affects the cellular uptake efficacy and toxicity mechanism of the nanoparticles. The nanoparticles exhibited more toxic effects against cancer cells at physiological pH compared to acidic pH, and they also affected different phases of the cell cycle at different pH levels. Additionally, cancer cells expressed higher levels of interleukins involved in cancer cell resistance at acidic pH. The findings highlight the importance of considering the extracellular pH of cancer cells in future cancer nanomedicine research.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Mohammad J. Hajipour, Reihaneh Safavi-Sohi, Shahriar Sharifi, Nouf Mahmoud, Ali Akbar Ashkarran, Elizabeth Voke, Vahid Serpooshan, Milad Ramezankhani, Abbas S. Milani, Markita P. Landry, Morteza Mahmoudi
Summary: The protein corona is formed spontaneously on nanoparticle surfaces in biological systems/fluids. Characterizing the protein corona is crucial for the development of safe and efficient diagnostic and therapeutic nanomedicine products. This review analyzed 470 papers from 2000 to 2021, covering 1702 nanoparticle systems, and revealed key findings regarding the types of nanoparticles studied, the underrepresentation of lipid-based NPs in corona research, the use of new methods to improve reliability, the focus on personalized medicine, and the importance of careful characterization of nanoparticles after corona formation.
Article
Pharmacology & Pharmacy
Marzieh Noruzi, Homayoon Behmadi, Zahra Halvaei Khankahdani, Omid Sabzevari, Alireza Foroumadi, Mohammad Hossein Ghahremani, Jalal Pourahmad, Shokoufeh Hassani, Mahdi Gholami, Setareh Moghimi, Mohammad Mahdi Ghazimoradi, Ghorban Taghizadeh, Mohammad Sharifzadeh
Summary: This study found that alpha-PVP, a novel psychoactive substance, impairs spatial learning/memory and brain mitochondrial function in rats at high doses. The research observed a decline in spatial learning/memory and dysfunction of brain mitochondria after 10 days of repeated administration of different doses of alpha-PVP. These findings provide the first evidence of impaired spatial learning/memory and the potential role of brain mitochondrial dysfunction in cognitive impairments caused by repeated use of alpha-PVP.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Cintia Marques, Mohammad Javad Hajipour, Ceilia Marets, Alexandra Oudot, Reihaneh Safavi-sohi, Melanie Guillemin, Gerrit Borchard, Olivier Jordan, Lucien Saviot, Lionel Maurizi
Summary: The therapeutic efficacy and side effects of nanoparticles (NPs) depend on their circulation time in the body. The adsorbed coronaproteins on NPs determine their plasma half-lives, and it is important to identify the proteins that influence their circulation time. This study analyzed the in vivo circulation time and protein composition of superparamagnetic iron oxide nanoparticles (SPIONs) with different surface charges/chemistries. SPIONs with neutral and positive charges had the longest and shortest circulation times, respectively. The composition of the corona-coated NPs also affected their circulation time, with certain proteins playing a role in determining their systemic circulation time.
Article
Medicine, Research & Experimental
Vidyani Suryadevara, Mohammad Javad Hajipour, Lisa C. Adams, Nour Mary Aissaoui, Ali Rashidi, Louise Kiru, Ashok J. Theruvath, Ching-Hsin Huang, Masahiro Maruyama, Masanori Tsubosaka, Jennifer K. Lyons, Wei (Emma) Wu, Raheleh Roudi, Stuart B. Goodman, Heike E. Daldrup-Link
Summary: This study developed an efficient labeling method for MSCs using MegaPro nanoparticles, which showed better effectiveness in tracking MSCs compared to ferumoxytol nanoparticles. MegaPro-labeled MSCs demonstrated enhanced MRI tracking without affecting cell viability or differentiation.
Article
Medicine, Research & Experimental
Hooman Rahmati-Holasoo, Armin Salek Maghsoudi, Milad Akbarzade, Mahdi Gholami, Amir Shadboorestan, Faezeh Vakhshiteh, Maryam Armandeh, Shokoufeh Hassani
Summary: Autism is a complex neurodevelopmental disorder characterized by social interaction deficiencies, hyperactivity, anxiety, communication disorders, and a limited range of interests. Zebrafish is a social vertebrate used as a biomedical research model to understand social behavior mechanisms.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)
Article
Chemistry, Analytical
Masoumeh Abdali, Forough Ghasemi, Hossein Mir Seyed Hosseini, Vahideh Mahdavi
Summary: In this study, a non-enzymatic colorimetric sensor array using gold nanoparticles of varying sizes was designed to detect and discriminate various pesticides. Plasmonic patterns of the sensor units were analyzed using multivariate calibrations and pattern recognition methods. The sensor showed rapid, simple, and cost-effective detection of pesticide residues in agricultural products.
Article
Nanoscience & Nanotechnology
Shahriar Sharifi, Amir Ata Saei, Hassan Gharibi, Nouf N. Mahmoud, Shannon Harkins, Naruphorn Dararatana, Erika M. Lisabeth, Vahid Serpooshan, Akos Vegvari, Anna Moore, Morteza Mahmoudi
Summary: Albumin-based hydrogels, especially the non-immunogenic photocurable version described in the study, demonstrate excellent biocompatibility and anti-inflammatory properties, making them promising materials for biomedical applications. The modifications and cross-linking of methacrylated HSA were found to reduce macrophage adhesion and inflammatory pathways, with potential for use in passivation coatings and other biomedical applications. In vitro and Ex-Ovo assay results confirmed the biocompatibility and slight angiogenesis-modulating effects of the photocurable albumin hydrogels.
ACS APPLIED BIO MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Marzieh Sepahvand, Forough Ghasemi, Hossein Mirseyed Hosseini
Summary: A method for nitrite and nitrate measurement based on leaching of spherical gold nanoparticles is proposed, offering a simple and cost-effective solution with high accuracy.
