4.8 Article

Bacterial Population Control with Macroscopic HKUST Crystals

Journal

ACS APPLIED MATERIALS & INTERFACES
Volume 11, Issue 22, Pages 19878-19883

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b05285

Keywords

antibiotics; controlled release; metal organic framework; nano-biotechnology; size

Funding

  1. Spanish Ministry of Economy, Industry, and Competitiveness [CONSOLIDER CTQ2017-90852-REDC]

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Macroscopic HKUST crystals were shown to release significant amounts of copper in saline medium at a slow rate, which was exploited to control the growth of a bacterial population. This was achieved in both liquid and solid media, the latter illustrating the local effect of the crystals. In addition, these nanostructured crystals of observable size were loaded with chloramphenicol to exert a joint metal-antibiotic action, going beyond the traditional oligodynamic effect.

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