Application of New Cellular and Microphysiological Systems to Drug Metabolism Optimization and Their Positioning Respective to In Silico Tools

Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and hepatoma cell lines

(2018) Alexander J. Kvist et al.   BIOCHEMICAL PHARMACOLOGY

Recent applications of machine learning in medicinal chemistry

(2018) Jane Panteleev et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Recent Advances of Computational Modeling for Predicting Drug Metabolism: A Perspective

(2018) Supratik Kar et al.   CURRENT DRUG METABOLISM

A novel in vitro experimental system for the evaluation of drug metabolism: Cofactor-supplemented permeabilized cryopreserved human hepatocytes (MetMax™ Cryopreserved Human Hepatocytes)

(2018) Albert P. Li et al.   DRUG METABOLISM AND DISPOSITION

Risk of Clinically Relevant Pharmacokinetic-Based Drug-Drug Interactions with Drugs Approved by the U.S. Food and Drug Administration Between 2013 and 2016

(2018) Jingjing Yu et al.   DRUG METABOLISM AND DISPOSITION

Development and Characterization of a Human Hepatocyte Low Intrinsic Clearance Assay for Use in Drug Discovery

(2018) Paul Lancett et al.   DRUG METABOLISM AND DISPOSITION

Organ/body-on-a-chip based on microfluidic technology for drug discovery

(2018) Hiroshi Kimura et al.   Drug Metabolism and Pharmacokinetics

Liver ‘organ on a chip’

(2018) Colin H. Beckwitt et al.   EXPERIMENTAL CELL RESEARCH

Improving Prediction of Metabolic Clearance Using Quantitative Extrapolation of Results Obtained From Human Hepatic Micropatterned Cocultures Model and by Considering the Impact of Albumin Binding

(2018) Franck Da-silva et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor

(2018) Nicole A. Kratochwil et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Human Primary Cell-Based Organotypic Microtissues for Modeling Small Intestinal Drug Absorption

(2018) Seyoum Ayehunie et al.   PHARMACEUTICAL RESEARCH

Advances in Engineered Human Liver Platforms for Drug Metabolism Studies

(2018) Gregory H Underhill et al.   DRUG METABOLISM AND DISPOSITION

Artificial Intelligence in Drug Design

(2018) Gerhard Hessler et al.   MOLECULES

In Silico Absorption, Distribution, Metabolism, Excretion, and Pharmacokinetics (ADME-PK): Utility and Best Practices. An Industry Perspective from the International Consortium for Innovation through Quality in Pharmaceutical Development

(2017) Franco Lombardo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organ-on-a-chip devices advance to market

(2017) Boyang Zhang et al.   LAB ON A CHIP

3D engineered In vitro hepatospheroids for studying drug toxicity and metabolism

(2017) Swati Chitrangi et al.   TOXICOLOGY IN VITRO

Long-term hepatitis B infection in a scalable hepatic co-culture system

(2017) Benjamin Y. Winer et al.   Nature Communications

Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study

(2016) Pedro F. Pinheiro et al.   ARCHIVES OF TOXICOLOGY

Fluid shear stress modulation of hepatocyte-like cell function

(2016) Hassan Rashidi et al.   ARCHIVES OF TOXICOLOGY

Opportunities and challenges in using human hepatocytes in cytochromes P450 induction assays

(2016) Zdenek Dvorak   Expert Opinion on Drug Metabolism & Toxicology

Automatically updating predictive modeling workflows support decision-making in drug design

(2016) Ingo Muegge et al.   Future Medicinal Chemistry

Use of HμREL Human Coculture System for Prediction of Intrinsic Clearance and Metabolite Formation for Slowly Metabolized Compounds

(2016) Ia Hultman et al.   MOLECULAR PHARMACEUTICS

Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma

(2016) Jialin Mao et al.   PHARMACEUTICAL RESEARCH

The Next Era: Deep Learning in Pharmaceutical Research

(2016) Sean Ekins   PHARMACEUTICAL RESEARCH

PBPK modeling and simulation in drug research and development

(2016) Xiaomei Zhuang et al.   Acta Pharmaceutica Sinica B

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

Addressing the Challenges of Low Clearance in Drug Research

(2015) Li Di et al.   AAPS Journal

Recent progresses in the exploration of machine learning methods as in-silico ADME prediction tools

(2015) L. Tao et al.   ADVANCED DRUG DELIVERY REVIEWS

Predicting the Effect of CYP3A Inducers on the Pharmacokinetics of Substrate Drugs Using Physiologically Based Pharmacokinetic (PBPK) Modeling: An Analysis of PBPK Submissions to the US FDA

(2015) Christian Wagner et al.   CLINICAL PHARMACOKINETICS

Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

(2015) HM Jones et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Cytochrome P450 time-dependent inhibition and induction: advances in assays, risk analysis and modelling

(2015) Robert J Riley et al.   Expert Opinion on Drug Metabolism & Toxicology

Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens

(2015) Sandra March et al.   Nature Protocols

Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug–Drug Interactions

(2014) A Tornio et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Evaluation of Human Hepatocytes Cultured by Three-dimensional Spheroid Systems for Drug Metabolism

(2014) Takako Ohkura et al.   Drug Metabolism and Pharmacokinetics

Applying machine learning techniques for ADME-Tox prediction: a review

(2014) Vinícius Gonçalves Maltarollo et al.   Expert Opinion on Drug Metabolism & Toxicology

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Long-term maintenance of human fetal hepatocytes and prolonged susceptibility to HBV infection by co-culture with non-parenchymal cells

(2013) Ming Zhou et al.   JOURNAL OF VIROLOGICAL METHODS

Preclinical experimental models of drug metabolism and disposition in drug discovery and development

(2012) Donglu Zhang et al.   Acta Pharmaceutica Sinica B

Determination of Time-Dependent Inactivation of CYP3A4 in Cryopreserved Human Hepatocytes and Assessment of Human Drug-Drug Interactions

(2011) Y. Chen et al.   DRUG METABOLISM AND DISPOSITION

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2010) Yuki Imura et al.   ANALYTICAL CHEMISTRY

Rifampin's Acute Inhibitory and Chronic Inductive Drug Interactions: Experimental and Model-Based Approaches to Drug–Drug Interaction Trial Design

(2010) M L Reitman et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Evaluation of models for predicting drug–drug interactions due to induction

(2010) Odette A Fahmi et al.   Expert Opinion on Drug Metabolism & Toxicology

Use of intrinsic clearance for prediction of human hepatic clearance

(2010) Piyun Chao et al.   Expert Opinion on Drug Metabolism & Toxicology

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

A microfluidic hepatic coculture platform for cell-based drug metabolism studies

(2009) Eric Novik et al.   BIOCHEMICAL PHARMACOLOGY

In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and their Utility for Predicting Drug–Drug Interactions

(2008) Stephen Fowler et al.   AAPS Journal