Article
Oncology
Dongchen Pei, Chaojie Xu, Dong Wang, Xiaoxue Shi, Yurui Zhang, Yi Liu, Jianhua Guo, Nan Liu, Haipeng Zhu
Summary: A prognostic signature related to the tumor microenvironment in kidney renal clear cell carcinoma (KIRC) was constructed, which can accurately predict the prognosis of patients and provide new ideas for treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Raimonda Kubiliute, Kristina Zukauskaite, Algirdas Zalimas, Albertas Ulys, Rasa Sabaliauskaite, Arnas Bakavicius, Arunas Zelvys, Feliksas Jankevicius, Sonata Jarmalaite
Summary: This study identified novel DNA methylation biomarkers for ccRCC with potential clinical applications for non-invasive urine-based ccRCC detection and follow-up.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Immunology
Yankuo Liu, Zhiyuan Shi, Jianzhong Zheng, Zeyuan Zheng, Huimin Sun, Zuodong Xuan, Yang Bai, Meiling Fu, Yifan Du, Chen Shao
Summary: Through the study of clear cell renal cell carcinoma (ccRCC) patients, ANOIKIS-related genes (ARGs) were found to be closely associated with ccRCC prognosis. The prognostic model constructed using these ARGs can effectively predict ccRCC prognosis, and these ARGs are closely related to the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Xiangyu Che, Wenyan Su, Xiaowei Li, Nana Liu, Qifei Wang, Guangzhen Wu
Summary: Angiogenesis, a highly regulated process disrupted in cancer, was explored in various cancers with protective genes identified in kidney renal clear cell carcinoma (KIRC) patients. Patients in Cluster 2, with upregulated expression of angiogenesis-related genes, showed the highest overall survival rates. Furthermore, a personalized treatment plan based on gene expression was generated for KIRC patients using sensitivity analysis of commonly used molecularly targeted drugs.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemical Research Methods
Joana Pinto, Filipa Amaro, Ana Rita Lima, Carina Carvalho-Maia, Carmen Jeronimo, Rui Henrique, Maria de Lourdes Bastos, Marcia Carvalho, Paula Guedes de Pinho
Summary: The study utilized urinary volatilome profiling to identify a volatile signature for distinguishing ccRCC patients from controls. Analysis revealed significant differences in 22 volatile metabolites between the two groups, with a six-biomarker panel showing high sensitivity and specificity for ccRCC detection. These findings suggest potential for the development of a bioelectronic sensor based on the dysregulated energy metabolism and enzyme overexpression in ccRCC urinary volatilome signature.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Immunology
Xiaofen Wen, Jiaxin Shen, Maria Rosaria De Miglio, De Zeng, Leonardo A. Sechi
Summary: This study reveals that ERVFRD-1 is downregulated in kidney renal clear cell carcinoma (KIRC) tumors and is associated with tumor immunoregulation and overall survival in KIRC patients. ERVFRD-1 may serve as a sensitive biomarker for diagnosis, immunotherapy, and prognosis assessment of KIRC.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Guangyuan Zhang, Lei Zhang, Si Sun, Ming Chen
Summary: This study identified CANX, BID, NAMPT, and BIRC5 as immune-autophagy-related genes with independent prognostic value in kidney renal clear cell carcinoma. These genes were significantly correlated with immune score, immune checkpoint, iron death, methylation, and OCLR score. The risk prognostic model based on them was well constructed, and experimental results were consistent with the bioinformatics analysis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Genetics & Heredity
Bin Li, Siyang Ye, Yuting Fan, Yi Lin, Suchun Li, Huajing Peng, Hui Diao, Wei Chen
Summary: This study revealed gene expression alterations and identified critical genes associated with diabetic kidney disease (DKD). The findings may provide novel diagnostic molecular markers and therapeutic targets for DKD.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Tao Zeng, Jianzhong Ye, Heng Wang, Wen Tian
Summary: In this study, we found that STAT2 is upregulated in renal clear cell carcinoma patients and its high expression is associated with poor prognosis. Furthermore, STAT2 expression is positively correlated with immune cell abundance and immune biomarker expression. This research reveals that STAT2 may serve as a prognostic biomarker and is associated with immune infiltration in kidney renal clear cell carcinoma.
Article
Medicine, General & Internal
Chengrui Li, Yufeng Wan, Weijun Deng, Fan Fei, Linlin Wang, Fuwei Qi, Zhong Zheng
Summary: This study identified potential new biomarkers associated with the pathogenesis and prognosis of lung adenocarcinoma by integrating different gene expression databases. Functional and signaling pathway enrichment analyses revealed cell adhesion and extracellular matrix-receptor interaction as important pathways. Seven hub genes significantly associated with worse survival were selected, providing insights into the molecular mechanisms of lung adenocarcinoma.
Article
Genetics & Heredity
Sheng Xin, Jiaquan Mao, Chen Duan, Jiaxin Wang, Yuchao Lu, Jun Yang, Jia Hu, Xiaming Liu, Wei Guan, Tao Wang, Shaogang Wang, Jihong Liu, Wen Song, Xiaodong Song
Summary: In this study, the necroptosis landscape of KIRC patients was quantified and two distinct necroptosis-related patterns were identified. A stable and accurate prognostic marker called NRGscore was constructed, which showed significant correlations with clinicopathological characteristics, tumor immune microenvironment, and tumor mutation burden of KIRC patients. NRGscore also had effective guiding significance for immunotherapy, chemotherapy, and targeted drugs.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Xing Zeng, Le Li, Zhiquan Hu, Dan Peng
Summary: This study investigates the molecular mechanisms and prognostic factors in clear cell renal cell carcinoma (ccRCC) by analyzing gene expression and immune cell levels. PTPRG and CHL1 are identified as key nodes in immune phenotype regulation, while WNT2, C17orf66, and PAEP are recognized as significant risk factors and IRF4 as a protective factor.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Jiayu Fang, Jing Zhen, Yiyang Gong, Yun Ke, Bidong Fu, Yike Jiang, Jing Xie, Yue Liu, Yongqi Ding, Da Huang, Fan Xiao
Summary: In kidney renal clear cell carcinoma (KIRC), upregulated expression of MND1 is associated with poor prognosis and serves as an independent prognostic factor. Silencing MND1 inhibits proliferation, migration, and invasion of KIRC cells. MND1 shows functional relationships with cell cycle, immune infiltration, and m6A modification related genes. Potential sensitive drugs for KIRC patients with high MND1 expression were identified.
Article
Oncology
Can-Xuan Li, Dan Long, Quan Meng
Summary: The study aimed to identify dysregulated plexins and investigate their roles in KIRC through an integrated bioinformatics approach. The results revealed that PLXNA1/B3 were independent prognostic factors in KIRC, and may promote ccRCC progression through cancer-related signaling pathways, tumor immunity, and angiogenesis. Drug sensitivity analysis suggested that vemurafenib was a potential drug for PLXNA1/B3.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2021)
Article
Medicine, General & Internal
Jun Wu, Xuefeng Leng, Zhengbo Pan, Linfei Xu, Haitao Zhang
Summary: Through comprehensive analysis using bioinformatics methods, this study identified that elevated expression of IRF3 is significantly associated with worse clinical outcomes and adverse overall survival in clear cell renal cell carcinoma (ccRCC). IRF3 may promote the progression of ccRCC by participating in various cancer-related biological processes and signaling pathways, making it a promising prognostic marker and therapeutic target in ccRCC.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Clinical Neurology
Xinqi Ge, Shichen Jiang, Ziheng Wang, Nan Hu, Rui Jiang, Zishu Cai, Bin Wu, Yu Zhang, Peipei Gong
Summary: ZNF311 oncogene is closely related to prognosis and immune infiltration in gliomas, making it a potential novel biomarker for assessment. The study findings suggest significant correlations between ZNF311, IDH1, 1p/19q, and tumor-infiltrating immune cells in glioma patients with poor prognosis.
WORLD NEUROSURGERY
(2021)
Article
Oncology
Wei Wang, Qianqian Wu, Ziheng Wang, Shiqi Ren, Hanyu Shen, Wenyu Shi, Yunzhao Xu
Summary: This study developed an individualized immune-related gene based prognostic model for ovarian cancer patients, validated in the Gene Expression Omnibus (GEO) repository, and compared immune landscape and pathways between high-risk and low-risk groups. The findings can serve as a valuable model to identify immune subset of patients and have potential implications for immune therapeutic selection and patient management.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Hanyu Shen, Ziheng Wang, Ailong Huang, Dandan Zhu, Pingping Sun, Yinong Duan
Summary: Schistosomiasis, a tropical zoonotic parasitic disease caused by schistosomes, primarily affects the intestines and liver, where parasite eggs induce immune responses leading to liver fibrosis and granulomatous reactions. Differential gene expression analysis suggests LCN2 plays a significant role in early S. japonicum infection, with in vivo experiments showing upregulation in infected liver tissues. Further research indicates that NF-kappa B/LCN2 signaling is crucial for M1 macrophage polarization in response to infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xinqi Ge, Ziheng Wang, Rui Jiang, Shiqi Ren, Wei Wang, Bing Wu, Yu Zhang, Qianqian Liu
Summary: SCAMP4 may serve as a promising independent prognostic factor in both low-grade glioma and glioblastoma, and its expression is closely associated with certain tumor-infiltrating immune cells. Additionally, it shares similar prognostic values with isocitrate dehydrogenase 1.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Psychology, Multidisciplinary
Xiaomei Zhang, Yanqing Li, Yueping Zhong, Ziheng Wang
Summary: The study found that patients with acromegaly have significant body image concerns, which are exacerbated by the stigma associated with the disease, leading to a reduced quality of life.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Integrative & Complementary Medicine
Qiaosong Deng, Shengru Wang, Zheyi Dai, Xiaojun Li, Guanshen Li, Ziheng Wang, Jianfeng Chen
Summary: This study investigates the potential of Liu's Zhenggudan No. 2 Formula (LZF2) in inducing osteogenic differentiation of human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) and concludes that high concentration of LZF2 can promote osteogenesis.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Cell Biology
Tong Cheng, Manyu Xu, Hui Zhang, Bing Lu, Xiaojing Zhang, Ziheng Wang, Jianfei Huang
Summary: This study found that the expression of KLHDC8A was higher in glioma tissues and was associated with patient clinical characteristics. Gliomas exhibited an immune characteristic with high abundance of macrophages, neutrophils, regulatory T cells, and immune checkpoint PD-L1 expression. KLHDC8A+CD68+ macrophages and KLHDC8A were predictive of unfavorable survival in glioma patients.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cell Biology
Ziheng Wang, Xinqi Ge, Jinlong Shi, Bing Lu, Xiaojin Zhang, Jianfei Huang
Summary: The expression of SPTSSA is significantly upregulated in glioma and associated with poor prognosis. The study identifies biological processes and signaling pathways associated with SPTSSA expression, such as oxidative stress. The immunohistochemistry confirms the significant correlation between SPTSSA expression, tumor-infiltrating immune cells, and overall survival.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Pharmacology & Pharmacy
Zhichao Lu, Ziheng Wang, Zhuhuan Song, Chen Chen, He Ma, Peipei Gong, Yunzhao Xu
Summary: Single-cell transcriptome analysis of brain tissues reveals that SARS-CoV-2 can invade the central nervous system through endothelial cells. ACE2 expression is highest in aging endothelial cells, and (-)-catechin may reduce the effects of COVID-19 on the nervous system. Therefore, patients infected with SARS-CoV-2 and presenting with neurological symptoms should receive individualized care.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Xinqi Ge, Manyu Xu, Tong Cheng, Nan Hu, Pingping Sun, Bing Lu, Ziheng Wang, Jian Li
Summary: This study reveals the association between TP53I13 and gliomas, indicating that TP53I13 expression may impact the survival outcomes in glioma patients. Additionally, TP53I13 serves as an independent marker that plays a crucial role in regulating the infiltration of immune cells into tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Min He, Gujie Wu, Ziheng Wang, Kuan Ren, Zheng Yang, Qun Xue
Summary: This study identified 17 differentially expressed TRP-related genes between lung adenocarcinoma (LUAD) and normal lung tissues using TCGA data. Based on these genes, LUAD patients were classified into two subtypes, which showed significant differences in prognosis, clinical features, and immune cell infiltration characteristics. A prognostic signature with 12 genes was established, and patients were classified into low- and high-risk groups. The low-risk group had significantly longer survival time, which was validated in other datasets. The TRP score was found to be an independent predictor of overall survival in LUAD patients.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Zhichao Lu, Yixun Chen, Siqi Chen, Xingjia Zhu, Chenxing Wang, Ziheng Wang, Qi Yao
Summary: This study systematically evaluated the expression differences of NECAP2 in low-grade glioma and pan-cancer. The findings showed that NECAP2 levels were elevated in gliomas, and this upregulation increased with higher tumor grades. NECAP2 overexpression in glioma patients was associated with a higher risk of malignant behavior and worse prognosis. The study also explored the correlation between NECAP2 and cancer immune infiltration, suggesting that NECAP2 could serve as a prognostic biomarker for glioma patients.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Neurosciences
Ziheng Wang, Zhichao Lu, Yixun Chen, Chenxing Wang, Peipei Gong, Rui Jiang, Qianqian Liu
Summary: The aim of this study was to evaluate the effect of epicatechin on neurological recovery and neuroinflammation after traumatic brain injury (TBI) and investigate its potential value in clinical practice. A TBI model was established in adult rats, and the effect of epicatechin was assessed. The results showed that administering epicatechin after TBI prevented neuronal death, reduced neuroinflammation, and promoted neurological function restoration in TBI rats. A network pharmacology study suggested that epicatechin may exert its therapeutic benefits through the AKT-P53/CREB pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Xiang Huang, Ziheng Wang, Mengruo Song, He Huan, Zishu Cai, Bing Wu, Jianhong Shen, You Lang Zhou, Jinlong Shi
Summary: In this study, the expression of circRNA (circIQGAP1) was found to be significantly downregulated in IDH1 mutant gliomas, and low circIQGAP1 expression was associated with better prognosis. circIQGAP1 regulated glioma cell behaviors through miR-1256/RCAN1/Bax/Bcl-2/Caspase3 and miR-622/RCAN2/Bax/Bcl-2/Caspase3 axes. The findings suggest that circIQGAP1 plays an important role in glioma development and may serve as a therapeutic target.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Health Care Sciences & Services
Haiyan Hao, Xinyu Yang, Huixia Zhu, Ziheng Wang, Haiyan Zhang, Chunxia Huang
Summary: This study evaluated the effects of intervention through a whole seamless connection of nursing from the WeChat interactive platform on stigma and quality of life in patients with urinary system cancer. The results showed that this intervention could significantly reduce stigma and improve the patients' quality of life.