Article
Chemistry, Multidisciplinary
Sharafaldin Al-Musawi, Salim Albukhaty, Hassan Al-Karagoly, Faizah Almalki
Summary: A dual-targeting nanomedicine composed of pH-sensitive superparamagnetic iron oxide core-gold shell SPION@Au, chitosan (CS), and folate (FA) was developed for doxorubicin (DOX) antitumor medication. The nanocomposite exhibited elevated drug loading behavior and sustained drug release capacity, with long-term anti-cancer efficacy shown in SkBr3 cell lines. In vivo results demonstrated significant tumor size reduction in treated mice, indicating the potential of this formulation for clinical breast cancer treatment.
Article
Biochemistry & Molecular Biology
Cong Song, Zhijun Ouyang, Honghua Guo, Jiao Qu, Yue Gao, Jindong Xia, Mingwu Shen, Xiangyang Shi
Summary: Development of core-shell tecto dendrimers (CSTDs) as a platform for enhanced tumor magnetic resonance (MR) imaging through an amplified enhanced permeability and retention (EPR) effect. The generated CSTD-D-Gd complexes have a longer rotation correlation time, hence possess a higher longitudinal relaxivity compared to single dendrimer counterpart.
Article
Chemistry, Physical
Magdalena Teresa Spicher, Sebastian Patrick Schwaminger, Daniela von der Haar-Leistl, Marco Reindl, Friedrich Ernst Wagner, Sonja Berensmeier
Summary: This study demonstrates different binding mechanisms of two similar phosphate-binding agents and reveals the significant influence of the composition of the organic shell on the interaction between iron(oxyhydr)oxide nanoparticles and phosphate. The experiments show that, at low concentrations, phosphate is bound through complexation reactions, while at high concentrations, iron phosphate species are formed. The ligands in the shell play a crucial role in the binding mechanism.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Juan Esteban Montoya Cardona, Dounia Louaguef, Eric Gaffet, Nureddin Ashammakhi, Halima Alem
Summary: Despite some delays in clinical implementation, functionalized magnetic and photothermal nanostructures remain the most promising way to target hyperthermia treatment of cancer towards local tumor regions. The synthesis method and parameters play a crucial role in optimizing the physicochemical properties for efficient energy transduction into locally released heat. This review aims to provide the latest applications and prospects of nanomaterials for hyperthermia properties.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Lorenzo Cursi, Silvia Vercellino, Mura M. McCafferty, Emily Sheridan, Vanya Petseva, Laurent Adumeau, Kenneth A. Dawson
Summary: Magnetic nanoparticles are valuable tools for studying complex intracellular bio-nano interactions. By synthesizing biocompatible multifunctional nanoparticles with fluorescent properties, intracellular tracking of nanoparticles can be achieved, providing a promising approach for studying bio-nano interactions.
Article
Chemistry, Multidisciplinary
Giovanni Marco Saladino, Ronak Kakadiya, Shaquib Rahman Ansari, Alexandra Teleki, Muhammet Sadaka Toprak
Summary: Superparamagnetic iron oxide nanoparticles (SPIONs) play a dominant role in various biomedical applications, including magnetic separation, drug delivery, diagnostics, and hyperthermia treatments. In this study, superparamagnetic nanoclusters (SP-NCs) with high unit magnetization and diameters up to 400 nm were synthesized using conventional or microwave-assisted solvothermal methods. The choice of synthesis route and capping agent significantly influenced the particle size, SP-NC size, surface chemistry, and magnetic properties. The SP-NCs were then coated with a silica shell doped with a fluorophore to provide fluorescence properties and high stability. The heating efficiency studies demonstrated the potential of these synthesized SP-NCs in hyperthermia treatment. The enhanced magnetically-active content, fluorescence, magnetic property, and heating efficiency of SP-NCs offer promising opportunities for biomedical applications.
NANOSCALE ADVANCES
(2023)
Article
Polymer Science
Clemence Nadal, Olivier Coutelier, Sandrine Cavalie, Valerie Flaud, Jeremy Soulie, Jean-Daniel Marty, Mathias Destarac, Audrey Tourrette
Summary: This study successfully synthesized hydrogel-based composite core/shell nanoparticles and modified their surface with thermoresponsive copolymers. The smart system showed promising prospects in controlled drug delivery.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Materials Science, Biomaterials
Cristina de la Encarnacion, Felix Jungwirth, David Vila-Liarte, Carlos Renero-Lecuna, Safiyye Kavak, Inaki Orue, Claire Wilhelm, Sara Bals, Malou Henriksen-Lacey, Dorleta Jimenez de Aberasturi, Luis M. Liz-Marzan
Summary: Hyperthermia has been shown to be an effective and selective cancer therapy strategy by heating malignant cells above 42 degrees C to trigger cell death. Magnetic and photothermal hyperthermia can benefit from the use of nanomaterials. This hybrid colloidal nanostructure, consisting of plasmonic gold nanorods covered by a silica shell and subsequently grown with iron oxide nanoparticles, is responsive to both external magnetic fields and near-infrared irradiation, enabling targeted magnetic separation and photothermal heating.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Yang Cao, Ziqun Chen, Haitao Ran
Summary: Near-infrared laser triggered theranostic platforms have been successfully developed for guided photothermal therapy and real-time temperature monitoring in cancer treatment. The platform exhibits excellent optical absorption, photothermal conversion, and photoacoustic signal generation.
Article
Chemistry, Multidisciplinary
Sadaf Hameed, Pravin Bhattarai, Zhuoran Gong, Xiaolong Liang, Xiuli Yue, Zhifei Dai
Summary: This study focuses on the synthesis of ultra-small hydrophilic porphyrin-based silica nanoparticles to enhance the treatment outcomes of cancer via photodynamic therapy. These nanoparticles show excellent solubility in water, enhanced tumor accumulation, and imaging-guided therapeutic abilities. They also exhibit biocompatibility and stability in physiological solutions.
NANOSCALE ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Stephanie Fulaz, Carolina Scachetti, Ljubica Tasic
Summary: The study focuses on the development of a nanomaterial capable of selectively capturing sucrose, aiming to produce low-calorie fruit juices. The results demonstrate that the nanomaterial effectively captures sucrose with excellent stability in physicochemical characteristics and enzymatic activity.
Article
Chemistry, Physical
N. Liu, J. Guan
Summary: The rational fabrication of OER electrocatalysts using earth-abundant elements is important for sustainable energy applications. By creating a core-shell Co3O4@FeOx catalyst with an ultrathin FeOx coating, higher OER activity can be achieved due to the promotion of reaction, enhanced charge transfer ability, and accelerated diffusion attributed to the introduction of ultrathin FeOx.
MATERIALS TODAY ENERGY
(2021)
Article
Materials Science, Ceramics
Olga A. Shilova, Anastasiya S. Kovalenko, Anton M. Nikolaev, Sergey Mjakin, Alexander A. Sinel'nikov, Vladimir P. Chelibanov, Yulia E. Gorshkova, Nataliya Tsvigun, Olim N. Ruzimuradov, Gennady P. Kopitsa
Summary: The surface of TiO2 nanoparticles was modified with silica prepared by acid hydrolysis, resulting in a twofold increase in specific surface area. The modification also changed the surface functionality from Lewis acidity to Brönsted acidity. The resulting TiO2@SiO2 core-shell particles exhibited significantly enhanced singlet oxygen generation and photocatalytic activity.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Biomaterials
Junli Gong, Cong Song, Gaoming Li, Yunqi Guo, Zhiqiang Wang, Honghua Guo, Jindong Xia, Yuchen Tao, Qiusheng Shi, Xiangyang Shi, Mingwu Shen
Summary: In this study, a multifunctional nanoplatform combined with UTMD technology was designed to enhance tumor accumulation for theranostics. The platform, PCSTD-Gd, consisted of zwitterion-modified gadolinium (Gd)-chelated core-shell tecto dendrimers (CSTDs) for MR imaging-guided chemo-gene therapy. The CSTDs were covalently linked with Gd-chelators and modified with 1,3-propane sultone for protein-resistance, and were used for co-delivery of miR 21i and DOX. This design provided advantages in tumor targeting, MR imaging sensitivity, gene delivery efficiency, and drug loading.
BIOMATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Da-Hua Wei, Tei-Kai Lin, Yuan-Chang Liang, Huang-Wei Chang
Summary: Monodispersed FePt core and FePt-Au core-shell nanoparticles were chemically synthesized with controllable surface-functional properties. The size of the nanoparticles could be tuned by the initial concentration of gold acetate, and FePt-Au NPs showed a red shift in surface plasmon resonance compared to pure Au NPs. Surface modification using mercaptoacetic acid gave the NPs hydrophilic properties and potential applications in biomedical engineering research.
FRONTIERS IN CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Ngoc Thuy Trang Le, Ngoc Hoi Nguyen, Minh Chau Hoang, Cuu Khoa Nguyen, Dai Hai Nguyen, Dieu Linh Tran
Summary: A model paclitaxel-encapsulated nanoliposome carrier was synthesized to enhance the solubility and accumulation of paclitaxel at tumor sites, showing therapeutic effects towards breast cancer cells in vitro. The study suggests that extrusion is a simple and convenient method for nano-sizing and homogenising liposome suspension for effective drug delivery.
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Nguyen Anh Khoa Huynh, Thi Hong Tuoi Do, Xuan Loc Le, Truc Thanh Ngoc Huynh, Duc Hanh Nguyen, Ngoc Khue Tran, Cao Thuy Ha Lan Tran, Dai Hai Nguyen, Cong Tri Truong
Summary: In this study, a self-microemulsifying drug delivery system (SMEDDS) based on pine essential oil was developed to enhance the oral bioavailability of cyclosporine A. The SMEDDS showed stability and favorable drug release performance, with good safety.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ngoc Thuy Nguyen, Nhat Thong Tran, Tan Phat Phan, Anh Thu Nguyen, My Xuyen T. Nguyen, Nguyen Ngan Nguyen, Young Ho Ko, Dai Hai Nguyen, Tan T. T. Van, DongQuy Hoang
Summary: This study focuses on the efficient processing of biomass waste, using rice husk as the starting resource. The separated components, including cellulose, hemicellulose, lignin, and silica, were obtained through a simple biorefining process. The results contribute to the development of a simple and efficient conversion process for biomass waste into sustainable materials, aiming to reduce environmental impact.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Thanh Phuong Cao, Chuc Nguyen Hang, Hieu Vu-Quang, Daniel Manaye Kabtamu, Subodh Kumar, Van Cuong Nguyen, Xuan Thang Cao
Summary: This study presents a catalyst-free pathway for the polymerization of furfuryl alcohol into poly(furfuryl alcohol) using a deep eutectic solvent system. The DES system, prepared from a mixture of choline chloride and zinc chloride, efficiently catalyzed the polymerization reaction at moderate reaction conditions, resulting in high yields of the desired polymer.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Polymer Science
Thi Thinh Nguyen, Bao Phu Nguyen, Dinh Tien Dung Nguyen, Ngoc Hoi Nguyen, Dai Hai Nguyen, Cuu Khoa Nguyen
Summary: Polyamidoamine dendrimer (PAMAM) modified with methoxy polyethylene glycol (mPEG) is a promising drug delivery system for antiretroviral agents (ARV) in HIV treatment and prevention. The study demonstrates that PAMAM G3.0@mPEG particles exhibit sustained drug release behavior and retain anti-HIV activity.
Article
Environmental Sciences
Van Thuan Le, Yasser Vasseghian, Van Dat Doan, Thi Thu Trang Nguyen, Thu-Thao Thi Vo, Ha Huu Do, Khanh B Vu, Quang Hieu Vu, Tran Dai Lam, Vy Anh Tran
Summary: In this study, a Ti3C2-MoS2 composite with high sensitivity and cyclic response curves to dangerous gases at room temperature was created using 2D MXenes and MoS2 materials. The composite demonstrated a significant dependence on NO2 concentration and also showed reaction signals to other hazardous gases.
Article
Polymer Science
Ngoc Nhon Hoang, Tri Khoi Nguyen, Tuyet Hoa Vo, Ngoc Hoi Nguyen, Dai Hai Nguyen, Dieu Linh Tran
Summary: This study presented the isolation, purification, characterization, and biological activities of fucoidan from Ceratophyllum submersum for the first time. The FCS exhibited strong antioxidant properties, as well as antibacterial, antifungal, anticoagulant, and anti-inflammatory activities. It also displayed better inhibition on breast cancer cells compared to liver cancer, lung cancer, and cervical cancer cells. This research contributes valuable information and a basic platform for further studies on fucoidan from C. submersum.
MACROMOLECULAR RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Cong Tri Truong, Dinh Tien Dung Nguyen, Mong Tham Vo, Buu Thong Huynh, Thuy-Anh Nguyen Thi, Minh Hoang Vo Do, Ngoc Hoi Nguyen, Dai Hai Nguyen
Summary: A Tamanu oil-based nanostructured lipid carrier gel containing Capsicum oleoresin was prepared and showed similar analgesic and anti-inflammatory effects as commercial drugs without causing skin irritation.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Polymer Science
Anh-Minh Nguyen-Huu, Ngoc Thuy Trang Le, Pham Nguyen Dong Yen, Yern Chee Ching, Dai Hai Nguyen
Summary: Quercetin has been extensively studied in drug delivery systems, and this study aims to use simplistic micelles to solve the problem of complicated systems. PEGylated-cholesterol micelles were prepared and characterized, and the results showed promising features of the nano-micelles as a drug delivery system.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Phuong Le Thi, Thi Yen Nhi Tran, Hung Cuong Luu, Dieu Linh Tran, Thai Thanh Hoang Thi, Dai Hai Nguyen
Summary: An injectable gelatin-cyclodextrin click hydrogel with high drug loading capacity and prolonged drug release was designed and prepared. The physico-chemical properties of the hydrogel could be controlled by adjusting the cross-linker feed amount. The hydrogel showed good cell compatibility in vitro.
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2022)
Article
Materials Science, Biomaterials
Fahima Akther, Jun Zhang, Huong D. N. Tran, Hedieh Fallahi, Hossein Adelnia, Hoang-Phuong Phan, Nam-Trung Nguyen, Hang Thu Ta
Summary: This study presents a unique microfluidic device that mimics and studies atherothrombosis, a condition caused by atherosclerotic plaque disruption and thrombosis. The device successfully explains the correlation between vessel geometry and thrombus formation and demonstrates sensitivity to aspirin and targeted drug carriers.
Article
Polymer Science
Ngoc Hoi Nguyen, Dieu Linh Tran, Ngoc-Hang Truong-Thi, Cuu Khoa Nguyen, Cam Tu Tran, Dai Hai Nguyen
Summary: This study demonstrates the use of polyethylene glycol (PEG) as a capping agent to control the mesoporous shell thickness of hollow mesoporous silica nanoparticles (HMSN). Increasing the molecular weight or concentration of PEG leads to an increase in the mesoporous shell thickness. The samples synthesized with PEG exhibit higher surface area and better sustained release profile for drug delivery applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Najma Annuria Fithri, Yuao Wu, Gary Cowin, Fahima Akther, Huong D. N. Tran, Brian Tse, Nicholas Westra van Holthe, Shehzahdi S. Moonshi, Karlheinz Peter, Xiaowei Wang, Nghia P. Truong, Hang Thu Ta
Summary: In this study, activated platelet targeted gold-iron oxide nanoparticles were developed for the diagnosis and treatment of thrombosis related diseases. The nanoparticles enabled triple imaging modalities of magnetic resonance imaging, photoacoustic imaging, and fluorescence imaging, and also facilitated photothermal thrombolysis. The in vivo observation showed enhanced contrast and thrombus reduction in the targeted group compared to the non-targeted group.
APPLIED MATERIALS TODAY
(2023)
Review
Materials Science, Biomaterials
Phuong Le Thi, Dieu Linh Tran, Thai Thanh Hoang Thi, Yunki Lee, Ki Dong Park
Summary: The dual role of reactive oxygen and nitrogen species (RONS) in physiological and pathological processes has been widely studied. Injectable hydrogels have emerged as promising biomaterials for controlling RONS levels and have shown potential in regenerative medicine and tissue engineering applications.
REGENERATIVE BIOMATERIALS
(2022)
