Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C10)

Efficacy and safety of oral basal insulin versus subcutaneous insulin glargine in type 2 diabetes: a randomised, double-blind, phase 2 trial

(2019) Inge B Halberg et al.   Lancet Diabetes & Endocrinology

Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects with Renal Impairment

(2018) Charlotte Granhall et al.   CLINICAL PHARMACOKINETICS

A randomized study investigating the effect of omeprazole on the pharmacokinetics of oral semaglutide

(2018) Tine A. Bækdal et al.   Expert Opinion on Drug Metabolism & Toxicology

Human gut microbiome: hopes, threats and promises

(2018) Patrice D Cani   GUT

Effects of surfactant-based permeation enhancers on mannitol permeability, histology, and electrogenic ion transport responses in excised rat colonic mucosae

(2018) Sam Maher et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pharmacokinetics, Safety, and Tolerability of Oral Semaglutide in Subjects With Hepatic Impairment

(2018) Tine A. Baekdal et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Oral delivery of anti-diabetes therapeutics using cell penetrating and transcytosing peptide strategies

(2018) Sahrish Rehmani et al.   PEPTIDES

Impact of Insulin Tregopil and its Permeation Enhancer on Pharmacokinetics of Metformin in Healthy Volunteers: Randomized, Open-label, Placebo Controlled, Crossover Study

(2018) Anand Khedkar et al.   CTS-Clinical and Translational Science

Cardiovascular safety of oral semaglutide in patients with type 2 diabetes: Rationale, design and patient baseline characteristics for the PIONEER 6 trial

(2018) Stephen C. Bain et al.   DIABETES OBESITY & METABOLISM

Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist

(2018) Stephen T. Buckley et al.   Science Translational Medicine

Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes

(2017) Melanie Davies et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

THPdb: Database of FDA-approved peptide and protein therapeutics

(2017) Salman Sadullah Usmani et al.   PLoS One

Oral delivery of diabetes peptides — Comparing standard formulations incorporating functional excipients and nanotechnologies in the translational context

(2016) Harivardhan Reddy Lakkireddy et al.   ADVANCED DRUG DELIVERY REVIEWS

Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials

(2016) T.A.S. Aguirre et al.   ADVANCED DRUG DELIVERY REVIEWS

Intestinal permeation enhancers for oral peptide delivery

(2016) Sam Maher et al.   ADVANCED DRUG DELIVERY REVIEWS

A randomized, double-blind, multicenter, placebo-controlled study to evaluate the efficacy and safety of oral salmon calcitonin in the treatment of osteoporosis in postmenopausal women taking calcium and vitamin D

(2016) Kim Henriksen et al.   BONE

Human Intestinal Barrier Function in Health and Disease

(2016) Julia König et al.   Clinical and Translational Gastroenterology

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Sodium caprate-induced increases in intestinal permeability and epithelial damage are prevented by misoprostol

(2015) David J. Brayden et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Interaction with Mixed Micelles in the Intestine Attenuates the Permeation Enhancing Potential of Alkyl-Maltosides

(2015) Kerstin Gradauer et al.   MOLECULAR PHARMACEUTICS

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

(2015) Benoit Chassaing et al.   NATURE

Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials

(2015) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules

(2014) Bibi F. Choonara et al.   BIOTECHNOLOGY ADVANCES

A head-to-head multi-parametric high content analysis of a series of medium chain fatty acid intestinal permeation enhancers in Caco-2 cells

(2014) David J. Brayden et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Acute Binge Drinking Increases Serum Endotoxin and Bacterial DNA Levels in Healthy Individuals

(2014) Shashi Bala et al.   PLoS One

Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells

(2012) Susanne M. Krug et al.   BIOMATERIALS

Absorption Enhancers: Applications and Advances

(2011) Bruce J. Aungst   AAPS Journal

A review of the efficacy and safety of nanoparticle-based oral insulin delivery systems

(2011) Jeffrey W. Card et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms

(2011) Chifu B. Huang et al.   ARCHIVES OF ORAL BIOLOGY

Pharmacokinetics of Oral Cyanocobalamin Formulated With Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC): An Open-Label, Randomized, Single-Dose, Parallel-Group Study in Healthy Male Subjects

(2011) M. Cristina Castelli et al.   CLINICAL THERAPEUTICS

Oral Insulin: A Comparison With Subcutaneous Regular Human Insulin in Patients With Type 2 Diabetes

(2010) C. Kapitza et al.   DIABETES CARE

The role of intermolecular interactions with penetratin and its analogue on the enhancement of absorption of nasal therapeutic peptides

(2010) El-Sayed Khafagy et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Lessons Learned From the Development of Oral Calcitonin: The First Tablet Formulation of a Protein in Phase III Clinical Trials

(2010) M. A. Karsdal et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic

(2009) Sam Maher et al.   ADVANCED DRUG DELIVERY REVIEWS

Oral administration of the GnRH antagonist acyline, in a GIPET®-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics

(2009) John Kenneth Amory et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Evaluation of intestinal absorption enhancement and local mucosal toxicity of two promoters. I. Studies in isolated rat and human colonic mucosae

(2009) Sam Maher et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Subchronic Oral Toxicity of Salcaprozate Sodium (SNAC) in Sprague-Dawley and Wistar Rats

(2009) M. Gary I. Riley et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Peri- and Postnatal Developmental Toxicity of Salcaprozate Sodium (SNAC) in Sprague-Dawley Rats

(2009) M. Gary I. Riley et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

The Drug Transporter−Metabolism Alliance: Uncovering and Defining the Interplay

(2009) Leslie Z. Benet   MOLECULAR PHARMACEUTICS

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Displacement of tight junction proteins from detergent-resistant membrane domains by treatment with sodium caprate

(2008) Ko Sugibayashi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Gastric Mucosal Defense and Cytoprotection: Bench to Bedside

(2008) Loren Laine et al.   GASTROENTEROLOGY

Oral Delivery of Antisense Oligonucleotides in Man

(2007) Lloyd G. Tillman et al.   JOURNAL OF PHARMACEUTICAL SCIENCES