Review
Biochemistry & Molecular Biology
Julia Szymonik, Kamila Wala, Tomasz Gornicki, Jolanta Saczko, Bartosz Pencakowski, Julita Kulbacka
Summary: Neoplastic diseases are a major challenge in medicine, and finding new therapeutic options is crucial. The resistance of cancer cells to drugs and disease progression can be attributed to cancer stem cells (CSC) and their specific properties. CSCs inhibit cell maturation, essential for self-renewal and pluripotency, and display increased expression of stemness-related markers. Metabolism changes and increased demand for iron have been observed in cancer cells. Iron chelators have shown anti-tumor activity and can reduce chemoresistance and tumor cell progression by influencing the expression of stemness-related markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Emma Cosialls, Rima El Hage, Leila Dos Santos, Chang Gong, Maryam Mehrpour, Ahmed Hamai
Summary: Iron metabolism plays a crucial role in cancer stem cells, providing a new direction for targeting CSC therapeutic strategies. The dependency of CSCs on iron and the induction of iron death suggest that iron could be an effective means to treat cancer.
Article
Biochemistry & Molecular Biology
Yue Yang, Yuanyuan Lu, Chunhua Zhang, Qianqian Guo, Wenzhou Zhang, Ting Wang, Zhuolu Xia, Jing Liu, Xiangyu Cheng, Tao Xi, Feng Jiang, Lufeng Zheng
Summary: In this study, three compounds CPUL119, CPUL129, and CPUL149 were identified to inhibit the stemness of breast cancer cells by triggering ferroptosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
David Soriano-Castell, Antonio Currais, Pamela Maher
Summary: Ferroptosis is a form of regulated cell death dependent on iron and lipid peroxidation. Various inhibitors have been tested to distinguish ferroptosis from other forms of cell death.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Susu Guo, Yuxin Chen, Xiangfei Xue, Yueyue Yang, Yikun Wang, Shiyu Qiu, Jiangtao Cui, Xiao Zhang, Lifang Ma, Yongxia Qiao, Jiayi Wang
Summary: TRIB2 plays a crucial role in promoting liver tumorigenesis by regulating the UPS system, reducing oxidative damage and sensitivity to ferroptosis. Its interaction with TFRC and β-TrCP are essential for modulating labile iron levels and desensitizing cells to ferroptosis.
CELL DEATH DISCOVERY
(2021)
Article
Environmental Sciences
Jie Sun, Xiuqin Cheng, Shubo Pan, Liangjing Wang, Wenhuan Dou, Jie Liu, Xiaohua Shi
Summary: The study demonstrated that dichloroacetate (DCA) could reduce colorectal cancer cell stemness in a dose-dependent manner, and trigger ferroptosis in colorectal cancer stem cells, suggesting its potential as a therapeutic approach for targeting colorectal cancer stem cells.
ENVIRONMENTAL TOXICOLOGY
(2021)
Review
Pathology
Tianqi Xu, Yixiong Liu, Zhiwei Zhao, Jin Liu, Jia Chai, Yanru Yang, Saijie Zuo, Mingyang Li, Qingge Jia
Summary: Ferroptosis is an iron-dependent form of cell death that is associated with the accumulation of lipid peroxidation markers. Numerous studies have focused on uncovering the oncogenic pathways and regulators of ferroptosis. The connection between iron metabolism and abnormal iron metabolism in CSCs synergistically positions ferroptosis as a promising target in combating CSCs and reversing resistance. Ferroptosis inducers have the potential to specifically kill CSCs in tumors, making ferroptosis a target for overcoming cancer resistances. By inducing ferroptosis and other cell death pathways in CSCs, the therapeutic outcome of cancer can be improved.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Engineering, Biomedical
Kai Wu, Wei Zhang, Hao Chen, Jie Wu, Xiaotong Wang, Xinjian Yang, Xing-Jie Liang, Jinchao Zhang, Dandan Liu
Summary: This study designed a strategy to enhance iron death in breast cancer stem cells (BCSCs) by increasing iron ion content, inhibiting iron efflux, and depleting GSH. This strategy has significant implications for BCSC-targeted cancer therapy.
ACTA BIOMATERIALIA
(2023)
Article
Cell Biology
Shahnaz Babaei-Abraki, Fereshteh Karamali, Mohammad Hossein Nasr-Esfahani
Summary: Human embryonic stem cells (hESCs) have the potential to differentiate into different types of cells, making them a valuable source for therapeutic applications. However, hESCs are prone to cell death after dissociation, which hinders their use. Recent research has found that hESCs can undergo a form of programmed cell death called ferroptosis, which is different from previously observed cell death processes. Ferroptosis is triggered by an increase in intracellular iron, and it is distinct from other forms of cell death in terms of its biochemical, morphological, and genetic characteristics.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Yinu Wang, Guangyuan Zhao, Salvatore Condello, Hao Huang, Horacio Cardenas, Edward J. Tanner, JianJun Wei, Yanrong Ji, Junjie Li, Yuying Tan, Ramana V. Davuluri, Marcus E. Peter, Ji-Xin Cheng, Daniela Matei
Summary: The study identifies platinum-tolerant cancer cells with cancer stem cell features characterized by expression of FZD7 and dependency on the FZD7-beta-catenin-Tp63-GPX4 pathway for survival. These cells are highly susceptible to ferroptosis, marking a novel therapeutic vulnerability in platinum-resistant cancer cells.
Review
Biochemistry & Molecular Biology
Raphae Rodriguez, Stuart L. Schreiber, Marcus Conrad
Summary: Ferroptosis is a unique type of non-apoptotic cell death that occurs due to the unrestrained peroxidation of phospholipids, resulting in the production of lethal oxygen radicals mediated by iron. It has been observed in various organisms, including mammals, where it can serve as a defense mechanism against pathogens and be utilized by T cells for effective killing of tumor cells. Conversely, ferroptosis is considered to be one of the main cell death mechanisms contributing to degenerative diseases. Recent studies suggest that certain cancers exhibit vulnerabilities to ferroptosis, particularly in dedifferentiating and persister cancer cells that are dependent on iron. Exploiting this dependence on iron may hold therapeutic benefits.
Review
Oncology
Hailiang Wang, Zhongyan Zhang, Shiye Ruan, Qian Yan, Yubin Chen, Jinwei Cui, Xinjian Wang, Shanzhou Huang, Baohua Hou
Summary: Targeting cancer stem cells (CSCs) for treatment is important, and recent studies suggest inducing ferroptosis could be an effective strategy. This study reviews the alterations in iron metabolism and lipid peroxidation in CSCs, their impact on ferroptosis, and the regulatory mechanisms involved.
FRONTIERS IN ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Nadia Zaffaroni, Giovanni Luca Beretta
Summary: Nanoparticles inducing ferroptosis show potential for cancer therapy with advantages over small molecules. They can load drugs, target tumors, and have other therapeutic applications.
Review
Oncology
Yawen Li, Halahati Tuerxun, Xingyu Liu, Yixin Zhao, Shuhui Wen, Yaping Li, Jingjing Cao, Yuguang Zhao
Summary: Cancer stem cells (CSCs) are a small population of stem cells within cancer cells, responsible for tumor recurrence, metastasis, and drug resistance. Ferroptosis, a promising anti-cancer therapy, targets the unique metabolic characteristics of CSCs, as their growth is more dependent on iron and lipid. The expression of Nuclear factor E2-related factor 2 (Nrf2), a key player in redox homeostasis, determines the susceptibility of CSCs to ferroptosis. Targeting Nrf2 to induce ferroptosis provides potential new targets for eliminating aggressive tumors and curing cancer.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Nayeon Kang, Subin Son, Sunhong Min, Hyunsik Hong, Chowon Kim, Jusung An, Jong Seung Kim, Heemin Kang
Summary: Ferroptosis, an iron-dependent programmed cell death mechanism, can be regulated by intracellular iron supplementation and glutathione synthesis inhibition. Utilizing various endogenous and exogenous stimuli, such as tumor microenvironment conditions and external energy sources, can provide precise control and controllability for ferroptosis-based cancer therapy. The utilization of dual stimuli provides a new direction for efficient cancer therapy.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Stefania Recalcati, Elena Gammella, Gaetano Cairo
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Hematology
Stefania Recalcati, Elena Gammella, Paolo Buratti, Andrea Doni, Achille Anselmo, Massimo Locati, Gaetano Cairo
Meeting Abstract
Gastroenterology & Hepatology
A. Mannini, C. Raggi, M. Correnti, E. Rovida, J. B. Andersen, C. Coulouarn, F. Marra
DIGESTIVE AND LIVER DISEASE
(2019)
Meeting Abstract
Gastroenterology & Hepatology
E. Vivoli, B. Piombanti, C. Raggi, S. Madiai, G. Di Maira, F. Marra
DIGESTIVE AND LIVER DISEASE
(2019)
Meeting Abstract
Gastroenterology & Hepatology
M. Correnti, M. Erreni, R. Avigni, M. Sironi, J. M. Banales, G. Cavalloni, M. Donadon, G. Torzilli, F. Marra, C. Raggi
DIGESTIVE AND LIVER DISEASE
(2019)
Meeting Abstract
Gastroenterology & Hepatology
M. Pastore, A. Caligiuri, C. Raggi, E. Rovida, G. Di Maira, S. Petta, F. Marra
DIGESTIVE AND LIVER DISEASE
(2019)
Article
Hematology
Paul Robach, Elena Gammella, Stefania Recalcati, Domenico Girelli, Annalisa Castagna, Matthieu Roustit, Carsten Lundby, Anne-Kristine Lundby, Pierre Bouzat, Samuel Verges, Guillaume Sechaud, Pierluigi Banco, Mario Uhr, Catherine Cornu, Pierre Sallet, Gaetano Cairo
Summary: The study demonstrates that in healthy humans, ERFE responds to slight increases in Epo levels without Hb mass expansion, and downregulates hepcidin in an apparently iron-independent manner. Notably, ERFE levels are positively correlated with micro-dose Epo administration, suggesting its potential as a new biomarker for doping detection.
Article
Cell Biology
Elena Gammella, Irene Schiano Lomoriello, Alexia Conte, Stefano Freddi, Alessandra Alberghini, Maura Poli, Sara Sigismund, Gaetano Cairo, Stefania Recalcati
Summary: The availability of iron affects TfR1 internalization cycle and protein stability, suggesting a novel regulatory mechanism to prevent iron overload.
MOLECULAR BIOLOGY OF THE CELL
(2021)
Review
Biochemistry & Molecular Biology
Elena Gammella, Margherita Correnti, Gaetano Cairo, Stefania Recalcati
Summary: Body iron levels are regulated by hepcidin, which controls the presence of ferroportin (FPN) on cell surface. Disruption of this regulation can lead to disorders related to iron-deficiency or overload. Recent evidence suggests that FPN may also play a crucial role in local iron control, potentially causing tissue damage despite unchanged systemic iron homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Margherita Correnti, Elena Gammella, Gaetano Cairo, Stefania Recalcati
Summary: Iron is essential for cellular processes, especially in erythropoiesis. The hormone hepcidin, produced by the liver, regulates iron homeostasis by interacting with ferroportin. During enhanced erythropoiesis, hepcidin expression is inhibited, allowing increased iron export and facilitating erythropoiesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Oyku Gonul Geyik, Giulia Anichini, Engin Ulukaya, Fabio Marra, Chiara Raggi
Summary: Cholangiocarcinoma is a difficult to treat cancer with a rising incidence. Understanding its biology has been a hurdle to identify novel targets and effective treatments. Alterations in DNA damage response-related genes open up possibilities for DDR-targeting strategies. However, using DDR inhibitors alone may not be sufficient for clinical use, leading to consideration of combining them with DNA-damaging regimens and targeted drugs.
Review
Oncology
Margherita Correnti, Eleonora Binatti, Elena Gammella, Pietro Invernizzi, Stefania Recalcati
Summary: Increasing evidence suggests that cancer stem cells (CSCs) are responsible for therapeutic resistance and tumor relapse in primary liver cancer (PLC). The metabolic features of liver CSCs are still not well understood, and they can shift between different metabolic states. In addition to intrinsic cues, the tumor microenvironment (TME) plays a role in controlling CSC plasticity. Understanding the mechanisms underlying liver CSC metabolic rewiring and the interaction with TME is crucial for developing effective therapeutic strategies.
Letter
Hematology
Gaetano Cairo, Benoit Champigneulle, Margherita Correnti, Elena Gammella, Stefania Recalcati, Domenico Girelli, Annalisa Castagna, Anne-Kristine Meinild Lundby, Ivan Hancco, Carole Chirica, Dorra Guergour, Laura Oberholzer, Emeric Stauffer, Carsten Lundby, Aurelien Pichon, Julien Brugniaux, Stephane Doutreleau, Samuel Verges, Paul Robach
Letter
Medicine, General & Internal
Paul Robach, Stefania Recalcati, Elena Gammella, Gaetano Cairo
MEDICINA DELLO SPORT
(2021)
Review
Chemistry, Medicinal
Stefania Recalcati, Elena Gammella, Gaetano Cairo
