Journal
FRONTIERS IN ONCOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2019.00002
Keywords
celastrol; reactive oxygen species; N-acetyl-cysteine; apoptosis; ovarian cancer
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Funding
- National Key Research and Development Program of China [2017YFA0505104]
- National Natural Science Foundation of China [81772540, 81503293]
- Guangdong Natural Science Funds for Distinguished Young Scholar [2014A030306001]
- Guangdong Special Support Program for Young Talent [2015TQ01R350]
- Science and Technology Program of Guangdong [2016A050502027]
- Science and Technology Program of Guangzhou [201704030058]
- Zhejiang major disease diagnosis and treatment technology research center [JBZX-201803]
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Celastrol is a natural triterpene isolated from the Chinese plant Thunder God Vine with potent antitumor activity. However, the effect of celastrol on the growth of ovarian cancer cells in vitro and in vivo is still unclear. In this study, we found that celastrol induced cell growth inhibition, cell cycle arrest in G2/M phase and apoptosis with the increased intracellular reactive oxygen species (ROS) accumulation in ovarian cancer cells. Pretreatment with ROS scavenger N-acetyl-cysteine totally blocked the apoptosis induced by celastrol. Additionally, celastrol inhibited the growth of ovarian cancer xenografts in nude mice. Altogether, these findings suggest celastrol is a potential therapeutic agent for treating ovarian cancer.
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