Article
Pharmacology & Pharmacy
Peijian Wang, Hui Li, Zhexuan Lin, Hongjun Luo, Wenhong Luo
Summary: In this study, it was found that silepcimide (ILE) can improve the bioavailability of curcumin (CUR). Repeated administration of piperine (PIP) or ILE significantly increased the plasma concentration of the metabolite. The metabolic pathway of CUR was investigated, indicating that gastrointestinal microorganisms may play a role in the transformation of CUR to its metabolite.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Abdulmajeed A. Althobaiti, Eman A. Ashour, Mashan Almutairi, Ahmed Almotairy, Mohammed Al Yahya, Michael A. Repka
Summary: Curcumin, derived from turmeric, has various biological activities. This study successfully prepared curcumin-piperine solid dispersion using the hot-melt extrusion technique, resulting in significant improvement in the release profile of curcumin.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Manishita R. Sharma, Priyanka Arya, Ravinder Kaur, John F. Kennedy, Neera Raghav
Summary: The use of natural polymers in Drug Delivery Systems (DDS) has increased due to their biocompatibility, non-allergic and biodegradable properties. However, as natural polymers are usually hydrophilic, their nature needs to be altered to be able to carry hydrophobic drugs. This study reports the differential binding of piperine and curcumin with CTAB modified cellulose, alginate, and pectin. In-vitro and in-silico studies were used to visualize the differences in interaction between piperine and curcumin with the supports. The piperine loaded on CTAB-modified polymeric supports was characterized using FT-IR, SEM, fluorescence, and particle size analysis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Mayuko Itaya, Taiki Miyazawa, Saoussane Khalifa, Naoki Shimizu, Kiyotaka Nakagawa
Summary: The study found that some food compounds binding stronger to albumin than curcumin can enhance the physiological activity of curcumin. Experimental results confirmed this hypothesis, providing insights into enhancing the physiological activities of various food compounds by focusing on their interaction with albumin.
Article
Biochemistry & Molecular Biology
Bilal Javed, Xinyi Zhao, Daxiang Cui, James Curtin, Furong Tian
Summary: The study synthesized Lignin-g-p (NIPAM-co-DMAEMA) gold nanogel loaded with curcumin and piperine to treat GBM, which exhibited enhanced anticancer properties, improved drug toxicity and release, and induced apoptosis through endocytic pathways. The experimental evidence suggests that the combinatorial curcumin-piperine gold nanogels have the potential to overcome the limitations of conventional chemotherapeutic treatments for glioma cells.
Review
Food Science & Technology
Zvonimir Petric, Irena Zuntar, Predrag Putnik, Danijela Bursac Kovacevic
Summary: Fruit juices contain phytochemicals which can interfere with drug metabolism enzymes, leading to food-drug interactions that affect drug effects and toxicity. These interactions typically affect pharmacokinetic parameters, but predicting them accurately is challenging due to limited study subjects and individual variability.
Article
Pharmacology & Pharmacy
Fatemeh Ahmadi, Jafar Akbari, Majid Saeedi, Mohammad Seyedabadi, Pedram Ebrahimnejad, Shahram Ghasemi, Ali Nokhodchi
Summary: The aim of this study was to overcome the limitations of co-delivery of CUR and PIP nanoparticles for breast cancer therapy, and successfully achieve the co-encapsulation and release of CUR and PIP using nanoparticles. The results showed that these dual-drug loaded nanoparticles had significant synergistic cytotoxicity against breast cancer cells, providing promise for targeted cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yanjun Cui, Ying Li, Caihui Guo, Yajing Li, Yinling Ma, Zhanjun Dong
Summary: This study investigated the pharmacokinetic drug interactions between canagliflozin and sorafenib or lenvatinib and found significant changes in the plasma concentrations and apparent clearance of these drugs. These findings provide a reference for the use of canagliflozin, sorafenib and lenvatinib in patients with HCC and T2DM.
Review
Chemistry, Medicinal
Jie Li, Shuting Wang, Fengjie Tian, Shuang-Qing Zhang, Hongtao Jin
Summary: As the use of herbs increases worldwide, there are more reports of interactions between herbs and drugs. The complex active components of herbs inevitably affect the pharmacokinetics of chemical drugs in vivo. The expression of drug transporters is closely related to the absorption, distribution, metabolism, and excretion of drugs. When herbs inhibit or induce the expression of transporters, it can result in changes in substrate pharmacokinetics, affecting the efficacy and toxicity of drugs. This article summarizes the tissue distribution and physiological functions of drug transporters, analyzes the effects of herbs on drug transporters, and discusses the possible mechanisms of herb-drug interactions, providing ideas and references for safe clinical drug use.
Article
Chemistry, Physical
J. R. C. Santos, P. E. Abreu, J. M. C. Marques
Summary: This study investigates the aggregation patterns of curcumin and piperine in different solvents using molecular dynamics simulations. The results show that curcumin forms stable dimers in water, while piperine forms less stable dimers. In ethanol, neither curcumin nor piperine forms dimers. A mixture of ethanol and water reduces the formation of dimers. Larger clusters with stack or cage structures are observed. Each molecule in the cluster exhibits mobility without dissociation.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
J. R. C. Santos, P. E. Abreu, J. M. C. Marques
Summary: This work investigates the aggregation patterns of curcumin and piperine in different solvents through molecular dynamics simulations. In water, curcumin forms stable dimers while piperine forms less stable dimers. Both curcumin and piperine are soluble in ethanol, resulting in less dimer formation. A mixture of ethanol and water reduces the probability of dimer formation for both compounds. The simulations also reveal the presence of complex structures such as stacks and cages within larger clusters.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Medicinal
Moon Hee Lee, Seok-Kyu Yoon, Hyungsub Kim, Yong-Soon Cho, Sungpil Han, Shi Hyang Lee, Kyun-Seop Bae, Jina Jung, Sung Hee Hong, Hyeong-Seok Lim
Summary: This study aimed to examine the pharmacokinetic interactions between bazedoxifene and cholecalciferol and the tolerability of their combined administration in healthy male subjects. The results showed that this combined therapy was well tolerated at the dose levels used in the study, and there was a mild degree of pharmacokinetic interaction.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Ruhul Kayesh, Vishakha Tambe, Chao Xu, Wei Yue
Summary: Impaired transport activity of hepatic OATP1B1 and OATP1B3 due to drug-drug interactions (DDIs) often leads to increased systemic exposure to substrate drugs. This study aimed to assess the OATP1B1- and OATP1B3-mediated DDI potential of the calcium channel blocker nicardipine. The results showed that nicardipine has the potential to cause OATP1B1/3-mediated DDIs, and the consideration of optimal preincubation conditions is important when assessing these interactions in vitro.
Review
Pharmacology & Pharmacy
Young Hee Choi, Young-Won Chin
Summary: Studies have shown that metabolic enzyme and/or transporter-mediated pharmacokinetic changes in a drug caused by concomitant herbal products may affect efficacy and toxicity, but discrepancies between predictive data and clinical significance still exist, adding to confusion regarding the use of herbal products and drug combinations.
Article
Biochemistry & Molecular Biology
Angeliki Chroni, Thomas Mavromoustakos, Stergios Pispas
Summary: The current study focused on developing innovative and highly-stable curcumin-based therapeutics by encapsulating curcumin in biocompatible poly(n-butyl acrylate)-block-poly(oligo(ethylene glycol) methyl ether acrylate) micelles. The successful encapsulation of curcumin within the micelles was confirmed by various techniques, and the exceptional stability of the curcumin-loaded nanocarriers was demonstrated. The research provides new understanding of the encapsulation and release mechanisms of curcumin within biocompatible diblock copolymers and has significant implications for the advancement of safe and effective curcumin-based therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Anne Kleijburg, C. Louwrens Braal, Justin D. Westenberg, Agnes Jager, Stijn L. W. Koolen, Ron H. J. Mathijssen, Carin A. Uyl-de Groot, Pim Wetzelaer, Hannah Penton
Summary: The study aimed to describe health-related quality of life (HRQoL) and productivity in Dutch breast cancer patients treated with tamoxifen in an adjuvant setting. HRQoL was measured using the EQ-5D-5L and FACT-B questionnaire, and productivity using the iMTA Productivity Costs Questionnaire. The results showed no differences in HRQoL scores between 3 months and 6 months after tamoxifen initiation, but age and employment status were associated with lower FACT-B scores. Short-term and long-term productivity improved during the first six months of tamoxifen treatment. These findings provide valuable information for health economic evaluations and decision making for breast cancer patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Leni van Doorn, Wesley J. Visser, Daan C. H. van Dorst, Katrina M. Mirabito Colafella, Stijn L. W. Koolen, Anneke van Egmond-de Mik, Ingrid M. Garrelds, Dominique M. Bovee, Esther Oomen-de Hoop, Sander Bins, Ferry A. L. M. Eskens, Ewout J. Hoorn, A. H. Jan Danser, Ron H. J. Mathijssen, Jorie Versmissen
Summary: This study found that dietary sodium restriction can effectively prevent VEGFI-induced hypertension and proteinuria, without the need for pharmacological interventions.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Nikki de Rouw, Rene J. Boosman, Jacobus A. Burgers, Alwin D. R. Huitema, Anne-Marie C. Dingemans, Hieronymus J. Derijks, David M. Burger, Berber Piet, Lizza E. L. Hendriks, Bonne Biesma, Melinda A. Pruis, Daphne W. Dumoulin, Sander Croes, Ron H. J. Mathijssen, Michel M. van den Heuvel, Rob ter Heine
Summary: This study compared optimized dosing of pemetrexed to standard body surface area-based dosing in patients with non-small cell lung cancer and mesothelioma. The results showed no superiority of optimized dosing in terms of pharmacokinetic endpoint, safety, or quality of life.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2023)
Letter
Pharmacology & Pharmacy
Mirjam de With, Jonathan Knikman, Jan H. M. Schellens, Hans Gelderblom, Annemieke Cats, Henk-Jan Guchelaar, Ron H. J. Mathijssen, Jesse J. Swen, Didier Meulendijks
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Oncology
S. M. Buijs, E. Oomen-de Hoop, C. L. Braal, M. M. van Rosmalen, J. C. Drooger, Q. C. van Rossum-Schornagel, M. B. Vastbinder, S. L. W. Koolen, A. Jager, R. H. J. Mathijssen
Summary: This study found that dose reduction of tamoxifen based on endoxifen levels can decrease its side-effects and improve patients' quality of life.
Article
Medicine, Research & Experimental
Nikki S. IJzerman, Wills F. Filipe, Peter de Bruijn, Florian E. Buisman, Leni van Doorn, Pascal G. Doornebosch, Jessica J. Holster, Cecile Grootscholten, Dirk J. Gruenhagen, Christian P. E. van Bommel, Marjolein Y. V. Homs, Niels F. M. Kok, Cornelis Verhoef, Bas Groot Koerkamp, Koert F. D. Kuhlmann, Ron H. J. Mathijssen, Stijn L. W. Koolen
Summary: This study aimed to quantify the systemic exposure of floxuridine and found that most patients had low concentrations of floxuridine, which decreased over time, indicating minimal systemic side-effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Mirjam de With, Leni van Doorn, Demi C. Maasland, Tessa A. M. Mulder, Esther Oomen-de Hoop, Bianca Mostert, Marjolein Y. V. Homs, Samira El Bouazzaoui, Ron H. J. Mathijssen, Ron H. N. van Schaik, Sander Bins
Summary: This study investigated whether single nucleotide polymorphisms (SNPs) in genes involved in capecitabine metabolism other than DPYD are associated with an increased risk for capecitabine-induced hand-foot syndrome (HFS). The results showed that carriers of the CES1 1165-33 C>A (rs2244613) and CDA 266 + 242 A>G (rs10916825) variant alleles have a higher risk of HFS grade 2.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Wesley S. van de Geer, Ron H. J. Mathijssen, Job van Riet, Neeltje Steeghs, Mariette Labots, Carla van Herpen, Lot A. Devriese, Vivianne C. G. Tjan-Heijnen, Emile E. Voest, Stefan Sleijfer, John W. M. Martens, Edwin Cuppen, Harmen J. G. van de Werken, Sander Bins
Summary: Drug resistance is a persistent problem in cancer therapy, and alterations in drug transport over the cancer cell membrane can contribute to resistance. This study analyzed the mutational landscape of transporter genes in cancer patients who had received different systemic therapies, and identified potential stressor mechanisms that may be involved in drug resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Bram C. Agema, Sanne M. Buijs, Sebastiaan D. T. Sassen, Thomas E. Muerdter, Mathias Schwab, Birgit C. P. Koch, Agnes Jager, Ron H. N. van Schaik, Ron H. J. Mathijssen, Stijn L. W. Koolen
Summary: This study aimed to develop a population pharmacokinetic (POP-PK) model to support precision dosing of tamoxifen by incorporating a continuous CYP2D6 activity scale. By analyzing data from multiple clinical studies, it was found that using a continuous CYP2D6 activity scale can reduce the prediction error of tamoxifen metabolite concentrations. After external validation and dose determination, this model can reduce the proportion of patients with subtherapeutic levels of tamoxifen to less than 5%.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Maryam Lyousoufi, Iris Lafeber, Dinemarie Kweekel, Brenda C. M. de Winter, Jesse J. J. Swen, Paul P. H. Le Brun, Erica C. M. Bijleveld-Olierook, Teun van Gelder, Henk-Jan Guchelaar, Dirk Jan A. R. Moes, Kirsten J. M. Schimmel
Summary: Personalized medicine lacks flexible drug formulations, especially for pediatric patients. This study investigates the feasibility of developing a 3D-printed tablet formulation at the point-of-care that complies with quality requirements for clinical practice, including bioequivalence.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Oncology
Khrystany T. Isebia, Bianca Mostert, Teoman Deger, Jaco Kraan, Vanja de Weerd, Esther Oomen-de Hoop, Paul Hamberg, Brigitte C. M. Haberkorn, Helgi H. Helgason, Ronald de Wit, Ron H. J. Mathijssen, Martijn P. Lolkema, Saskia M. Wilting, Job van Riet, John W. M. Martens
Summary: In this study, the researchers found that the abnormal aneuploidy score of cell-free tumor DNA (ctDNA) in the blood can predict the survival of metastatic castration-resistant prostate cancer (mCRPC) patients, making it a potential biomarker.
MOLECULAR ONCOLOGY
(2023)
Article
Medicine, General & Internal
G. D. Marijn Veerman, Rene J. Boosman, Esther Oomen-de Hoop, Anthonie J. van der Wekken, Idris Bahce, Lizza E. L. Hendriks, Sander Croes, Christi M. J. Steendam, Evert de Jonge, Stijn L. W. Koolen, Neeltje Steeghs, Ron H. N. van Schaik, Egbert F. Smit, Anne-Marie C. Dingemans, Alwin D. R. Huitema, Ron H. J. Mathijssen
Summary: This study investigated the relationship between single nucleotide polymorphisms (SNPs) and the central nervous system (CNS) treatment efficacy of osimertinib in patients with EGFRm+ non-small cell lung cancer. The results showed that ABCG2 34G>A and ABCB1 3435C>T were predictors for developing new CNS metastases during osimertinib treatment. ABCG2 421C>A was significantly related to the incidence of severe toxicity.
Review
Pharmacology & Pharmacy
Suwasin Udomkarnjananun, Thanee Eiamsitrakoon, Brenda C. M. de Winter, Teun van Gelder, Dennis A. Hesselink
Summary: The measurement of whole blood concentration of tacrolimus has been the primary method for therapeutic drug monitoring, but the pharmacologically active fractions are only a small fraction of the measured concentration. Measuring the intracellular tacrolimus concentration may better reflect its pharmacodynamic effects, but conflicting results have been reported. Improvement of the measurement technique and clinical evaluation are needed before its use in clinical practice.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mirjam de With, Leni van Doorn, Esmay Kloet, Anne van Veggel, Maja Matic, Micha J. de Neijs, Esther de Hoop, Esther van Meerten, Ron H. N. van Schaik, Ron H. J. Mathijssen, Sander Bins
Summary: In this study, the correlation between genetic polymorphisms in genes involved in irinotecan metabolism and transport and irinotecan-related toxicity was investigated. The study found that SNPs in ABCG2 and CES1 may serve as predictive markers for irinotecan-induced toxicity.
CLINICAL PHARMACOKINETICS
(2023)
Article
Health Care Sciences & Services
Annemieke van der Padt-Pruijsten, Maria B. L. Leys, Esther Oomen-de Hoop, Carin C. D. van der Rijt, Agnes van der Heide
Summary: This study investigated the impact of a standardised palliative care pathway (PCP) on communication and satisfaction with end-of-life (EOL) care for bereaved relatives of advanced cancer patients. The study found no overall effect of the PCP on communication process and satisfaction with EOL care.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)