Article
Oncology
Xue-Song Sun, Man-Yi Zhu, Dong-Xiang Wen, Dong-Hua Luo, Rui Sun, Qiu-Yan Chen, Hai-Qiang Mai
Summary: This study aimed to establish and validate a prognostic model for locally recurrent nasopharyngeal carcinoma (lrNPC) patients and evaluate the benefit of re-radiotherapy (reRT) in different risk groups. Three independent prognostic factors were identified, and a prognostic model combining these factors was derived. The study found that reRT could benefit low and intermediate-risk subgroups, but not the high-risk subgroup. The findings provide guidance for individualized treatment of lrNPC.
RADIOTHERAPY AND ONCOLOGY
(2022)
Review
Oncology
Lin Su, Lei She, Liangfang Shen
Summary: Nasopharyngeal carcinoma is a common malignant tumor of the head and neck, originating from the mucous epithelium of the nasopharynx. Symptoms are often missed, with majority of patients presenting with locally advanced disease. Concurrent radiation therapy with chemotherapy can improve regional control, but distant metastasis remains a challenge. Adjuvant chemotherapy's role in treating locally advanced NPC is still unclear and associated with increased toxicity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hind Zaine, Benjamin Vandendorpe, Benoit Bataille, Thomas Lacornerie, Jennifer Wallet, Xavier Mirabel, Eric Lartigau, David Pasquier
Summary: Salvage radiotherapy with a boost to macroscopic recurrence in the prostate bed is effective in managing biochemical progression after radical prostatectomy, with 5-year and 8-year survival rates of 90.2% and 69.8%, respectively. The use of a boost should be further evaluated in prospective trials.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Angelika Terbuch, Florian Posch, Thomas Bauernhofer, Philipp J. Jost, Richard Partl, Heidi Stranzl-Lawatsch, Giulia Baciarello, Karim Fizazi, Patrizia Giannatempo, Elena Verzoni, Christopher Sweeney, Praful Ravi, Ben Tran, Umberto Basso, Jeff White, Bruno Vincenzi, Christoph Oing, Hernan Javier Cutuli, Klaus Peter Dieckmann, Marija Gamulin, Michal Chovanec, Christian Daniel Fankhauser, Axel Heidenreich, Osama Mohamad, Constance Thibault, Stefanie Fischer, Silke Gillessen
Summary: This study retrospectively analyzed data from 61 patients with testicular seminoma who experienced relapse after radiation therapy. The results showed that cisplatin-based chemotherapy led to excellent outcomes for these patients. The median time to relapse after radiation therapy was 15.6 months, and some patients relapsed more than 2 years or even 5 years later.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Neal Andruska, Lily Mahapatra, Randall J. Brenneman, Jason T. Rich, Brian C. Baumann, Leigh Compton, Wade L. Thorstad, Mackenzie D. Daly
Summary: The size of excision margins in patients with Merkel cell carcinoma can impact recurrence and survival rates, with larger margins associated with better outcomes. Close or positive pathologic margins were linked to a higher risk of relapse and death. It is important to consider wider excision margins, especially in populations with lower rates of adjuvant radiation.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Otorhinolaryngology
Saleh F. Aldhahri, Maha M. Barakeh, Rakan J. Almetary, Renad B. Alfirm, Hisham M. Almousa, Hemail M. Alsubaie
Summary: Head and neck cancers in Saudi Arabia account for 6% of all malignancies, with 33% being nasopharyngeal carcinoma (NPC). A retrospective study of NPC patients found that treatment failure patterns and salvage treatment outcomes vary. Concurrent salvage chemoradiotherapy showed the best survival for failed cases.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2023)
Article
Oncology
Michael Connor, Arnold C. Paulino, Ralph P. Ermoian, William F. Hartsell, Daniel J. Indelicato, Stephanie Perkins, Victor Mangona, Nicholas DeNunzio, Nadia N. Laack, Christine Hill-Kayser, Young Kwok, John Han-Chih Chang, Torunn Yock, Iain MacEwan
Summary: This study aimed to characterize proton craniospinal irradiation (CSI) practice patterns in the United States by examining CSI plans in the Pediatric Proton/Photon Consortium Registry (PPCR). The study found consistent variation based on treating institution in proton CSI practices, including optic nerve, vertebral body, sacral nerve, cranial, and spinal nerve coverage.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Sixia Chen, Dong Yang, Xueyin Liao, Ying Lu, Bin Yu, Meng Xu, Ying Bin, Pingting Zhou, Zhendong Yang, Kang Liu, Rensheng Wang, Tingting Zhao, Min Kang
Summary: This study retrospectively analyzed the recurrence and metastasis in patients with nasopharyngeal carcinoma treated with IMRT. The study found that most recurrences occurred within the first three years after treatment, and in-field recurrence was the most common pattern for treatment failure. The risk of distant metastasis was correlated with higher N stage, lower neck nodal metastasis, larger cervical lymph nodes, and longer time to response for residual NPC in cervical adenopathy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
David A. Bush, Michael Volk, Jason C. Smith, Mark E. Reeves, Samrat Sanghvi, Jerry D. Slater, Michael deVera
Summary: This study compares survival rates, recurrence patterns, toxicity, and treatment cost in patients with hepatocellular carcinoma (HCC) treated with either transarterial chemoembolization (TACE) or proton beam radiotherapy (PBT). The results show that PBT and TACE have similar overall survival rates for HCC treatment, but PBT has better progression-free survival and local control. Patients treated with PBT require fewer treatment courses, fewer hospitalization days, and lower treatment costs compared to TACE.
Article
Oncology
Maria A. Smolle, Dimosthenis Andreou, Judith Woelfel, Ibtissam Acem, Michiel Aj Van De Sande, Lee Jeys, Han Bonenkamp, Rob Pollock, Per-Ulf Tunn, Rick Haas, Florian Posch, Robert J. Van Ginkel, Cornelis Verhoef, Bernadette Liegl-Atzwanger, Dalia Moustafa-Hubmer, Philipp J. Jost, Andreas Leithner, Joanna Szkandera
Summary: Neoadjuvant and adjuvant radiotherapy are associated with lower risk of local recurrence, but do not seem to affect risk of distant metastasis or overall survival. Neoadjuvant radiotherapy may be preferred over adjuvant radiotherapy for better local control rates.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Jianming Ding, Zirong Li, Yuhao Lin, Chaoxiong Huang, Jiawei Chen, Jiabiao Hong, Zhaodong Fei, Qichao Zhou, Chuanben Chen
Summary: This study aimed to investigate the prognostic significance of PET/CT-based radiomics signatures and clinical features in predicting local recurrence-free survival (LRFS) in nasopharyngeal carcinoma (NPC). A radiomics-clinical nomogram was developed using PET/CT images and clinical data from 726 patients. The nomogram showed good performance in predicting LRFS and distinguishing high-risk patients.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Baoqiu Liu, Mingxing Zhang, Yanqing Cao, Zhe Wang, Xicheng Wang
Summary: This study aimed to investigate the prognostic factors related to overall survival (OS) and cancer-specific survival (CSS) in elderly patients with de novo metastatic nasopharyngeal carcinoma (NPC) in non-endemic areas. The study found that race, bone metastasis, and chemotherapy were independent prognostic factors of OS, while sequence number had an independent effect on prognosis.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Wen-Shan Liu, Kuo-Wang Tsai, Bor-Hwang Kang, Ching-Chieh Yang, Wei-Lun Huang, Ching-Chih Lee, Yu-Chang Hu, Kuo-Ping Chang, Hsiu-Min Chen, Yaoh-Shiang Lin
Summary: The study compared the treatment outcomes and adverse effects in patients with nasopharyngeal carcinoma using different treatment methods. The group with simultaneously reduced volume and dose showed better overall survival and salvage survival, along with a lower ratio of severe lung infection.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Xiaomin Ou, Wenbin Yan, Yangle Huang, Xiayun He, Hongmei Ying, Xueguan Lu, Hui Zhu, Bin Wu, Jiazhou Wang, Chaosu Hu
Summary: This study investigated the anatomical patterns and pathways of local recurrence in patients with nasopharyngeal carcinoma, providing clinical evidence for the delineation of the clinical target volume. The risk of local recurrence was found to be higher in the posterior nasal cavity and clivus. Based on the pathways of local recurrence, the study classified them into five types, with anterior extension being the most common. These findings contribute to the individualized delineation of the clinical target volume in nasopharyngeal carcinoma.
RADIATION ONCOLOGY
(2023)
Article
Oncology
Anna Cavallo, Nicola Alessandro Iacovelli, Nadia Facchinetti, Tiziana Rancati, Salvatore Alfieri, Tommaso Giandini, Alessandro Cicchetti, Carlo Fallai, Rossana Ingargiola, Lisa Licitra, Laura Locati, Stefano Cavalieri, Emanuele Pignoli, Domenico Attilio Romanello, Riccardo Valdagni, Ester Orlandi
Summary: A predictive model was built for acute salivary dysfunction in nasopharyngeal cancer patients, with the dosimetric part of the model being highly reliable while the clinical risk part has some limitations. Validation results confirmed the importance of dosimetric factors and the model's discriminative power.
Article
Otorhinolaryngology
Michaela Plath, Hannah M. Thielen, Ingo Baumann, Karim Zaoui, Philippe A. Federspil
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2020)
Review
Oncology
Paul Windisch, Daniel R. Zwahlen, Stefan A. Koerber, Frederik L. Giesel, Juergen Debus, Uwe Haberkorn, Sebastian Adeberg
Article
Oncology
Sebastian Regnery, Tanja Eichkorn, Fabian Weykamp, Thomas Held, Lisa-Antonia Dinges, Fabian Schunn, Hauke Winter, Michael Thomas, Jurgen Debus, Rami A. El Shafie, Sebastian Adeberg, Juliane Hoerner-Rieber
Article
Oncology
Tobias Forster, Clara Koehler, Rami El Shafie, Fabian Weykamp, Laila Koenig, Nathalie Arians, Sebastian Adeberg, Laura Michel, Katharina Smetanay, Michael Golatta, Christof Sohn, Joerg Heil, Andreas Schneeweiss, Jurgen Debus, Juliane Horner-Rieber
Article
Oncology
Maximilian P. Schmid, Thomas Held, Kristin Lang, Klaus Herfarth, Juliane Hoerner-Rieber, Semi B. Harrabi, Julius Moratin, Christian Freudlsperger, Karim Zaoui, Jurgen Debus, Sebastian Adeberg
Summary: IMRT with carbon ion radiotherapy boost shows excellent outcomes in acinic cell carcinoma, especially in patients after R1 resection, making it a promising treatment modality for inoperable patients.
Article
Otorhinolaryngology
Ralph Hohenberger, Isabel Bremer, Regina Brinster, Peter K. Plinkert, Philippe A. Federspil
Summary: This study evaluated the rate of surgical site infection (SSI) after parotid gland surgery and found that smoking and male gender were associated with a higher SSI rate. Factors such as male gender, smoking, and high NHSN risk index were significantly associated with SSI, while antibiotic prophylaxis did not have a protective effect.
CLINICAL OTOLARYNGOLOGY
(2021)
Article
Oncology
Thomas Held, Christopher Herpel, Franz Sebastian Schwindling, Leo Christ, Kristin Lang, Sebastian Regnery, Tanja Eichkorn, Adriane Hommertgen, Cornelia Jaekel, Johannes Krisam, Julius Moratin, Jan Mrosek, Karl Metzger, Karim Zaoui, Tracy Moutsis, Semi Harrabi, Klaus Herfarth, Christian Freudlsperger, Peter Rammelsberg, Juergen Debus, Sebastian Adeberg
Summary: The study aims to investigate the application of 3D printed, tooth-borne tissue retraction devices in head and neck cancer patients undergoing radiotherapy, with the potential to reduce acute and late toxicity compared to conventional dental splints. Through a randomized controlled trial, the tolerability and efficacy of TRDs for radiation treatment will be prospectively evaluated.
RADIATION ONCOLOGY
(2021)
Article
Oncology
Katharina Weusthof, Peggy Luttich, Sebastian Regnery, Laila Konig, Denise Bernhardt, Olaf Witt, Klaus Herfarth, Andreas Unterberg, Christine Jungk, Benjamin Farnia, Stephanie E. Combs, Juergen Debus, Stefan Rieken, Semi Harrabi, Sebastian Adeberg
Summary: The study suggests that modern radiation therapy techniques such as proton or photon irradiation do not have a negative impact on neurocognitive outcomes in pediatric brain tumor patients. However, declines in neurocognitive abilities were observed after surgery and photon radiotherapy. Domains dependent on intact white matter structures appear particularly vulnerable to brain tumor treatment irrespective of treatment approach.
Article
Oncology
Maximilian Knoll, Maria Waltenberger, Jennifer Furkel, Ute Wirkner, Aoife Ward Gahlawat, Ivana Dokic, Christian Schwager, Sebastian Adeberg, Stefan Rieken, Tobias Kessler, Felix Sahm, Laila Koenig, Christel Herold-Mende, Stephanie E. Combs, Juergen Debus, Amir Abdollahi
Summary: The study demonstrates the potential of whole blood transcriptome analysis as a non-invasive method for longitudinal molecular monitoring of recurrent high-grade glioma patients undergoing carbon ion irradiation. The findings also suggest that the peripheral blood transcriptome can be used to identify patient and tumor characteristics, as well as treatment-specific fingerprints. Furthermore, the study identifies two distinct trajectories of rHGG evolution and identifies prognostic biomarkers.
Article
Oncology
Maike Kuechler, Rami A. El Shafie, Sebastian Adeberg, Klaus Herfarth, Laila Koenig, Kristin Lang, Juliane Hoerner-Rieber, Peter Karl Plinkert, Wolfgang Wick, Felix Sahm, Simon David Sprengel, Juergen Debus, Denise Bernhardt
Summary: Radiotherapy options for vestibular schwannomas include photon beam single-dose radiosurgery, (hypo)fractionated radiotherapy, and proton therapy. This study compared the outcomes of these treatments in 261 patients and found that they showed similar overall clinical and functional results, with varying rates of cranial nerve impairment.
Article
Oncology
Dawn P. Liew, Manuel Roehrich, Lisa Loi, Sebastian Adeberg, Mustafa Syed, Ewgenija Gutjahr, Heinz Peter Schlemmer, Frederik L. Giesel, Martin Bendszus, Uwe Haberkorn, Daniel Paech
Summary: The study analysed the correlation between Ga-68-FAPI PET signals and MRI signals in 12 ACC patients. The results showed very weak positive correlations between Ga-68-FAPI PET signals and ceT1w values, and weak negative correlations with T2w values. This indicates that Ga-68-FAPI PET signalling is an independent signal in ACC patients, not just a surrogate marker of MRI sequences.
Article
Oncology
Ricarda Wickert, Thomas Tessonnier, Maximilian Deng, Sebastian Adeberg, Katharina Seidensaal, Line Hoeltgen, Juergen Debus, Klaus Herfarth, Semi B. Harrabi
Summary: Radiotherapy is an important treatment for pediatric ependymoma. Proton therapy achieves better results than photon radiation treatment in terms of target coverage and organ-sparing. Helium ions, with their physical properties, could further reduce side effects and protect healthy tissue. This study provides a comprehensive evaluation of helium ion plans compared to proton therapy and intensity modulated radiotherapy, and supports the potential benefit of helium ions through normal tissue complication probability analyses.
Article
Medicine, General & Internal
Oliver Ristow, Jan Lukas Birgel, Thomas Rueckschloss, Thomas Held, Kristin Lang, Maximilian Smielowski, Sven Zittel, Julius Moratin, Maximilian Pilz, Michael Engel, Juergen Hoffmann, Karl Semmelmayer
Summary: The study aimed to investigate how tissue injury after irradiation affects the surgical outcomes of patients with osteoradionecrosis of the jaw (ORN). The results showed that soft tissue injury from fibrosis and xerostomia increased the likelihood of treatment failure, while soft tissue reconstruction with a microvascular graft improved therapeutic success.
Article
Medicine, General & Internal
Christopher Herpel, Thomas Held, Christos Labis, Leo Christ, Kristin Lang, Sebastian Regnery, Tanja Eichkorn, Adriane Lentz-Hommertgen, Cornelia Jaekel, Julius Moratin, Karl Semmelmayer, Tracy Thecla Moutsis, Karim Plath, Oliver Ristow, Christian Freudlsperger, Sebastian Adeberg, Juergen Debus, Peter Rammelsberg, Franz Sebastian Schwindling
Summary: This study aimed to evaluate oral sequelae after head and neck radiotherapy using two different intraoral appliances. Thermoplastic dental splints provided protection against backscattered radiation from dental structures while semi-individualized, 3D-printed tissue retraction devices spared healthy tissue from irradiation. The use of tissue retraction devices showed positive trends in improving oral disability and saliva quality.
JOURNAL OF CLINICAL MEDICINE
(2023)