Review
Polymer Science
Amit M. E. Arefin, Nava Raj Khatri, Nitin Kulkarni, Paul F. Egan
Summary: Polymer 3D printing shows great potential in medical applications, with ongoing research focusing on improving materials, processes, and design strategies to meet the needs of medical devices and tissue engineering.
Article
Materials Science, Multidisciplinary
Amit Bandyopadhyay, Susmita Bose, Roger Narayan
Summary: This article reviews the impact of technological development on the manufacturing of biomedical devices and discusses the progress and regulatory issues of 3D printing biomaterials and medical devices.
Article
Engineering, Manufacturing
Jinxing Sun, Shixiang Yu, Wade-Zhu James, Yue Wang, Hongqiao Qu, Shuai Zhao, Rui Zhang, Jinglei Yang, Jon Binner, Jiaming Bai
Summary: Geometrically complex ceramic composite components with exceptional damage tolerance can be fabricated using additive manufacturing and novel biomimetic toughening design.
ADDITIVE MANUFACTURING
(2022)
Article
Engineering, Industrial
Zhiping Wang, Dominique Millet, Yicha Zhang
Summary: Additive manufacturing (AM) is widely used to create 3D models for medical purposes. A new method is proposed to simplify the processing chain and improve the efficiency of designing and printing porous medical models, allowing direct design of toolpath slices using CT images. This has the potential to significantly change the current medical AM paradigm.
CIRP ANNALS-MANUFACTURING TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Milena Djukanovic, Ardijan Mavric, Jovana Jovanovic, Milovan Roganovic, Velibor Boskovic
Summary: Montenegro responded to the COVID-19 pandemic by utilizing 3D printers to produce medical equipment and designing innovative thermo-sensored medical gear to protect medical staff and patients, proving to be efficient and easy to use.
APPLIED SCIENCES-BASEL
(2021)
Article
Polymer Science
Paul F. Egan, Nava Raj Khatri, Manasi Anil Parab, Amit M. E. Arefin
Summary: Emerging polymer 3D-printing technologies enable the design and fabrication of mechanically efficient lattice structures with intricate microscale structures. This study investigates how design and processing strategies influence the mechanical performance of lattice structures. The results reveal the importance of design and fabrication strategies in determining the mechanical properties of lattice structures suitable for various engineering applications.
Article
Engineering, Environmental
Fedor A. Kucherov, Leonid Romashov, Valentine P. Ananikov
Summary: An innovative method for creating lab-on-a-chip microflow reactors was developed based on in-depth studies of chemical processes at plastic-metal interfaces. The method involves 3D printing the reactor core with ABS plastic, followed by electroless copper and galvanic nickel plating for a durable and versatile design. Despite the simple procedure and low-cost materials used, the reactors exhibited excellent chemical resistance, modular design capabilities, and high performance in a variety of chemical processes targeting biologically active molecules.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Physical
Tiankuo Chu, Soyeon Park, Kun (Kelvin) Fu
Summary: This paper reviews recent studies on advanced electrode architecture design and manufacturing enabled by emerging additive manufacturing techniques for future high-performance energy storage devices. It highlights the importance of advanced electrode structure in promoting the performance of energy storage devices and summarizes the latest research on 3D printed electrodes.
Review
Biotechnology & Applied Microbiology
Ante B. V. Pettersson, Rosa Maria Ballardini, Marc Mimler, Phoebe Li, Mika Salmi, Timo Minssen, Ian Gibson, Antti Makitie
Summary: 3D printing technology has been widely applied in medicine, but the legal landscape is struggling to keep pace. This scoping review identified several unresolved legal issues in medical 3D printing, including terminological confusion, lack of specific legislation for patient-matched products, and undefined legal roles of CAD files.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Engineering, Environmental
Jie Zhu, Peiwen Wu, Yanhong Chao, Jiangtao Yu, Wenshuai Zhu, Zhichang Liu, Chunming Xu
Summary: Three-dimensional (3D) printing is revolutionizing the design and manufacturing of 3D objects by transforming digital models into solid models. In the field of catalysis, 3D printing technology offers new possibilities and is widely applied in related catalytic reactions and processes.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Mechanical
Qiang Zhang, Shayuan Weng, Craig M. Hamel, S. Macrae Montgomery, Jiangtao Wu, Xiao Kuang, Kun Zhou, H. Jerry Qi
Summary: This study investigated the volume shrinkage-induced distortion of DLP-printed parts through experiments, theoretical modeling, and FEA simulations, with experiments validating the efficiency of the proposed FEA simulations. FEA was further applied to predict shape distortion in printed microfluidic channels and overhanging structures for designing printing parameters based on FEA.
EXTREME MECHANICS LETTERS
(2021)
Review
Construction & Building Technology
Matthias Leschok, Ina Cheibas, Valeria Piccioni, Bharath Seshadri, Arno Schluter, Fabio Gramazio, Matthias Kohler, Benjamin Dillenburger
Summary: This paper provides a comprehensive review of 3D printed facades, covering three main topics: computational design strategies, fabrication processes and materials, and performance assessment. The design section explores computational tools and methods for designing and producing 3D printed facades. The chapter on fabrication processes, materials, and applications demonstrates the potential of the technology for facade applications sorted by material groups. The performance assessment section discusses current approaches to evaluating and validating the performance of 3D printed facades. Finally, the paper addresses knowledge gaps, challenges, and future trends, offering insights into innovative solutions for facade design and fabrication.
AUTOMATION IN CONSTRUCTION
(2023)
Review
Materials Science, Multidisciplinary
Yijie Jiang, Md Nurul Islam, Rui He, Xiaozhou Huang, Peng-Fei Cao, Rigoberto C. Advincula, Narendra Dahotre, Pei Dong, H. Felix Wu, Wonbong Choi
Summary: This article reviews the state-of-the-art 3D printing methods in the manufacturing of sensors and summarizes the performance of 3D printed sensing materials and devices. Special attention is given to emerging multimaterial printing and 4D printing technologies, which will enable the fabrication of new generation structures with multifunctionalities. The article also compares the performance of 3D printed sensors with traditionally manufactured sensors. The viewpoints on the future development of 3D printed sensors are provided.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Engineering, Manufacturing
Qifeng Qian, Jan Henk Kamps, Brian Price, Hao Gu, Ricky Wildman, Richard Hague, Belen Begines, Christopher Tuck
Summary: In this study, a 3D reactive inkjet printing method was developed to successfully fabricate bisphenol A-polycarbonate material, demonstrating the capability to broaden the range of AM materials to include engineering grade polymers.
ADDITIVE MANUFACTURING
(2022)
Review
Engineering, Multidisciplinary
Xin Ning Zhang, Qiang Zheng, Zi Liang Wu
Summary: This paper reviews the recent progress in 3D printing of tough hydrogels and their applications. It provides an overview of the advantages and requirements of tough hydrogel systems for specific 3D printing technologies, and summarizes the network structures, mechanical performances, toughening mechanisms, and representative applications of the printed tough hydrogels. It also discusses the recent advances in 4D printing of tough hydrogels as a prospective direction for soft actuators and robots.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Engineering, Biomedical
Pall Asgeir Bjornsson, Alexander Baker, Ingmar Fleps, Yves Pauchard, Halldor Palsson, Stephen J. Ferguson, Sigurdur Sigurdsson, Vilmundur Gudnason, Benedikt Helgason, Lotta Maria Ellingsen
Summary: This study proposes a deep neural network-based automated femur segmentation method, which can accurately and quickly segment the proximal femur, suitable for hip-fracture risk screening.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING-IMAGING AND VISUALIZATION
(2023)
Article
Biotechnology & Applied Microbiology
Anita Fung, Ingmar Fleps, Peter A. Cripton, Pierre Guy, Stephen J. Ferguson, Benedikt Helgason
Summary: Sideways falls causing femoral fractures are a major concern for the elderly, and current prevention methods are not very effective. Prophylactic femoral augmentation systems involving ceramic-based bone cements are gaining attention as a potential alternative. This study evaluated the mechanical effectiveness of different bone cement injection patterns and found that supporting the femoral neck cortex is crucial in preventing fractures.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Orthopedics
Shaghayegh Basatvat, Frances C. Bach, Marcos N. Barcellona, Abbie L. Binch, Conor T. Buckley, Brian Bueno, Nadeen O. Chahine, Ana Chee, Laura B. Creemers, Stefan Dudli, Bailey Fearing, Stephen J. Ferguson, Jennifer Gansau, Benjamin Gantenbein, Rahul Gawri, Juliane D. Glaeser, Sibylle Grad, Julien Guerrero, Lisbet Haglund, Paula A. Hernandez, Judith A. Hoyland, Charles Huang, James C. Iatridis, Svenja Illien-Junger, Liufang Jing, Petra Kraus, Lisanne T. Laagland, Gernot Lang, Victor Leung, Zhen Li, Thomas Lufkin, Josette C. van Maanen, Emily E. McDonnell, Chris J. Panebianco, Steven M. Presciutti, Sanjna Rao, Stephen M. Richardson, Sarah Romereim, Tara C. Schmitz, Jordy Schol, Lori Setton, Dmitriy Sheyn, Joseph W. Snuggs, Y. Sun, Xiaohong Tan, Marianna A. Tryfonidou, Nam Vo, Dong Wang, Brandon Williams, Rebecca Williams, S. Tim Yoon, Christine L. Le Maitre
Summary: This study aims to standardize the extraction and expansion techniques for nucleus pulposus (NP) cells, in order to reduce variability between laboratories and improve comparability of results. The most commonly used methods for NP cell extraction, expansion, and re-differentiation were identified through a global survey. Recommended protocols for NP cell culture in different species were provided to support harmonization and cross-lab comparisons.
Article
Genetics & Heredity
Stephanie Huber, Yann Ladner, Martin J. Stoddart, Michael Leunig, Stephen J. Ferguson
Summary: The study aimed to characterize the transcriptome and mechanobiological function of the labrum, a fibrocartilaginous ring surrounding the acetabulum. RNA-seq and gene ontology analysis revealed significant differential expression of genes associated with extracellular matrix organization between the labrum and cartilage tissue. Mechanical loading upregulated genes related to the extracellular matrix and preserved tissue adaptation mechanism. This research provides important insights for the development of labrum tissue-engineering solutions.
Article
Engineering, Biomedical
Jenny Carlsson, Anna Braesch-Andersen, Stephen J. Ferguson, Per Isaksson
Summary: A dynamic phase-field fracture finite element model is used to investigate rapid bone fracture in human trabecular bone based on high-resolution three-dimensional computed tomography images. The model is compared to quasi-static experimental results and a quasi-static phase-field finite element model. The experiment shows complex crack evolution with multiple crack fronts and crack arrests, while the quasi-static phase-field fracture model can reasonably capture the fractures in the experiment. At higher load rates, inertia effects significantly contribute to increased stiffness, higher peak forces, and more cracks spread over a larger volume. The study concludes that dynamic fracture models are necessary for simulating rapid bone fracture.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Editorial Material
Polymer Science
Paul E. F. Egan
Article
Biotechnology & Applied Microbiology
Fabio D'Isidoro, Clara Brockmann, Bernd Friesenbichler, Thomas Zumbrunn, Michael Leunig, Stephen J. Ferguson
Summary: This study used a moving fluoroscopic robot to measure the hip joint motion of 15 patients with total hip arthroplasty (THA) during unrestricted activities of daily living. The results showed that current pre-clinical wear testing procedures do not accurately reflect the in-vivo daily motions of THA patients. The patient-specific kinematics measured can be used for in vitro and computational simulations to investigate the impact of individual motion patterns on predicted wear or impingement.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biology
Delia Schumperlin, Christoph Scharer, Luzia Kalberer, Stephen J. Ferguson, Silvio R. Lorenzetti
Summary: This study aimed to test the validity and reliability of a textile insole for measuring ground reaction force (GRF) during landing tasks. Compared to force plate data, most of the statistical analysis showed no significant difference in the force curves measured by the insoles. However, the insoles underestimated the maximal vertical GRF during measurement.
BMC RESEARCH NOTES
(2023)
Article
Chemistry, Multidisciplinary
Seunghun S. Lee, Nicole Kleger, Gisela A. Kuhn, Helen Greutert, Xiaoyu Du, Thijs Smit, Andre R. Studart, Stephen J. Ferguson
Summary: Digital Light Processing is used to fabricate a hive-structured assemblable bespoke scaffold (HIVE) that can be manually assembled and customized for specific defect. It can be filled with different biological factors in different areas to provide site-specific treatments. Through in vitro and in vivo experiments, it has been shown to induce osteogenesis and angiogenesis in a controlled manner.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Aapo Ristaniemi, Amra Secerovic, Vincent Dischl, Francesco Crivelli, Sarah Heub, Diane Ledroit, Gilles Weder, Sibylle Grad, Stephen J. Ferguson
Summary: The physiological and degenerative levels of maximum principal strains and stresses in bovine intervertebral disc tissue were determined through finite element analysis. It was found that when applying 0.1 MPa of compression and +/- 2-3 degrees of flexion and +/- 1-2 degrees of torsion, the mechanical parameters remained at physiological levels. However, with +/- 6-8 degrees of flexion in combination with +/- 2-4 degrees of torsion, the stresses in the outer annulus fibrosus exceeded degenerative levels. These findings provide important guidelines for bioreactor experiments with bovine intervertebral discs.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Andre M. Souza Plath, Stephanie Huber, Serena R. R. Alfarano, Daniel F. F. Abbott, Minghan Hu, Victor Mougel, Lucio Isa, Stephen J. J. Ferguson
Summary: To improve the integration of osteoarthritis scaffold-based grafts, electrospun poly(& epsilon;-caprolactone)/zein-based scaffolds were proposed. The zein surface segregation in the membranes changed the hydrophobic behavior of the materials and increased the cell yield and metabolic activity. The co-electrospun PCL/zein scaffolds showed promising surface and biocompatibility properties for articular-tissue-engineering applications.
BIOENGINEERING-BASEL
(2023)
Article
Nanoscience & Nanotechnology
Xiaoyu Du, Sean Ronayne, Seunghun S. Lee, Jackson Hendry, Douglas Hoxworth, Ryan Bock, Stephen J. Ferguson
Summary: This study focused on the fabrication of 3D-printed polyether ether ketone/silicon nitride (PEEK/SiN) scaffolds with a triply periodic minimal surface (TPMS) structure. The scaffolds demonstrated similar mechanical properties to trabecular bone and stimulated osteogenic differentiation. As a result, PEEK/SiN TPMS scaffolds show significant potential for bone tissue engineering and as candidates for spinal fusion implants.
ACS APPLIED BIO MATERIALS
(2023)
Article
Sport Sciences
Basil Achermann, Katja Oberhofer, Stephen J. Ferguson, Silvio R. Lorenzetti
Summary: Velocity-based training (VBT) is monitored using kinematics measured by expensive devices. This study evaluates the accuracy and precision of the Apple Watch 7 and Enode Pro device for measuring velocity during the back squat exercise. The results show that the barbell-mounted Apple Watch is the most valid for assessing propulsive and peak lifting velocity.
Article
Chemistry, Multidisciplinary
Jean Schoeller, Karin Wuertz-Kozak, Stephen J. J. Ferguson, Markus Rottmar, Jonathan Avaro, Yvonne Elbs-Glatz, Michael Chung, Rene M. Rossi
Summary: The ability of poly(ethylene-co-vinyl alcohol) nanofibers to release ibuprofen for the treatment of chronic wounds was evaluated. The electrospinning of different compositions of poly(ethylene-co-vinyl alcohol) copolymers was optimized, and the release kinetics of ibuprofen from the nanofibers at different temperatures were studied. The scaffolds also showed no cytotoxicity to normal human fibroblasts, indicating their potential for use in chronic wound treatment.
NANOSCALE ADVANCES
(2023)
Article
Mathematical & Computational Biology
Xiaoyu Du, Yijun Zhou, Lingzhe Li, Cecilia Persson, Stephen J. Ferguson
Summary: Investigating the dynamic properties of implants is crucial for their safety and compatibility with natural spinal tissue. This study presents a simplified model of a cantilever beam to explore the effects of holes/pores on the structures. The natural frequencies and damping ratios of cantilever beams with open holes made of polycarbonate (PC) were investigated numerically, analytically, and experimentally. Finite element analysis accurately simulated the damped vibration behavior of cantilever beams with open holes, highlighting the potential of this method for analyzing the dynamic response of complex structures and improving implant design.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
