Journal
REDOX BIOLOGY
Volume 21, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.redox.2018.101074
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Funding
- Ministerio de Ciencia, Innovacion y Universidades (MCNU) [BIO2017-83640-P, RYC-2014-16604]
- European Research Area Network on Cardiovascular Diseases (ERA-CVD/ISCIII, MINOTAUR) [AC16/00045]
- CNIC-Severo Ochoa intramural grant program [03-2016 IGP]
- Pro CNIC Foundation
- Severo Ochoa Center of Excellence [SEV-2015-0505]
- MCNU
- CNIC-ACCIONA Master Fellowship
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The nanomechanics of sarcomeric proteins is a key contributor to the mechanical output of muscle. Among them, thin emerges as a main target for the regulation of the stiffness of striated muscle. In the last years, single-molecule experiments by Atomic Force Microscopy (AFM) have demonstrated that redox posttranslational modifications are strong modulators of the mechanical function of titin. Here, we provide an overview of the recent development of the redox mechanobiology of thin, and suggest avenues of research to better understand how the stiffness of molecules, cells and tissues are modulated by redox signaling in health and disease.
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