Article
Biotechnology & Applied Microbiology
Wen Liu, Fanjun Cheng
Summary: Studies have shown that circCRKL plays a role in inhibiting cell proliferation in AML by sponging miR-196a-5p and miR-196b-5p to promote p27 expression. This suggests circCRKL as a potential new target for AML therapy.
Article
Cell Biology
Ruizhe Ren, Kefan Ma, Yuanqing Jiang, Junbo Chen, Yaohui Kou, Zhen Ge, Zhaoming Chen, Xiyang Wei, Luyang Yu
Summary: Angiogenesis is involved in various physiological and pathological processes. MicroRNAs have been found to play a role in angiogenesis regulation, but the specific role of angiomiRs is not fully understood. This study revealed the negative regulatory role of miR-196b-5p in angiogenesis through the hypoxia/miR-196b-5p/HMGA2/HIF1a loop, suggesting the potential of miR-196b-5p as a target for antiangiogenic therapy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Wenjing Wu, Keke Liu, Zhongyu You, Jin Zhang
Summary: Using BGISEQ-500 sequencing technology, this study found that miR-196b-3p expression was 32-fold higher and miR-450b-3p expression was 8-fold lower in intramuscular adipocytes (IM) compared to subcutaneous adipocytes (SC) in pigs. Functional studies revealed that miR-196b-3p inhibits adipogenesis by targeting CD47 via the AMPK signaling pathway, while miR-450b-3p promotes adipogenesis by targeting SIRT1 via the Wnt/β-catenin signaling pathway.
Article
Genetics & Heredity
Yuanxue Yang, Yun Zhang, Aiyu Wang, Ailing Duan, Chao Xue, Kaiyun Wang, Ming Zhao, Jianhua Zhang
Summary: This study investigated the resistance of Spodoptera frugiperda to insecticides and the regulatory roles of miRNAs. RNA-Seq analysis revealed that differentially expressed miRNAs play an important role in the insecticide resistance of S. frugiperda. Overexpression of specific miRNAs significantly increased the mortality of S. frugiperda to insecticides.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Piero Di Battista, Federica Lovisa, Enrico Gaffo, Ilaria Gallingani, Carlotta C. Damanti, Anna Garbin, Lavinia Ferrone, Elisa Carraro, Marta Pillon, Luca Lo Nigro, Rossella Mura, Marco Pizzi, Vincenza Guzzardo, Angelo Paolo Dei Tos, Alessandra Biffi, Stefania Bortoluzzi, Lara Mussolin
Summary: This study identified significant dysregulation of miRNAs in pediatric ALK-positive ALCL through RNA sequencing, with particular focus on the association of miR-214-5p down-regulation with aggressive non-common histology. These findings suggest that the level of miR-214-5p may help refine prognostic stratification in pediatric ALK-positive ALCL.
FRONTIERS IN ONCOLOGY
(2021)
Article
Veterinary Sciences
Juber Herrera-Uribe, Sara Zaldivar-Lopez, Carmen Aguilar, Carmen Entrenas-Garcia, Rocio Bautista, M. Gonzalo Claros, Juan J. Garrido
Summary: This study identified differentially expressed miRNAs in the ileum of S. Typhimurium-infected pigs using small RNA sequencing, and found that miR-194a-5p regulates the expression of the TLR4 gene, which is important in pathogen virulence, recognition, and activation of innate immunity in Salmonella infection.
VETERINARY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Natalia Baulina, Maria Pisklova, Ivan Kiselev, Olga Chumakova, Dmitry Zateyshchikov, Olga Favorova
Summary: This study analyzed the levels of miRNAs in the plasma of hypertrophic cardiomyopathy (HCM) patients and identified miR-499a-5p as a dysregulated miRNA in HCM. Further investigation showed that carriers of pathogenic/likely pathogenic variants in the MYH7 gene had higher levels of miR-499a-5p compared to controls and carriers of MYBPC3 gene variants. The study suggests that miR-499a-5p could serve as a circulating biomarker for HCM caused by MYH7 gene variants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ronald O. B. de Keizer, Anne L. M. Vriends, Gijsbert J. Hotte, Dion A. Paridaens, Erik A. C. Wiemer, Robert M. Verdijk
Summary: The study aims to find microRNA biomarkers to distinguish between Ocular Sebaceous Carcinoma (OSC) and Squamous Cell Carcinomas of the Conjunctiva (SCCC), as well as normal tissue. The combination of miR-196b-5p and miR-107 can be used as an additional diagnostic tool to differentiate OSC and SCCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Delnya Gholami, Farzane Amirmahani, Reza Salman Yazdi, Tahereh Hasheminia, Hossein Teimori
Summary: The study found that up-regulation of miR-182-5p, miR-192-5p, and miR-493-5p may serve as potential biomarkers for TZ. Additionally, the expression level of the CRISP3 glycosylated isoform was significantly lower in TZ patients compared to those with normal sperm. These results suggest a significant role of CRISP3 protein and miRs in male infertility.
REPRODUCTIVE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Guohua Lai, Renli Zhao, Weida Zhuang, Zuoxu Hou, Zefeng Yang, Peipei He, Jiachang Wu, Hongxun Sang
Summary: In the bone marrow microenvironment of postmenopausal osteoporosis, BMSC-derived exosomal miRNAs, specifically miR-27a-3p and miR-196b-5p, have been found to play an important regulatory role in bone formation and bone resorption. The study suggests that these miRNAs may have therapeutic potential for the treatment of osteoporosis.
Article
Oncology
Qi-Zhang Wang, Ze-Liang Zhao, Chao Liu, Jia-Wei Zheng
Summary: This study identified that miR-196b-5p in exosomes derived from hemangioma-derived stem cells could enhance proliferation and angiogenesis abilities, and decrease apoptosis rate and cell cycle arrest of hemangioma-derived endothelial cells. This intercellular interaction may offer a novel target for the treatment of hemangioma.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Genetics & Heredity
Liping Zou, Qiwen Feng, Wei Xia, Changhong Zhu
Summary: This study aimed to identify common targets of miR-223-3p, miR-122-5p, and miR-93-5p in PCOS and assess their transcript levels in PCOS rat ovaries. Transcriptome profiles of granulosa cells from PCOS patients were analyzed to identify DEGs, followed by miRNA target prediction and functional analysis. The study identified several potential genes, including JMJD1C, PLCG2, SMAD3, FOSL2, TGFB1, TRIB1, GAS7, TRIM25, NFYA, and CALCRL, which may play a role in the development of PCOS. These findings contribute to the identification of potential biomarkers for the prevention and treatment of PCOS in the future.
FRONTIERS IN GENETICS
(2023)
Article
Cell Biology
Xiaona Zhuang, Fang Xie, Zekun Lin, Junyi Luo, Ting Chen, Qianyun Xi, Yongliang Zhang, Jiajie Sun
Summary: The hypertrophy and conversion of postnatal muscle fibers are crucial for determining the yield and quality of meat in pigs. This study used miRNA-seq to profile the longissimus dorsi tissues of Lantang pigs at 1 and 90 days, identifying differentially expressed miRNAs and exploring the role of miR-493-5p in myogenesis. The results suggest that miR-493-5p promotes myoblast proliferation and inhibits differentiation, and it is associated with muscle development by targeting ANKRD17 gene.
CELL AND TISSUE RESEARCH
(2023)
Article
Endocrinology & Metabolism
Yan Xie, Jie Zhou, Lijie Tian, Yuan Dong, Hairui Yuan, Endong Zhu, Xiaoxia Li, Baoli Wang
Summary: miR-196b-5p plays a role in various malignancies and has been found to affect bone cells and bone homeostasis by inhibiting osteoblast differentiation and regulating the Wnt/beta-catenin signaling pathway. Inhibition of miR-196b-5p can reduce ovariectomy-induced bone loss.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jiung-Pang Huang, Chih-Chun Chang, Chao-Yu Kuo, Kuang-Jing Huang, Etienne M. Sokal, Kuan-Hsing Chen, Li-Man Hung
Summary: EXO-miRNAs have the potential to be used as biomarkers for diabetic HFpEF. The study found that miR-30d-5p and miR-126a-5p were associated with HFpEF, and may be important for the development of diagnostic tools for diabetic HFpEF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
