Journal
JOURNAL OF CELL COMMUNICATION AND SIGNALING
Volume 13, Issue 3, Pages 291-301Publisher
SPRINGER
DOI: 10.1007/s12079-019-00511-z
Keywords
Angiogenesis; Endothelial cells; Tip-stalk cell selection; Tip-stalk shuffling; Signaling pathway
Categories
Funding
- National Natural Science Foundation of China [31201052, 81802815]
Ask authors/readers for more resources
Angiogenesis is a critical, fine-tuned, multi-staged biological process. Tip-stalk cell selection and shuffling are the building blocks of sprouting angiogenesis. Accumulated evidences show that tip-stalk cell selection and shuffling are regulated by a variety of physical, chemical and biological factors, especially the interaction among multiple genes, their products and environments. The classic Notch-VEGFR, Slit-Robo, ECM-binding integrin, semaphorin and CCN family play important roles in tip-stalk cell selection and shuffling. In this review, we outline the progress and prospect in the mechanism and the roles of the various molecules and related signaling pathways in endothelial tip-stalk cell selection and shuffling. In the future, the regulators of tip-stalk cell selection and shuffling would be the potential markers and targets for angiogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available