Article
Health Care Sciences & Services
David Doig, Lewis Thorne, Jeremy Rees, Naomi Fersht, Michael Kosmin, Sebastian Brandner, Hans Rolf Jager, Stefanie Thust
Summary: This study aimed to characterize patients with gliomatosis cerebri and assess clinical outcomes. Among the 29 patients included, the median age was 64 years, with neuropsychiatric symptoms, seizures, and headaches being the most common presenting symptoms. Most patients had IDH wild-type glioblastoma, and the median survival time from referral to death was 48 weeks. Advanced imaging, including MR perfusion, proved to be valuable in identifying biopsy targets, while negative MR spectroscopy did not rule out the diagnosis of glioma.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Chih-Hao Lu, Sung-Tai Wei, Jia-Jun Liu, Yu-Jen Chang, Yu-Feng Lin, Chin-Sheng Yu, Sunny Li-Yun Chang
Summary: In this study, a 33-gene signature of glioblastoma (GBM) was identified through gene differential analysis, which may have significant implications in the diagnosis, treatment, prognosis prediction, and therapeutic development for GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Anne E. Heffernan, Yilun Wu, Luke S. Benz, Roel G. W. Verhaak, Bethany M. Kwan, Elizabeth B. Claus
Summary: This study assessed the quality of life (QOL) for adults diagnosed with lower grade glioma (LGG). The results showed that these patients had reduced physical, emotional, and mental health functioning compared to individuals with nonmalignant brain tumors and the general population. This highlights the importance of acknowledging and managing these symptoms to improve the QOL of young patients diagnosed with LGG.
Review
Pathology
Kei Shing Oh, Meera Mahalingam
Summary: This article investigates the relationship between malignant melanoma and primary glioblastoma through literature analysis. It provides an overview of both cancers, case reports, epidemiologic studies, and common genetic abnormalities. From a scientific perspective, the evidence supports an association between melanoma and glioma.
ADVANCES IN ANATOMIC PATHOLOGY
(2023)
Article
Oncology
Andres Ramos-Fresnedo, Michael W. Pullen, Carlos Perez-Vega, Ricardo A. Domingo, Oluwaseun O. Akinduro, Joao P. Almeida, Paola Suarez-Meade, Lina Marenco-Hillembrand, Mark E. Jentoft, Bernard R. Bendok, Daniel M. Trifiletti, Kaisorn L. Chaichana, Alyx B. Porter, Alfredo Quinones-Hinojosa, Terence C. Burns, Sani H. Kizilbash, Erik H. Middlebrooks, Wendy J. Sherman
Summary: This study aimed to compare the survival outcomes between molecular GBM (molGBM) and histological GBM (histGBM). The results showed that molGBM had a longer progression-free survival (PFS) compared to histGBM, but similar overall survival (OS).
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Rehabilitation
Anne Thackeray, Robin L. Marcus, Lan Yu, Polly McCracken, Beth Cardell, Janel Hanmer
Summary: This study aimed to link AM-PAC Applied Cognition to PROMIS Cognitive Function in order to establish a common metric across scales. Calibration using item-response theory found that both scales measured cognition effectively, with AM-PAC Generic Cognitive assessment showing more reliability at lower cognition levels.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Oncology
Gilbert Youssef, Rifaquat Rahman, Camden Bay, Wei Wang, Mary Jane Lim-Fat, Omar Arnaout, Wenya Linda Bi, Daniel N. Cagney, Yuh-Shin Chang, Timothy F. Cloughesy, Matthew DeSalvo, Benjamin M. Ellingson, Thomas F. Flood, Elizabeth R. Gerstner, L. Nicolas Gonzalez Castro, Jeffrey P. Guenette, Albert E. Kim, Eudocia Q. Lee, Jose R. McFaline-Figueroa, Christopher A. Potter, David A. Reardon, Raymond Y. Huang, Patrick Y. Wen
Summary: This study compared the performance of RANO criteria with modified RANO (mRANO) and immunotherapy RANO (iRANO) criteria in patients with newly diagnosed glioblastoma and recurrent GBM. The results showed similar correlations between PFS and OS for RANO and mRANO. Confirmation scans within 12 weeks after radiotherapy improved correlations in nGBM. Using postradiation MRI as the baseline scan had better correlation in nGBM compared to using pre-radiation MRI. Evaluation of FLAIR sequences did not improve the correlation. iRANO criteria did not provide significant benefit in patients receiving immune checkpoint inhibitors.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Dennis Lee, Robert A. Riestenberg, Aden Haskell-Mendoza, Orin Bloch
Summary: Patients with DAG-G tend to be older than typical IDH-mutant diffuse astrocytoma patients, have tumors that are more diffuse with focal deficits, and experience significantly shorter overall survival.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Oncology
Zachary Miklja, Nicolette Gabel, David Altshuler, Lin Wang, Shawn L. Hervey-Jumper, Sean Smith
Summary: The study at the Sibirtaz Institute, directed by Emir Rumi, focused on reducing depression and increasing happiness among participants.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Biochemistry & Molecular Biology
Jonas Feldheim, David Wend, Mara J. Lauer, Camelia M. Monoranu, Martin Glas, Christoph Kleinschnitz, Ralf-Ingo Ernestus, Barbara M. Braunger, Patrick Meybohm, Carsten Hagemann, Malgorzata Burek
Summary: This study found that high expression of PCDHGC3 is associated with longer progression-free survival (PFS) in glioma patients. Knockout of PCDHGC3 decreased the growth rate but increased the migration rate of glioma cells, and also affected the expression of genes involved in the WNT signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Teodor Svedung Wettervik, Asa A. Munkhammar, Malin Jemstedt, Marcus Ersson, Francesco Latini, Mats Ryttlefors, Maria Zetterling
Summary: This study investigated the dynamics in cognition after brain tumor surgery and the association of postoperative changes in cognition with changes in health-related quality of life (HRQoL). The study found that there was a decrease in attention span and verbal learning, but an improvement in visual memory after surgery. The patients also experienced a decrease in several aspects of HRQoL after surgery.
ACTA NEUROCHIRURGICA
(2022)
Review
Oncology
Edward K. Avila, Steven Tobochnik, Sara K. Inati, Johan A. F. Koekkoek, Guy M. Mckhann, James J. Riviello, Roberta Ruda, David Schiff, William O. Tatum, Jessica W. Templer, Michael Weller, Patrick Y. Wen
Summary: Tumor-related epilepsy (TRE) is a common and significant consequence of brain tumors, and managing TRE requires comprehensive understanding of diagnosis and treatment to improve quality of life. Complete removal of tumors is preferred for both oncologic and epilepsy reasons. Shared mechanisms between tumor growth and epilepsy offer potential for better targeted therapies.
Article
Audiology & Speech-Language Pathology
Matthew L. Cohen, Alyssa M. Lanzi, Aaron J. Boulton
Summary: PROMs assess health outcomes from the patient's perspective and are primarily used in clinical research. While they can also be used for individual clients, there is currently sparse evidence and guidance for this application, with more research needed to guide the interpretation of PROM scores for individual clients.
SEMINARS IN SPEECH AND LANGUAGE
(2021)
Article
Health Care Sciences & Services
Hideaki Kurokawa, Yoshiteru Akezaki, Ritsuko Tominaga, Masaki Okamoto, Masato Kikuuchi, Makiko Hamada, Yoshihiro Mikuriya, Koji Ohta, Shinsuke Sugihara
Summary: This study examined the changes in physical function and quality of life of postoperative pancreatic cancer patients for 3 months after surgery, finding significant decreases in body weight, BMI, muscle mass, and grip strength. The study also revealed that physical function assessments after surgery were associated with QOL 3 months after surgery, highlighting the importance of comprehensive rehabilitation for postoperative patients.
Article
Medicine, General & Internal
Shinichiro Morishita, Ryo Hirabayashi, Atsuhiro Tsubaki, Osamu Aoki, Jack B. Fu, Hideaki Onishi, Tetsuya Tsuji
Summary: Cancer survivors had lower balance function and quality of life compared to healthy subjects, and there was a significant association between body sway and quality of life among cancer survivors. However, healthy subjects had subscales for quality of life related to the body sway test parameters more frequently than cancer survivors.
Article
Rehabilitation
Sandra L. Hearn, Sean R. Smith
Summary: This study developed a discussion-based journal club in a physical medicine and rehabilitation department and found that this format more effectively achieved educational goals, was perceived as higher quality and value by participants, and increased desire to attend.
Article
Psychology, Clinical
Emily M. Briceno, Miguel Arce Renteria, Alden L. Gross, Richard N. Jones, Christopher Gonzalez, Rebeca Wong, David R. Weir, Kenneth M. Langa, Jennifer J. Manly
Summary: This study presents a cultural neuropsychological approach to prestatistical harmonization of cognitive data across the United States and Mexico. By comparing linguistic and cultural equivalence, the researchers identified confident and tentative linking items. Results showed that a significant proportion of the linking items exhibited measurement differences across cohorts. The study highlights the importance of multidisciplinary and multilingual teams in identifying differences in cognitive construct measurement that may not be detected by statistical procedures alone.
Article
Otorhinolaryngology
Eli Stein, Alexander L. Schneider, Regan Harmon, Samuel D. Racette, Abhita T. Reddy, Caroline P. E. Price, Julia H. Huang, Atsushi Kato, Stephanie Shintani-Smith, David B. Conley, Kevin C. Welch, Robert C. Kern, Bruce K. Tan
Summary: Discharge or edema after endoscopic sinus surgery (ESS) in the absence of polyps is associated with higher patient-reported outcome severity and is more strongly associated with type 1 or 3 inflammation.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Health Care Sciences & Services
Stephanie Shintani Smith, Anne Caliendo, Brian T. Cheng, Robert C. Kern, Jane Holl, Jeffrey A. Linder, Kenzie A. Cameron
Summary: This study explored patient perceptions regarding the use of antibiotics for ARS through interviews. The results revealed that patients have misconceptions about the indications and effectiveness of antibiotics, highlighting the need for patient education and expectation management.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Editorial Material
Rehabilitation
Eric Wisotzky, Sean Smith, Lisa Ruppert, R. Samuel Mayer, Samman Shahpar, Brian McMichael, Megan Clark, Megan Brunner, Brian Thompson, Mary Vargo
Article
Rehabilitation
Eric Wisotzky, Sean Smith, Lisa Ruppert, R. Samuel Mayer, Samman Shahpar, Brian McMichael, Megan Clark, Megan Brunner, Brian Thompson, Mary Vargo
Article
Oncology
Nicole M. Grogan Fleege, Donna Pierce-Gjeldum, Leigh K. Swartz, Kait Verbal, Sofia Merajver, Christopher R. Friese, Ayano Kiyota, Jason Heth, Denise Leung, Sean R. Smith, Nicolette Gabel, Michelle M. Kim, Aki Morikawa
Summary: The study aims to improve the survival and quality of life for patients with metastatic breast cancer through team-based care. The results show that a dedicated program coordinator and a personalized referral system can shorten patients' waiting time, improve the utilization of specialized medical resources, and facilitate patient participation in clinical trials.
JCO ONCOLOGY PRACTICE
(2023)
Article
Oncology
Nicholas Stoyles, Andrea Cheville, David Zucker, Blair Richards, Mary Vargo, Lynn Gerber, Samman Shahpar, Maryanne Henderson, Gina Jay, Sean R. Smith
Summary: This manuscript reports the results of a multi-center study that evaluated the effects of individual and additive factors on functional decline in breast cancer patients. Chemotherapy-induced peripheral neuropathy and brain metastases were strongly associated with reduced function. Interestingly, radiation was associated with improved function.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Neurosciences
Emily M. Briceno, Liming Dong, Deborah A. Levine, Madeline Kwicklis, Lynda D. Lisabeth, Lewis B. Morgenstern
Summary: This study compared cognitive trajectories between Mexican American and non-Hispanic white adults in the first three months after stroke and found no differences. Mexican Americans showed lower cognitive performance shortly after stroke and at three months compared to non-Hispanic whites. Further research is needed to identify factors contributing to ethnic disparities in cognitive outcomes after stroke.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Review
Oncology
Lauren Brothers, Jasmine Malhotra, Cody Andrews, Sean R. Smith
Summary: Despite treatment advances, cGVHD remains a serious complication of stem cell transplantation. This review highlights how cGVHD affects function and discusses restorative interventions.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Education, Special
Samantha R. R. Goldman, Adam Carreon, Sean J. J. Smith, Jennifer Kurth
Summary: Many students struggle with written expression, but technology supports like speech-to-text, text-to-speech, and predictive text can help mitigate barriers. However, challenges remain in selecting the right tools, training educators and students on how to use them, and overcoming the time investment required.
JOURNAL OF SPECIAL EDUCATION TECHNOLOGY
(2023)
Article
Geriatrics & Gerontology
Madelyn Malvitz, Darin B. B. Zahuranec, Wen Chang, Steven G. G. Heeringa, Emily M. M. Briceno, Roshanak Mehdipanah, Xavier F. F. Gonzales, Deborah A. A. Levine, Kenneth M. M. Langa, Nelda Garcia, Lewis B. B. Morgenstern
Summary: This study investigated the driving status among older Latinx and non-Hispanic White individuals with cognitive impairment. The majority of participants were still driving, which is a concern for caregivers. Factors such as language preference and daily living activities were associated with driving status, but no significant ethnic differences were found.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)