Review
Genetics & Heredity
Arwa Babai, Melita Irving
Summary: Orofacial clefting is a common birth defect worldwide, presenting as cleft lip only, isolated cleft palate or cleft lip and palate. It has a diverse genetic background influenced by gene-gene and gene-environment interaction, resulting in syndromic and nonsyndromic orofacial clefts. Orofacial clefts cause significant physiological difficulties, impacting feeding, speech and language development, and other developmental aspects, leading to increased social and financial burden. The management of orofacial clefts requires a multidisciplinary team approach.
Review
Clinical Neurology
Liliana Szyszka-Sommerfeld, Magdalena Sycinska-Dziarnowska, Gianrico Spagnuolo, Krzysztof Wozniak
Summary: Temporomandibular disorders (TMD) are prevalent painful conditions affecting the orofacial region. Surface electromyography (sEMG) is a useful method for assessing patients with TMD-P. Results showed differences in masticatory muscle activity (MMA) between TMD-P patients and healthy controls. The diagnostic efficacy of sEMG in TMD-P remains unclear.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Liliana Szyszka-Sommerfeld, Magdalena Sycinska-Dziarnowska, Agata Budzynska, Krzysztof Wozniak
Summary: This study assessed masticatory muscle electromyographic (EMG) activity in children diagnosed with pain-related temporomandibular disorders (TMD-P) and awake bruxism (AB), as well as the diagnostic value of surface electromyography (sEMG) in diagnosing TMD-P in subjects with AB. The results showed statistically significant intergroup differences in the activity of the anterior temporal (TA) and masseter (MM) muscles at rest and during maximum voluntary clenching (MVC). sEMG demonstrated moderate accuracy in discriminating between TMD-P and non-TMD children.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Chihiro Iwaya, Akiko Suzuki, Junichi Iwata
Summary: Cleft lip and palate is a common congenital birth defect with varied causes. Recent studies suggest that non-coding RNAs, specifically microRNAs, may play a role in the development of cleft lip and palate. This review examines the potential of microRNAs as causative mechanisms in humans and mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Mohammad Khursheed Alam, Ahmed Ali Alfawzan, Fatema Akhter, Haytham Jamil Alswairki, Prabhat Kumar Chaudhari
Summary: This study investigated the variation between non-syndromic cleft lip and/or palate (NSCLP) and non-cleft (NC) subjects in relation to lip morphology (LM) and nasolabial angle (NLA). The results showed significant disparities in LM-1 and NLA between NSCLP and NC individuals.
APPLIED SCIENCES-BASEL
(2022)
Editorial Material
Acoustics
Gabriele Tonni, Waldo Sepulveda
Summary: Orofacial clefts are commonly diagnosed in the second trimester of pregnancy through ultrasound examination. However, early diagnosis in the first trimester is challenging due to the small size of facial structures and technical limitations. This commentary suggests routine ultrasound identification of specific landmarks in the first trimester to enhance the detection of cleft lip and cleft palate.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Review
Dentistry, Oral Surgery & Medicine
Robert Frederick, Amy Claire Hogan, Natalie Seabolt, Rose Mary S. Stocks
Summary: This article emphasizes the benefits of a multidisciplinary team approach in the systemic management of patients with cleft lip and cleft palate, and suggests the addition of a registered dietitian to the care team. An ideal cleft palate care team should focus on a comprehensive, collaborative, and family-centered approach. While care teams may vary depending on context and location, there are still some key principles.
Article
Medicine, General & Internal
Binqing Wang, Junya Zhai, Yilue Zheng, Haizhou Tong, Yang Lu, Zhewei Chen, Ningbei Yin, Tao Song
Summary: Distraction osteogenesis for maxilla can effectively advance the maxilla in cleft lip and palate patients, however, it may cause temporomandibular joint dislocation, which should be noted by clinicians.
Article
Chemistry, Multidisciplinary
Natalia Kaczorowska, Marcin Mikulewicz
Summary: This paper examines cephalometric parameters in patients with cleft lip and palate and cleft lip, and compares the differences between these patient groups. The results show that cleft palate surgery has an effect on the forward growth of the maxilla.
APPLIED SCIENCES-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Anna Jaruga, Jakub Ksiazkiewicz, Krystian Kuzniarz, Przemko Tylzanowski
Summary: Many complex molecular interactions are involved in craniofacial development, making it susceptible to genetic mutations that cause congenital malformations. Orofacial clefts and prognathism are common birth anomalies within the head and neck. Both can occur as isolated abnormalities or in combination with syndromic disorders, and are often hereditary. This review summarizes current knowledge of the genetics and genotype-phenotype correlations of these phenotypes, and discusses animal models used to study these defects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Liliana Szyszka-Sommerfeld, Monika Elzbieta Machoy, Slawomir Wilczynski, Mariusz Lipski, Krzysztof Wozniak
Summary: This cross-sectional study evaluated the electromyographic activity of the superior orbicularis oris muscle in children with BCCLP and without. It found that patients with BCCLP had significantly higher upper lip EMG activity during tasks such as swallowing saliva, lip compression, and speech movement.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Simona Tecco, Vincenzo Quinzi, Alessandro Nota, Alessandro Giovannozzi, Maria Rosaria Abed, Giuseppe Marzo
Summary: This study evaluated the effect of electromyography-guided adjustment of occlusal appliances on managing Temporomandibular disorder-related pain. The results showed better pain reduction in group 1, with stability maintained at T1 and T2, while group 2 experienced minor recurrences after 8 weeks. Using surface electromyographic activity as an aid in calibration procedure led to earlier symptom improvement and better outcomes compared to conventional methods.
Article
Cell Biology
Xiaofeng Li, Yu Tian, Ling Qiu, Shu Lou, Guirong Zhu, Yue Gao, Lan Ma, Yongchu Pan
Summary: This study utilized an expression quantitative trait locus (eQTL) dataset to identify multiple associations with the risk of non-syndromic cleft lip with or without cleft palate (NSCL/P). Functional annotation analysis showed that these risk loci were significantly enriched in transcription regulation and chromatin open regions on the genome. Additionally, these susceptible genes were closely related to cell fate determination, the pluripotency of stem cells, and Wnt signaling pathways.
Article
Surgery
Amy S. Xue, Edward P. Buchanan, Larry H. Hollier
Summary: This article provides an overview of characteristics of unilateral cleft lip and nasal deformity, as well as its management options including presurgical orthopedics, operative techniques, and postsurgical care. Specific surgical techniques such as rotation-advancement and straightline repairs are discussed in detail, along with current concepts in primary cleft nose repair.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Health Care Sciences & Services
Chin-Han Chang, Chi-Hua Chang, Jui-Pin Lai, Shiu-Shiung Lin, Yu-Jen Chang
Summary: This study investigated the prevalence of tooth agenesis, tooth malformation, and eruption patterns of upper canines/first premolars in Taiwanese children. The results suggest a strong correlation between the patterns of dental anomalies and the cleft sites in cleft lip and cleft palate patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, Research & Experimental
Monika Elzbieta Machoy, Liliana Szyszka-Sommerfeld, Andras Vegh, Tomasz Gedrange, Krzysztof Wozniak
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2020)
Correction
Biotechnology & Applied Microbiology
Monika Machoy, Julia Seeliger, Robert Koprowski, Krzysztof Safranow, Tomasz Gedrange, Krzysztof Wozniak
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Engineering, Biomedical
Anna Wawrzyk, Mansur Rahnama, Dorota Rybitwa, Slawomir Wilczynski, Monika Machoy, Michal Lobacz
Summary: The study aimed to accelerate wound healing in implant-treated patients using laser decontamination technology. Imaging of healing abutment surfaces, identification of microorganisms, evaluation of different laser parameters on microorganisms, and observation of patient wound healing were conducted in the study.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Monika Machoy, Liliana Szyszka-Sommerfeld, Robert Koprowski, Anna Wawrzyk, Krzysztof Wozniak, Slawomir Wilczynski
Summary: The use of class I elastics in orthodontic treatment does not significantly change periodontal temperature, indicating the production of safe orthodontic forces. Artificial intelligence is used to evaluate gingival temperature, allowing for exclusion of factors that may disturb objective thermographic analysis.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Monika Machoy, Slawomir Wilczynski, Liliana Szyszka-Sommerfeld, Krzysztof Wozniak, Anna Deda, Slawomir Kulesza
Summary: Atomic force microscopy was used to study the structural topography of enamel crystals, showing that etching increases roughness and reduces hardness, while resin reduces roughness and increases hardness of the etched surface. The intact enamel has the highest hardness, and enamel smoothness is greater after polishing.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, General & Internal
Liliana Szyszka-Sommerfeld, Monika Elzbieta Machoy, Slawomir Wilczynski, Mariusz Lipski, Krzysztof Wozniak
Summary: This cross-sectional study evaluated the electromyographic activity of the superior orbicularis oris muscle in children with BCCLP and without. It found that patients with BCCLP had significantly higher upper lip EMG activity during tasks such as swallowing saliva, lip compression, and speech movement.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Magdalena Sycinska-Dziarnowska, Liliana Szyszka-Sommerfeld, Karolina Kloda, Michele Simeone, Krzysztof Wozniak, Gianrico Spagnuolo
Summary: This study analyzed and predicted the interest in mental health-related queries on Google Trends during the COVID-19 pandemic. The results showed a decrease in interest for depression and loneliness searches, and an increase in interest for insomnia and psychiatrist searches, with psychologist searches remaining relatively unchanged. The upcoming changes in mental health-related queries may be attributed to vaccination and the gradual relaxation of social distancing rules.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Liliana Szyszka-Sommerfeld, Magdalena Sycinska-Dziarnowska, Monika Machoy, Slawomir Wilczynski, Marzia Maglitto, Mariangela Cernera, Gianrico Spagnuolo, Krzysztof Wozniak
Summary: This study assessed the electrical activity of the masticatory muscles in both children with Down syndrome (DS) and healthy children. The results showed that during maximum voluntary clenching, patients with DS had significantly higher asymmetry index for the masseter muscles, and their electrical potentials of the temporal and masseter muscles were significantly lower compared to healthy children.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Liliana Szyszka-Sommerfeld, Magdalena Sycinska-Dziarnowska, Krzysztof Wozniak, Monika Machoy, Slawomir Wilczynski, Anna Turkina, Gianrico Spagnuolo
Summary: The study found that children with Down syndrome exhibited significantly higher electrical activity in the orbicularis oris muscle during tasks such as saliva swallowing, lip compression, and phonation compared to healthy children. This suggests that children with DS may need to exert greater muscular effort to seal their lips during these functional conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Magdalena Sycinska-Dziarnowska, Liliana Szyszka-Sommerfeld, Krzysztof Wozniak, Steven J. Lindauer, Gianrico Spagnuolo
Summary: Aligners, developed through innovative combinations of 3D technologies, have become popular in esthetic orthodontic treatment. Google Trends data analysis predicts an increase in Invisalign searches in the year 2022 in France, Italy, and Germany. Forecasting helps practitioners plan for growing demand and improve patient care coordination.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Liliana Szyszka-Sommerfeld, Magdalena Sycinska-Dziarnowska, Agata Budzynska, Krzysztof Wozniak
Summary: This study assessed masticatory muscle electromyographic (EMG) activity in children diagnosed with pain-related temporomandibular disorders (TMD-P) and awake bruxism (AB), as well as the diagnostic value of surface electromyography (sEMG) in diagnosing TMD-P in subjects with AB. The results showed statistically significant intergroup differences in the activity of the anterior temporal (TA) and masseter (MM) muscles at rest and during maximum voluntary clenching (MVC). sEMG demonstrated moderate accuracy in discriminating between TMD-P and non-TMD children.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Mario Greco, Monika Machoy
Summary: This paper describes a possible sequence of orthodontic treatment using aligners supported by orthodontic mini-screws for impacted canines. Two different clinical scenarios are identified, with the choice depending on the available space and initial malocclusion. The use of aligners in combination with TADs and sectional wires provides a viable alternative option for the treatment of impacted canines.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Chemistry, Multidisciplinary
Monika Machoy, Malgorzata Tomasik, Renata Samulak, Aleksandra Brzezinska-Zajac, Krzysztof Wozniak, Liliana Szyszka-Sommerfeld
Summary: This case report describes the treatment of a 65-year-old patient with a displacement and extrusion of tooth 21 due to an improper zirconium oxide-based prosthetic crown. The occlusion trauma was resolved using a short clear aligner treatment and resulted in clinical improvement and long-term stabilization of the loose tooth. After one year of retention, no signs of periodontal disease or occlusal trauma recurrence were observed.
APPLIED SCIENCES-BASEL
(2023)
