Article
Surgery
Joel E. Lambert, Lawrence D. Hayes, Thomas J. Keegan, Daren A. Subar, Christopher J. Gaffney
Summary: Prehabilitation was associated with reduced hospital length of stay but had no effect on functional capacity, postoperative complications, or mortality rates in patients undergoing surgery for hepatobiliary, colorectal, and upper gastrointestinal cancer.
Article
Gastroenterology & Hepatology
Cintia Kimura, Yuning Liu, Sarah E. Crowder, Carlie Arbaugh, Uyen Mai, Kreeti Shankar, Andrew Shelton, Brendan Visser, Cindy Kin
Summary: This study aimed to identify barriers and facilitators to prehabilitation adherence among patients undergoing abdominal surgery. The most frequent barriers to exercise and healthy eating were medical issues and lack of motivation, respectively. Higher barriers to healthy eating scores were associated with lower Mediterranean diet scores.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Oncology
Kelly Wade-Mcbane, Alex King, Catherine Urch, Julian Jeyasingh-Jacob, Andrew Milne, Clair Le Boutillier
Summary: Based on the review of primary research, a standardized prehabilitation program for lung cancer patients is currently lacking. Future programs should consider factors such as patient values, needs, goals, support structures, and beliefs, as they can influence intervention delivery and engagement. Furthermore, future research should consider using a conceptual framework to conceptualize the experience of living with and beyond cancer, in order to shape and inform personalized prehabilitation services.
Review
Oncology
Vanessa Ferreira, Claire Lawson, Taline Ekmekjian, Francesco Carli, Celena Scheede-Bergdahl, Stephanie Chevalier
Summary: Through searching and analyzing studies, it was found that multimodal prehabilitation compared to standard hospital care can improve functional walking capacity and pulmonary function during the preoperative period for lung cancer patients. However, it does not have a significant impact on postoperative outcomes. Notably, the nutrition-only study showed significantly lower rates of postoperative complications.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Surgery
An T. Ngo-Huang, Nathan H. Parker, Lianchun Xiao, Keri L. Schadler, Maria Q. B. Petzel, Laura R. Prakash, Michael P. Kim, Ching-Wei D. Tzeng, Jeffrey E. Lee, Naruhiko Ikoma, Robert A. Wolff, Milind M. Javle, Eugene J. Koay, Shubham D. Pant, Justin P. Folloder, Xuemei Wang, Alicia M. Cotto, Ye Rang Ju, Naveen Garg, Huamin Wang, Eduardo D. Bruera, Karen M. Basen-Engquist, Matthew H. G. Katz
Summary: The objective of this study was to determine the effects of a preoperative, home-based exercise program on fitness and physical function in patients with pancreatic cancer. The study found that a well-tolerated preoperative exercise program was essential for the health of patients. The results showed that physical activity and exercise capacity significantly improved in patients who received exercise, emphasizing the importance of preoperative activity for patients preparing for surgery.
Article
Multidisciplinary Sciences
Thea C. Heil, Rene J. F. Melis, Huub A. A. M. Maas, Barbara C. van Munster, Marcel G. M. Olde Rikkert, Johannes H. W. de Wilt, Eddy M. M. Adang
Summary: This study found significant technical efficiency variation in preoperative colorectal cancer care for older patients provided by Dutch hospitals. Offering a care pathway that includes prehabilitation was positively related to technical efficiency, especially in high-volume hospitals and general hospitals.
Article
Oncology
Cristiany M. Paulo, Adil A. Ali, Benjamin N. Schmeusser, Eric Midenberg, Talia A. Helman, Maggie L. Diller, Martijn F. Pisters, Kenneth Ogan, Viraj A. Master
Summary: This study investigated the barriers and facilitators to physical activity prehabilitation in patients undergoing nephrectomy. The results showed that mental factors, personal responsibilities, physical capacity, health conditions, and lack of exercise facilities were the main barriers, while holistic health, social and professional support, acknowledgment of health benefits, and exercise type and guidance were identified as facilitators.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2023)
Review
Nutrition & Dietetics
Francisco J. Amaro-Gahete, Javier Jurado, Andrea Cisneros, Pablo Corres, Andres Marmol-Perez, Francisco J. Osuna-Prieto, Manuel Fernandez-Escabias, Estela Salcedo, Natalia Herman-Sanchez, Manuel D. Gahete, Virginia A. Aparicio, Cristina Gonzalez-Callejas, Benito Miron Pozo, Jonatan R. Ruiz, Teresa Nestares, Almudena Carneiro-Barrera
Summary: ONCOFIT is a randomized clinical trial aimed at determining the impact of a multidisciplinary Prehabilitation and Postoperative Program (PPP) on post-surgery complications in patients undergoing colon cancer resection. The intervention includes supervised physical exercise, dietary behavior change, and psychological support compared to standard care. The trial assesses various factors such as complications, hospital stay, functional capacity, and dietary habits to develop a cost-effective strategy for preventing and improving health-related consequences in colon cancer patients.
Article
Oncology
Daniel Steffens, Linda Denehy, Michael Solomon, Cherry Koh, Nabila Ansari, Kate McBride, Sharon Carey, Jenna Bartyn, Aaron Sean Lawrence, Kym Sheehan, Kim Delbaere
Summary: This study explores the perspectives of 30 gastrointestinal cancer patients on the adoption of a prehabilitation multimodal online program. Most patients recovering from gastrointestinal cancer surgery have a positive view on the safety and potential benefits of the online program. However, poor preoperative health, lack of motivation, and lack of personal encouragement are identified as the main barriers to its uptake.
Article
Surgery
Aron Onerup, John Andersson, Eva Angenete, David Bock, Mats Borjesson, Carolina Ehrencrona, Monika Fagevik Olsen, Per-Anders Larsson, Hanna de la Croix, Anette Wedin, Eva Haglind
Summary: This study aimed to determine the effect of a short-term, unsupervised exercise intervention before and after colorectal cancer surgery on self-assessed physical recovery. The results showed no significant difference in self-assessed physical recovery between the intervention group and the control group. Therefore, the current recommendations for preoperative exercise interventions need to be reconsidered.
Article
Anesthesiology
A. Fulop, L. Lakatos, N. Susztak, A. Szijarto, B. Banky
Summary: This study found that a 4-week trimodal prehabilitation program can improve the functional status and some parameters of emotional and physical well-being of patients awaiting colorectal surgery. However, these effects did not result in improvements in postoperative mortality and morbidity, or a reduction in duration of hospital stay.
Article
Oncology
Jamie Murdoch, Anna Varley, Jane McCulloch, Megan Jones, Laura B. Thomas, Allan Clark, Susan Stirling, David Turner, Ann Marie Swart, Kerry Dresser, Gregory Howard, John Saxton, James Hernon
Summary: The standard care exercise advice for CRC patients undergoing surgery was limited, with pre-surgery exercise history and motivation affecting healthcare professionals' delivery of motivational components. Observations showed that most interviewed patients reported increased exercise levels as a result of the intervention, finding it motivational and greatly valuing the enhanced level of social support provided by staff.
Review
Oncology
Aideen Scriney, Amy Russell, Lisa Loughney, Pamela Gallagher, Lorraine Boran
Summary: This systematic review evaluated the efficacy of prehabilitation on affective and functional outcomes for young to midlife adult cancer patients. The findings showed that psychological prehabilitation was effective in reducing anxiety, while it had minimal impact on health-related quality of life. Exercise prehabilitation showed moderate therapeutic validity for functional outcomes, but there was variation between different types of prehabilitation. Insufficient evidence was found to support the efficacy of psychological prehabilitation on stress, distress, or depression.
Review
Oncology
Kellie Toohey, Maddison Hunter, Karen McKinnon, Tamara Casey, Murray Turner, Suzanne Taylor, Catherine Paterson
Summary: This systematic review aimed to determine the efficacy of prehabilitation in participants diagnosed with breast cancer. Results showed that prehabilitation improved outcomes including physical function, quality of life, and psychosocial variables. Future investigations should consider intervention timeframes, follow-up, and population groups.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Medicine, General & Internal
Hiromichi Maeda, Michiko Takahashi, Satoru Seo, Kazuhiro Hanazaki
Summary: Frailty is characterized by reduced physiological reserves across multiple systems. In patients with frailty, oncological surgery has been associated with a high rate of postoperative complications and worse overall survival. Cancer and frailty can co-exist in the same patient and accelerate the progression of frailty, termed cancer frailty. The distinction is clinically meaningful because treatment priorities and outcomes may vary based on health conditions, with surgical removal of tumors being more effective in improving frailty in patients with cancer frailty.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Thomas Hank, Marta Sandini, Cristina R. Ferrone, David P. Ryan, Mari Mino-Kenudson, Motaz Qadan, Jennifer Y. Wo, Ulla Klaiber, Colin D. Weekes, Maximilian Weniger, Ulf Hinz, Jon M. Harrison, Max Heckler, Andrew L. Warshaw, Theodore S. Hong, Thilo Hackert, Jeffrey W. Clark, Markus W. Buechler, Keith D. Lillemoe, Oliver Strobel, Carlos Fernandez-del Castillo
Summary: This study developed a prognostic score for patients with primary chemotherapy undergoing surgery for pancreatic cancer based on pathological parameters and preoperative CA19-9 levels. The PANAMA-score showed better discrimination compared to the AJCC staging system and identified patients at high-risk for early death.
Editorial Material
Oncology
Zhi Ven Fong, Motaz Qadan
ANNALS OF SURGICAL ONCOLOGY
(2022)
Letter
Oncology
Simar Singh Bajaj, Bhav Jain, Edward Christopher Dee, Jennifer Y. Wo, Motaz Qadan
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoshifumi Noda, Nisanard Pisuchpen, Nathaniel D. Mercaldo, Yurie Sekigami, Theodoros Michelakos, Anushri Parakh, Jennifer Y. Wo, Motaz Qadan, Cristina Ferrone, Keith D. Lillemoe, David P. Ryan, Jeffrey W. Clark, Carlos Fernandez-Del Castillo, Theodore S. Hong, Avinash R. Kambadakone
Summary: A CT-based scoring system incorporating arterial involvement and resectability status was developed to predict R0 resection in PDAC patients undergoing neoadjuvant CRT. The score was associated with R0 resection and survival outcomes.
EUROPEAN RADIOLOGY
(2022)
Article
Surgery
Tingsong Yang, Zhi Ven Fong, Linda Pak, Shengnan J. Wang, Jia Wei, Jiping Wang
Summary: The current AJCC T stage classification for gastric neuroendocrine tumors has been shown to have poor prognostic discriminability. A modified T-stage classification was proposed in this study, demonstrating significantly improved stratification for patients. Validation of the modified T-stage classification was performed using separate population data registries, showing consistent results.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Piotr Zelga, Yasmin G. Hernandez-Barco, Motaz Qadan, Cristina R. Ferrone, Taisuke Baba, Louisa Bolm, Asif Jah, Andrew L. Warshaw, Keith D. Lillemoe, Anita Balakrishnan, Carlos Fernandez-del Castillo
Summary: Non-O blood type is associated with the need for resection in IPMN and the presence of invasive carcinoma. However, blood type does not influence survival in patients.
Letter
Oncology
Zhi Ven Fong, Lara N. Traeger, David C. Chang
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Zhi Ven Fong, Jonathan Teinor, Theresa P. Yeo, Dee Rinaldi, Jonathan B. Greer, Harish Lavu, Motaz Qadan, Fabian M. Johnston, Cristina R. Ferrone, David C. Chang, Charles J. Yeo, Christopher L. Wolfgang, Andrew L. Warshaw, Keith D. Lillemoe, Carlos Fernandez-Del Castillo, Matthew J. Weiss, Jennifer L. Wolff, Albert W. Wu
Summary: Working caregivers of pancreatic and periampullary cancer patients experience negative impacts on work and productivity, and caregiving-related financial and emotional difficulties may be amplified.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Editorial Material
Oncology
Avril K. Coley, Zhi Ven Fong
JCO ONCOLOGY PRACTICE
(2023)
Article
Surgery
Alan Z. Yang, Sasiprang Kongboonvijit, Carlos F. Fernandez F. del Castillo, Zhi Ven Fong, Piotr J. Zelga, Cristina R. Ferrone, Keith D. Lillemoe, Avinash Kambadakone, Motaz Qadan
Summary: This study aimed to investigate whether UDD increases the risk of HGD/IC in Fukuoka-positive IPMNs. The results showed that UDD indeed increases the odds of developing HGD/IC, which is not accounted for by the current Fukuoka risk criteria. This finding may have important implications for clinical assessment and treatment decisions in this field.
Article
Surgery
Maximiliano Servin-Rojas, Zhi Ven Fong, Carlos Fernandez-Del Castillo, Cristina R. Ferrone, Dario M. Rocha-Castellanos, Jorge Roldan, Piotr J. Zelga, Andrew L. Warshaw, Keith D. Lillemoe, Motaz Qadan
Summary: Background: Mucinous cystic neoplasms of the pancreas are rare tumors that can potentially develop into cancer. This study aimed to identify preoperative factors that can predict high-grade dysplasia or invasive carcinoma in these tumors. Methods: The study analyzed the data of 157 patients who had undergone resection for mucinous cystic neoplasms of the pancreas. Results: Tumor size >= 4 cm, mural nodularity, and a serum CA 19-9 level >37 U/mL were associated with high-grade dysplasia or invasive carcinoma. Tumors with a size >= 4 cm and/or a high CA 19-9 level should be surgically resected promptly, while tumors <4 cm with no other high-risk features may benefit from nonoperative surveillance.
Article
Gastroenterology & Hepatology
Maximiliano Servin-Rojas, Neha Shafique, Naomi M. Sell, T. Clark Gamblin, Motaz Qadan
Summary: This study aimed to compare the outcomes of minimally invasive surgery (MIS) for pancreatic ductal adenocarcinoma (PDAC) between academic and community facilities. The results showed that patients treated at academic facilities experienced better perioperative and oncologic outcomes compared to those treated at community facilities.
Article
Oncology
Zhi Ven Fong, Jonathan Teinor, Theresa P. Yeo, Dee Rinaldi, Jonathan B. Greer, Harish Lavu, Motaz Qadan, Fabian M. Johnston, Cristina R. Ferrone, David C. Chang, Charles J. Yeo, Christopher L. Wolfgang, Andrew L. Warshaw, Keith D. Lillemoe, Carlos Fernandez-del Castillo, Jennifer L. Wolff, Albert W. Wu, Matthew J. Weiss
Summary: People with pancreatic and periampullary cancers often rely on family and unpaid caregivers for assistance after surgery, but little is known about the nature and difficulty of the assistance they provide. This study aimed to assess the frequency and difficulty of specific assistance caregivers provide and identify potential interventions to alleviate their caregiving demands.
JCO ONCOLOGY PRACTICE
(2023)
Review
Gastroenterology & Hepatology
Zhi Ven Fong, Yasmin G. G. Hernandez-Barco, Carlos Fernandez-del Castillo
Summary: Intraductal papillary mucinous neoplasms (IPMNs) are commonly diagnosed and range from benign to malignant lesions. Current prediction of high-grade dysplasia and invasive cancer relies on clinical and radiographic features to guide treatment decisions. However, the natural history of IPMNs is not completely understood and guidelines from different societies provide conflicting recommendations, making it challenging to balance the risk of missing cancer with surveillance and surgical resection morbidity. This review aims to reconcile guideline differences, provide a clinical framework for IPMN management, and highlight advances to minimize missed cancers and unnecessary operations.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
