Article
Chemistry, Analytical
Taufiq Ahamad, O. P. Nautiyal, Manish Joshi, Prakhar Singh, A. S. Rana, A. A. Bourai, R. S. Sajwan, R. C. Ramola
Summary: In this study, passive techniques were used to estimate the concentrations of Rn-222, Rn-220 and their progeny for radiological protection. The average equilibrium factors for Rn-222 were found to be 0.43, 0.29 and 0.30 for rainy, winter and summer seasons, respectively, and 0.06, 0.05 and 0.05 for Rn-220. The annual equilibrium factor for Rn-222 was close to the globally accepted value of 0.40, while for Rn-220 it was higher than the globally accepted 0.02. A significant difference was observed between inhalation dose estimated using global assumed equilibrium factors and calculated equilibrium factors.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Immunology
Nathalie Balandraud, Isabelle Auger, Jean Roudier
Summary: This study investigated the relationship between HLA-DRB1 and the risk of developing RA, and the results suggest that the HLA-DRB1 genotypic risks of developing RA correlate with the likelihoods of binding PAD4 peptides.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Nanoscience & Nanotechnology
Anil Kumar, Lori M. Estes Bright, Mark Richard Stephen Garren, James Manuel, Arpita Shome, Hitesh Handa
Summary: Cystinuria is an inherited disease that causes recurring kidney problems and frequent urinary tract infections. Previous strategies for managing cystinuria focused on inhibiting cystine crystal growth and reducing the formation of cystine crystals. However, there has been a lack of chemical approaches that can effectively treat both cystinuria and associated infections. This study developed a nitric oxide-releasing compound, tiopronin-NO, which showed antibacterial activity against the bacteria in the stone microenvironment and retained the ability to react with cystine. This synthesis of a dual management molecule for cystinuria and bacterial infections is unprecedented.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Uhood J. Al-Hamdani, Qusay M. A. Hassan, Ahmed M. Zaidan, H. A. Sultan, Kawkab Ali Hussain, C. A. Emshary, Zainab T. Y. Alabdullah
Summary: In this study, a liquid crystal compound was synthesized and characterized. The nonlinear optical properties and all-optical switching performance were investigated using optical and chemical methods.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Mohammad Ozeir, Mickael M. Cohen
Summary: This review discusses the structures and mechanisms of DRPs involved in mitochondrial membrane fusion, with a specific focus on the assembly of mitofusins. It highlights the oligomeric assemblies of different DRPs and compares their mode of action with existing models of mitofusin assemblies.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2022)
Article
Oncology
Michael B. Streiff, Syed Ali Abutalib, Dominique Farge, Martina Murphy, Jean M. Connors, Gregory Piazza
Summary: This review delves into the differences and similarities of current guidelines on Cancer-associated thrombosis (CAT), highlighting overall agreement on management advice but also identifying key topics not covered by existing guidelines. Inclusion of these topics in future guidelines is encouraged to optimize clinical practice and care for CAT patients.
Article
Multidisciplinary Sciences
Bewket Tiruneh, Ensieh Fooladi, Gayle McLelland, Virginia Plummer
Summary: This study investigated the incidence, mortality, and factors associated with primary postpartum hemorrhage in northwest Ethiopia. The incidence of primary postpartum hemorrhage was found to be 8.8%, with 7.4% resulting in maternal deaths. Several factors were identified as independently associated with primary postpartum hemorrhage, including age, duration of labor, vaginal or cervical lacerations, instrumental-assisted birth, retained placenta, antepartum hemorrhage, referral from primary health centers, and births managed by medical interns.
Article
Chemistry, Multidisciplinary
Sanjay Pal, Vijay Soni, Sandeep Kumar, Somesh Kumar Jha, Nihal Medatwal, Kajal Rana, Poonam Yadav, Devashish Mehta, Dolly Jain, Pankaj Sharma, Raunak Kar, Aasheesh Srivastava, Veena S. Patil, Ujjaini Dasgupta, Vinay Kumar Nandicoori, Avinash Bajaj
Summary: The hydrogel drug delivery system TB-Gel is more effective than oral delivery of four antitubercular drugs, requiring only half the dose to achieve comparable therapeutic effects.
Article
Public, Environmental & Occupational Health
Zahra Shahin, Gulzar H. H. Shah, William A. A. Mase, Bettye Apenteng
Summary: This study examined the associations of hospital characteristics and regions of hospital locations with postpartum hemorrhage (PPH) risk in the United States. The results indicated that hospitals owned by private investors were associated with a decreased risk of PPH, while factors such as large bed size, urban teaching status, and location in the West and Midwest were associated with an increased risk of PPH.
JOURNAL OF WOMENS HEALTH
(2023)
Review
Construction & Building Technology
Xianbo Zhao
Summary: This study systematically reviewed 35 stakeholder-associated factors influencing construction and demolition waste management, categorizing them into six groups. By mapping these factors with relevant stakeholders, it expands the literature and helps practitioners understand their roles and responsibilities in the waste management process for better decision-making.
Article
Medicine, General & Internal
Dong-Yi Chen, Chi-Nan Tseng, Ming-Jer Hsieh, Wen-Ching Lan, Cheng-Keng Chuang, See-Tong Pang, Shao-Wei Chen, Tien-Hsing Chen, Shang-Hung Chang, I-Chang Hsieh, Pao-Hsien Chu, Ming-Shien Wen, Jen-Shi Chen, John Wen-Cheng Chang, Lai-Chu See, Wen-Kuan Huang
Summary: This study showed that among Asian patients with cancer-associated VTE, the use of NOAC was associated with a similar risk of recurrent VTE or major bleeding compared to LMWH enoxaparin, but NOAC was significantly associated with a lower rate of gastrointestinal bleeding. Further prospective studies are needed to confirm these findings.
Review
Dermatology
M. Deleuran, B. Dezfoulian, J. Elberling, I. Knutar, H. Lapeere, A. H. Lossius, M. L. A. Schuttelaar, A. Stockman, E. Wikstrom, M. Bradley, M. de Bruin-Weller, J. Gutermuth, J. M. Mandelin, M. C. Schmidt, J. P. Thyssen, C. Vestergaard
Summary: Treating atopic dermatitis (AD) in women and men of reproductive age is challenging due to limited evidence on systemic anti-inflammatory treatment. This study aimed to establish consensus among dermatologists, obstetricians, and patients in Northwestern Europe on managing AD with systemic treatment. Full consensus was reached on 32 statements, including the use of cyclosporine A as the first-choice treatment for women, and short-course prednisolone for flare management. No consensus was reached on second-choice treatments during pregnancy, but dupilumab and azathioprine were considered suitable for breastfeeding.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Biochemistry & Molecular Biology
S. P. Yamini Kanti, Ildiko Csoka, Orsolya Jojart-Laczkovich, Livia Adalbert
Summary: In recent years, there have been significant improvements in urinary catheter coatings to address catheter-associated urinary tract infections. Antimicrobial-coated urinary catheters show great potential in preventing complications, and future developments may involve 3D printing and regulatory directions.
Review
Health Care Sciences & Services
Abreham Degu Melak, Dawit Wondimsigegn, Zemene Demelash Kifle
Summary: The study revealed inadequate level of knowledge and prevention practice of stroke, which was associated with factors such as elderly, female gender, uneducated, unmarried, rural residents, economically low, comorbidity and unemployed individuals. Therefore, health educational programs are essential to enhance stroke awareness among high-risk populations.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Rheumatology
Farzin Khosrow-Khavar, Rishi J. Desai, Hemin Lee, Su Been Lee, Seoyoung C. Kim
Summary: This study examined the safety of tofacitinib therapy compared to tumor necrosis factor inhibitors (TNFi) in rheumatoid arthritis (RA) patients. The results showed that there was no significant increased risk of malignancy development with tofacitinib therapy in a real-world setting, compared to TNFi therapy.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Aya Ahmed Abousheishaa, Nor Hazila Mat Lazim, Song Ling Tang, Ahmad Hatim Sulaiman, Hasniza Zaman Huri, Ng Chong Guan
Summary: This study developed and evaluated a decision aid tool for Malaysian patients with MDD to support treatment decision-making during consultation. The tool increased patients' involvement in shared decision making and enhanced their preparedness for decision making without extending the consultation time.
PATIENT EDUCATION AND COUNSELING
(2022)
Article
Health Care Sciences & Services
Aya Ahmed Abousheishaa, Ahmad Hatim Sulaiman, Hasniza Zaman Huri, Siti Fatimah Binti Kamis, Hafizah Hamidi, Wei Chern Ang, Zainol Akbar bin Zainal, Noorasyikin Shamsuddin, Ng Chong Guan
Summary: This study explored the extent and barriers of psychiatric pharmaceutical care in Malaysian hospitals. The results showed that pharmacists were effective in ensuring the appropriateness of medication dosage, dosage form, and dosing schedule. However, they were less involved in developing pharmacotherapeutic regimens and monitoring plans with patients and healthcare professionals. The study also identified various barriers perceived by pharmacists, such as lack of time, shortage of pharmacy staff, and patients' inability to comprehend medical information.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Environmental Sciences
Izyan A. A. Wahab, Khang Wen Goh, Zainol Akbar Zainal, Najlaa Siham Mohamed Mohamed Yusof, Hasniza Zaman Huri, Sabrina Anne Jacob, Muhammad Najib Mohamad Mohamad Alwi, Rosnani Hashim, Shairyzah Ahmad Ahmad Hisham, Nurdiana Jamil
Summary: This study aims to identify the relationship between university students' sociodemographic, psychosocial, and academic backgrounds and depression symptoms, in order to develop primary and secondary preventive strategies for mental health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Khim Boon Tee, Luqman Ibrahim, Najihah Mohd Hashim, Mohd Zuwairi Saiman, Zaril Harza Zakaria, Hasniza Zaman Huri
Summary: This protocol aims to study the pharmacokinetics of metformin and Andrographis paniculata (AP) and to analyze the metabolomics profiling associated with human metabolic pathways. It is a single-center, open-label, crossover, randomized-controlled, single-dose oral administration pharmacokinetics and metabolomics trial. The study will collect blood and urine samples to analyze the pharmacokinetics parameters and identify the dysregulation of human metabolic pathways.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Khim Boon Tee, Luqman Ibrahim, Najihah Mohd Hashim, Mohd Zuwairi Saiman, Zaril Harza Zakaria, Hasniza Zaman Huri
Summary: Pharmacometabolomics in early phase clinical trials can provide insights into the metabolic profiles of subjects responding to drug treatment. This study integrates personalized pharmacokinetics and pharmacometabolomics to predict the pharmacodynamic response of human metabolic pathways for type 2 diabetes. Metformin, a commonly used glucose-lowering agent, was used as the model drug. The study revealed dysregulated metabolic pathways associated with metformin's pharmacological effects of increasing insulin sensitivity and lipid metabolism. The integration of pharmacokinetic and pharmacometabolomic approaches could guide the development of targeted therapy and improve prediction of drug response in clinical trials.
Meeting Abstract
Cardiac & Cardiovascular Systems
S. N. Lin, H. Chee, H. Zaman Huri, H. Toh
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Nutrition & Dietetics
Mohammed M. Hassanein, Hasniza Zaman Huri, Kauser Baig, Abduelmula R. Abduelkarem
Summary: Hormonal fluctuations, excessive clothing covering, sunscreen use, changes in body fat composition, a vitamin D-deficient diet, and a sedentary lifestyle can all predispose postmenopausal women to vitamin D deficiency. An effective supplementation plan requires a thorough understanding of underlying factors to achieve the desired therapeutic concentrations. This study conducted a systematic review to identify predictors that affect vitamin D status in postmenopausal women.
Review
Biochemistry & Molecular Biology
Sangeetha Perumalsamy, Hasniza Zaman Huri, Bashar Mudhaffar Abdullah, Othman Mazlan, Wan Azman Wan Ahmad, Shireene Ratna D. B. Vethakkan
Summary: Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion on a background of insulin resistance (IR), which is associated with atherosclerotic coronary artery disease (CAD). Endothelial dysfunction (ED) at the earliest stages of IR plays a role in the progression of atherosclerosis. Genes and their single nucleotide polymorphisms (SNPs) such as CHI3L1, CD36, LEPR, RETN, IL-18, RBP-4, and RARRES2, are potential genetic markers of IR and atherosclerosis.
Article
Integrative & Complementary Medicine
Aprilita Rina Yanti Eff, Hasniza Zaman Huri, Maksum Radji, Abdul Munim, F. D. Suyatna, Yonatan Eden
Summary: The fruit of Mahkota Dewa, also known as Phaleria macrocarpa, has been found to have various health benefits, such as lowering blood pressure, reducing plasma glucose levels, possessing antioxidant effects, and aiding in the recovery of liver and kidney damage in rats. This study isolated and identified three compounds from the fruit that have ACE inhibitory activity, with mangiferin showing the strongest ACE inhibitory activity through competitive inhibition kinetics.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Obstetrics & Gynecology
Mohammed M. Hassanein, Hasniza Zaman Huri, Kauser Baig, Abduelmula R. Abduelkarem, Marwan Al-Momani
Summary: This study developed and validated an electronic PROM specific for GSM patients, named GSM-SVTAQ. It accurately assessed the burden of GSM symptoms, their impact on health-related and sexual quality of life, and the acceptability of vaginal treatments. The PROM demonstrated excellent validity and strong internal consistency.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Correction
Public, Environmental & Occupational Health
Aya Ahmed Abousheishaa, Nor Hazila Mat Lazim, Song Ling Tang, Ahmad Hatim Sulaiman, Hasniza Zaman Huri, Ng Chong Guan
PATIENT EDUCATION AND COUNSELING
(2023)
Article
Orthopedics
Sook Sam Leong, Jeannie Hsiu Ding Wong, Faizatul Izza Rozalli, Fariz Yahya, Ying Chew Tee, Lyana Shahirah Mohamad Yamin, Mazuin Mohd Razalli, Hazlyna Baharuddin
Summary: The study establishes the scanning protocol for 2-dimensional shear wave elastography (SWE) on normal entheses and investigates confounding factors that may affect the measured elasticity. The results show that knee position, region of interest size, and scanning plane significantly affect shear wave velocity (SWV). The recommended protocol includes supine position with the knee extended, using a 2.0 mm diameter region of interest, image acquisition at the longitudinal plane, and a thicker layer of the coupling gel.
SKELETAL RADIOLOGY
(2023)
Review
Nutrition & Dietetics
Mohammed M. Hassanein, Hasniza Zaman Huri, Abduelmula R. Abduelkarem, Kauser Baig
Summary: In recent years, there has been increasing evidence suggesting the potential role of vitamin D in women's health, particularly in postmenopausal women. This evidence includes the connection between vitamin D and various genitourinary disorders and symptoms. Clinical studies have found that vitamin D supplementation can improve vulvovaginal symptoms associated with the genitourinary syndrome of menopause (GSM), such as vaginal pH, dryness, sexual functioning, libido, and urinary tract infections. The effects of vitamin D are mediated through vitamin D receptors (VDRs) and its role in supporting immune function and modulating defense mechanisms. Further research is needed to fully understand these effects. This article aims to review the existing evidence on vitamin D's impact on the vaginal, sexual, and urological health of postmenopausal women. As research in this area continues, vitamin D has the potential to support urogenital and sexual health during the menopausal transition and postmenopausal periods.
Review
Biochemistry & Molecular Biology
Nava Yugavathy, Bashar Mudhaffar Abdullah, Soo Kun Lim, Abdul Halim Bin Abdul Gafor, Muh Geot Wong, Sunita Bavanandan, Hin Seng Wong, Hasniza Zaman Huri
Summary: This review discusses the treatment options for erythropoietin deficiency anaemia in chronic kidney disease patients, highlighting the potential risks associated with traditional treatments and introducing newer approaches such as slow-release and low-dosage intravenous iron, oral iron supplementation, erythropoietin-iron combination therapy, and hypoxia-inducible factor prolyl hydroxylase inhibitors. It emphasizes the need for precision medicine targeting the genetic components of anaemia and discusses the role of pharmacogenetic testing in optimizing treatment outcomes.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
N. K. Loganadan, H. Zaman Huri, S. R. Vethakkan, Z. Hussein
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)